Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth

For a list of all zodiac signs, see Signs of the Zodiac.

Zodiac is an unlockable passive item added in The Binding of Isaac: Afterbirth.


  • Gives Isaac a random Zodiac item effect that changes each floor.


  • Getting 15►Capricorn Capricorn, 15►Cancer Cancer and 15►Libra Libra does not grant coins, bombs, keys or Soul Hearts.
  • Removed in Repentance Getting 15►Leo Leo will not change Isaac's size.
  • If already in possession of the item given by Zodiac, most have no effect. The only exceptions are 15►Capricorn Capricorn giving an additional +0.5 damage, and 15►Gemini Gemini giving another familiar.
  • Added in Repentance Getting 15►Virgo Virgo does not provide the 15►PHD PHD effect for the floor it is obtained. It does grant the chance to trigger a protective shield on taking damage however.

In-game Footage[]


  • This item's appearance is a reference to the Zodiac Killer, who used the symbol as his signature.
  • This item's icon used to share the almost same icon as 15►Marked Marked but white instead of red.


PC Normal and hard modes only ZXMH RH2C (Treasure Room adjacent to spawn)