Due to the floors being much bigger, it makes important rooms like Treasure Rooms and Shops take significantly longer to find, which can make the run difficult if Isaac has rather weak items. It also makes Secret and Super Secret Rooms much harder to find. Although all floors are technically XL, there is only one treasure and boss room on each floor. On the plus side, since there are more rooms, there are more opportunities to generate pickup items.
Teleportation cards, such as The Stars and The Hermit, are very valuable, as they allow easy access to Special Rooms. The Emperor is especially powerful, as it can be used to skip the entirety of a floor.
Avoid items that teleport Isaac at random, such as Cursed Skull, as they can significantly slow down progress by potentially teleporting him to the other side of the map. Picking up the Cursed Eye is not recommended for the same reasons.
This page was last edited on 20 March 2020, at 03:02.
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