For a list of all zodiac signs, see Signs of the Zodiac.
Effects[edit | edit source]
- Gives Isaac a random Zodiac item effect that changes each floor.
Notes[edit | edit source]
- Getting Capricorn, Cancer and Libra does not grant coins, bombs, keys or Soul Hearts. Leo will not change Isaac's size.
- If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Capricorn giving an additional +0.5 damage, and Gemini giving another familiar.
In-game Footage[edit | edit source]
Trivia[edit | edit source]
- This item's appearance is a reference to the Zodiac Killer, who used the symbol as his signature.
- This item's icon shares the almost same icon as Marked but white instead of red.
Seeds[edit | edit source]
|The Lost Unlocks|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|