Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
[edit]

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Anarchist Cookbook 5.100.65
Anarchist Cookbook
3 rooms
Summon bombs Spawns six Troll Bombs around the room. 1
Blank Card 5.100.286
Blank Card
Variable
Card mimic Removed in Repentance Has the same effect as the card or rune currently held by Isaac.
Added in Repentance Has the same effect as the card currently held by Isaac.
2
Book of Secrets 5.100.287
Book of Secrets
6 rooms
Tome of knowledge Gives the effect of 15►Treasure Map Treasure Map, 15►The Compass The Compass, or 15►Blue Map Blue Map for the duration of the current floor. 0
Box of Spiders 5.100.288
Box of Spiders
2 rooms
It's a box of spiders Removed in Repentance Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.
Added in Repentance Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
1
Breath of Life 5.100.326
Breath of Life
6 seconds
Invincibility at a cost Grants a brief moment of invincibility when the charge bar hits zero. If the spacebar is held for an additional second after hitting zero, Isaac will take damage. 0
Butter Bean 5.100.294
Butter Bean
3 seconds
Reusable knock-back Upon use, Isaac farts and knocks back nearby enemies Added in Afterbirth and projectiles. Added in Repentance Enemies pushed into walls or obstacles take 12 damage. 0
Crack the Sky 5.100.160
Crack the Sky
4 rooms
Holy white death Summons 5 beams of light in random locations on the ground, dealing large amounts of damage to any enemies that touch them. 2
Crystal Ball 5.100.158
Crystal Ball
6 rooms
I see my future Upon use, reveals the map (except the Super Secret Room) and drops a Soul Heart or random card/rune. 2
D100 5.100.283
D100
6 rooms
REEROLLLLL! Removed in Repentance Combines the effects of 15►D4 D4, 15►The D6 The D6, and 15►D20 D20.
Added in Repentance Combines the effects of 15►D1 D1, 15►D4 D4, 15►The D6 The D6, 15►D7 D7, 15►D8 D8, 15►D10 D10, 15►D12 D12, and 15►D20 D20.
3
Mom's Pad 5.100.41
Mom's Pad
3 rooms
Mass fear Inflicts fear to all enemies in the room for 5 seconds. 0
Monstro's Tooth 5.100.86
Monstro's Tooth
3 rooms
Summon Monstro A friendly Monstro jumps on a random enemy, dealing 120 area damage. Lands on Isaac if used in a room without enemies. 1
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
Temporary badass Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies. 1
Unicorn Stump 5.100.298
Unicorn Stump
1 rooms
You feel stumped Gives invulnerability and increased speed for five seconds, but removes the ability to shoot tears. 1
White Pony 5.100.181
White Pony
2 rooms
Flight + holy death Passively gives flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge and dealing 40 damage while also casting the effect of Crack the Sky. 2

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to 15►Forever Alone Forever Alone for the current room dealing Removed in Repentance75 Added in Repentance150 damage per second. 0
Breakfast 5.100.25 Breakfast HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Bucket of Lard 5.100.129 Bucket of Lard HP up Grants two Removed in Repentanceempty Added in Repentancefull Red Heart containers and heals Isaac by half a Red Heart, but decreases speed by 0.2. 1
Caffeine Pill 5.100.340 Caffeine Pill Speed up + size down Grants +0.3 speed, reduces character size, and gives a random pill. 1
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac. 0
Cursed Eye 5.100.316 Cursed Eye Cursed charge shot Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room. 0
Daddy Longlegs 5.100.170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. 3
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight. 3
Distant Admiration 5.100.57 Distant Admiration Attack fly Spawns an attack fly that circles further out than 15►Halo of Flies Halo of Flies, but closer than 15►Forever Alone Forever Alone, dealing 75 damage per second. 2
Epic Fetus 5.100.168 Epic Fetus On-demand air strike Isaac's tears are replaced with guided missiles, like those used by the 15►Doctor's Remote Doctor's Remote. 4
Ghost Baby 5.100.163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears. 1
Guillotine 5.100.206 Guillotine DMG + tears up. An out-of-body experience! Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay. 3
Headless Baby 5.100.269 Headless Baby Bloody friend Spawns a familiar that follows Isaac, leaving blood creep on the ground. 1
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Lazarus' Rags 5.100.332 Lazarus' Rags Eternal life? Upon dying, resurrect as Lazarus Risen Lazarus Risen with one heart container and Anemic. 1
Lil Haunt 5.100.277 Lil Haunt Fear him Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. 1
Lost Contact 5.100.213 Lost Contact Shielded tears Isaac's tears can hit and destroy enemy projectiles. -0.16 shot speed. 2
Mom's Eye 5.100.55 Mom's Eye Eye in the back of your head Allows Isaac to fire tears from the back of his head. 1
My Reflection 5.100.5 My Reflection Boomerang tears Gives Isaac's tears a boomerang effect. +1.5 range, +1 tear height, x1.6 shot speed multiplier. 0
PHD 5.100.75 PHD Better pills Converts all bad pills into good pills, spawns one pill pickup, and identifies all pills. Restores two Red Hearts and increases the payout of Blood Donation Machines. 2
Polyphemus 5.100.169 Polyphemus Mega tears Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, the tear travels on with any leftover damage. 4
Robo-Baby 5.100.95 Robo-Baby Friends 'till the bbbbzzzt Spawns a familiar that shoots 15►Technology Technology lasers. 1
Speed Ball 5.100.143 Speed Ball Speed + shot speed up +0.3 speed, +0.2 shot speed. 2
The Inner Eye 5.100.2 The Inner Eye Triple shot Grants triple shot but decreases tears. 2
The Ludovico Technique 5.100.329 The Ludovico Technique Controlled tears Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. 3
The Pact 5.100.80 The Pact DMG + tears up Grants two Removed in RepentanceSoul Hearts Added in RepentanceBlack Hearts, +0.5 damage, and +0.7 tears. 3
The Peeper 5.100.155 The Peeper Plop! Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through. 0
The Polaroid 5.100.327 The Polaroid Fate chosen If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into Chest Chest. Added in Repentance Also allows access to Home Home. 2
There's Options 5.100.249 There's Options More options Two items spawn after defeating a boss. Only one can be taken; the other will disappear. 3

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Book of Shadows 5.100.58
Book of Shadows
3 rooms
Temporary invincibility Creates a protective shield, nullifying all types of damage for 10 seconds. 2
Doctor's Remote 5.100.47
Doctor's Remote
2 rooms
Reusable air strike Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion. 1
Flush! 5.100.291
Flush!
4 rooms
... Turns all non-boss monsters in the room into poop. Instantly kills poop-themed bosses. 1
Forget Me Now 5.100.127
Forget Me Now
One time use
I don't remember... On use, re-generates the current floor with a new layout. Isaac loses Forget Me Now, but keeps other items and consumables picked up on the original floor. 3
Head of Krampus 5.100.293
Head of Krampus
3 rooms
Krampus rage Fires a powerful 15►Brimstone Brimstone beam in four cardinal directions, much like Krampus shoots.

Added in Afterbirth / Removed in Afterbirth † Fires a powerful 15►Brimstone Brimstone beam in four cardinal directions, much like Krampus shoots with a 50% chance to rotate all beams around Isaac 90 degrees.

2
How to Jump 5.100.282
How to Jump
Unlimited
It's time you learned how Upon use, Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies. 1
Mr. Boom 5.100.37
Mr. Boom
2 rooms
Reusable bomb buddy Places a Mr. Mega bomb that deals 110 damage. 1
Notched Axe 5.100.147
Notched Axe
Unlimited
Rocks don't stand a chance Removed in Repentance Isaac destroys obstacles and opens Secret Rooms by walking into them, but cannot shoot or pick up items until it's cancelled.

Added in Repentance Toggles between tears and the pickaxe, which can be swung to attack and break obstacles. Using it depletes the charge, and it can't be used until next floor once the charge runs out.

0
Razor Blade 5.100.126
Razor Blade
Unlimited
Feel my pain On use, takes one heart of health and grants +1.2 damage for the current room. 0
Scissors 5.100.325
Scissors
4 rooms
Lose your head Removed in Repentance Turns Isaac's head into a stationary familiar for the current room which fires tears automatically.

Added in Repentance Turns Isaac's head into a stationary familiar for the current room which fires tears automatically, while causing Isaac to shoot a controllable fountain of blood shots.

0
Spider Butt 5.100.171
Spider Butt
2 rooms
Mass enemy slowdown + damage Deals 10 damage to all enemies in the room and slows them for 4 seconds. 1
The Gamekid 5.100.93
The Gamekid
4 rooms
Temporary Man-Pac Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed. 2
The Nail 5.100.83
The Nail
6 rooms
Temporary demon form Gives Removed in Repentance one Soul Heart Added in Repentance half a Black Heart. For the current room; +0.7 damage, -0.18 speed, allows Isaac to break rocks and damage enemies by walking over them. 3
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
Cut and run Gives flight for the current room, while turning Isaac's body into a fast, high damage familiar. 3

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
A Quarter 5.100.74 A Quarter +25 coins Gives Isaac 25 coins. 2
Ankh 5.100.161 Ankh Eternal life? Upon death, the player will respawn as ??? ??? with 3 Soul Hearts. 2
Bogo Bombs 5.100.250 Bogo Bombs 1+1 BOOM! All Bomb pickups become Double Bombs. 1
Bomb Bag 5.100.131 Bomb Bag Gives bombs Spawns a familiar that drops a bomb every 3 rooms. 2
Boom! 5.100.19 Boom! 10 bombs Grants 10 bombs. 0
Cupid's Arrow 5.100.48 Cupid's Arrow Piercing shots Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them. 3
Death's Touch 5.100.237 Death's Touch Piercing shots + DMG up +1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes. 3
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering 15►The Necronomicon The Necronomicon effect. 3
Hot Bombs 5.100.256 Hot Bombs Burning blast +5 bombs Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact. 1
Iron Bar 5.100.201 Iron Bar DMG up + concussive tears Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly. 3
Match Book 5.100.344 Match Book Evil up Grants Isaac one Black Heart, spawns two or three Bombs. 1
Mom's Knife 5.100.114 Mom's Knife Stab stab stab Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power. 4
Mr. Mega 5.100.106 Mr. Mega Bigger boom Grants 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage. 2
Old Bandage 5.100.219 Old Bandage HP up Grants an empty Red Heart container. Adds a chance of dropping a Red Heart after taking damage. 2
Pyro 5.100.190 Pyro 99 bombs Grants 99 bombs. 3
Robo-Baby 2.0 5.100.267 Robo-Baby 2.0 We worked out all the kinks Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 0
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots. 3
Sad Bombs 5.100.220 Sad Bombs Tear blasts +5 bombs +5 Bombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers. 3
Safety Pin 5.100.339 Safety Pin Evil + range + shot speed up Grants one Black Heart, +5.25 range, +0.5 tear height, +0.16 shot speed. 1
Screw 5.100.255 Screw Tears + shot speed up +0.5 tears, +0.2 shot speed. 3
Sharp Plug 5.100.205 Sharp Plug Infinite charge... at a cost Damages Isaac in exchange for fully recharging Isaac's current activated item. 1
Skeleton Key 5.100.17 Skeleton Key 99 keys Gives Isaac 99 keys. 3
Spelunker Hat 5.100.91 Spelunker Hat See-through doors Reveals type of adjacent rooms, including location for Secret Rooms and Super Secret Rooms. 2
Spoon Bender 5.100.3 Spoon Bender Homing shots Grants Isaac homing tears. 3
Synthoil 5.100.345 Synthoil DMG + range up +1 damage, +5.25 range, +0.5 tear height. 3
Tech.5 5.100.244 Tech.5 It's still being tested... Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets. 3
Technology 5.100.68 Technology Laser tears Replaces tears with a piercing laser with unlimited range. 3
Technology 2 5.100.152 Technology 2 Extra laser Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously. 2
The Battery 5.100.63 The Battery Stores energy Activated collectibles can be "overcharged" to allow for an additional use. 2
The Small Rock 5.100.90 The Small Rock DMG up Increases damage by 1, increases tears by 0.2, and decreases speed by 0.2. 3
Tiny Planet 5.100.233 Tiny Planet Orbiting tears + range up Range up and makes shot tears revolve around Isaac until they drop. 0
Torn Photo 5.100.341 Torn Photo Tears + shot speed up +0.7 tears, +0.16 shot speed. 3
Tough Love 5.100.150 Tough Love Tooth shot Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears. 3

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Guppy's Head 5.100.145
Guppy's Head
1 rooms
Reusable fly hive Spawns 2-4 friendly Blue Flies that damage enemies. 3
Guppy's Paw 5.100.133
Guppy's Paw
Unlimited
Soul converter Upon use, converts one Heart Container into three Soul Hearts. 3
Kamikaze! 5.100.40
Kamikaze!
Unlimited
Become the bomb! Upon use, creates an explosion in the same place as Isaac, damaging him for half a heart of health and dealing Removed in Repentance40 damage/Added in Repentance185 damage to all enemies caught in the blast. 0
Satanic Bible 5.100.292
Satanic Bible
6 rooms
Reusable evil... but at what cost? Gives one Black Heart. Added in Repentance Replaces the boss room item on the current floor with a Devil deal. 4
The Book of Belial 5.100.34
The Book of Belial
3 rooms
Temporary DMG up +2 damage for the current room.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Added in Afterbirth Increases the chance by 12.5%.
3
The Book of Sin 5.100.97
The Book of Sin
4 rooms
Reusable item generator Spawns a random pickup, pill, card, or trinket. 2
The Jar 5.100.290
The Jar
Unlimited
Save your life When at full health, up to 4 extra Red Hearts can be stored in The Jar. 0

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
20/20 5.100.245 20/20 Double shot Isaac fires two tears at once, one from each eye. 4
9 Volt 5.100.116 9 Volt Quicker charge Reduces the charge of any activated item by 1. Any 1 charge items instead have timed recharges. 2
A Lump of Coal 5.100.132 A Lump of Coal My Xmas present The more distance tears travel, the more damage they will do. 3
Ball of Tar 5.100.231 Ball of Tar Sticky feet... Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed. 2
BBF 5.100.272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. 1
Black Candle 5.100.260 Black Candle Curse immunity + evil up Prevents curses. Grants one Black Heart. Increases the chance for a Devil or Angel Room to appear. 3
Black Lotus 5.100.226 Black Lotus HP up x3! Grants one Red Heart, one Soul Heart, and one Black Heart. 2
Bobby-Bomb 5.100.125 Bobby-Bomb Homing bombs! +5 bombs. Bombs gain a homing effect, slowly moving towards the nearest enemy. 2
Cat-O-Nine-Tails 5.100.165 Cat-O-Nine-Tails Shot speed + damage up +1 damage, +0.23 shot speed. 3
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the 15►Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
Ceremonial Robes 5.100.216 Ceremonial Robes DMG + evil up Grants 3 Black Hearts, and +1 damage. 3
Charm of the Vampire 5.100.62 Charm of the Vampire Kills heal Heals Isaac for half of a Red Heart for every 13 enemies killed. Added in Repentance +0.3 damage. 0
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red Hearts for himself. For every 1½ Red Hearts collected, Dark Bum will give a Removed in RepentanceSoul Heart, a Black Heart, a hostile Spider, a friendly Blue Spider, Added in Repentance or a random card, rune, or pill. 4
Dark Matter 5.100.259 Dark Matter DMG up + fear shot +1 damage, adds a chance to shoot fear tears. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second. 0
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Demon Baby 5.100.113 Demon Baby Auto-turret friend Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. 2
Eve's Mascara 5.100.310 Eve's Mascara DMG up, tears + shot speed down Doubles damage, halves tears stat, and greatly reduces shot speed. 1
Gimpy 5.100.225 Gimpy Sweet suffering Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed. 2
Guppy's Tail 5.100.134 Guppy's Tail Cursed? Room clear awards have a 1/3 chance of being replaced with a chest and a 1/3 chance being replaced with nothing. 2
Habit 5.100.156 Habit Item martyr When Isaac is hit, his active item gains 1 room's worth of charge. 3
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 3
Judas' Shadow 5.100.311 Judas' Shadow Sweet revenge Adds an extra life; upon death, it respawns Isaac as Dark Judas Dark Judas with two Black Hearts. 4
Leech 5.100.270 Leech Blood sucker Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy. 1
Lil Brimstone 5.100.275 Lil Brimstone Evil friend Grants a familiar that charges a thin 15►Brimstone Brimstone laser while Isaac is shooting. 3
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. 2
Little Steven 5.100.100 Little Steven Psychic friend Spawns a familiar who follows Isaac around and fires homing tears. 1
Loki's Horns 5.100.87 Loki's Horns Cross tears Gives a random chance for projectiles to fire in all 4 cardinal directions. 1
Magic 8 Ball 5.100.194 Magic 8 Ball Shot speed up +0.16 shot speed, spawns a random tarot card. Added in Repentance Increases the chance of finding a Planetarium. 1
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies. 1
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles. 1
Skatole 5.100.9 Skatole Fly love Flies become harmless or less dangerous depending on the type. 0
Spider Bite 5.100.89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. 2
Spirit of the Night 5.100.159 Spirit of the Night Scary Grants spectral tears and flight. 3
Steven 5.100.50 Steven DMG up Increases damage by 1. 3
Strange Attractor 5.100.315 Strange Attractor Magnetic tears Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears. 0
The Black Bean 5.100.180 The Black Bean Toot on touch When taking damage, Isaac farts, causing poison damage to all enemies in range. 0
The Negative 5.100.328 The Negative Fate chosen If Isaac has half a red heart or no red hearts after taking damage, all enemies in the room take significant damage (same effect as 15►The Necronomicon The Necronomicon). Allows entrance into the Dark Room Dark Room. Added in Repentance Also allows access to Home Home. 1
Whore of Babylon 5.100.122 Whore of Babylon Curse up Grants +1.5 damage and +0.3 speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any Soul or Black Hearts. 2
Wire Coat Hanger 5.100.32 Wire Coat Hanger Tears up Increases tears by 0.7. 3
X-Ray Vision 5.100.76 X-Ray Vision I've seen everything Reveals and opens all Secret Room and Super Secret Room entrances. 2

Active[]

Name ID Icon Quote Description Added in Repentance Quality
D20 5.100.166
D20
6 rooms
Reroll the basics Rerolls all pickups in the current room. 2
IV Bag 5.100.135
IV Bag
Unlimited
Portable blood bank Upon use, Isaac loses half a heart of health (one in Womb Womb onward) for a random amount of coins, similar to a Blood Donation Machine. 1
Portable Slot 5.100.177
Portable Slot
Unlimited
Gamble 24/7 Upon use, consumes 1 coin and has a chance to drop a random pickup, like a slot machine. 0
Red Candle 5.100.289
Red Candle
4 seconds
Flame on Throws a flame that that can pass over gaps (but not through obstacles). The flame damages everything in its path, diminishing in size as it hits enemies or blocks shots. 2
Remote Detonator 5.100.137
Remote Detonator
Unlimited
Remote bomb detonation Bombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs. 1
Shoop Da Whoop! 5.100.49
Shoop Da Whoop!
2 rooms
BLLLARRRRGGG! Fires a laser from Isaac's mouth. 1
The D6 5.100.105
The D6
6 rooms
Reroll your destiny Re-rolls all items in the current room into other items, depending on the current room's Item Pool. 4
Undefined 5.100.324
Undefined
6 rooms
Undefined Teleports Isaac to the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR. 2
Yum Heart 5.100.45
Yum Heart
4 rooms
Reusable regeneration Restores one Red Heart of Isaac's health. 1

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
Abaddon 5.100.230 Abaddon Evil + DMG up + fear shot Removed in Repentance+1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
Added in Repentance+1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart containers into Black Hearts, and adds a chance to shoot fear tears.
4
Anemic 5.100.214 Anemic Toxic blood Increases range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. 0
BFFS! 5.100.247 BFFS! Your friends rule! Increases the size and effectiveness of most familiars. 2
Blood Bag 5.100.119 Blood Bag HP up Grants one Red Heart container, restores 5 Red Hearts, and increases speed by 0.3. 2
Blood Clot 5.100.254 Blood Clot DMG + range up Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear height. 2
Bloody Lust 5.100.157 Bloody Lust RAGE! Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor. 3
Brimstone 5.100.118 Brimstone Blood laser barrage Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period. 4
Champion Belt 5.100.208 Champion Belt DMG + challenge up Increases damage, but also increases the chance of champion enemies appearing. 3
Contract From Below 5.100.241 Contract From Below Wealth... but at what cost? Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3. 3
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. 2
E Coli 5.100.236 E Coli Turdy touch Enemies that touch Isaac are transformed into poop. 1
Harlequin Baby 5.100.167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. 1
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. Added in Repentance The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red Heart every 3 rooms. 2
Lord of the Pit 5.100.82 Lord of the Pit Demon wings Grants flight and +0.3 speed. 3
Magic Mushroom 5.100.12 Magic Mushroom All stats up! Makes Isaac bigger. Adds one Red Heart container, +0.3 damage, x1.5 damage multiplier, +5.25 range, and +0.3 speed. Restores all health on pickup. 4
Magic Scab 5.100.253 Magic Scab HP + luck up Grants one full Red Heart container, +1 luck. 2
Magneto 5.100.53 Magneto Item snatcher Pulls pickups towards Isaac. 1
MEAT! 5.100.193 MEAT! DMG + HP up Grants one full Red Heart container, +0.3 damage. 2
Missing Page 2 5.100.262 Missing Page 2 Evil up. Your enemies will pay! Grants one Black Heart. Upon taking damage that reduces Isaac's health to one heart or less, deals damage to all enemies in the room. Added in Repentance Increases the damage of Black Hearts and 15►The Necronomicon The Necronomicon-like effects by 40. 0
Mom's Contacts 5.100.110 Mom's Contacts Freeze effect +0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. 3
Mom's Heels 5.100.30 Mom's Heels Range up +5.25 range, +0.5 tear height. Added in Repentance Enemies that touch Isaac take 12 damage. 1
Mom's Lipstick 5.100.31 Mom's Lipstick Range up +5.25 range, +0.5 tear height. Added in Repentance Spawns one random heart. 1
Pentagram 5.100.51 Pentagram DMG up +1 damage, increases Devil Room / Angel Room chance by 10%. 3
Proptosis 5.100.261 Proptosis Short range mega tears Tears start out massive with high damage, and then shrink down and become weaker over a short range. 4
Sister Maggy 5.100.67 Sister Maggy Friends 'till the end Spawns a familiar that follows Isaac around shooting normal tears. 0
Steam Sale 5.100.64 Steam Sale 50% off Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup. 2
Stem Cells 5.100.176 Stem Cells HP + shot speed up Grants one full Red Heart container and +0.16 shot speed. 1
The Body 5.100.334 The Body I feel all Adds 3 Red Heart containers. 3
The Compass 5.100.21 The Compass The end is near Reveals all special rooms (except secret rooms of any kind). 2
The Mark 5.100.79 The Mark DMG + speed up Grants one Soul Heart, +1 damage, and +0.2 speed. 3
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. Removed in Repentance -0.1 speed. Added in Repentance +0.2 speed. Added in Afterbirth / Removed in Repentance Poisoned enemies have a chance to drop a black heart when killed. 0

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Best Friend 5.100.136
Best Friend
3 rooms
Friends 'till the end Spawns a decoy Isaac that eventually explodes with an increased blast radius. 1

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
3 Dollar Bill 5.100.191 3 Dollar Bill Rainbow tears Removed in Afterbirth Gives Isaac a random tear effect every room.
Added in Afterbirth Gives Isaac a random tear effect every few seconds.
2
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. 2
Bum Friend 5.100.144 Bum Friend He's greedy Spawns a familiar that picks up coins for himself, giving random pickups in return. Does not spawn collectibles. 0
Dr. Fetus 5.100.52 Dr. Fetus ??? Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired. 4
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guppy's Collar 5.100.212 Guppy's Collar Eternal life? Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death. 2
Lucky Foot 5.100.46 Lucky Foot Luck up +1 luck. Increases chance of winning Shell Games and Fortune Tellers (independent from the luck stat).
Added in Repentance Converts all bad pills into good pills, without identifying them.
2
Maggy's Bow 5.100.312 Maggy's Bow HP up + you feel healthy Gives one Red Heart container and doubles the healing provided by Red Hearts. 2
Mom's Underwear 5.100.29 Mom's Underwear Range up +5.25 range, +0.5 tear height. Added in Repentance Spawns 3-6 Blue Flies on pickup. 1
Monstro's Lung 5.100.229 Monstro's Lung Charged burst attack Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Monstro. 2
Pageant Boy 5.100.141 Pageant Boy Ultimate grand supreme Spawns seven random coins around Isaac. 0
Piggy Bank 5.100.227 Piggy Bank My life savings Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny. 1
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Rosary 5.100.72 Rosary Tears + faith up Adds 3 Soul Hearts. The Bible will appear in any item pool.
Added in RepentanceAlso a +0.5 tears up.
1
Sacred Heart 5.100.182 Sacred Heart Homing shots + DMG up Grants homing tears, x2.3 damage multiplier, +1 flat damage, +4.125 range, +0.75 tear height, -0.4 tears, -0.25 shot speed, a red Heart Container and replenishes all Red Hearts. 4
Super Bandage 5.100.92 Super Bandage +2 hearts Grants one full Red Heart container and 2 Soul Hearts. 2
The Parasite 5.100.104 The Parasite Split shot Isaac's tears split in two when they hit something. 2

Active[]

Name ID Icon Quote Description Added in Repentance Quality
D10 5.100.285
D10
1 rooms
Reroll enemies Rerolls the monsters in the room. Only rerolls monsters that are still alive (does not spawn new enemies). 0
Mom's Bottle of Pills 5.100.102
Mom's Bottle of Pills
6 rooms
Reusable pill generator Gives Isaac a random pill. 1

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
Fire Mind 5.100.257 Fire Mind Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion. 2
Infestation 2 5.100.234 Infestation 2 Infestation shot Spawns allied Blue Spiders from killed enemies. 4
Mom's Wig 5.100.217 Mom's Wig You feel itchy... Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart. 3
Pyromaniac 5.100.223 Pyromaniac It hurts so good +5 bombs +5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. Added in Repentance Also grants immunity to fire. 4
Rubber Cement 5.100.221 Rubber Cement Bouncing tears Tears bounce off walls, enemies, and environmental objects. 3

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Lemon Mishap 5.100.56
Lemon Mishap
2 rooms
Oops... Creates a tiny pool of yellow creep, damaging enemies that cross it. 1
Magic Fingers 5.100.295
Magic Fingers
Unlimited
Pay to win Uses 1 coin to deal twice Isaac's damage Added in Repentance + 10 to all enemies in the room. 1
Prayer Card 5.100.146
Prayer Card
6 rooms
Reusable eternity Gives an Eternal Heart per use. 3
Telepathy for Dummies 5.100.192
Telepathy for Dummies
2 rooms
Temporary psychic shot Gives homing tears for the current room. 0

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
Experimental Treatment 5.100.240 Experimental Treatment Some stats up, some stats down Removed in Afterbirth † Randomly increases and decreases some of Isaac's stats.
Added in Afterbirth † Increases four random stats and decreases the other two.
1
Infestation 5.100.148 Infestation Fly revenge Removed in Repentance 1-3 Blue Flies randomly spawn every time Isaac gets hit.
Added in Repentance 2-6 Blue Flies randomly spawn every time Isaac gets hit.
0
Key Piece 1 5.100.238 Key Piece 1 ??? Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. 0
Key Piece 2 5.100.239 Key Piece 2 ??? Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. 0
Little Chubby 5.100.88 Little Chubby Attack buddy Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path. 1
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop coins. 2
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red Heart pickups into Soul Hearts instead. 3
Mom's Key 5.100.199 Mom's Key Better chest loot +2 keys Adds 2 keys. Chests will drop additional pickups. 3
Mom's Perfume 5.100.228 Mom's Perfume Fear shot + tears up Adds a chance to shoot fear tears and decreases tear delay by 1. 2
Number One 5.100.6 Number One Tears up + range down Grants +1.5 tears, but severely reduces range. 2
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 3
Soy Milk 5.100.330 Soy Milk DMG down + tears way up Tears are smaller and do much less damage, but fire in very rapid succession. 2
The Halo 5.100.101 The Halo All stats up Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height. 2
The Mind 5.100.333 The Mind I know all Reveals the entire map, including all special rooms and Secret Rooms. 3
The Wafer 5.100.108 The Wafer Damage resistance All sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead. 4
Thunder Thighs 5.100.314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed. 1
Toothpicks 5.100.183 Toothpicks Tears + shot speed up +0.7 tears, +0.16 shot speed. 3
Added in Afterbirth More Options 5.100.414 More Options There's options Two items spawn in every Treasure Room. Only one can be taken; the other will disappear. 3

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Blood Rights 5.100.186
Blood Rights
Unlimited
Mass enemy damage at a cost Upon use, takes a full heart of health and deals 40 damage to all enemies in the room. 0
Dad's Key 5.100.175
Dad's Key
2 rooms
Opens all doors... Opens all doors in the current room when activated, including doors which require a key to open and entrances to Secret Rooms. Opens the big doors in the first room of both Chest Chest and the Dark Room Dark Room. 1
Dead Sea Scrolls 5.100.124
Dead Sea Scrolls
2 rooms
It's a mystery Triggers the effect of a random activated item from a list of possible options (not every activated item is included). 1
Deck of Cards 5.100.85
Deck of Cards
6 rooms
Reusable card generator Gives Isaac a random card. 1
Tammy's Head 5.100.38
Tammy's Head
1 rooms
Reusable tear burst Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears. 3
The Bean 5.100.111
The Bean
1 rooms
Toot on command Isaac farts, poisoning any enemy in close range. 0
The Bible 5.100.33
The Bible
4 rooms
Temporary flight On use, Isaac gains flight for the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but kills Isaac when used on Satan. 1
The Hourglass 5.100.66
The Hourglass
2 rooms
Temporary enemy slowdown All enemies in the room are slowed for 8 seconds. 1
The Necronomicon 5.100.35
The Necronomicon
4 rooms
Mass room damage Deals 40 damage to every enemy in the room. 1
The Poop 5.100.36
The Poop
1 rooms
Plop! Spawns a pile of poop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop. 0

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
A Snack 5.100.346 A Snack HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Blood of the Martyr 5.100.7 Blood of the Martyr DMG up Increases damage by 1, and turns Isaac's tears into blood tears. 3
Box 5.100.198 Box Stuff Spawns various pickups: 1 coin, 1 key, 1 bomb, 1 Red Heart, 1 card/rune, 1 pill and 1 trinket. 1
Butt Bombs 5.100.209 Butt Bombs Toxic blast +5 bombs +5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies. 2
Chocolate Milk 5.100.69 Chocolate Milk Charge shots Grants charged tears that deal greater damage when fully charged. 3
Cricket's Body 5.100.224 Cricket's Body Bursting shots + tears up Grants -1 tear delay and reduces range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's. 3
Cricket's Head 5.100.4 Cricket's Head DMG up Increases damage by 0.5, and multiplies it by 1.5x. 4
Dead Onion 5.100.336 Dead Onion Toxic aura tears Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed. 3
Dessert 5.100.24 Dessert HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Dinner 5.100.23 Dinner HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Fanny Pack 5.100.204 Fanny Pack Filled with goodies Has a chance to drop a random pickup when Isaac takes damage. 1
Goat Head 5.100.215 Goat Head He accepts your offering A Devil Room / Angel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4. 3
Guppy's Hair Ball 5.100.187 Guppy's Hair Ball Swing it Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. 1
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. 3
Humbling Bundle 5.100.203 Humbling Bundle 1+1 free 4Evar Removed in Repentance Replaces all regular red hearts, pennies, keys, and bombs with double versions worth twice as much.
Added in Repentance Regular red hearts, pennies, keys, and bombs have a chance to be replaced with double versions worth twice as much.
3
Latch Key 5.100.343 Latch Key Luck up Grants 1 Soul Heart and +1 luck. Spawns 2 Keys. 2
Lunch 5.100.22 Lunch HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Mom's Coin Purse 5.100.195 Mom's Coin Purse What's all this...? Spawns 4 random pills near Isaac. 1
Odd Mushroom 5.100.121 Odd Mushroom HP + DMG up, speed down Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear height, and -0.1 speed. 2
Odd Mushroom 5.100.120 Odd Mushroom Tears + speed up, DMG down +1.7 tears, +0.3 speed, slightly reduces damage. 3
Ouija Board 5.100.115 Ouija Board Spectral tears Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them. 2
Raw Liver 5.100.16 Raw Liver HP up Grants 2 Red Heart containers and completely restores health. 2
Rotten Meat 5.100.26 Rotten Meat HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart. 2
Squeezy 5.100.196 Squeezy Tears up Increases tears by 0.4, spawns 2 Soul Hearts. 3
Starter Deck 5.100.251 Starter Deck Extra card room Isaac can hold 2 cards at once and all pills are replaced by cards. 2
Stigmata 5.100.138 Stigmata DMG + HP up Increases damage, and adds 1 heart container. 2
The Belt 5.100.28 The Belt Speed up Increases speed by 0.3. 2
The Ladder 5.100.60 The Ladder Building bridges Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. 1
Transcendence 5.100.20 Transcendence We all float down here... Grants flight. 3
Treasure Map 5.100.54 Treasure Map Full visible map Reveals all rooms for every floor. However, it does not reveal icons or secret rooms. 2
Wooden Spoon 5.100.27 Wooden Spoon Speed up Increases speed by 0.3. 1

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
Reusable ranged bomb Upon use, Isaac holds a poison bomb which can be thrown in the cardinal directions and explodes on impact. 1
D4 5.100.284
D4
6 rooms
Reroll into something else Rerolls all of Isaac's passive items. 3

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health and lose the 1up!. 2
A Dollar 5.100.18 A Dollar $$$ Gives Isaac 100 coins. 2
Abel 5.100.188 Abel Mirrored buddy Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction. 0
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Bob's Curse 5.100.140 Bob's Curse +5 poison bombs Gives 5 bombs and grants Isaac's bombs a poison effect. 1
Chemical Peel 5.100.154 Chemical Peel DMG up Tears fired from the left eye have +2 flat damage. 1
Gnawed Leaf 5.100.210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. 1
Mutant Spider 5.100.153 Mutant Spider Quad shot Grants quadruple shot but decreases tears. 3
Mysterious Liquid 5.100.317 Mysterious Liquid Toxic splash damage Tears leave a small, short lasting pool of creep on impact or when their range is depleted. 1
Roid Rage 5.100.14 Roid Rage Speed and range up Removed in Repentance +0.6 speed, Added in Repentance +0.3 speed, +5.25 range, +0.5 tear height. 2
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
The Common Cold 5.100.103 The Common Cold Poison damage Adds a chance to shoot poison tears, dealing damage over time when inflicted. 1
The Sad Onion 5.100.1 The Sad Onion Tears up Increases tears by 0.7. 3

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Converter 5.100.296
Converter
Unlimited
Convert your soul Removed in Repentance Upon use, converts two Soul Hearts into one full Heart Container.

Added in Repentance Upon use, converts one Soul or Black Heart into one full Heart Container.

1
Isaac's Tears 5.100.323
Isaac's Tears
6 rooms
Collected tears Fires 8 tears around Isaac, which retain the damage, range, shot speed, and special tear effects. Each tear shot by Isaac increases item charge by one. 0
Monster Manual 5.100.123
Monster Manual
6 rooms
Temporary buddy generator Removed in Repentance Spawns a familiar from a specific selection for the current room.

Added in Repentance Spawns a familiar from a specific selection for the current floor.

0
Pandora's Box 5.100.297
Pandora's Box
One time use
?? Upon use, spawns specific pickups or items depending on the floor it is used on. Disappears after use. 2
Teleport 5.100.44
Teleport
2 rooms
Teleport! Teleports Isaac to a random room on the current floor. 0
The Boomerang 5.100.338
The Boomerang
2 seconds
It will never leave you Throws a boomerang which retrieves pickups, as well as damages and petrifies enemies hit for 2 seconds. 1
The Candle 5.100.164
The Candle
4 seconds
Reusable flames Throws out a temporary flame that can pass over gaps (but not through rocks). The flame damages anything in its path. 2

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
???'s Only Friend 5.100.320 ???'s Only Friend Controlled friend Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys 2
Anti-Gravity 5.100.222 Anti-Gravity Anti-gravity tears + tears up -2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. 3
Aquarius 5.100.308 Aquarius Trail of tears A trail of blue creep is left behind Isaac, which damages enemies. 0
Aries 5.100.300 Aries Ramming speed +0.25 Speed. Running into enemies while at a high speed will deal damage. Removed in Repentance Does not prevent contact damage. 1
Blue Cap 5.100.342 Blue Cap HP + tears up + shot speed down Removed in Repentance Gives one full Red Heart container, +0.7 tears, and -0.16 shot speed.

Added in Repentance Gives one Red Heart container, 2 Hearts of health, +0.7 tears, and -0.16 shot speed.

3
Blue Map 5.100.246 Blue Map Secrets Shows Secret and Super Secret Room locations on the map. 2
Broken Watch 5.100.337 Broken Watch I think it's broken Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up. 1
Brother Bobby 5.100.8 Brother Bobby Friends 'till the end A familiar that follows Isaac around shooting normal tears. 0
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul Hearts. Grants {{i{The Wafer}} effect for the current room upon taking damage. 3
Capricorn 5.100.307 Capricorn All stats up Increases health, damage, speed, and range, lowers tear delay, and gives one coin, bomb, and key. 3
Fate 5.100.179 Fate Flight eternal Grants flight and one Eternal Heart. 3
Forever Alone 5.100.128 Forever Alone Attack fly Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. 1
Gemini 5.100.318 Gemini Conjoined friend Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second. 1
Hive Mind 5.100.248 Hive Mind Giant spiders and flies Increases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal. Added in Repentance Also increases the effectiveness of fly and spider familiars. 2
Holy Mantle 5.100.313 Holy Mantle Holy shield Upon entering a room, grants a shield that negates the first damage taken. 4
Holy Water 5.100.178 Holy Water Splash! Removed in Repentance Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
Added in Repentance A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
0
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Libra 5.100.304 Libra You feel balanced Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes. 1
Mini Mush 5.100.71 Mini Mush Speed + range up Decreases Isaac's size, making him less likely to be hit. Removed in Repentance+0.3 speed, +1.5 tear height, -4.25 range (effective range is increased). Added in Repentance +0.3 speed, +1.50 range. 2
Pisces 5.100.309 Pisces Tears up + knock-back shots -1 Tear Delay, adds knock-back shots and increases tear size. 2
Sagittarius 5.100.306 Sagittarius Piercing shots + speed up Increases speed by +0.2 and grants piercing tears. 3
Scorpio 5.100.305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted. 2
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. 1
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... Removed in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth / Removed in Repentance Upon taking damage, inflicts slow to all enemies for the current room.
Added in Repentance Slows all enemies in every room to 80% speed.
4
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the 15►My Little Unicorn My Little Unicorn effect for 5 seconds. 1
The Mulligan 5.100.151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. 3
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul Heart every 5-6 rooms. 4
The Soul 5.100.335 The Soul I am all Grants two Soul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles. 3
Trinity Shield 5.100.243 Trinity Shield You feel guarded Isaac gains a shield that protects him from enemy shots. It aims in the direction Isaac fires from. 3
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2

Active[]

Name ID Icon Quote Description Added in Repentance Quality
Book of Revelations 5.100.78
Book of Revelations
6 rooms
Reusable soul protection Gives one Soul Heart, increases the chance for a Devil or Angel Room, and changes the boss of the current floor to a Harbinger if possible. 3

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
Growth Hormones 5.100.70 Growth Hormones Speed + DMG up +1 damage, Removed in Repentance +0.4 speed, Added in Repentance +0.2 speed. 3
Infamy 5.100.242 Infamy Blocks damage... sometimes Chance to block projectiles coming from any direction. 2
Ipecac 5.100.149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. 4
Jesus Juice 5.100.197 Jesus Juice Damage + range up +0.5 damage, +0.25 range, +0.5 tear height. 2
Mom's Purse 5.100.139 Mom's Purse More trinket room Allows Isaac to hold 1 additional trinket. 3
Mystery Sack 5.100.271 Mystery Sack ? Spawns a familiar that drops a Heart, coin, bomb, or key every 5-6 rooms. 2
Placenta 5.100.218 Placenta Regeneration + HP up Grants one full Red Heart container, and a chance to regenerate a Half Red Heart of health every minute of gameplay. 2
Sack of Pennies 5.100.94 Sack of Pennies Gives money Spawns a familiar that drops a coin every 2 rooms. 1

Passive[]

Name ID Icon Quote Description Added in Repentance Quality
Godhead 5.100.331 Godhead God tears Grants homing tears with a damaging halo. +0.5 damage, -0.3 tears, +1.2 range, -0.3 shot speed, +0.8 tear height. 4
Little Baggy 5.100.252 Little Baggy Extra pill room Isaac can hold 2 pills at once and all cards and runes are replaced by pills. 1
Missing No. 5.100.258 Missing No. Syntax error Randomizes all passive items and stats upon pickup and at the start of each succeeding floor. 2
Mongo Baby 5.100.322 Mongo Baby Mongo friend Spawns a familiar that copies the tears of Isaac's other familiars. 2
Rainbow Baby 5.100.174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects. 1