Ultra Secret Room (Item Pool)

Items in this pool can be found in the Ultra Secret Room. All these items have a red color scheme, matching the method to find the corresponding room. Prior to Patch 1.7.5, Ultra Secret Rooms contained Angel Room items.

Activated Collectibles[]

Name	ID	Weight	Description
Abyss	5.100.706	1	Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. Some items generate locusts with special effects.
Berserk!	5.100.704	1	Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms.
The D6	5.100.105	1	Re-rolls all items in the current room into other items, depending on the current room's Item Pool.
D20	5.100.166	1	Rerolls all pickups in the current room.
Dark Arts	5.100.705	1	Briefly grants +1 speed and makes Isaac invulnerable and intangible. When the effect ends, destroys all projectiles and damages all enemies Isaac ran through.
Dataminer	5.100.481	1	Displaces enemy sprites for the current room, randomly increases one stat and decreases another.
Esau Jr.	5.100.703	1	Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
Flip	5.100.711	1	Item pedestals have a second uninteractable "ghostly" item behind them. Activating will flip the real and ghostly items around. If playing as Tainted Lazarus, also flips between them and Dead Tainted Lazarus.
Gello	5.100.728	1	Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
IV Bag	5.100.135	1	Upon use, Isaac loses half a heart of health (or a full heart in Chapter 4 onward) for a random amount of coins, similar to a Blood Donation Machine.
Kamikaze!	5.100.40	1	Creates an explosion around Isaac, damaging him and nearby enemies as well as destroying obstacles.
Kidney Bean	5.100.421	1	Isaac farts, charming all nearby enemies.
Plan C	5.100.475	1	Kills all enemies in the room, then kills Isaac three seconds later.
Plum Flute	5.100.650	1	Summons the boss Baby Plum to fight for Isaac in the current room.
Portable Slot	5.100.177	1	Upon use, consumes 1 Penny and has a chance to drop a random pickup, like a Slot Machine.
Red Candle	5.100.289	1	Throws out a flame that damages everything in its path, diminishing in size as it hits enemies or blocks shots.
Red Key	5.100.580	1	Creates a Red Room adjacent to a viable wall, indicated by the outline of a door. These rooms have a 10% chance to be a special room.
Remote Detonator	5.100.137	1	Bombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs.
Shoop Da Whoop!	5.100.49	1	Fires a laser from Isaac's mouth.
Sulfur	5.100.556	1	Grants Brimstone for the current room.
Yum Heart	5.100.45	1	Restores one full Red Heart.

Passive Collectibles[]

Name	ID	Weight	Description
<3	5.100.15	1	Grants Isaac one Red Heart container and fully restores Isaac's health.
2Spooky	5.100.554	1	Enemies near Isaac are afflicted with fear.
Abaddon	5.100.230	1	+1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears. +1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart Containers into Black Hearts, and adds a chance to shoot fear tears.
Anemic	5.100.214	1	+5 +1.5 range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room.
Angry Fly	5.100.511	1	Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with.
Apple!	5.100.443	1	+0.3 tears. Adds a chance to fire a razor blade that deals 4x Isaac's damage.
Backstabber	5.100.506	1	Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
BFFS!	5.100.247	1	Increases the size and effectiveness of most familiars.
Bird's Eye	5.100.616	1	Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Blood Bag	5.100.119	1	Grants one filled Red Heart container, restores 4 Red Hearts, and increases speed by 0.3.
Blood Bombs	5.100.614	1	Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place Bombs at the cost of half a heart if he doesn't have any.
Blood Clot	5.100.254	1	Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear height.
Blood Puppy	5.100.565	1	Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Attacking it returns it to normal.
Bloody Gust	5.100.695	1	The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively.
Bloody Lust	5.100.157	1	Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
The Body	5.100.334	1	Adds 3 Red Heart Containers.
Boiled Baby	5.100.607	1	Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
Brimstone	5.100.118	1	Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Cambion Conception	5.100.412	1	After taking damage a certain amount of times, a permanent demonic familiar spawns.
Candy Heart	5.100.671	1	Gives Isaac a permanent stat boost whenever he heals with Red Heart pickups.
Champion Belt	5.100.208	1	Increases damage, but also increases the chance of champion enemies appearing.
Contagion	5.100.466	1	The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Cube of Meat	5.100.73	1	Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage.
Dead Eye	5.100.373	1	Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Echo Chamber	5.100.700	1	When Isaac uses a Card, Pill, or Rune, he also uses a copy of the previous three Cards/Pills/Runes he used after picking up Echo Chamber.
Eye of Belial	5.100.462	1	Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Eye of the Occult	5.100.572	1	Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed.
False PHD	5.100.654	1	Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart.
Haemolacria	5.100.531	1	Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Harlequin Baby	5.100.167	1	Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Heartbreak	5.100.694	1	Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.
Hemoptysis	5.100.726	1	Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him.
Hungry Soul	5.100.684	1	Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time.
Hypercoagulation	5.100.724	1	After Isaac takes damage from an enemy or donates health, launches Red Hearts from Isaac that despawn after 1.5 seconds.
Immaculate Heart	5.100.573	1	Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him.
Isaac's Heart	5.100.276	1	Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.
Knockout Drops	5.100.637	1	Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
Lil Loki	5.100.435	1	Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern.
Little C.H.A.D.	5.100.96	1	Spawns a familiar who drops a Half Red Heart every 3 rooms.
Lord of the Pit	5.100.82	1	Grants flight and +0.3 speed.
Lusty Blood	5.100.411	1	Isaac's damage increases for the current room each time he kills an enemy.
Magic Mushroom	5.100.12	1	Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, +5.25 / +1.5 Range, and +0.3 Speed, and restores all Health.
Magic Scab	5.100.253	1	Grants one full Red Heart container, +1 luck. Heals 1 additional Red Heart.
Magneto	5.100.53	1	Pulls pickups towards Isaac.
The Mark	5.100.79	1	Grants one Soul Heart, +1 damage, and +0.2 speed. Grants one Black Heart, +1 damage, and +0.2 speed.
Marked	5.100.394	1	Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, +3.15 range.
Marrow	5.100.541	1	Grants one Bone Heart and spawns three Red Hearts.
Maw of the Void	5.100.399	1	Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. +1 damage, the ring can cause enemies to drop Black Hearts.
MEAT!	5.100.193	1	Grants one full Red Heart container, +0.3 damage. Heals 1 additional Red Heart
Mom's Contacts	5.100.110	1	+0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking.
Mom's Heels	5.100.30	1	+5.25 range, +0.5 tear height. Enemies that touch Isaac take 12 damage.
Mom's Lipstick	5.100.31	1	+5.25 range, +0.5 tear height. Heart.
Money = Power	5.100.109	1	Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Ocular Rift	5.100.606	1	Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources.
The Pact	5.100.80	1	Grants two Soul Hearts, +0.5 damage, and +0.7 tears. Grants two Black Hearts, +0.5 damage, and +0.7 tears.
Pentagram	5.100.51	1	+1 damage, increases Devil Room / Angel Room chance by 10%.
Proptosis	5.100.261	1	Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Red Stew	5.100.621	1	Refills all heart containers. Grants an enormous damage boost that wears off over time.
Rosary	5.100.72	1	Grants 3 Soul Hearts. Causes The Bible to appear in any item pool. +0.5 tears.
Rotten Tomato	5.100.618	1	Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies.
Sacred Heart	5.100.182	1	Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, -0.25 Shot Speed, and +4.125 Range. Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, and -0.25 Shot Speed.
Sanguine Bond	5.100.692	1	Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward.
Sister Maggy	5.100.67	1	Spawns a familiar that follows Isaac around shooting normal tears.
Spirit of the Night	5.100.159	1	Grants spectral tears and flight.
Stem Cells	5.100.176	1	Grants one full Red Heart container and +0.16 shot speed. Heals 1 additional Red Heart
Varicose Veins	5.100.452	1	Taking damage releases a ring of 10 high damage tears.
Vasculitis	5.100.657	1	Enemies explode into tears upon death, which inherit the effects of Isaac's tears.
Vengeful Spirit	5.100.702	1	After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
The Virus	5.100.13	1	Isaac poisons enemies on contact. -0.1 speed. +0.2 speed. Poisoned enemies have a chance to drop a black heart when killed.
Whore of Babylon	5.100.122	1	Grants +1.5 Damage and +0.3 Speed whenever Isaac has a Half Red Heart or less.
Worm Friend	5.100.682	1	Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.