Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

Twisted Pair is a passive item added in The Binding of Isaac: Repentance.


  • Spawns two demon familiars that float by Isaac's side, and fire tears that use Isaac's tears, range, shot speed, and tear effects, and scale with Isaac's damage.
    • Each familiar deals damage equal to 0.375x Isaac's damage.
  • This item belongs to the Conjoined set. Collecting three items from this set will transform Isaac into a three-faced version of himself.


  • Twisted Pair is very similar to the item Incubus Incubus. It provides the same total damage per second increase in the form of a familiar (familiars in this case).
  • When playing as Lilith Lilith, the demon familiars will not inherit Lilith's damage stats as Incubus does.
  • Holding the up/down + left/right attack buttons will make one demon go further behind and the other one in front of Isaac.
  • Because the demons need time to adjust their position while firing, the left\right directional buttons can be tapped to shoot more precise, straight lines of tears.



  • Epic Fetus Epic Fetus: Each familiar will fire a missile from a two additional crosshairs. Not Recommended, as the twisted pair crosshairs are not synced to Isaac's crosshair and move at a much slower rate, making self damage much more likely as the additional crosshairs will struggle to make distance from Isaac.
  • Eye of Greed Eye of Greed When the tear effect triggers, it occurs 3 times and costs you 3 coins.
  • Found Soul Found Soul: While the soul is alive, decreases Twisted Pair's damage by 20%.
  • Sacrificial Altar Sacrificial Altar: Only 1 item pedestal is spawned for their sacrifice.

In-game footage[]


  • Twisted Pair is one of the four items added in Repentance with an internal quality rating of 4 that isn't exclusive to secret rooms. The other 3 are Abyss Abyss, Sacred Orb Sacred Orb, and Revelation Revelation.
  • The name is a reference to Neil Breen's film of the same name.


Bug Bug! The player can take damage from the Twisted pair poison cloud created by Epic Fetus Epic Fetus + Scorpio Scorpio