Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Whore of Babylon is a passive item.


  • Increases damage by 1.5 and speed by 0.3 while Isaac has half of a red heart or less.
  • Eve Eve starts with this item by default, and has the following extra effects:
    • The item is activated at one red heart or less.
    • Her damage multiplier increases from 0.75 to 1.0 when active.


  • The effect is removed after leaving a room with more than half a heart (more than one full heart for Eve Eve).
  • The effect may not be immediately applied if Isaac has lost red hearts without taking damage; the effect will activate upon entering a new room.
  • The effect is always active for characters without heart containers, such as ??? ??? and The Lost The Lost, though other characters can also lose their heart containers through Devil deals or items like Guppy's Paw Guppy's Paw or Abaddon Abaddon.
  • III - The Empress III - The Empress grants a similar effect to Whore of Babylon for the current room which does stack with Whore of Babylon.
    • Stacking The Empress on Whore of Babylon either via multiple cards or multiple activations of Blank Card Blank Card increases damage by the number of uses squared, e.g. +1.5 * 2 * 2 total damage bonus for using the card on top of activated Whore of Babylon.
  • Upon obtaining the Whore of Babylon effect, a popup displaying the text "What a horrible night to have a curse" appears on-screen. This can be disabled in the game options.
  • As a Rotten Heart counts as a full heart of health, it is impossible to activate Whore of Babylon without getting rid of Isaac's Rotten Hearts beforehand (unless playing as Eve).
  • Added in Afterbirth As Keeper Keeper cannot have half of a health coin, this item creates no effect on him.
  • Added in Afterbirth † If the player has acquired any, the effect will be applied at one half full Bone Heart.
  • Synergizes with self damaging items that ignore soul/black hearts such as Added in RepentanceBlood Oath Blood Oath, IV Bag IV Bag, Razor Blade Razor Blade, and Sharp Plug Sharp Plug.


In-game Footage[]