Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Active Items[]

Name ID Icon Quote Description Added in Repentance Quality
Blood Rights 5.100.186
Blood Rights
Mass enemy damage at a cost Upon use, takes a full heart of health and deals 40 damage to all enemies in the room. 0
Book of Revelations 5.100.78
Book of Revelations
6 rooms
Reusable soul protection Gives one Soul Heart, increases the chance for a Devil or Angel Room, and changes the boss of the current floor to a Harbinger if possible. 3
Breath of Life 5.100.326
Breath of Life
6 seconds
Invincibility at a cost Grants a brief moment of invincibility when the charge bar hits zero. If the spacebar is held for an additional second after hitting zero, Isaac will take damage. 0
Converter 5.100.296
Convert your soul Removed in Repentance Upon use, converts two Soul Hearts into one full Heart Container.

Added in Repentance Upon use, converts one Soul or Black Heart into one full Heart Container.

Guppy's Paw 5.100.133
Guppy's Paw
Soul converter Upon use, converts one Heart Container into three Soul Hearts. 3
How to Jump 5.100.282
How to Jump
It's time you learned how Upon use, Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies. 1
IV Bag 5.100.135
IV Bag
Portable blood bank Upon use, Isaac loses half a heart of health (one in Womb Womb onward) for a random amount of coins, similar to a Blood Donation Machine. 1
Kamikaze! 5.100.40
Become the bomb! Upon use, creates an explosion in the same place as Isaac, damaging him for half a heart of health and dealing Removed in Repentance40 damage/Added in Repentance185 damage to all enemies caught in the blast. 0
Prayer Card 5.100.146
Prayer Card
6 rooms
Reusable eternity Gives an Eternal Heart per use. 3
Razor Blade 5.100.126
Razor Blade
Feel my pain On use, takes one heart of health and grants +1.2 damage for the current room. 0
Satanic Bible 5.100.292
Satanic Bible
6 rooms
Reusable evil... but at what cost? Gives one Black Heart. Added in Repentance Replaces the boss room item on the current floor with a Devil deal. 4
The Jar 5.100.290
The Jar
Save your life When at full health, up to 4 extra Red Hearts can be stored in The Jar. 0
The Nail 5.100.83
The Nail
6 rooms
Temporary demon form Gives Removed in Repentance one Soul Heart Added in Repentance half a Black Heart. For the current room; +0.7 damage, -0.18 speed, allows Isaac to break rocks and damage enemies by walking over them. 3
The Poop 5.100.36
The Poop
1 rooms
Plop! Spawns a pile of poop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop. 0
Unicorn Stump 5.100.298
Unicorn Stump
1 rooms
You feel stumped Gives invulnerability and increased speed for five seconds, but removes the ability to shoot tears. 1
Yum Heart 5.100.45
Yum Heart
4 rooms
Reusable regeneration Restores one Red Heart of Isaac's health. 1
Added in Afterbirth † Clicker 5.100.482
6 rooms
Change Transforms Isaac into a random character and removes the last item collected. 0
Added in Afterbirth † Dull Razor 5.100.486
Dull Razor
2 rooms
I feel numb... Hurts Isaac without depleting health, activating any items that trigger upon taking damage. 1
Added in Afterbirth † Potato Peeler 5.100.487
Potato Peeler
A pound of flesh Removes a heart container, increases damage and range, and grants a Cube of Meat. 3
Added in Repentance Bag of Crafting 5.100.710
Bag of Crafting
Make your destiny Collects and holds up to 8 pickups. Holding the activate button crafts them into a passive item, with the power level based on the quality of pickups used. 3
Added in Repentance Broken Glass Cannon 5.100.474
Broken Glass Cannon
4 rooms
You broke it! Begins with no charges and turns into 15►Glass Cannon Glass Cannon when used. Only acquired by taking damage while holding Glass Cannon. 0
Added in Repentance Death Certificate 5.100.628
Death Certificate
One time use
Where am I? Takes Isaac to an abandoned and expanded version of Home, which has one copy of every item in the game. After taking an item, Isaac returns to the room he used Death Certificate in. 4
Added in Repentance Flip 5.100.711
6 rooms
Life and death Switch characters between Tainted Lazarus and Dead Tainted Lazarus. 3
Added in Repentance Hold 5.100.715
Saved for later Exclusive to Tainted ??? Tainted ???. Allows him to save one poop bomb for later, allowing him to gather more over time. 0
Added in Repentance Larynx 5.100.611
12 rooms
Hear my pain Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage. 2
Added in Repentance Recall 5.100.714
3 seconds
Come back Retrieves the Forgotten's body from any distance. Only available as the 15►Birthright Birthright effect for Tainted Forgotten Tainted Forgotten. 0
Added in Repentance Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Added in Repentance Sumptorium 5.100.713
1 seconds
Return Holding down the fire button converts hearts into familiars that fire tears but can be destroyed. Activating converts the familiars back into hearts. 3
Added in Repentance Suplex! 5.100.709
6 seconds
Angel breaker Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave. 3

Passive Items[]

Name ID Icon Quote Description Added in Repentance Quality
<3 5.100.15 <3 HP up Grants Isaac one Red Heart container and fully restores Isaac's health. 2
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health and lose the 1up!. 2
A Dollar 5.100.18 A Dollar $$$ Gives Isaac 100 coins. 2
A Snack 5.100.346 A Snack HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Anemic 5.100.214 Anemic Toxic blood Increases range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. 0
Ankh 5.100.161 Ankh Eternal life? Upon death, the player will respawn as ??? ??? with 3 Soul Hearts. 2
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Black Lotus 5.100.226 Black Lotus HP up x3! Grants one Red Heart, one Soul Heart, and one Black Heart. 2
Blood Bag 5.100.119 Blood Bag HP up Grants one Red Heart container, restores 5 Red Hearts, and increases speed by 0.3. 2
Bloody Lust 5.100.157 Bloody Lust RAGE! Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor. 3
Breakfast 5.100.25 Breakfast HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Broken Watch 5.100.337 Broken Watch I think it's broken Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up. 1
Bucket of Lard 5.100.129 Bucket of Lard HP up Grants two Removed in Repentanceempty Added in Repentancefull Red Heart containers and heals Isaac by half a Red Heart, but decreases speed by 0.2. 1
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul Hearts. Grants {{i{The Wafer}} effect for the current room upon taking damage. 3
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the 15►Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
Charm of the Vampire 5.100.62 Charm of the Vampire Kills heal Heals Isaac for half of a Red Heart for every 13 enemies killed. Added in Repentance +0.3 damage. 0
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second. 0
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight. 3
Dessert 5.100.24 Dessert HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Dinner 5.100.23 Dinner HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering 15►The Necronomicon The Necronomicon effect. 3
E Coli 5.100.236 E Coli Turdy touch Enemies that touch Isaac are transformed into poop. 1
Fanny Pack 5.100.204 Fanny Pack Filled with goodies Has a chance to drop a random pickup when Isaac takes damage. 1
Fate 5.100.179 Fate Flight eternal Grants flight and one Eternal Heart. 3
Gimpy 5.100.225 Gimpy Sweet suffering Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed. 2
Gnawed Leaf 5.100.210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. 1
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guppy's Collar 5.100.212 Guppy's Collar Eternal life? Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death. 2
Habit 5.100.156 Habit Item martyr When Isaac is hit, his active item gains 1 room's worth of charge. 3
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 3
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. 3
Holy Mantle 5.100.313 Holy Mantle Holy shield Upon entering a room, grants a shield that negates the first damage taken. 4
Holy Water 5.100.178 Holy Water Splash! Removed in Repentance Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
Added in Repentance A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
Infamy 5.100.242 Infamy Blocks damage... sometimes Chance to block projectiles coming from any direction. 2
Infestation 5.100.148 Infestation Fly revenge Removed in Repentance 1-3 Blue Flies randomly spawn every time Isaac gets hit.
Added in Repentance 2-6 Blue Flies randomly spawn every time Isaac gets hit.
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. Added in Repentance The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Judas' Shadow 5.100.311 Judas' Shadow Sweet revenge Adds an extra life; upon death, it respawns Isaac as Dark Judas Dark Judas with two Black Hearts. 4
Lazarus' Rags 5.100.332 Lazarus' Rags Eternal life? Upon dying, resurrect as Lazarus Risen Lazarus Risen with one heart container and Anemic. 1
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red Heart every 3 rooms. 2
Lord of the Pit 5.100.82 Lord of the Pit Demon wings Grants flight and +0.3 speed. 3
Lunch 5.100.22 Lunch HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Maggy's Bow 5.100.312 Maggy's Bow HP up + you feel healthy Gives one Red Heart container and doubles the healing provided by Red Hearts. 2
Magic Scab 5.100.253 Magic Scab HP + luck up Grants one full Red Heart container, +1 luck. 2
Magneto 5.100.53 Magneto Item snatcher Pulls pickups towards Isaac. 1
MEAT! 5.100.193 MEAT! DMG + HP up Grants one full Red Heart container, +0.3 damage. 2
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop coins. 2
Missing Page 2 5.100.262 Missing Page 2 Evil up. Your enemies will pay! Grants one Black Heart. Upon taking damage that reduces Isaac's health to one heart or less, deals damage to all enemies in the room. Added in Repentance Increases the damage of Black Hearts and 15►The Necronomicon The Necronomicon-like effects by 40. 0
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red Heart pickups into Soul Hearts instead. 3
Old Bandage 5.100.219 Old Bandage HP up Grants an empty Red Heart container. Adds a chance of dropping a Red Heart after taking damage. 2
Ouija Board 5.100.115 Ouija Board Spectral tears Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them. 2
Piggy Bank 5.100.227 Piggy Bank My life savings Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny. 1
Placenta 5.100.218 Placenta Regeneration + HP up Grants one full Red Heart container, and a chance to regenerate a Half Red Heart of health every minute of gameplay. 2
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Pyromaniac 5.100.223 Pyromaniac It hurts so good +5 bombs +5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. Added in Repentance Also grants immunity to fire. 4
Raw Liver 5.100.16 Raw Liver HP up Grants 2 Red Heart containers and completely restores health. 2
Rosary 5.100.72 Rosary Tears + faith up Adds 3 Soul Hearts. The Bible will appear in any item pool.
Added in RepentanceAlso a +0.5 tears up.
Rotten Meat 5.100.26 Rotten Meat HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots. 3
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles. 1
Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart. 2
Sharp Plug 5.100.205 Sharp Plug Infinite charge... at a cost Damages Isaac in exchange for fully recharging Isaac's current activated item. 1
Skatole 5.100.9 Skatole Fly love Flies become harmless or less dangerous depending on the type. 0
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 3
Spiderbaby 5.100.211 Spiderbaby Spider revenge Removed in Repentance When hit, spawns 1-2 Blue Spiders.
Added in Repentance When hit, spawns 3-5 Blue Spiders.
Spirit of the Night 5.100.159 Spirit of the Night Scary Grants spectral tears and flight. 3
Stem Cells 5.100.176 Stem Cells HP + shot speed up Grants one full Red Heart container and +0.16 shot speed. 1
Stigmata 5.100.138 Stigmata DMG + HP up Increases damage, and adds 1 heart container. 2
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... Removed in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth / Removed in Repentance Upon taking damage, inflicts slow to all enemies for the current room.
Added in Repentance Slows all enemies in every room to 80% speed.
Super Bandage 5.100.92 Super Bandage +2 hearts Grants one full Red Heart container and 2 Soul Hearts. 2
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the 15►My Little Unicorn My Little Unicorn effect for 5 seconds. 1
The Black Bean 5.100.180 The Black Bean Toot on touch When taking damage, Isaac farts, causing poison damage to all enemies in range. 0
The Body 5.100.334 The Body I feel all Adds 3 Red Heart containers. 3
The Ladder 5.100.60 The Ladder Building bridges Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. 1
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul Heart every 5-6 rooms. 4
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. Removed in Repentance -0.1 speed. Added in Repentance +0.2 speed. Added in Afterbirth / Removed in Repentance Poisoned enemies have a chance to drop a black heart when killed. 0
The Wafer 5.100.108 The Wafer Damage resistance All sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead. 4
Thunder Thighs 5.100.314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed. 1
Transcendence 5.100.20 Transcendence We all float down here... Grants flight. 3
Trinity Shield 5.100.243 Trinity Shield You feel guarded Isaac gains a shield that protects him from enemy shots. It aims in the direction Isaac fires from. 3
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
Added in Afterbirth Athame 5.100.408 Athame Call to the void When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies. 2
Added in Afterbirth Betrayal 5.100.391 Betrayal Turn your enemy Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac. 0
Added in Afterbirth Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 2
Added in Afterbirth Circle of Protection 5.100.423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears. 1
Added in Afterbirth Crack Jacks 5.100.354 Crack Jacks HP up. Don't swallow the prize! Grants one full Red Heart container and drops a random trinket. 2
Added in Afterbirth Curse of the Tower 5.100.371 Curse of the Tower Embrace chaos Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower XVI - The Tower. 1
Added in Afterbirth Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2
Added in Afterbirth Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
Added in Afterbirth Host Hat 5.100.375 Host Hat Blast resistance A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. 3
Added in Afterbirth Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 1
Added in Afterbirth Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. 1
Added in Afterbirth My Shadow 5.100.433 My Shadow Me! And my shaaaadow! Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much. 0
Added in Afterbirth PJs 5.100.428 PJs You feel cozy Grants 4 Soul Hearts and fully restores Isaac's health. 2
Added in Afterbirth Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. 1
Added in Afterbirth Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart. 3
Added in Afterbirth † Adrenaline 5.100.493 Adrenaline Panic = power Increases damage based on how many empty Red Heart containers Isaac has. 1
Added in Afterbirth † Brittle Bones 5.100.549 Brittle Bones Everything hurts Replaces all Red Hearts with 6 empty Bone Hearts. Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up. 3
Added in Afterbirth † Cone Head 5.100.457 Cone Head Hard headed! Grants a Soul Heart. Gives Isaac a chance to ignore any damage taken. 2
Added in Afterbirth † Dark Prince's Crown 5.100.442 Dark Prince's Crown Loss is power When at exactly one Red Heart, grants Removed in Repentance+0.75 Added in Repentance+2.0 tears, +1.5 range, +1 tear height, +0.2 shot speed. 1
Added in Afterbirth † Greed's Gullet 5.100.501 Greed's Gullet Money = health! Grants a Red Heart container for every 25 coins Isaac has. 1
Added in Afterbirth † Hallowed Ground 5.100.543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. 1
Added in Afterbirth † Leprosy 5.100.525 Leprosy You're tearing me apart! Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. 1
Added in Afterbirth † Marbles 5.100.538 Marbles Choking hazard Spawns 3 random trinkets, 5% chance to swallow held trinket after taking damage, gaining its effect permanently. 2
Added in Afterbirth † Marrow 5.100.541 Marrow HP up? Grants one bone heart and spawns three red heart pickups. 1
Added in Afterbirth † Metal Plate 5.100.449 Metal Plate It itches... Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears. 1
Added in Afterbirth † Midnight Snack 5.100.456 Midnight Snack HP up Grants one full Red Heart container. Added in Repentance Heals 1 additional heart of health. 1
Added in Afterbirth † Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room. 1
Added in Afterbirth † Shard of Glass 5.100.448 Shard of Glass Blood and guts! Upon taking damage, Isaac has a chance to drop a full red heart, Removed in Repentancegain 5 range, and leave a trail of damaging red creep for the current room.
Added in RepentanceTaking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
Added in Afterbirth † Varicose Veins 5.100.452 Varicose Veins I'm leaking... Taking damage releases a ring of 10 high damage tears. 2
Added in Repentance A Pound of Flesh 5.100.672 A Pound of Flesh Blood money Devil deals now cost coins, shop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Added in Repentance Astral Projection 5.100.677 Astral Projection The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Added in Repentance Belly Jelly 5.100.690 Belly Jelly Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 2
Added in Repentance Binge Eater 5.100.664 Binge Eater All you can eat +1 red heart container and fully heals Isaac. Item pedestals cycle between their normal items and food, and collecting food grants a temporary damage boost and permanent bonuses to 2 stats. 3
Added in Repentance Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to 15►Dead Bird Dead Bird. 1
Added in Repentance Bird's Eye 5.100.616 Bird's Eye It burns Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. 2
Added in Repentance Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Added in Repentance Blood Puppy 5.100.565 Blood Puppy What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal. 2
Added in Repentance Bloody Gust 5.100.695 Bloody Gust May your rage bring haste When Isaac takes damage, he gains speed and tears for the rest of the floor. 3
Added in Repentance Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Added in Repentance Candy Heart 5.100.671 Candy Heart Power of love Gives Isaac a permanent stat boost whenever he heals with red heart pickups. 2
Added in Repentance Cracked Orb 5.100.675 Cracked Orb Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Added in Repentance Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Added in Repentance Dad's Note 5.100.668 Dad's Note ... Begins the sequence to access Home. 0
Added in Repentance Divine Intervention 5.100.568 Divine Intervention Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. 2
Added in Repentance Dogma 5.100.633 Dogma Ascended Grants flight, +0.1 speed, +2 damage, and the 15►Holy Mantle Holy Mantle effect. Grants enough health to have 6 full hearts, if possible. Automatically given to Isaac after defeating Dogma. 0
Added in Repentance Empty Heart 5.100.676 Empty Heart It multiplies If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container. 2
Added in Repentance Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies. 1
Added in Repentance Guppy's Eye 5.100.665 Guppy's Eye An eye for secrets Shows the contents of Chests, Sacks, and Fire Places before they're opened. 2
Added in Repentance Heartbreak 5.100.694 Heartbreak Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Added in Repentance Hypercoagulation 5.100.724 Hypercoagulation Thick blooded After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds. 3
Added in Repentance Inner Child 5.100.688 Inner Child Let him free Upon death, Isaac respawns in the current room with half a heart left, a massive size down, and +0.2 speed. 3
Added in Repentance It Hurts 5.100.560 It Hurts No it doesn't... Releases a ring of tears and increases tears for the current room when Isaac takes damage. 1
Added in Repentance Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with 15►Knife Piece 2 Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Added in Repentance Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with 15►Knife Piece 1 Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Added in Repentance Lost Soul 5.100.612 Lost Soul Protect him Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items. 2
Added in Repentance Mucormycosis 5.100.553 Mucormycosis Spore shot Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores. 3
Added in Repentance Orphan Socks 5.100.571 Orphan Socks Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 soul hearts. 1
Added in Repentance Purgatory 5.100.634 Purgatory Help from beyond While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. 2
Added in Repentance Sanguine Bond 5.100.692 Sanguine Bond He awaits your offering Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward. 1
Added in Repentance Soul Locket 5.100.686 Soul Locket Power of faith Gives Isaac a permanent stat boost whenever he picks up a soul heart. 2
Added in Repentance Spirit Shackles 5.100.674 Spirit Shackles Unfinished business On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a soul heart. 3
Added in Repentance Strawman 5.100.667 Strawman A helping hand Spawns Keeper to fight enemies alongside Isaac. If Keeper dies, he spawns blue spiders and Strawman is removed from Isaac's inventory. 2
Added in Repentance Supper 5.100.707 Supper HP up Grants one full Red Heart container. Heals 1 additional heart of health. 1
Added in Repentance The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Added in Repentance Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Added in Repentance Vanishing Twin 5.100.697 Vanishing Twin He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. 3
Added in Repentance Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 2
Added in Afterbirth † / Removed in Repentance Tonsil 5.100.474 Tonsil Gross... Grants a familiar that can block enemy shots.