Binding of Isaac: Rebirth Wiki

Added in Repentance

Twisted Pair is an unlockable passive item added in The Binding of Isaac: Repentance.


  • Spawns two demon familiars that float by Isaac's side, and fire tears that use Isaac's tears, range, shot speed, and tear effects, and scale with Isaac's damage.
    • Each familiar deals damage equal to 0.375x Isaac's damage.
  • This item belongs to the Conjoined set. Collecting three items from this set will transform Isaac into a three-faced version of himself.


  • Twisted Pair is very similar to the item Incubus Incubus. It provides the same total damage per second increase in the form of a familiar (familiars in this case).
  • When playing as Lilith Lilith, the demon familiars will deal 50% of Lilith's damage each.
  • Holding the up/down + left/right attack buttons will make one demon go further behind and the other one in front of Isaac.
  • Because the demons need time to adjust their position while firing, the left\right directional buttons can be tapped to shoot more precise, straight lines of tears.



  • Epic Fetus Epic Fetus: Each familiar will fire a missile from a two additional crosshairs. Not Recommended, as the twisted pair crosshairs are not synced to Isaac's crosshair and move at a much slower rate, making self damage much more likely as the additional crosshairs will struggle to make distance from Isaac.
  • Eye of Greed Eye of Greed The two familiars will also fire coin tears which spend Isaac's coins. Their shot counter is independent from Isaac's.
  • Found Soul Found Soul: While the soul is alive, decreases Twisted Pair's damage by 20%.
  • Sacrificial Altar Sacrificial Altar: Only 1 item pedestal is spawned for their sacrifice, unless they were spawned through Cambion Conception Cambion Conception, in which case they will count for two.
  • Forgotten Lullaby Forgotten Lullaby will increase the fire rate of Twisted Pair.

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