Binding of Isaac: Rebirth Wiki

(except in Rebirth)

For a list of all zodiac signs, see Signs of the Zodiac.

Zodiac is an unlockable passive item added in The Binding of Isaac: Afterbirth.

Effects[ | ]

  • Gives Isaac a random Zodiac item effect that changes each floor.

Notes[ | ]

  • Getting Collectible Capricorn iconCapricorn, Collectible Cancer iconCancer and Collectible Libra iconLibra does not grant PennyCoins, BombBombs, KeyKeys or Soul HeartSoul Hearts.
  • (except in Repentance) Getting Collectible Leo iconLeo will not change Isaac's size.
  • If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Collectible Capricorn iconCapricorn giving an additional +0.5 damage, and Collectible Gemini iconGemini giving another familiar.
  • (in Repentance) Getting Collectible Virgo iconVirgo does not provide the Collectible PHD iconPHD effect for the floor it is obtained. It does grant the chance to trigger a protective shield on taking damage however.

In-game Footage[ | ]

Trivia[ | ]

  • This item's appearance is a reference to the Zodiac Killer, who used the symbol as his signature.
  • This item's icon used to share the almost same icon as Collectible Marked iconMarked but white instead of red.