Binding of Isaac: Rebirth Wiki
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The Treasure Room item pool contains the majority of the game's items. All of the items in this pool are able to be found in the Treasure Room.

Activated Collectibles[ | ]

Name ID Icon Weight Description
Anarchist Cookbook 5.100.65
Anarchist Cookbook
3 rooms
1
Spawns six Troll BombTroll Bombs around the room.
The Bean 5.100.111
The Bean
1 room
1
Isaac farts, poisoning any enemy in close range.
Best Friend 5.100.136
Best Friend
3 rooms
1
Spawns a decoy Isaac that explodes after 5 seconds. Enemies will always target the decoy and ignore Isaac.
Blood Rights 5.100.186
Blood Rights
Unlimited
1
Upon use, takes a full heart of health and deals 40 damage to all enemies in the room. (in Repentance) Repeated uses in the same room only take half a heart.
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
1
Upon use, Isaac holds a poison BombBomb which can be thrown in the cardinal directions and explodes on impact.
Book of Revelations 5.100.78
Book of Revelations
6 rooms
1
Increases the chance of a Devil RoomDevil Room / Angel RoomAngel Room appearing while held. On use, gives one Soul HeartSoul Heart, and replaces the boss of the current floor with a Harbinger if possible.
Book of Secrets 5.100.287
Book of Secrets
6 rooms
1
Gives the effect of Collectible Treasure Map iconTreasure Map, Collectible The Compass iconThe Compass, or Collectible Blue Map iconBlue Map for the duration of the current floor. (in Repentance) If all effects are active, Collectible X-Ray Vision iconX-Ray Vision is provided for the floor instead. Highlights any Tinted Rocks and rocks with Crawl SpaceCrawl Space in the room.
Book of Shadows 5.100.58
Book of Shadows
3 rooms
1
Creates a protective shield, nullifying all types of damage in the current room for 10 seconds.
The Book of Sin 5.100.97
The Book of Sin
4 rooms
1
Generates a random pickup, pill, card, or rune.
Box of Spiders 5.100.288
Box of Spiders
2 rooms
1
(except in Repentance) Spawns 1-4 Blue Spiders that deal 2.5x Isaac's damage to enemies.
(in Repentance) Spawns 4-8 Blue Spiders that deal 2x Isaac's damage to enemies.
Butter Bean 5.100.294
Butter Bean
3 seconds
1
Upon use, Isaac farts and knocks back nearby enemies (except in Rebirth) and projectiles. (in Repentance) Enemies pushed into walls or obstacles take 12 damage.
Crack the Sky 5.100.160
Crack the Sky
4 rooms
1
Summons 5 beams of light in random locations on the ground, dealing large amounts of damage to any enemies that touch them.
D10 5.100.285
D10
2 rooms
1
(except in Repentance) Re-rolls all monsters in the room.
(in Repentance) Replaces all monsters in the room with weaker monsters.
D100 5.100.283
D100
6 rooms
1
(except in Repentance) Combines the effects of Collectible D4 iconD4, Collectible The D6 iconThe D6, and Collectible D20 iconD20.
(in Repentance) Combines the effects of Collectible D1 iconD1, Collectible D4 iconD4, Collectible The D6 iconThe D6, Collectible D7 iconD7, Collectible D8 iconD8, Collectible D10 iconD10, Collectible D12 iconD12, and Collectible D20 iconD20.
D20 5.100.166
D20
6 rooms
1
Rerolls all pickups in the current room.
D4 5.100.284
D4
6 rooms
1
Rerolls all of Isaac's passive items.
The D6 5.100.105
The D6
6 rooms
1
Re-rolls all items in the current room into other items, depending on the current room's Item Pool.
Dad's Key 5.100.175
Dad's Key
2 rooms
1
Upon activation, opens all doors in the current room in almost all circumstances, including doors which require a KeyKey to open, entrances to Secret RoomSecret Rooms, and the door to Mega Satan Head ingameMega Satan.
Dead Sea Scrolls 5.100.124
Dead Sea Scrolls
2 rooms
1
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards 5.100.85
Deck of Cards
6 rooms
1
Gives Isaac a random card.
Doctor's Remote 5.100.47
Doctor's Remote
2 rooms
1
Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion.
Flush! 5.100.291
Flush!
4 rooms
1
Turns all non-boss monsters in the room into PoopPoop. Instantly kills poop-themed bosses.
Forget Me Now 5.100.127
Forget Me Now
One time use
1
On use, re-generates the current floor with a new layout. Isaac loses Forget Me Now, but keeps other items and consumables picked up on the original floor.
The Gamekid 5.100.93
The Gamekid
4 rooms
1
Turns Isaac into a Pac-Man-like creature for 6.5 seconds, granting invulnerability, inflicting fear on all enemies, and has a chance of replenishing a Half Red HeartHalf Red Heart every time an enemy is killed.
The Hourglass 5.100.66
The Hourglass
2 rooms
1
All enemies in the room are slowed for 8 seconds.
How to Jump 5.100.282
How to Jump
Unlimited
1
Upon use, Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies.
Isaac's Tears 5.100.323
Isaac's Tears
6 rooms
1
Fires 8 tears around Isaac, which retain the damage, range, shot speed, and special tear effects of his tears. Each tear shot by Isaac increases item charge by one. (in Repentance) Tears from this item have a +5 flat damage bonus.
Kamikaze! 5.100.40
Kamikaze!
Unlimited
1
Creates an explosion around Isaac, damaging him and nearby enemies as well as destroying obstacles.
Lemon Mishap 5.100.56
Lemon Mishap
2 rooms
1
Creates a tiny pool of yellow creep, damaging enemies that cross it.
Magic Fingers 5.100.295
Magic Fingers
Unlimited
1
Uses 1 PennyPenny to deal damage to all enemies in the room.
Mom's Bottle of Pills 5.100.102
Mom's Bottle of Pills
6 rooms
1
On use, gives Isaac a random pill.
Mom's Bra 5.100.39
Mom's Bra
3 rooms
1
Petrifies all enemies in the current room for 4 seconds.
Mom's Pad 5.100.41
Mom's Pad
2 rooms
1
Inflicts fear to all enemies in the room for 4 seconds. (in Repentance) Spawns a blue fly.
Monster Manual 5.100.123
Monster Manual
6 rooms
1
(except in Repentance) Spawns a familiar from a specific selection for the current room.
(in Repentance) Spawns a familiar from a specific selection for the current floor.
Monstro's Tooth 5.100.86
Monstro's Tooth
3 rooms
1
A friendly Boss Monstro ingameMonstro jumps on a random enemy, dealing 120 area damage. Targets Isaac if used in a room without enemies.
Mr. Boom 5.100.37
Mr
2 rooms
1
(except in Repentance) Places a Collectible Mr. Mega iconMr. Mega BombBomb that deals 110 damage.
(in Repentance) Places a Collectible Mr. Mega iconMr. Mega BombBomb that deals 185 damage.
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
1
Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
1
Separates Isaac's head from his body for the current room, granting flight and turning the body into a familiar that chases enemies.
The Poop 5.100.36
The Poop
1 room
1
Spawns a pile of PoopPoop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop.
Prayer Card 5.100.146
Prayer Card
6 rooms
1
Gives an Eternal HeartEternal Heart per use.
Remote Detonator 5.100.137
Remote Detonator
Unlimited
1
BombBombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs.
Satanic Bible 5.100.292
Satanic Bible
6 rooms
1
Gives one Black HeartBlack Heart. (in Repentance) Replaces the boss room item on the current floor with a Devil Deal.
Scissors 5.100.325
Scissors
4 rooms
1
Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. (in Repentance) Isaac's body also shoots a controllable fountain of blood shots for the room.
Shoop da Whoop! 5.100.49
Shoop da Whoop!
2 rooms
1
Fires a laser from Isaac's mouth.
Spider Butt 5.100.171
Spider Butt
2 rooms
1
Deals 10 damage to all enemies in the room and slows them for 4 seconds. (in Repentance) Enemies killed by Spider Butt spawn Blue Spiders.
Telepathy For Dummies 5.100.192
Telepathy For Dummies
2 rooms
1
Gives homing tears for the current room. (in Repentance) Also gives +3 range.
Teleport! 5.100.44
Teleport!
2 rooms
1
Teleports Isaac to a random room on the current floor.
Undefined 5.100.324
Undefined
6 rooms
1
Teleports Isaac to the Secret RoomSecret Room, Super Secret RoomSuper Secret Room, Treasure RoomTreasure Room, or I AM ERRORI AM ERROR.
Unicorn Stump 5.100.298
Unicorn Stump
1 room
1
Gives invulnerability and increased speed for six seconds, but removes the ability to shoot tears.
Yum Heart 5.100.45
Yum Heart
4 rooms
1
Restores one full Red HeartRed Heart.
(except in Repentance) Blank Card 5.100.286
Blank Card
Variable
1
(except in Repentance) Copies the effect of the card or rune currently held by Isaac.
(in Repentance) Copies the effect of the card currently held by Isaac. The charge time is based on the power of the card.
(except in Repentance) Crystal Ball 5.100.158
Crystal Ball
6 rooms
1
Upon use, reveals the map (except the Super Secret RoomSuper Secret Room and Ultra Secret RoomUltra Secret Room) and drops a Soul HeartSoul Heart or random card/rune.
(except in Repentance) Notched Axe 5.100.147
Notched Axe
Unlimited
1
(except in Repentance) Isaac destroys obstacles and opens Secret RoomSecret Rooms by walking into them, but cannot shoot or pick up items until it's cancelled.
(in Repentance) Toggles between tears and the pickaxe, which can be swung to attack and break obstacles. Using it depletes the charge, and it can't be used until next floor once the charge runs out.
(except in Rebirth) D12 5.100.386
D12
3 rooms
1
(except in Repentance) Re-rolls all Rocks and Metal Blocks in the current room into other random obstacles.
(in Repentance) Re-rolls most types of Obstacles in the current room into other random obstacles.
(except in Rebirth) D7 5.100.437
D7
3 rooms
1
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
(except in Rebirth) D8 5.100.406
D8
4 rooms
1
Re-rolls Isaac's damage, tears, range, and speed.
(except in Rebirth) Friendly Ball 5.100.382
Friendly Ball
2 rooms
1
Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
(except in Rebirth) Glass Cannon 5.100.352
Glass Cannon
4 seconds
1
(except in Repentance) Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
(in Repentance) Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes Collectible Broken Glass Cannon iconBroken Glass Cannon.
(except in Rebirth) Glowing Hourglass 5.100.422
Glowing Hourglass
Unlimited
1
Rewinds time, putting Isaac back in the previous room and undoing anything that happened in the current room. (in Repentance) Can only be used three times per floor, after which it functions like Collectible The Hourglass iconThe Hourglass until the next floor.
(except in Rebirth) Kidney Bean 5.100.421
Kidney Bean
1 room
1
Isaac farts, charming all nearby enemies.
(except in Rebirth) Mega Bean 5.100.351
Mega Bean
3 rooms
1
Petrifies all enemies in the current room for about 1.5 seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing.
(except in Rebirth) Mine Crafter 5.100.427
Mine Crafter
1 room
1
Places a Movable TNTMovable TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used again in the same room while the previous TNT barrel is still intact, remotely detonates the TNT.
(except in Rebirth) Teleport 2.0 5.100.419
Teleport 2
4 rooms
1
Teleports Isaac to a room that has not been explored yet. Normal rooms are prioritized over special rooms, and common special rooms take priority over rarer ones.
(in Afterbirth † and Repentance) Black Hole 5.100.512
Black Hole
4 rooms
1
Throws a black hole on the ground which sucks in and damages enemies and destroys nearby obstacles.
(in Afterbirth † and Repentance) Book of the Dead 5.100.545
Book of the Dead
6 rooms
1
(except in Repentance) Creates a friendly BonyBony, Black BonyBlack Bony, or an orbital bone for each enemy killed in the current room.
(in Repentance)Creates a friendly BonyBony, Black BonyBlack Bony, Bone FlyBone Fly, RevenantRevenant, or an orbital bone for each enemy killed in the current room.
(in Afterbirth † and Repentance) Brown Nugget 5.100.504
Brown Nugget
8 seconds
1
Spawns a stationary fly turret that lasts for the current room and fires tears at nearby enemies.
(in Afterbirth † and Repentance) Clicker 5.100.482
Clicker
6 rooms
1
Transforms Isaac into a random character and removes the last item collected.
(in Afterbirth † and Repentance) Crooked Penny 5.100.485
Crooked Penny
4 rooms
1
Spawns a penny and has a 50% chance to double all items and pickups in the room. If the effect fails, the items and pickups disappear.
(in Afterbirth † and Repentance) D1 5.100.476
D1
4 rooms
1
Duplicates a random pickup in the room. (in Repentance) The new pickup may be different than the original (i.e. a different card, etc).
(in Afterbirth † and Repentance) Dataminer 5.100.481
Dataminer
4 rooms
1
Displaces enemy sprites for the current room, randomly increases one stat and decreases another.
(in Afterbirth † and Repentance) Metronome 5.100.488
Metronome
2 rooms
1
Grants a random item effect for the current room.
(in Afterbirth † and Repentance) Pause 5.100.478
Pause
2 rooms
1
Freezes all enemies until a fire button is pressed.
(in Afterbirth † and Repentance) Sharp Straw 5.100.507
Sharp Straw
10 seconds
1
(except in Repentance) Damages all enemies in the room. Has a chance to drop a Half Red HeartHalf Red Heart or Half Soul HeartHalf Soul Heart if an enemy is hit.
(in Repentance) Damages all enemies in the room. Has a chance to drop a Half Red HeartHalf Red Heart if an enemy is hit.
(in Afterbirth † and Repentance) Sprinkler 5.100.516
Sprinkler
4 rooms
1
Upon use, creates a stationary sprinkler that rotates and fires tears in 8 directions. The tears copy Isaac's stats and most tear effects.
(in Afterbirth † and Repentance) Telekinesis 5.100.522
Telekinesis
7 seconds
1
Upon use, for the next three seconds, any enemy shots that come near Isaac are held in place and then later reflected.
(in Afterbirth †) D infinity 5.100.489
D infinity
Variable
1
(except in Repentance) Grants a random die item that changes each use.
(in Repentance) Acts as any die item, and can by cycled by pressing the drop key.
(in Afterbirth †) Wait What? 5.100.484
Wait What?
10 seconds
1
Isaac farts, sending out rock waves.
(in Repentance) Anima Sola 5.100.722
Anima Sola
15 seconds
1
Chains down the nearest enemy for 5 seconds, preventing them from acting.
(in Repentance) Bag of Crafting 5.100.710
Bag of Crafting
Unlimited
1
Collects and holds up to 8 pickups, which can then be used to craft an item. The power level of the item is based on the quality of pickups used.
(in Repentance) Decap Attack 5.100.729
Decap Attack
4 seconds
1
Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it.
(in Repentance) Everything Jar 5.100.720
Everything Jar
12 rooms
1
Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects.
(in Repentance) Fortune Cookie 5.100.557
Fortune Cookie
2 rooms
1
Gives Isaac a fortune, Soul HeartSoul Heart, Card, Rune, or trinket, similar to a Fortune Telling MachineFortune Telling Machine. Fortunes are much more likely to be given than anything else.
(in Repentance) Free Lemonade 5.100.578
Free Lemonade
4 rooms
1
Creates a large pool of yellow creep beneath Isaac.
(in Repentance) Friend Finder 5.100.687
Friend Finder
4 rooms
1
Spawns a random friendly monster that mimics Isaac's movements and attacks.
(in Repentance) Golden Razor 5.100.555
Golden Razor
Unlimited
1
Spends five PennyPennies to increase Isaac's damage by 1.2 for the current room.
(in Repentance) Larynx 5.100.611
Larynx
12 rooms
1
Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage.
(in Repentance) Meat Cleaver 5.100.631
Meat Cleaver
2 rooms
1
Splits all enemies in the room into two smaller versions of themselves with much less health.
(in Repentance) Razor Blade 5.100.126
Razor Blade
Unlimited
1
Takes one Red HeartHeart of health and grants +1.2 damage for the current room. (in Repentance) Repeated uses in the same room only take half a heart.
(in Repentance) The Scooper 5.100.605
The Scooper
3 rooms
1
Summons Collectible The Peeper iconThe Peeper for the current room, which leaves a trail of red creep.
(in Repentance) Spin to Win 5.100.655
Spin to Win
3 seconds
1
When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held.
(in Repentance) Stitches 5.100.635
Stitches
3 seconds
1
Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.
(in Repentance) Sumptorium 5.100.713
Sumptorium
10 seconds
1
Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As Character Tainted Eve iconTainted Eve, passively converts health into Clots while firing. Activating returns all Clots to health.
(in Repentance) Suplex! 5.100.709
Suplex!
7 seconds
1
Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave.
(in Repentance) Tammy's Head 5.100.38
Tammy's Head
1 room
1
Shoots 10 tears in a circle around Isaac, which retain the damage, range, shot speed, and special effects (such as poison) of Isaac's tears. Tears from this item have a +25 flat damage bonus.
(in Repentance) Yuck Heart 5.100.639
Yuck Heart
4 rooms
1
Gives Isaac a Rotten HeartRotten Heart.
(in Repentance) Esau Jr. 5.100.703
Esau Jr.
1 room
0.5
Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
(in Repentance) Eternal D6 5.100.609
Eternal D6
2 rooms
0.5
Rerolls all items in the room. Each item has a 25% chance to disappear instead.
(in Repentance) Gello 5.100.728
Gello
2 rooms
0.5
Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
(in Repentance) Plum Flute 5.100.650
Plum Flute
4 rooms
0.5
Summons the boss Boss Baby Plum ingameBaby Plum to fight for Isaac in the current room.
(in Repentance) Mega Mush 5.100.625
Mega Mush
12 rooms
0.1
Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.
(in Repentance) Spindown Dice 5.100.723
Spindown Dice
6 rooms
0.1
Reduces the internal ID number of all items in the room by one, turning them into the item with that number.

Passive Collectibles[ | ]

Name ID Icon Weight Description
20/20 5.100.245 20/20
1
Isaac fires two tears at once, one from each eye. (in Repentance) 0.8x damage multiplier.
3 Dollar Bill 5.100.191 3 Dollar Bill
1
(in Rebirth) Gives Isaac a random tear effect every room.
(except in Rebirth) Gives Isaac a random tear effect every few seconds.
<3 5.100.15 <3
1
Grants Isaac one Red Heart container and fully restores Isaac's health.
???'s Only Friend 5.100.320 ???'s Only Friend
1
Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys
Abel 5.100.188 Abel
1
(in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
(except in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots towards him.
Anemic 5.100.214 Anemic
1
After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. (except in Repentance) +5 range. (in Repentance) +1.5 range.
Ankh 5.100.161 Ankh
1
Upon death, Isaac will respawn as Character ??? (Character) icon??? in the previous room, with 3 Soul HeartSoul Hearts.
Anti-Gravity 5.100.222 Anti-Gravity
1
Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. (except in Repentance) -2 Tear Delay. (in Repentance) +1 Fire Rate.
Aquarius 5.100.308 Aquarius
1
A trail of blue creep is left behind Isaac, which damages enemies. (in Repentance) The creep inherits most of Isaac's tear effects, like homing, etc.
Aries 5.100.300 Aries
1
+0.25 Speed. Running into enemies while at a high speed will deal damage. (in Repentance) Prevents Isaac from taking contact damage while moving at high speed.
BBF 5.100.272 BBF
1
Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds.
Ball of Tar 5.100.231 Ball of Tar
1
Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud 5.100.274 Best Bud
1
When hit, spawns a quickly orbiting attack fly similar to Collectible Forever alone iconForever alone for the current room that deals high damage.
Big Fan 5.100.279 Big Fan
1
Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies.
The Black Bean 5.100.180 The Black Bean
1
(except in Repentance) When taking damage, Isaac farts, poisoning enemies in range.
(in Repentance) When taking damage, Isaac farts five times, poisoning and knocking back nearby enemies and leaving lingering poison clouds.
Blood of the Martyr 5.100.7 Blood of the Martyr
1
+1 damage. Isaac shoots blood tears.
Bloody Lust 5.100.157 Bloody Lust
1
Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Bob's Brain 5.100.273 Bob's Brain
1
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse 5.100.140 Bob's Curse
1
+5 BombBombs. Grants Isaac's bombs a poison effect. (in Repentance) They also leave a lingering poison cloud, and Isaac becomes immune to poison.
Bobby-Bomb 5.100.125 Bobby-Bomb
1
+5 BombBombs. Bombs gain a homing effect, slowly moving towards the nearest enemy.
Bomb Bag 5.100.131 Bomb Bag
1
Spawns a familiar that drops a BombBomb every 3 rooms.
Boom! 5.100.19 Boom!
1
Grants 10 BombBombs.
Brother Bobby 5.100.8 Brother Bobby
1
Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. (in Repentance) He shoots more frequently than most familiars.
Bucket of Lard 5.100.129 Bucket of Lard
1
(except in Repentance) Grants two empty Red Heart containers, heals Isaac for a Half Red HeartHalf Red Heart, -0.2 speed.
(in Repentance) Grants two Red Heart containers, -0.2 speed.
Bum Friend 5.100.144 Bum Friend
1
Spawns a familiar that picks up Pennycoins for himself, giving random pickups in return. (in Repentance) Can spawn Items from the Beggar Item Pool.
Butt Bombs 5.100.209 Butt Bombs
1
+5 BombBombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
Cain's Other Eye 5.100.319 Cain's Other Eye
1
(except in Repentance) Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac.
(in Repentance) Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage.
Cancer 5.100.301 Cancer
1
Adds 3 Soul HeartSoul Hearts. Grants Collectible The Wafer iconThe Wafer effect for the current room after taking damage.
Capricorn 5.100.307 Capricorn
1
(except in Repentance) Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +1.5 Range, and -1.0 Tear Delay, and gives 1 BombBomb, PennyPenny, and KeyKey.
(in Repentance) Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +0.75 Range, and +0.5 Fire Rate, and gives 1 BombBomb, PennyPenny, and KeyKey.
Celtic Cross 5.100.162 Celtic Cross
1
Grants a chance to trigger the Collectible Book of Shadows iconBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire 5.100.62 Charm of the Vampire
1
Heals Isaac for a Half Red HeartHalf Red Heart for every 13 enemies killed. (in Repentance) +0.3 damage.
Chemical Peel 5.100.154 Chemical Peel
1
Tears fired from the left eye have +2 flat damage.
Chocolate Milk 5.100.69 Chocolate Milk
1
Grants charged tears that deal greater damage when fully charged.
The Common Cold 5.100.103 The Common Cold
1
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Cricket's Body 5.100.224 Cricket's Body
1
When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's. (except in Repentance) Grants -1 tear delay and reduces range. (in Repentance) Grants +0.5 fire rate and reduces range.
Cricket's Head 5.100.4 Cricket's Head
1
Increases Damage by 0.5, and increases damage multiplier by x1.5.
Cupid's Arrow 5.100.48 Cupid's Arrow
1
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Cursed Eye 5.100.316 Cursed Eye
1
Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
Daddy Longlegs 5.100.170 Daddy Longlegs
1
Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.
Dark Bum 5.100.278 Dark Bum
1
Spawns a familiar that follows Isaac around and collects Red HeartRed Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward.
Dead Bird 5.100.117 Dead Bird
1
After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second.
Dead Onion 5.100.336 Dead Onion
1
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Demon Baby 5.100.113 Demon Baby
1
Spawns a familiar that follows Isaac and automatically fires at enemies in its reach.
Distant Admiration 5.100.57 Distant Admiration
1
Spawns an attack fly that circles further out than Collectible Halo of Flies iconHalo of Flies, but closer than Collectible Forever alone iconForever alone, dealing 75 damage per second.
Dr. Fetus 5.100.52 Dr
1
Tears are replaced by BombBombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Dry Baby 5.100.265 Dry Baby
1
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering Collectible The Necronomicon iconThe Necronomicon effect.
E. Coli 5.100.236 E
1
Enemies that touch Isaac are transformed into PoopPoop.
Eve's Mascara 5.100.310 Eve's Mascara
1
(except in Repentance) Doubles damage, halves tears stat, and greatly reduces shot speed.
(in Repentance) Doubles damage, 0.66x tears multiplier, and greatly reduces shot speed.
Experimental Treatment 5.100.240 Experimental Treatment
1
(in Rebirth and Afterbirth) Randomly increases and decreases some of Isaac's stats.
(in Afterbirth † and Repentance) Increases four random stats and decreases the other two.
Fire Mind 5.100.257 Fire Mind
1
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever Alone 5.100.128 Forever Alone
1
Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second.
Gemini 5.100.318 Gemini
1
Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second.
Ghost Baby 5.100.163 Ghost Baby
1
Spawns a familiar that follows Isaac around and fires spectral tears.
Gimpy 5.100.225 Gimpy
1
Gives chance of spawning a Soul HeartSoul Heart when taking damage. Enemies have a chance to drop a Half Red HeartHalf Red Heart after being killed.
Gnawed Leaf 5.100.210 Gnawed Leaf
1
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Guillotine 5.100.206 Guillotine
1
Isaac's head is removed from his body and floats around him as an orbital. (except in Repentance) Gives +1 damage and grants -1 tear delay. (in Repentance) Gives +1 damage and grants +0.5 fire rate.
Halo of Flies 5.100.10 Halo of Flies
1
Spawns two Pretty Flies that block enemy shots and deal contact damage to flies.
Harlequin Baby 5.100.167 Harlequin Baby
1
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby 5.100.269 Headless Baby
1
Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Holy Water 5.100.178 Holy Water
1
(except in Repentance) Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
(in Repentance) A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
Hot Bombs 5.100.256 Hot Bombs
1
+5 BombBombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Infamy 5.100.242 Infamy
1
Gives Isaac a 50% chance to block projectiles coming from any direction.
Infestation 2 5.100.234 Infestation 2
1
Spawns allied Blue Spiders from killed enemies.
Infestation 5.100.148 Infestation
1
(except in Repentance) 1-3 Blue Flies randomly spawn every time Isaac gets hit.
(in Repentance) 2-6 Blue Flies
The Inner Eye 5.100.2 The Inner Eye
1
Grants triple shot but decreases tears.
Ipecac 5.100.149 Ipecac
1
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar 5.100.201 Iron Bar
1
+0.3 damage. Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Isaac's Heart 5.100.276 Isaac's Heart
1
Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. (in Repentance) The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.
Juicy Sack 5.100.266 Juicy Sack
1
Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.
Lazarus' Rags 5.100.332 Lazarus' Rags
1
(except in Repentance) Upon dying, resurrect as Character Lazarus Risen iconLazarus Risen in the current room with one Red Heart container and Collectible Anemic iconAnemic.
(in Repentance) Upon dying, resurrect as Character Lazarus Risen iconLazarus Risen in the current room with one less Red Heart container, Collectible Anemic iconAnemic, and +0.5 Damage. Transform into Character Lazarus iconLazarus when reaching the next floor.
Leech 5.100.270 Leech
1
Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red HeartHalf Red Heart whenever Leech kills an enemy.
Leo 5.100.302 Leo
1
Isaac can destroy rocks by walking into them.
Libra 5.100.304 Libra
1
Gives 6 PennyCoins, 6 BombBombs, and 6 KeyKeys and balances out all attributes.
Lil Brimstone 5.100.275 Lil Brimstone
1
Grants a familiar that charges a thin Collectible Brimstone iconBrimstone laser while Isaac is shooting.
Lil Haunt 5.100.277 Lil Haunt
1
Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear.
Little C.H.A.D. 5.100.96 Little C.H.A.D.
1
Spawns a familiar who drops a Half Red HeartHalf Red Heart every 3 rooms.
Little Chubby 5.100.88 Little Chubby
1
Spawns a ChargerCharger familiar that charges forward and deals contact damage to any enemies in its path.
Little Gish 5.100.99 Little Gish
1
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven 5.100.100 Little Steven
1
Spawns a familiar who follows Isaac around and fires homing tears.
Loki's Horns 5.100.87 Loki's Horns
1
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact 5.100.213 Lost Contact
1
Isaac's tears can hit and destroy enemy projectiles. -0.15 shot speed.
Lucky Foot 5.100.46 Lucky Foot
1
+1 luck. Improves Isaac's chances at various random events (independent from the luck stat). (in Repentance) Converts all bad pills into good pills, without identifying them.
The Ludovico Technique 5.100.329 The Ludovico Technique
1
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Maggy's Bow 5.100.312 Maggy's Bow
1
Gives one Red Heart Container and doubles the healing provided by Red HeartRed Hearts. (in Repentance) Also heals 1 Red Heart when obtained.
Magneto 5.100.53 Magneto
1
Pulls pickups towards Isaac.
Midas' Touch 5.100.202 Midas' Touch
1
Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop PennyPennies.
Mini Mush 5.100.71 Mini Mush
1
Decreases Isaac's size, making him less likely to be hit. (except in Repentance)+0.3 speed, +1.5 tear falling speed, -4.25 range (effective range is increased). (in Repentance) +0.3 speed, +2.5 range.
Mitre 5.100.173 Mitre
1
Grants a chance of converting any Red HeartRed Heart pickups into Soul HeartSoul Hearts instead.
Mom's Contacts 5.100.110 Mom's Contacts
1
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. (except in Repentance) +0.25 range. (in Repentance) +1.5 range.
Mom's Eye 5.100.55 Mom's Eye
1
Gives Isaac a chance to fire tears from the back of his head.
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow
1
Tears have a chance to charm enemies.
Mom's Perfume 5.100.228 Mom's Perfume
1
Adds a chance to shoot fear tears. (except in Repentance) Decreases tear delay by 1. (in Repentance) +0.5 fire rate.
Mom's Wig 5.100.217 Mom's Wig
1
Adds a chance to spawn Blue Spiders when firing tears. Restores 1 Red HeartRed Heart.
Money = Power 5.100.109 Money = Power
1
Increases damage by 0.04 for every Pennycoin Isaac has, up to +3.96 damage at 99 coins.
Mongo Baby 5.100.322 Mongo Baby
1
Spawns a familiar that copies the tears of Isaac's other familiars.
Monstro's Lung 5.100.229 Monstro's Lung
1
Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Boss Monstro ingameMonstro.
Mr. Mega 5.100.106 Mr
1
+5 BombBombs. Increases the size, blast radius, and damage of Isaac's bombs.
The Mulligan 5.100.151 The Mulligan
1
Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy.
Mutant Spider 5.100.153 Mutant Spider
1
Grants quadruple shot but decreases Tears.
My Reflection 5.100.5 My Reflection
1
Gives Isaac's tears a boomerang effect. (except in Repentance) +1.5 range, +1 tear falling speed, x1.6 shot speed multiplier. (in Repentance) 2x + 1.5 range, +1.5 damage, -1 luck, 1.6x shot speed multiplier.
Mysterious Liquid 5.100.317 Mysterious Liquid
1
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery Sack 5.100.271 Mystery Sack
1
Spawns a familiar that drops a Heart, coin, BombBomb, or KeyKey every 5-6 rooms.
Number One 5.100.6 Number One
1
Grants +1.5 tears, but severely reduces range.
Odd Mushroom 5.100.121 Odd Mushroom
1
(except in Repentance) Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear falling speed, and -0.1 speed.
(in Repentance) Grants one full Heart container, +1 damage, +1.5 range, and -0.2 speed
Odd Mushroom 5.100.120 Odd Mushroom
1
+1.7 tears, +0.3 speed, slightly reduces damage.
Ouija Board 5.100.115 Ouija Board
1
Grants spectral tears that travel through obstacles (but not enemies). (in Repentance) +0.5 tears.
The Parasite 5.100.104 The Parasite
1
Isaac's tears split in two when they hit something.
The Peeper 5.100.155 The Peeper
1
Spawns a familiar that slowly floats around the room in a zig-zag pattern, damaging enemies it passes through. (in Repentance) Increases the damage of tears from Isaac's left eye by 35%.
PHD 5.100.75 PHD
1
Converts all bad pills into good pills, spawns one pill pickup, and identifies all pills. Restores two Red HeartRed Hearts and increases the payout of Blood Donation MachineBlood Donation Machines.
Piggy Bank 5.100.227 Piggy Bank
1
Gives 3 PennyPennies on pick-up. Every time Isaac is damaged, he will drop one or two additional pennies.
Pisces 5.100.309 Pisces
1
(except in Repentance) -1 Tear Delay, adds knock-back shots and increases tear size.
(in Repentance) +0.5 Fire Rate, adds knock-back shots and increases tear size.
Polyphemus 5.100.169 Polyphemus
1
Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage.
Proptosis 5.100.261 Proptosis
1
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag 5.100.281 Punching Bag
1
Spawns a MulliganMulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer.
Pyromaniac 5.100.223 Pyromaniac
1
+5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. (in Repentance) Also grants immunity to fire.
Rainbow Baby 5.100.174 Rainbow Baby
1
Spawns a familiar that follows Isaac around and fires tears with random effects.
Robo-Baby 2.0 5.100.267 Robo-Baby 2
1
Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Robo-Baby 5.100.95 Robo-Baby
1
Spawns a familiar that shoots Collectible Technology iconTechnology lasers.
Roid Rage 5.100.14 Roid Rage
1
(except in Repentance) +0.6 speed, +5.25 range, +0.5 tear falling speed.
(in Repentance) +0.3 speed, +2.5 range
Rosary 5.100.72 Rosary
1
Grants 3 Soul HeartSoul Hearts. Causes Collectible The Bible iconThe Bible to appear in any item pool. (in Repentance) +0.5 tears.
Rotten Baby 5.100.268 Rotten Baby
1
Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Rubber Cement 5.100.221 Rubber Cement
1
Tears bounce off walls, enemies, and environmental objects.
SMB Super Fan 5.100.189 SMB Super Fan
1
(except in Repentance) +1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear falling speed. Fully restores all red hearts.
(in Repentance) +1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +2.5 range. Fully restores all red hearts.
Sack of Pennies 5.100.94 Sack of Pennies
1
Spawns a familiar that drops a Pennycoin every 2 rooms.
Sacrificial Dagger 5.100.172 Sacrificial Dagger
1
Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact.
Sad Bombs 5.100.220 Sad Bombs
1
+5 BombBombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers.
The Sad Onion 5.100.1 The Sad Onion
1
+0.7 tears.
Sagittarius 5.100.306 Sagittarius
1
Increases speed by +0.2 and grants piercing tears.
Samson's Chains 5.100.321 Samson's Chains
1
Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles.
Scapular 5.100.142 Scapular
1
Once per room, when Isaac is reduced to his last half heart, he is granted one Soul HeartSoul Heart.
Scorpio 5.100.305 Scorpio
1
Grants poison tears, which deal damage over time when inflicted.
Sissy Longlegs 5.100.280 Sissy Longlegs
1
Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. (in Repentance) Briefly charms enemies on contact.
Sister Maggy 5.100.67 Sister Maggy
1
(except in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage.
(in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 6 damage.
Smart Fly 5.100.264 Smart Fly
1
Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second.
Soy Milk 5.100.330 Soy Milk
1
Tears are smaller and do much less damage, but fire in very rapid succession.
Speed Ball 5.100.143 Speed Ball
1
+0.3 speed, +0.2 shot speed.
Spelunker Hat 5.100.91 Spelunker Hat
1
Reveals type of adjacent rooms, including location for Secret RoomSecret Rooms and Super Secret RoomSuper Secret Rooms. (in Repentance) Reveals rooms up to 2 rooms away and blocks projectiles falling from above.
Spider Bite 5.100.89 Spider Bite
1
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spiderbaby 5.100.211 Spiderbaby
1
(except in Repentance) Spawns 1-2 Blue Spiders when Isaac takes damage.
(in Repentance) Spawns 3-5 Blue Spiders when Isaac takes damage.
Spoon Bender 5.100.3 Spoon Bender
1
Grants Isaac homing tears.
Stem Cells 5.100.176 Stem Cells
1
Grants one full Red Heart container and +0.16 shot speed. (in Repentance) Heals 1 additional Red HeartRed Heart
Stigmata 5.100.138 Stigmata
1
+0.3 damage, grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart.
Strange Attractor 5.100.315 Strange Attractor
1
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Super Bandage 5.100.92 Super Bandage
1
Grants one full Red Heart container and 2 Soul HeartSoul Hearts.
Taurus 5.100.299 Taurus
1
-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the Collectible My Little Unicorn iconMy Little Unicorn effect for 5 seconds.
Tech.5 5.100.244 Tech
1
Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets.
Technology 2 5.100.152 Technology 2
1
Replaces the tears fired from Isaac's right eye with a rapid-firing low damage piercing laser. (except in Repentance) Damage down.
Technology 5.100.68 Technology
1
Replaces tears with a piercing laser with unlimited range.
Thunder Thighs 5.100.314 Thunder Thighs
1
Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed.
Tiny Planet 5.100.233 Tiny Planet
1
Massively increases Range and grants spectral tears. Tears orbit around Isaac at a fixed distance until they hit the ground.
Tough Love 5.100.150 Tough Love
1
Adds a chance to shoot a tooth instead of a tear, which deals x3.2 Isaac's damage.
Virgo 5.100.303 Virgo
1
Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
The Virus 5.100.13 The Virus
1
Isaac poisons enemies on contact. (except in Repentance) -0.1 speed. (in Repentance) +0.2 speed. (in Afterbirth and Afterbirth †) Poisoned enemies have a chance to drop a black heart when killed.
The Wafer 5.100.108 The Wafer
1
Most sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead.
X-Ray Vision 5.100.76 X-Ray Vision
1
Reveals and opens all Secret RoomSecret Room and Super Secret RoomSuper Secret Room entrances.
The Halo 5.100.101 The Halo
(except in Repentance)1
(in Repentance)0.5
(except in Repentance) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear falling speed.
(in Repentance) Grants one full Red Heart container, +0.3 damage, +0.2 tears, +1.5 range, and +0.3 speed. Heals 1 additional Red HeartRed Heart.
Magic Mushroom 5.100.12 Magic Mushroom
(except in Repentance)1
(in Repentance)0.5
(except in Repentance) Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, +5.25 Range, +0.3 Speed, and restores all Health.
(in Repentance) Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, +2.5 Range, +0.3 Speed, and restores all Health.
The Body 5.100.334 The Body
(except in Repentance)1
(in Repentance)0.2
Adds 3 Red Heart Containers.
Death's Touch 5.100.237 Death's Touch
(except in Repentance)1
(in Repentance)0.2
+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Holy Mantle 5.100.313 Holy Mantle
(except in Repentance)1
(in Repentance)0.2
Grants a shield that negates the first instance of damage taken, once per room. Does not apply to or negate self-damage (Blood Donation MachineBlood Donation Machines, etc).
The Mind 5.100.333 The Mind
(except in Repentance)1
(in Repentance)0.2
Reveals the entire map, including all special rooms and Secret RoomSecret Rooms.
Mom's Knife 5.100.114 Mom's Knife
(except in Repentance)1
(in Repentance)0.2
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
The Relic 5.100.98 The Relic
(except in Repentance)1
(in Repentance)0.2
Spawns a cross familiar that drops a Soul HeartSoul Heart after clearing enough rooms.
The Soul 5.100.335 The Soul
(except in Repentance)1
(in Repentance)0.2
Grants two Soul HeartSoul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles.
Epic Fetus 5.100.168 Epic Fetus
(except in Repentance)1
(in Repentance)0.1
Isaac's tears are replaced with guided missiles, like those used by the Collectible Doctor's Remote iconDoctor's Remote.
Pyro 5.100.190 Pyro
(except in Repentance)1
(in Repentance)0.1
Grants 99 BombBombs.
(except in Repentance) A Quarter 5.100.74 A Quarter
1
Gives Isaac 25 Pennycoins.
(except in Repentance) Judas' Shadow 5.100.311 Judas' Shadow
1
Upon death, respawns Isaac as Character Dark Judas iconDark Judas with two Black HeartBlack Hearts in the previous room.
(except in Rebirth) 8 Inch Nails 5.100.359 8 Inch Nails
1
+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.
(except in Rebirth) Betrayal 5.100.391 Betrayal
1
(except in Repentance) Charms all enemies in the room when Isaac takes damage.
(in Repentance) Enemies are able to damage each other. If an enemy is damaged by another enemy, they will attack that enemy instead of Isaac.
(except in Rebirth) Bomber Boy 5.100.353 Bomber Boy
1
+5 BombBombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll BombTroll Bombs.
(except in Rebirth) Bumbo 5.100.385 Bumbo
1
Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage.
(except in Rebirth) Bursting Sack 5.100.377 Bursting Sack
1
Spider enemies no longer target or deal contact damage to Isaac.
(except in Rebirth) Continuum 5.100.369 Continuum
1
Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room.
(except in Rebirth) Curse of the Tower 5.100.371 Curse of the Tower
1
Upon taking damage, spawns six Troll BombTroll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower.
(except in Rebirth) Dead Eye 5.100.373 Dead Eye
1
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
(except in Rebirth) Eden's Blessing 5.100.381 Eden's Blessing
1
+0.7 tears up. Grants a random item at the start of the next run.
(except in Rebirth) Epiphora 5.100.368 Epiphora
1
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
(except in Rebirth) Evil Eye 5.100.410 Evil Eye
1
Adds a chance to fire a slow-moving eye that fires tears in the same direction as Isaac. The eye is destroyed when it hits an enemy or obstacle.
(except in Rebirth) Explosivo 5.100.401 Explosivo
1
Isaac's tears have a chance to stick to enemies and explode.
(except in Rebirth) Farting Baby 5.100.404 Farting Baby
1
Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies.
(except in Rebirth) Fate's Reward 5.100.361 Fate's Reward
1
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
(except in Rebirth) Friend Zone 5.100.364 Friend Zone
1
Spawns a white attack fly that orbits somewhere between Collectible Distant Admiration iconDistant Admiration and Collectible Forever alone iconForever alone, dealing 45 damage per second.
(except in Rebirth) Fruit Cake 5.100.418 Fruit Cake
1
Isaac's tears gain a random effect that changes every shot.
(except in Rebirth) GB Bug 5.100.405 GB Bug
1
(except in Repentance) Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
(in Repentance) Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
(except in Rebirth) Glitter Bombs 5.100.432 Glitter Bombs
1
+5 BombBombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
(except in Rebirth) God's Flesh 5.100.398 God's Flesh
1
Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
(except in Rebirth) Host Hat 5.100.375 Host Hat
1
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
(except in Rebirth) Key Bum 5.100.388 Key Bum
1
Spawns a familiar that follows Isaac and collects KeyKeys for himself, giving random ChestChests in return.
(except in Rebirth) Kidney Stone 5.100.440 Kidney Stone
1
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage.
(except in Rebirth) Lil Chest 5.100.362 Lil Chest
1
Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room.
(except in Rebirth) Lil Gurdy 5.100.384 Lil Gurdy
1
A Boss Gurdy Jr. ingameGurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed.
(except in Rebirth) Lil Loki 5.100.435 Lil Loki
1
Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern.
(except in Rebirth) Lost Fly 5.100.365 Lost Fly
1
Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. (except in Repentance) It deals 105 damage per second on contact. (in Repentance) It deals 56 damage per second and forces nearby enemies to attack it.
(except in Rebirth) Lusty Blood 5.100.411 Lusty Blood
1
Isaac's damage increases for the current room each time he kills an enemy.
(except in Rebirth) Marked 5.100.394 Marked
1
Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, increases range.
(except in Rebirth) Milk! 5.100.436 Milk!
1
Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room.
(except in Rebirth) Multidimensional Baby 5.100.431 Multidimensional Baby
1
Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
(except in Rebirth) Number Two 5.100.378 Number Two
1
Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.
(except in Rebirth) Obsessed Fan 5.100.426 Obsessed Fan
1
Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies.
(except in Rebirth) Papa Fly 5.100.430 Papa Fly
1
Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
(except in Rebirth) Pupula Duplex 5.100.379 Pupula Duplex
1
Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size.
(except in Rebirth) Purity 5.100.407 Purity
1
Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.
(except in Rebirth) Rune Bag 5.100.389 Rune Bag
1
Spawns a familiar that drops a random rune after clearing enough rooms.
(except in Rebirth) Scatter Bombs 5.100.366 Scatter Bombs
1
+5 BombBombs. Isaac's bombs explode into 2-4 tiny bombs.
(except in Rebirth) Seraphim 5.100.390 Seraphim
1
Spawns an angel familiar who follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed.
(except in Rebirth) Serpent's Kiss 5.100.393 Serpent's Kiss
1
Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a Black HeartBlack Heart when killed.
(except in Rebirth) Sticky Bombs 5.100.367 Sticky Bombs
1
+5 BombBombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. (in Repentance) They also leave a long-lasting puddle of slowing white creep.
(except in Rebirth) Tech X 5.100.395 Tech X
1
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring.
(except in Rebirth) Toxic Shock 5.100.350 Toxic Shock
1
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground.
(except in Rebirth) Tractor Beam 5.100.397 Tractor Beam
1
Isaac's tears are bound to a beam emitting in the direction he's firing. (except in Repentance) +0.5 Tears, +5.25 Range, +0.16 Shot Speed. (in Repentance) +1 Fire Rate, +2.5 Range, +0.16 Shot Speed.
(except in Rebirth) The Wiz 5.100.358 The Wiz
1
Grants spectral tears. Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill.
(except in Rebirth) Zodiac 5.100.392 Zodiac
1
Gives Isaac a random zodiac item effect that changes every floor.
(except in Rebirth) Holy Light 5.100.374 Holy Light
(except in Repentance)1
(in Repentance)0.2
Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
(in Afterbirth † and Repentance) Acid Baby 5.100.491 Acid Baby
1
Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned.
(in Afterbirth † and Repentance) Adrenaline 5.100.493 Adrenaline
1
Increases damage based on how many empty Red Heart containers Isaac has.
(in Afterbirth † and Repentance) Analog Stick 5.100.465 Analog Stick
1
+0.35 tears up. Allows Isaac to fire tears diagonally.
(in Afterbirth † and Repentance) Angry Fly 5.100.511 Angry Fly
1
Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with.
(in Afterbirth † and Repentance) Apple! 5.100.443 Apple!
1
+0.3 tears. Adds a chance to fire a razor blade that deals 4x Isaac's damage.
(in Afterbirth † and Repentance) Backstabber 5.100.506 Backstabber
1
Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
(in Afterbirth † and Repentance) Big Chubby 5.100.473 Big Chubby
1
Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.
(in Afterbirth † and Repentance) Bloodshot Eye 5.100.509 Bloodshot Eye
1
Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
(in Afterbirth † and Repentance) Bozo 5.100.513 Bozo
1
+0.1 flat damage, grants a Soul HeartSoul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow PoopRainbow Poop.
(in Afterbirth † and Repentance) Brittle Bones 5.100.549 Brittle Bones
1
Replaces all Red HeartRed Heart Containers with 6 empty Bone HeartBone Hearts. (except in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up. (in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a fire rate up.
(in Afterbirth † and Repentance) Camo Undies 5.100.497 Camo Undies
1
Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused. (in Repentance) Isaac gains +0.5 Speed while camouflaged, and gains Tears and Damage upon breaking it.
(in Afterbirth † and Repentance) Compound Fracture 5.100.453 Compound Fracture
1
Increases Range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
(in Afterbirth † and Repentance) Cone Head 5.100.457 Cone Head
1
Grants a Soul HeartSoul Heart. Gives Isaac a chance to ignore any damage taken.
(in Afterbirth † and Repentance) Contagion 5.100.466 Contagion
1
The first enemy killed in a room releases a gas cloud that poisons nearby enemies. Affected enemies will also release gas upon death, spreading the effect.
(in Afterbirth † and Repentance) Dead Tooth 5.100.446 Dead Tooth
1
While firing, Isaac gains a green aura that poisons nearby enemies.
(in Afterbirth † and Repentance) Depression 5.100.469 Depression
1
Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
(in Afterbirth † and Repentance) Dog Tooth 5.100.445 Dog Tooth
1
+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret RoomSecret Rooms or Crawl SpaceCrawl Spaces.
(in Afterbirth † and Repentance) Euthanasia 5.100.496 Euthanasia
1
Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
(in Afterbirth † and Repentance) Fast Bombs 5.100.517 Fast Bombs
1
+7 BombBombs. Removes the delay between bomb placements, allowing them to be placed rapidly. (in Repentance) Bombs will no longer knock each other away.
(in Afterbirth † and Repentance) Finger! 5.100.467 Finger!
1
Spawns a finger familiar that faces in the same direction as Isaac, rapidly damaging enemies it points at for 10% of Isaac's damage.
(in Afterbirth † and Repentance) Flat Stone 5.100.540 Flat Stone
1
Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area.
(in Afterbirth † and Repentance) Ghost Pepper 5.100.495 Ghost Pepper
1
(except in Repentance)Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
(in Repentance)Gives a chance to shoot blue fires alongside tears that become smaller as they travel.
(in Afterbirth † and Repentance) Glaucoma 5.100.460 Glaucoma
1
Adds a chance to shoot tears that confuse enemies for an extremely long time.
(in Afterbirth † and Repentance) Haemolacria 5.100.531 Haemolacria
1
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
(in Afterbirth † and Repentance) Hallowed Ground 5.100.543 Hallowed Ground
1
Spawns a white poop familiar, which turns into a White PoopWhite Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. (in Repentance) The aura also increases damage by 20% and gives homing.
(in Afterbirth † and Repentance) Hushy 5.100.470 Hushy
1
Spawns a Boss Hush ingameHush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving.
(in Afterbirth † and Repentance) Jacob's Ladder 5.100.494 Jacob's Ladder
1
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
(in Afterbirth † and Repentance) Jaw Bone 5.100.548 Jaw Bone
1
Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
(in Afterbirth † and Repentance) Lachryphagy 5.100.532 Lachryphagy
1
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
(in Afterbirth † and Repentance) Large Zit 5.100.502 Large Zit
1
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
(in Afterbirth † and Repentance) Lead Pencil 5.100.444 Lead Pencil
1
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
(in Afterbirth † and Repentance) Leprosy 5.100.525 Leprosy
1
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
(in Afterbirth † and Repentance) Lil Monstro 5.100.471 Lil Monstro
1
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
(in Afterbirth † and Repentance) Lil Spewer 5.100.537 Lil Spewer
1
Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
(in Afterbirth † and Repentance) Linger Bean 5.100.447 Linger Bean
1
Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies.
(in Afterbirth † and Repentance) Metal Plate 5.100.449 Metal Plate
1
Grants one Soul HeartSoul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
(in Afterbirth † and Repentance) Mom's Razor 5.100.508 Mom's Razor
1
Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
(in Afterbirth † and Repentance) Mystery Egg 5.100.539 Mystery Egg
1
Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage.
(in Afterbirth † and Repentance) Parasitoid 5.100.461 Parasitoid
1
Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.
(in Afterbirth † and Repentance) Pointy Rib 5.100.544 Pointy Rib
1
Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage.
(in Afterbirth † and Repentance) Pop! 5.100.529 Pop!
1
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
(in Afterbirth † and Repentance) Shard of Glass 5.100.448 Shard of Glass
1
(except in Repentance) Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
(in Repentance) Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red HeartRed Heart.
(in Afterbirth † and Repentance) Sinus Infection 5.100.459 Sinus Infection
1
Adds a chance to fire a booger that sticks to enemies and deals damage over time.
(in Afterbirth † and Repentance) Slipped Rib 5.100.542 Slipped Rib
1
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
(in Afterbirth † and Repentance) Sulfuric Acid 5.100.463 Sulfuric Acid
1
+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles and open doors.
(in Afterbirth † and Repentance) Technology Zero 5.100.524 Technology Zero
1
Connects Isaac's tears with electricity that can damage enemies.
(in Afterbirth † and Repentance) Varicose Veins 5.100.452 Varicose Veins
1
Taking damage releases a ring of 10 high damage tears.
(in Afterbirth † and Repentance) YO LISTEN! 5.100.492 YO LISTEN!
1
+1 luck. Spawns a fairy familiar that points out Secret RoomSecret Rooms, Crawl SpaceCrawl Space entrances, and tinted rocks.
(in Repentance) 120 Volt 5.100.559 120 Volt
1
Repeatedly zaps enemies that are close to Isaac.
(in Repentance) Akeldama 5.100.641 Akeldama
1
While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.
(in Repentance) Almond Milk 5.100.561 Almond Milk
1
Quadruples fire rate, with x0.3 damage multiplier. Each tear is a given random effect that alters its movement.
(in Repentance) Belly Button 5.100.458 Belly Button
1
Drops a random trinket. Grants a second trinket slot.
(in Repentance) Belly Jelly 5.100.690 Belly Jelly
1
Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots.
(in Repentance) Bird Cage 5.100.610 Bird Cage
1
The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Collectible Dead Bird iconDead Bird.
(in Repentance) Bird's Eye 5.100.616 Bird's Eye
1
Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
(in Repentance) Blood Bombs 5.100.614 Blood Bombs
1
Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place BombBombs at the cost of half a heart if he doesn't have any.
(in Repentance) Blood Puppy 5.100.565 Blood Puppy
1
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red HeartHalf Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal.
(in Repentance) Bloody Gust 5.100.695 Bloody Gust
1
The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively.
(in Repentance) Boiled Baby 5.100.607 Boiled Baby
1
Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
(in Repentance) Bone Spurs 5.100.683 Bone Spurs
1
Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them.
(in Repentance) Bot Fly 5.100.629 Bot Fly
1
Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
(in Repentance) Candy Heart 5.100.671 Candy Heart
1
Gives Isaac a permanent stat boost whenever he heals with Red HeartRed Heart pickups.
(in Repentance) Cracked Orb 5.100.675 Cracked Orb
1
Unlocks doors and reveals a random room on the map when Isaac takes damage.
(in Repentance) C Section 5.100.678 C Section
1
Replaces tears with fetuses that chase down enemies and deal contact damage. Each shot requires a brief charge up.
(in Repentance) Cube Baby 5.100.652 Cube Baby
1
Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
(in Repentance) Dirty Mind 5.100.576 Dirty Mind
1
Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.
(in Repentance) Empty Heart 5.100.676 Empty Heart
1
If Isaac has one red heart or fewer at the beginning of a floor, he gains an empty red heart container.
(in Repentance) Eye Sore 5.100.558 Eye Sore
1
Causes Isaac to occasionally fire extra tears in random directions while shooting.
(in Repentance) Freezer Baby 5.100.608 Freezer Baby
1
Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them.
(in Repentance) Fruity Plum 5.100.649 Fruity Plum
1
Gives Isaac a miniature Boss Baby Plum ingameBaby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
(in Repentance) Ghost Bombs 5.100.727 Ghost Bombs
1
+5 BombBombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds.
(in Repentance) Giant Cell 5.100.658 Giant Cell
1
Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies.
(in Repentance) Hemoptysis 5.100.726 Hemoptysis
1
Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. Affected enemies are cursed and take more damage from Collectible Brimstone iconBrimstone-like attacks.
(in Repentance) Hypercoagulation 5.100.724 Hypercoagulation
1
After Isaac takes damage from an enemy or donates health, launches Red HeartRed Hearts from Isaac that despawn after 1.5 seconds.
(in Repentance) IBS 5.100.725 IBS
1
Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies.
(in Repentance) It Hurts 5.100.560 It Hurts
1
Releases a ring of tears and increases fire rate for the current room when Isaac takes damage.
(in Repentance) Keeper's Kin 5.100.717 Keeper's Kin
1
Rocks and other Obstacles spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.
(in Repentance) Knockout Drops 5.100.637 Knockout Drops
1
Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
(in Repentance) Lil Dumpy 5.100.615 Lil Dumpy
1
Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him.
(in Repentance) Lil Portal 5.100.681 Lil Portal
1
A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room.
(in Repentance) Lodestone 5.100.617 Lodestone
1
Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources.
(in Repentance) Lost Soul 5.100.612 Lost Soul
1
Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul HeartSoul Hearts, Eternal HeartEternal Hearts, or an Item.
(in Repentance) Montezuma's Revenge 5.100.680 Montezuma's Revenge
1
While firing, Isaac charges up a short-ranged Collectible Brimstone iconBrimstone-like diarrhea beam that shoots behind him.
(in Repentance) Mucormycosis 5.100.553 Mucormycosis
1
Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
(in Repentance) Nancy Bombs 5.100.563 Nancy Bombs
1
+5 BombBombs. Each bomb gains 1-4 random bomb synergies.
(in Repentance) Playdough Cookie 5.100.570 Playdough Cookie
1
Grants multicolored tears. Each color comes with a different status or tear effect.
(in Repentance) Polydactyly 5.100.454 Polydactyly
1
Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
(in Repentance) Psy Fly 5.100.581 Psy Fly
1
Spawns a fly orbital familiar that chases and blocks enemy shots.
(in Repentance) Quints 5.100.661 Quints
1
The first five enemies killed in a room will spawn stationary shooting familiars where they died.
(in Repentance) Rocket in a Jar 5.100.583 Rocket in a Jar
1
+5 BombBombs. If Isaac is currently firing, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing.
(in Repentance) Rotten Tomato 5.100.618 Rotten Tomato
1
Adds a chance to fire tears that mark enemies with the Bait status effect. Enemies marked as bait are attacked by other enemies.
(in Repentance) The Intruder 5.100.575 The Intruder
1
A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
(in Repentance) The Swarm 5.100.693 The Swarm
1
Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly.
(in Repentance) Tinytoma 5.100.645 Tinytoma
1
Gives Isaac a Boss Teratoma ingameTeratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders.
(in Repentance) Tooth and Nail 5.100.663 Tooth and Nail
1
Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage.
(in Repentance) Vasculitis 5.100.657 Vasculitis
1
Enemies explode into tears upon death, which inherit the effects of Isaac's tears.
(in Repentance) Worm Friend 5.100.682 Worm Friend
1
Gives Isaac a Nerve EndingNerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.
(in Repentance) Astral Projection 5.100.677 Astral Projection
0.2
Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes.
(in Repentance) Skeleton Key 5.100.17 Skeleton Key
0.1
Gives Isaac 99 KeyKeys.


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