Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Virgo is a passive Zodiac item.


  • Grants a chance to trigger the Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds.
    • The activation chance depends on the luck stat and goes up to 100% with 10 Luck.
  • Converts all negative pills into positive ones, but does not identify them.


  • The shield negates health loss from Blood Donation Machines and Devil Beggars.
  • Does not prevent Red Heart container loss from Devil Room deals.
  • Bad pills already obtained/dropped will be converted to their "good" counterpart.
  • As bad pills will turn into good pills, it is possible for two different colored pills to have the same effect.


  • Added in RepentanceCeltic Cross Celtic Cross, The Polaroid The Polaroid: Can trigger as the same time as Celtic Cross or The Polaroid, cumulating to up to 22 seconds of shield.


  • Added in RepentanceFalse PHD False PHD: Pills can be both good and bad again. Taking bad pills still applies the benefits from False PHD.

In-game Footage[]


PC K0TA K2ZC (Treasure Room adjacent to spawn)

PC QWNA GPLP (Treasure Room adjacent to spawn)

PS4 6N2H LQ49 (Treasure Room adjacent to spawn)

Vita HEAJ 1T43 (Treasure Room adjacent to spawn)

Switch Greed mode only GF08 T1GR (First Golden Treasure Room)