Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
When   Life   Gives   You   Lemons
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Table dividing line 1.png
Challenge Number
Starting Items
15►9 Volt 9 Volt
15►Habit Habit
15►Lemon Mishap Lemon Mishap
1 Lemon Party pill
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom.png

When Life Gives You Lemons is Challenge #12. Start off with 15►Lemon Mishap Lemon Mishap, 15►9 Volt 9 Volt, 15►Habit Habit and 1 Lemon Party pill. The goal is to defeat Mom. This Challenge is available by default. Treasure rooms are not present.


The lack of Treasure Rooms makes the challenge more difficult than a normal run.


  • Lemon Mishap has a small range, making it difficult to use. The Habit and 9 Volt will allow more frequent uses of it but their combination is more important than that. Because every run starts with 9 Volt, any activated item obtained will take less time to recharge. The Habit makes taking damage charge it faster as well. The only catch would be finding a better activated collectible.
  • The Added in Afterbirth †Lost Cork Lost Cork is an extremely beneficial trinket in this run, expanding the area of Lemon Mishap and thus making it safer to use since Isaac doesn't need to be as close to the enemy.
  • A good item to find is 15►Shoop Da Whoop! Shoop Da Whoop!, simply for being usable every room because of 9 Volt.



  • The challenge name is a reference to the proverbial phrase "When life gives you lemons, make lemonade."
  • One of the fortune teller's fortunes is "When life gives you lemons, reroll!"

MainPageChallenges.png Challenges MainPageChallenges.png

1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
8. Cat Got Your Tongue 9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards
15. Slow Roll 16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
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