Binding of Isaac: Rebirth Wiki

Added in Afterbirth

For a list of all zodiac signs, see Signs of the Zodiac.

Zodiac is an unlockable passive item added in The Binding of Isaac: Afterbirth.


  • Gives Isaac a random Zodiac item effect that changes each floor.


  • Getting Capricorn Capricorn, Cancer Cancer and Libra Libra does not grant Penny Coins, Bomb Bombs, Key Keys or Soul Heart Soul Hearts.
  • Removed in Repentance Getting Leo Leo will not change Isaac's size.
  • If already in possession of the item given by Zodiac, most have no effect. The only exceptions are Capricorn Capricorn giving an additional +0.5 damage, and Gemini Gemini giving another familiar.
  • Added in Repentance Getting Virgo Virgo does not provide the PHD PHD effect for the floor it is obtained. It does grant the chance to trigger a protective shield on taking damage however.

In-game Footage[]


  • This item's appearance is a reference to the Zodiac Killer, who used the symbol as his signature.
  • This item's icon used to share the almost same icon as Marked Marked but white instead of red.


PC Normal and hard modes only ZXMH RH2C (Treasure Room adjacent to spawn)