Binding of Isaac: Rebirth Wiki

Added in Afterbirth

For a list of all zodiac signs, see Signs of the Zodiac.

Zodiac is an unlockable passive item added in The Binding of Isaac: Afterbirth.


  • Gives Isaac a random Zodiac item effect that changes each floor.


  • Getting Capricorn Capricorn, Cancer Cancer and Libra Libra does not grant coins, bombs, keys or Soul Hearts. Leo Leo will not change Isaac's size.
  • If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Capricorn Capricorn giving an additional +0.5 damage, and Gemini Gemini giving another familiar.

In-game Footage


  • This item's appearance is a reference to the Zodiac Killer, who used the symbol as his signature.
  • {{This item's icon shares the same icon as Marked Marked but white instead of red.


PC Normal and hard modes only ZXMH RH2C (Treasure Room adjacent to spawn)