|Guppy||Beelzebub||Super Bum||Yes Mother?||Bob||Fun Guy||Leviathan||Conjoined|
|Spun||Seraphim||Oh Crap||Bookworm||Spider Baby||Adult||Stompy|
Isaac turns into his mom after picking up any three distinct items in the following list. In this form, Isaac gains a stationary Mom's Knife that trails behind Isaac as he moves, dealing 2x Isaac's tear damage on contact. The knife synergizes like Mom's Knife would.
|Mom's Bottle of Pills||5.100.102||Reusable pill generator||Gives Isaac a random pill.||1|
|Mom's Bra||5.100.39||Mass paralysis||Petrifies all enemies in the current room for around 4 seconds.||1|
|Mom's Pad||5.100.41||Mass fear||Inflicts fear to all enemies in the room for 5 seconds.||0|
|Mom's Box||5.100.439||What's inside?||Increases Luck by 1 and doubles the effects of trinkets while held. When used, drops a random trinket on the ground.||3|
|Mom's Shovel||5.100.552||Lost but not forgotten||Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in Dark Room.||4|
|Mom's Bracelet||5.100.604||Mother's strength||Lets Isaac pick up and throw rocks, TNT, poops, and other obstacles.||2|
|Mom's Coin Purse||5.100.195||What's all this...?||Spawns 4 random pills near Isaac.||1|
|Mom's Contacts||5.100.110||Freeze effect||+0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking.||3|
|Mom's Eye||5.100.55||Eye in the back of your head||Gives Isaac a chance to fire tears from the back of his head.||1|
|Mom's Eyeshadow||5.100.200||Charm tears||Tears have a chance to charm enemies.||1|
|Mom's Heels||5.100.30||Range up||+5.25 range, +0.5 tear height. Enemies that touch Isaac take 12 damage.||1|
|Mom's Key||5.100.199||Better chest loot +2 keys||Adds 2 keys. Chests will drop additional pickups.||3|
|Mom's Knife||5.100.114||Stab stab stab||Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.||4|
|Mom's Lipstick||5.100.31||Range up||+5.25 range, +0.5 tear height. Spawns one random heart.||1|
|Mom's Perfume||5.100.228||Fear shot + tears up||Adds a chance to shoot fear tears and decreases tear delay by 1.||2|
|Mom's Purse||5.100.139||More trinket room||Allows Isaac to hold 1 additional trinket.||3|
|Mom's Underwear||5.100.29||Range up||+5.25 range, +0.5 tear height. Spawns 3-6 Blue Flies on pickup.||1|
|Mom's Wig||5.100.217||You feel itchy...||Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.||3|
|Mom's Pearls||5.100.355||Range + luck up||+1.25 range, +0.5 tear height, +1 luck. Grants one Soul Heart.||2|
|Mom's Razor||5.100.508||It's sharp!||Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.||1|
- This is a reference to the horror film Psycho.
- Mom's Box does not count towards this transformation even though it has the name "Mom" in it.
- Mom's Box now counts towards this transformation.
- The Yes Mother? transformation resembles the original Flash costume for Mom's Knife.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|