For a list of all zodiac signs, see Signs of the Zodiac.
Zodiac is an unlockable passive item added in The Binding of Isaac: Afterbirth.
- Gives Isaac a random Zodiac item effect that changes each floor.
- Getting Capricorn, Cancer and Libra does not grant coins, bombs, keys or Soul Hearts.
- Getting Leo will not change Isaac's size.
- If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Capricorn giving an additional +0.5 damage, and Gemini giving another familiar.
- Getting Virgo does not provide the PHD effect for the floor it is obtained. It does grant the chance to trigger a protective shield on taking damage however.
- This item's appearance is a reference to the Zodiac Killer, who used the symbol as his signature.
- This item's icon used to share the almost same icon as Marked but white instead of red.
PC ZXMH RH2C (Treasure Room adjacent to spawn)