Binding of Isaac: Rebirth Wiki
When   Life   Gives   You   Lemons
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Table dividing line 1.png
Challenge Number
Starting Items
9 Volt 9 Volt
Habit Habit
Lemon Mishap Lemon Mishap
1 Lemon Party pill
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom portrait.png

When Life Gives You Lemons is Challenge #12. Start off with Lemon Mishap Lemon Mishap, 9 Volt 9 Volt, Habit Habit and 1 Lemon Party pill. The goal is to defeat Mom Mom. This challenge is available by default. Treasure rooms are not present.


The lack of Treasure Room Treasure Rooms makes the challenge more difficult than a normal run.


  • Lemon Mishap has a small range, making it difficult to use. The Habit and 9 Volt will allow more frequent uses of it but their combination is more important than that. Because every run starts with 9 Volt, any activated item obtained will take less time to recharge. The Habit makes taking damage charge it faster as well. The only catch would be finding a better activated collectible.
  • The Added in Afterbirth †Lost Cork Lost Cork is an extremely beneficial trinket in this run, expanding the area of Lemon Mishap and thus making it safer to use since Isaac doesn't need to be as close to the enemy.
  • A good item to find is Shoop Da Whoop! Shoop Da Whoop!, simply for being usable every room because of 9 Volt.



  • The challenge name is a reference to the proverbial phrase "When life gives you lemons, make lemonade."
  • One of the Fortune Telling Machine.png Fortune Telling Machine's fortunes is "When life gives you lemons, reroll!"