Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Varicose Veins is a passive item added in The Binding of Isaac: Afterbirth †.


  • When Isaac gets hit, 10 tears are fired in a circle around him (similar to Tammy's Head Tammy's Head).
    • Tears spawned on hit have a +25 damage bonus.
  • When Isaac gets hit, has a chance to activate the Anemic Anemic effect for 2 seconds.
    • The effect doesn't seem affected by luck.


  • 20/20 20/20 / The Inner Eye The Inner Eye / Mutant Spider Mutant Spider: No effect. When Isaac gets damaged, only ten tears will be fired.
  • Apple! Apple!: Each tear has a chance to fire the razor tear.
  • Azazel Azazel: Fires ten short-ranged brimstone beams in a circle.
  • Anti-Gravity Anti-Gravity: No effect.
  • Chocolate Milk Chocolate Milk: Fires ten minimally charged tears. Damage of tears is reduced slightly.
  • Dr. Fetus Dr. Fetus: Taking damage releases 10 bombs around Isaac, which often leads to taking damage again.
  • Epic Fetus Epic Fetus: Fires ten normal tears when taking damage.
  • Added in RepentanceEye of the Occult Eye of the Occult: Tears are controllable.
  • Added in RepentanceIt Hurts It Hurts: Two rings of tears are released at once.
  • The Ludovico Technique The Ludovico Technique: No effect.
  • Marked Marked: No effect.
  • Monstro's Lung Monstro's Lung: Fires ten red tears when taking damage. No other effects.
  • Added in RepentancePlaydough Cookie Playdough Cookie: Each one of the 10 tears spawned on hit has one of the available random effects applied to it.
  • Soy Milk Soy Milk: Fires ten tiny tears when taking damage. Tear damage is only slightly reduced.
  • Tainted Azazel Tainted Azazel: Fires ten brimstone beams in a circle. These beams do not have the damage penalty T. Azazel's attacks have, and can be further boosted by his Added in RepentanceHemoptysis Hemoptysis sneeze.
  • Tech X Tech X: No effect.
  • Technology Technology: Fires ten lasers in a circle.
  • Tractor Beam Tractor Beam: No effect.

In-game Footage[]


  • Varicose veins is a medical condition where veins (typically on the extremities) become swollen and more visible. They can also cause aching pain or discomfort.


PC Hard mode only B88V GJVN (Treasure Room adjacent to spawn)

Switch Greedier mode only HA1R GPTA (First Golden Treasure Room)