Binding of Isaac: Rebirth Wiki
Advertisement
Binding of Isaac: Rebirth Wiki


The Treasure Room item pool contains the majority of the game's items. All of the items in this pool are able to be found in the Treasure Room.

Activated Collectibles[]

Name ID Icon Weight Description
Anarchist Cookbook 5.100.65
Anarchist Cookbook
3 rooms
1
Spawns six Troll Bombs around the room.
The Bean 5.100.111
The Bean
1 rooms
1
Isaac farts, poisoning any enemy in close range.
Best Friend 5.100.136
Best Friend
3 rooms
1
Spawns a decoy Isaac that explodes after 5 seconds, dealing Removed in Repentance 110 Added in Repentance 185 damage. Enemies will always target the decoy and ignore Isaac.
Blood Rights 5.100.186
Blood Rights
Unlimited
1
Upon use, takes a full heart of health and deals 40 damage to all enemies in the room.
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
1
Upon use, Isaac holds a poison bomb which can be thrown in the cardinal directions and explodes on impact.
Book of Revelations 5.100.78
Book of Revelations
6 rooms
1
Gives one Soul Heart, increases the chance for a Devil Room Devil Room or Angel Room Angel Room, and changes the boss of the current floor to a Harbinger if possible.
Book of Secrets 5.100.287
Book of Secrets
6 rooms
1
Gives the effect of 15►Treasure Map Treasure Map, 15►The Compass The Compass, or 15►Blue Map Blue Map for the duration of the current floor.
Book of Shadows 5.100.58
Book of Shadows
3 rooms
1
Creates a protective shield, nullifying all types of damage in the current room for 10 seconds.
The Book of Sin 5.100.97
The Book of Sin
4 rooms
1
Generates a random pickup, pill, card, or rune.
Box of Spiders 5.100.288
Box of Spiders
2 rooms
1
Removed in Repentance Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.
Added in Repentance Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
Butter Bean 5.100.294
Butter Bean
3 seconds
1
Upon use, Isaac farts and knocks back nearby enemies Added in Afterbirth and projectiles. Added in Repentance Enemies pushed into walls or obstacles take 12 damage.
Crack the Sky 5.100.160
Crack the Sky
4 rooms
1
Summons 5 beams of light in random locations on the ground, dealing large amounts of damage to any enemies that touch them.
D10 5.100.285
D10
1 rooms
1
Rerolls the monsters in the room. Only rerolls monsters that are still alive (does not spawn new enemies).
D100 5.100.283
D100
6 rooms
1
Removed in Repentance Combines the effects of 15►D4 D4, 15►The D6 The D6, and 15►D20 D20.
Added in Repentance Combines the effects of 15►D1 D1, 15►D4 D4, 15►The D6 The D6, 15►D7 D7, 15►D8 D8, 15►D10 D10, 15►D12 D12, and 15►D20 D20.
D20 5.100.166
D20
6 rooms
1
Rerolls all pickups in the current room.
D4 5.100.284
D4
6 rooms
1
Rerolls all of Isaac's passive items.
The D6 5.100.105
The D6
6 rooms
1
Re-rolls all items in the current room into other items, depending on the current room's Item Pool.
Dad's Key 5.100.175
Dad's Key
2 rooms
1
Opens all doors in the current room when activated, including doors which require a key to open and entrances to Secret Rooms. Opens the big doors in the first room of both Chest Chest and the Dark Room Dark Room.
Dead Sea Scrolls 5.100.124
Dead Sea Scrolls
2 rooms
1
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards 5.100.85
Deck of Cards
6 rooms
1
Gives Isaac a random card.
Doctor's Remote 5.100.47
Doctor's Remote
2 rooms
1
Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion.
Flush! 5.100.291
Flush!
4 rooms
1
Turns all non-boss monsters in the room into poop. Instantly kills poop-themed bosses.
Forget Me Now 5.100.127
Forget Me Now
One time use
1
On use, re-generates the current floor with a new layout. Isaac loses Forget Me Now, but keeps other items and consumables picked up on the original floor.
The Gamekid 5.100.93
The Gamekid
4 rooms
1
Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed.
The Hourglass 5.100.66
The Hourglass
2 rooms
1
All enemies in the room are slowed for 8 seconds.
How to Jump 5.100.282
How to Jump
Unlimited
1
Upon use, Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies.
Isaac's Tears 5.100.323
Isaac's Tears
6 rooms
1
Fires 8 tears around Isaac, which retain the damage, range, shot speed, and special tear effects. Each tear shot by Isaac increases item charge by one.
Kamikaze! 5.100.40
Kamikaze!
Unlimited
1
Creates an explosion around Isaac, damaging him and nearby enemies as well as destroying obstacles.
Lemon Mishap 5.100.56
Lemon Mishap
2 rooms
1
Creates a tiny pool of yellow creep, damaging enemies that cross it.
Magic Fingers 5.100.295
Magic Fingers
Unlimited
1
Uses 1 coin to deal a large amount of damage to all enemies in the room.
Mom's Bottle of Pills 5.100.102
Mom's Bottle of Pills
6 rooms
1
Gives Isaac a random pill.
Mom's Bra 5.100.39
Mom's Bra
3 rooms
1
Petrifies all enemies in the current room for around 4 seconds.
Mom's Pad 5.100.41
Mom's Pad
3 rooms
1
Inflicts fear to all enemies in the room for 5 seconds.
Monster Manual 5.100.123
Monster Manual
6 rooms
1
Removed in Repentance Spawns a familiar from a specific selection for the current room.
Added in Repentance Spawns a familiar from a specific selection for the current floor.
Monstro's Tooth 5.100.86
Monstro's Tooth
3 rooms
1
A friendly Monstro jumps on a random enemy, dealing 120 area damage. Lands on Isaac if used in a room without enemies.
Mr. Boom 5.100.37
Mr. Boom
2 rooms
1
Places a Mr. Mega bomb that deals 110 damage.
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
1
Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies.
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
1
Gives flight for the current room, while turning Isaac's body into a fast, high damage familiar.
The Poop 5.100.36
The Poop
1 rooms
1
Spawns a pile of poop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop.
Prayer Card 5.100.146
Prayer Card
6 rooms
1
Gives an Eternal Heart per use.
Remote Detonator 5.100.137
Remote Detonator
Unlimited
1
Bombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs.
Satanic Bible 5.100.292
Satanic Bible
6 rooms
1
Gives one Black Heart. Added in Repentance Replaces the boss room item on the current floor with a Devil Deal.
Scissors 5.100.325
Scissors
4 rooms
1
Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. Added in Repentance Isaac's body also shoots a controllable fountain of blood shots for the room.
Shoop Da Whoop! 5.100.49
Shoop Da Whoop!
2 rooms
1
Fires a laser from Isaac's mouth.
Spider Butt 5.100.171
Spider Butt
2 rooms
1
Deals 10 damage to all enemies in the room and slows them for 4 seconds. Added in Repentance Enemies killed by Spider Butt spawn Blue Spiders.
Telepathy for Dummies 5.100.192
Telepathy for Dummies
2 rooms
1
Gives homing tears for the current room. Added in Repentance Also gives +3 range.
Teleport! 5.100.44
Teleport!
2 rooms
1
Teleports Isaac to a random room on the current floor.
Undefined 5.100.324
Undefined
6 rooms
1
Teleports Isaac to the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR.
Unicorn Stump 5.100.298
Unicorn Stump
1 rooms
1
Gives invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
Yum Heart 5.100.45
Yum Heart
4 rooms
1
Restores one full Red Heart.
Removed in Repentance Blank Card 5.100.286
Blank Card
Variable
1
Removed in Repentance Copies the effect of the card or rune currently held by Isaac.
Added in Repentance No longer copies the effects of runes.
Removed in Repentance Crystal Ball 5.100.158
Crystal Ball
6 rooms
1
Upon use, reveals the map (except the Super Secret Room) and drops a Soul Heart or random card/rune.
Removed in Repentance Notched Axe 5.100.147
Notched Axe
Unlimited
1
Removed in Repentance Isaac destroys obstacles and opens Secret Rooms by walking into them, but cannot shoot or pick up items until it's cancelled.
Added in Repentance Toggles between tears and the pickaxe, which can be swung to attack and break obstacles. Using it depletes the charge, and it can't be used until next floor once the charge runs out.
Added in Afterbirth D12 5.100.386
D12
3 rooms
1
Re-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poops.
Added in Afterbirth D7 5.100.437
D7
3 rooms
1
Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.
Added in Afterbirth D8 5.100.406
D8
4 rooms
1
Re-rolls Isaac's damage, tears, range, and speed.
Added in Afterbirth Friendly Ball 5.100.382
Friendly Ball
2 rooms
1
Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
Added in Afterbirth Glass Cannon 5.100.352
Glass Cannon
4 seconds
1
Removed in Repentance Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
Added in Repentance Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes 15►Broken Glass Cannon Broken Glass Cannon.
Added in Afterbirth Glowing Hour Glass 5.100.422
Glowing Hour Glass
3 rooms
1
Rewinds time, putting Isaac back in the previous room and undoing anything that happened in the current room.
Added in Afterbirth Kidney Bean 5.100.421
Kidney Bean
1 rooms
1
Isaac farts, charming all nearby enemies.
Added in Afterbirth Mega Bean 5.100.351
Mega Bean
3 rooms
1
Petrifies all enemies in the current room for a couple of seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing.
Added in Afterbirth Mine Crafter 5.100.427
Mine Crafter
1 rooms
1
Places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies when used. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.
Added in Afterbirth Teleport 2.0 5.100.419
Teleport 2.0
4 rooms
1
Teleports Isaac to a room that has not been explored yet. Normal rooms are prioritized over special rooms, and common special rooms take priority over rarer ones.
Added in Afterbirth † Black Hole 5.100.512
Black Hole
4 rooms
1
Throws a black hole on the ground which sucks in and damages enemies.
Added in Afterbirth † Book of the Dead 5.100.545
Book of the Dead
6 rooms
1
Upon use, creates a friendly Bony, Black Bony, or an orbital bone for each enemy killed in the current room.
Added in Repentance Can also create a friendly Bone Fly or Revenant.
Added in Afterbirth † Brown Nugget 5.100.504
Brown Nugget
7 seconds
1
Spawns a stationary fly turret that fires tears at nearby enemies.
Added in Afterbirth † Clicker 5.100.482
Clicker
6 rooms
1
Transforms Isaac into a random character and removes the last item collected.
Added in Afterbirth † Crooked Penny 5.100.485
Crooked Penny
4 rooms
1
Spawns a penny and has a 50% chance to double all items and pickups in the room. If the effect fails, the items and pickups disappear.
Added in Afterbirth † D1 5.100.476
D1
4 rooms
1
Duplicates a random pickup in the room.
Added in Afterbirth † Dataminer 5.100.481
Dataminer
4 rooms
1
Displaces enemy sprites for the current room, randomly increases one stat and decreases another.
Added in Afterbirth † Metronome 5.100.488
Metronome
2 rooms
1
Grants a random item effect for the current room.
Added in Afterbirth † Pause 5.100.478
Pause
2 rooms
1
Freezes all enemies until a fire button is pressed.
Added in Afterbirth † Sharp Straw 5.100.507
Sharp Straw
10 seconds
1
Damages all enemies in the room. Has a chance to drop a half red heart Removed in Repentanceor half soul heart if an enemy is hit.
Added in Afterbirth † Sprinkler 5.100.516
Sprinkler
4 rooms
1
Upon use, creates a stationary sprinkler that rotates and fires tears in 8 directions. The tears copy Isaac's stats and most tear effects.
Added in Afterbirth † Telekinesis 5.100.522
Telekinesis
3 seconds
1
Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
Added in Afterbirth † / Removed in Repentance D Infinity 5.100.489
D Infinity
Variable
1
Removed in Repentance Grants a random die item that changes each use.
Added in Repentance Acts as any die item, and can by cycled by pressing the drop key.
Added in Afterbirth † / Removed in Repentance Wait What? 5.100.484
Wait What?
10 seconds
1
Isaac farts, sending out rock waves.
Added in Repentance Anima Sola 5.100.722
Anima Sola
15 seconds
1
Chains down the nearest enemy for 5 seconds, preventing them from acting.
Added in Repentance Decap Attack 5.100.729
Decap Attack
4 seconds
1
Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it.
Added in Repentance Everything Jar 5.100.720
Everything Jar
12 rooms
1
Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects.
Added in Repentance Fortune Cookie 5.100.557
Fortune Cookie
2 rooms
1
Gives Isaac a fortune, Soul Heart, Card, Rune, or trinket, similar to a Fortune Telling Machine. Fortunes are much more likely to be given than anything else.
Added in Repentance Free Lemonade 5.100.578
Free Lemonade
4 rooms
1
Creates a large pool of yellow creep beneath Isaac.
Added in Repentance Friend Finder 5.100.687
Friend Finder
4 rooms
1
Spawns a random friendly monster that mimics Isaac's movements and attacks.
Added in Repentance Golden Razor 5.100.555
Golden Razor
Unlimited
1
Spends five coins to increase Isaac's damage by 1.2 for the current room.
Added in Repentance Larynx 5.100.611
Larynx
12 rooms
1
Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage.
Added in Repentance Meat Cleaver 5.100.631
Meat Cleaver
2 rooms
1
Splits all enemies in the room into two smaller versions of themselves with much less health.
Added in Repentance The Scooper 5.100.605
The Scooper
3 rooms
1
Summons a Peeper familiar for the current room, which leaves a trail of red creep.
Added in Repentance Spin to Win 5.100.655
Spin to Win
3 seconds
1
When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held.
Added in Repentance Stitches 5.100.635
Stitches
3 seconds
1
Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.
Added in Repentance Suplex! 5.100.709
Suplex!
6 seconds
1
Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave.
Added in Repentance Yuck Heart 5.100.639
Yuck Heart
6 rooms
1
Gives Isaac a Rotten Heart.
Added in Repentance Esau Jr. 5.100.703
Esau Jr.
1 rooms
0.5
Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
Added in Repentance Eternal D6 5.100.609
Eternal D6
2 rooms
0.5
Rerolls all items in the room. Each item has a 30% chance to disappear instead.
Added in Repentance Gello 5.100.728
Gello
2 rooms
0.5
Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
Added in Repentance Plum Flute 5.100.650
Plum Flute
4 rooms
0.5
Summons the boss Baby Plum to fight for Isaac in the current room.
Added in Repentance Mega Mush 5.100.625
Mega Mush
12 rooms
0.1
Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.
Added in Repentance Spindown Dice 5.100.723
Spindown Dice
6 rooms
0.1
Transforms all items in the room by decreasing their internal ID number.

Passive Collectibles[]

Name ID Icon Weight Description
20/20 5.100.245 20/20
1
Isaac fires two tears at once, one from each eye.
Added in Repentance 0.75x damage multiplier.
3 Dollar Bill 5.100.191 3 Dollar Bill
1
Removed in Afterbirth Gives Isaac a random tear effect every room.
Added in Afterbirth Gives Isaac a random tear effect every few seconds.
<3 5.100.15 <3
1
Grants Isaac one Red Heart container and fully restores Isaac's health.
???'s Only Friend 5.100.320 ???'s Only Friend
1
Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys
Abel 5.100.188 Abel
1
Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
Anemic 5.100.214 Anemic
1
Increases range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room.
Ankh 5.100.161 Ankh
1
Upon death, Isaac will respawn as ??? ??? in the most recent non-hostile room, with 3 Soul Hearts.
Anti-Gravity 5.100.222 Anti-Gravity
1
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Aquarius 5.100.308 Aquarius
1
A trail of blue creep is left behind Isaac, which damages enemies.
Aries 5.100.300 Aries
1
+0.25 Speed. Running into enemies while at a high speed will deal damage. Removed in Repentance Does not prevent contact damage.
BBF 5.100.272 BBF
1
Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds.
Ball of Tar 5.100.231 Ball of Tar
1
Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud 5.100.274 Best Bud
1
When hit, spawns a quickly orbiting attack fly similar to 15►Forever Alone Forever Alone for the current room dealing Removed in Repentance75 Added in Repentance150 damage per second.
Big Fan 5.100.279 Big Fan
1
Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies.
The Black Bean 5.100.180 The Black Bean
1
When taking damage, Isaac farts, causing poison damage to all enemies in range.
Blood of the Martyr 5.100.7 Blood of the Martyr
1
Increases damage by 1, and turns Isaac's tears into blood tears.
Bloody Lust 5.100.157 Bloody Lust
1
Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Bob's Brain 5.100.273 Bob's Brain
1
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse 5.100.140 Bob's Curse
1
Gives 5 bombs and grants Isaac's bombs a poison effect. Added in Repentance Gives Isaac immunity to poison.
Bobby-Bomb 5.100.125 Bobby-Bomb
1
+5 bombs. Bombs gain a homing effect, slowly moving towards the nearest enemy.
Bomb Bag 5.100.131 Bomb Bag
1
Spawns a familiar that drops a bomb every 3 rooms.
Boom! 5.100.19 Boom!
1
Grants 10 bombs.
Brother Bobby 5.100.8 Brother Bobby
1
A familiar that follows Isaac around shooting normal tears.
Bucket of Lard 5.100.129 Bucket of Lard
1
Grants two Removed in Repentanceempty Added in Repentancefull Red Heart containers and heals Isaac by half a Red Heart, but decreases speed by 0.2.
Bum Friend 5.100.144 Bum Friend
1
Spawns a familiar that picks up coins for himself, giving random pickups in return. Does not spawn collectibles.
Butt Bombs 5.100.209 Butt Bombs
1
+5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
Cain's Other Eye 5.100.319 Cain's Other Eye
1
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Cancer 5.100.301 Cancer
1
Adds 3 Soul Hearts. Grants 15►The Wafer The Wafer effect for the current room after taking damage.
Capricorn 5.100.307 Capricorn
1
Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, Removed in Repentance +1.5 / Added in Repentance +0.75 Range, and -1.0 Tear Delay, and gives 1 Bomb, Coin, and Key.
Celtic Cross 5.100.162 Celtic Cross
1
Grants a chance to trigger the 15►Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire 5.100.62 Charm of the Vampire
1
Heals Isaac for half of a Red Heart for every 13 enemies killed. Added in Repentance +0.3 damage.
Chemical Peel 5.100.154 Chemical Peel
1
Tears fired from the left eye have +2 flat damage.
Chocolate Milk 5.100.69 Chocolate Milk
1
Grants charged tears that deal greater damage when fully charged.
The Common Cold 5.100.103 The Common Cold
1
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Cricket's Body 5.100.224 Cricket's Body
1
Grants -1 tear delay and reduces range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's.
Cricket's Head 5.100.4 Cricket's Head
1
Increases Damage by 0.5, and increases damage multiplier by x1.5.
Cupid's Arrow 5.100.48 Cupid's Arrow
1
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Cursed Eye 5.100.316 Cursed Eye
1
Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
Daddy Longlegs 5.100.170 Daddy Longlegs
1
Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.
Dark Bum 5.100.278 Dark Bum
1
Spawns a familiar that follows Isaac around and collects Red Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward.
Dead Bird 5.100.117 Dead Bird
1
After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second.
Dead Onion 5.100.336 Dead Onion
1
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Demon Baby 5.100.113 Demon Baby
1
Spawns a familiar that follows Isaac and automatically fires at enemies in its reach.
Distant Admiration 5.100.57 Distant Admiration
1
Spawns an attack fly that circles further out than 15►Halo of Flies Halo of Flies, but closer than 15►Forever Alone Forever Alone, dealing 75 damage per second.
Dr. Fetus 5.100.52 Dr. Fetus
1
Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Dry Baby 5.100.265 Dry Baby
1
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering 15►The Necronomicon The Necronomicon effect.
Eve's Mascara 5.100.310 Eve's Mascara
1
Doubles damage, halves tears stat, and greatly reduces shot speed.
Experimental Treatment 5.100.240 Experimental Treatment
1
Removed in Afterbirth † Randomly increases and decreases some of Isaac's stats.
Added in Afterbirth † Increases four random stats and decreases the other two.
Fire Mind 5.100.257 Fire Mind
1
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever Alone 5.100.128 Forever Alone
1
Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second.
Gemini 5.100.318 Gemini
1
Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second.
Ghost Baby 5.100.163 Ghost Baby
1
Spawns a familiar that follows Isaac around and fires spectral tears.
Gimpy 5.100.225 Gimpy
1
Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Gnawed Leaf 5.100.210 Gnawed Leaf
1
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Guillotine 5.100.206 Guillotine
1
Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay.
Halo of Flies 5.100.10 Halo of Flies
1
Spawns two Pretty Flies that block enemy shots and deal contact damage to flies.
Harlequin Baby 5.100.167 Harlequin Baby
1
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby 5.100.269 Headless Baby
1
Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Holy Water 5.100.178 Holy Water
1
Removed in Repentance Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
Added in Repentance A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
Hot Bombs 5.100.256 Hot Bombs
1
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Infamy 5.100.242 Infamy
1
Chance to block projectiles coming from any direction.
Infestation 2 5.100.234 Infestation 2
1
Spawns allied Blue Spiders from killed enemies.
Infestation 5.100.148 Infestation
1
Removed in Repentance 1-3 Blue Flies randomly spawn every time Isaac gets hit.
Added in Repentance 2-6 Blue Flies randomly spawn every time Isaac gets hit.
The Inner Eye 5.100.2 The Inner Eye
1
Grants triple shot but decreases tears.
Ipecac 5.100.149 Ipecac
1
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar 5.100.201 Iron Bar
1
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Isaac's Heart 5.100.276 Isaac's Heart
1
Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. Added in Repentance The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.
Juicy Sack 5.100.266 Juicy Sack
1
Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.
Lazarus' Rags 5.100.332 Lazarus' Rags
1
Upon dying, resurrect as Lazarus Risen Lazarus Risen in the current room with one Red Heart container and 15►Anemic Anemic.
Leech 5.100.270 Leech
1
Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy.
Leo 5.100.302 Leo
1
Isaac can destroy rocks by walking into them.
Libra 5.100.304 Libra
1
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Lil Brimstone 5.100.275 Lil Brimstone
1
Grants a familiar that charges a thin 15►Brimstone Brimstone laser while Isaac is shooting.
Lil Haunt 5.100.277 Lil Haunt
1
Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear.
Little C.H.A.D. 5.100.96 Little C.H.A.D.
1
Spawns a familiar who drops a Half Red Heart every 3 rooms.
Little Chubby 5.100.88 Little Chubby
1
Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path.
Little Gish 5.100.99 Little Gish
1
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven 5.100.100 Little Steven
1
Spawns a familiar who follows Isaac around and fires homing tears.
Loki's Horns 5.100.87 Loki's Horns
1
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact 5.100.213 Lost Contact
1
Isaac's tears can hit and destroy enemy projectiles. -0.16 shot speed.
Lucky Foot 5.100.46 Lucky Foot
1
+1 luck. Increases chance of winning Shell Games and Fortune Tellers (independent from the luck stat).
Added in Repentance Converts all bad pills into good pills, without identifying them.
The Ludovico Technique 5.100.329 The Ludovico Technique
1
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Maggy's Bow 5.100.312 Maggy's Bow
1
Gives one Red Heart Container and doubles the healing provided by Red Hearts. Added in Repentance Also heals 1 Red Heart when obtained.
Magneto 5.100.53 Magneto
1
Pulls pickups towards Isaac.
Midas' Touch 5.100.202 Midas' Touch
1
Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop coins.
Mini Mush 5.100.71 Mini Mush
1
Decreases Isaac's size, making him less likely to be hit. Removed in Repentance+0.3 speed, +1.5 tear height, -4.25 range (effective range is increased). Added in Repentance +0.3 speed, +1.50 range.
Mitre 5.100.173 Mitre
1
Grants a chance of converting any Red Heart pickups into Soul Hearts instead.
Mom's Contacts 5.100.110 Mom's Contacts
1
+0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking.
Mom's Eye 5.100.55 Mom's Eye
1
Gives Isaac a chance to fire tears from the back of his head.
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow
1
Tears have a chance to charm enemies.
Mom's Perfume 5.100.228 Mom's Perfume
1
Adds a chance to shoot fear tears and decreases tear delay by 1.
Mom's Wig 5.100.217 Mom's Wig
1
Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.
Money = Power 5.100.109 Money = Power
1
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Mongo Baby 5.100.322 Mongo Baby
1
Spawns a familiar that copies the tears of Isaac's other familiars.
Monstro's Lung 5.100.229 Monstro's Lung
1
Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Monstro.
Mr. Mega 5.100.106 Mr. Mega
1
Grants 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
The Mulligan 5.100.151 The Mulligan
1
Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy.
Mutant Spider 5.100.153 Mutant Spider
1
Grants quadruple shot but decreases tears.
My Reflection 5.100.5 My Reflection
1
Gives Isaac's tears a boomerang effect. +1.5 range, +1 tear height, x1.6 shot speed multiplier.
Mysterious Liquid 5.100.317 Mysterious Liquid
1
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery Sack 5.100.271 Mystery Sack
1
Spawns a familiar that drops a Heart, coin, bomb, or key every 5-6 rooms.
Number One 5.100.6 Number One
1
Grants +1.5 tears, but severely reduces range.
Odd Mushroom 5.100.121 Odd Mushroom
1
Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear height, and -0.1 speed.
Odd Mushroom 5.100.120 Odd Mushroom
1
+1.7 tears, +0.3 speed, slightly reduces damage.
Ouija Board 5.100.115 Ouija Board
1
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
The Parasite 5.100.104 The Parasite
1
Isaac's tears split in two when they hit something.
The Peeper 5.100.155 The Peeper
1
Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through.
PHD 5.100.75 PHD
1
Converts all bad pills into good pills, spawns one pill pickup, and identifies all pills. Restores two Red Hearts and increases the payout of Blood Donation Machines.
Piggy Bank 5.100.227 Piggy Bank
1
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.
Pisces 5.100.309 Pisces
1
-1 Tear Delay, adds knock-back shots and increases tear size.
Polyphemus 5.100.169 Polyphemus
1
Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage.
Proptosis 5.100.261 Proptosis
1
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag 5.100.281 Punching Bag
1
Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer.
Rainbow Baby 5.100.174 Rainbow Baby
1
Spawns a familiar that follows Isaac around and fires tears with random effects.
Robo-Baby 2.0 5.100.267 Robo-Baby 2.0
1
Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Robo-Baby 5.100.95 Robo-Baby
1
Spawns a familiar that shoots 15►Technology Technology lasers.
Roid Rage 5.100.14 Roid Rage
1
Removed in Repentance +0.6 speed, +5.25 range, +0.5 tear height.
Added in Repentance +0.3 speed, +1.50 range, +0.5 tear height.
Rosary 5.100.72 Rosary
1
Adds 3 Soul Hearts. The Bible will appear in any item pool.
Added in RepentanceAlso a +0.5 tears up.
Rotten Baby 5.100.268 Rotten Baby
1
Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Rubber Cement 5.100.221 Rubber Cement
1
Tears bounce off walls, enemies, and environmental objects.
SMB Super Fan 5.100.189 SMB Super Fan
1
+1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear height. Fully restores all red hearts.
Sack of Pennies 5.100.94 Sack of Pennies
1
Spawns a familiar that drops a coin every 2 rooms.
Sacrificial Dagger 5.100.172 Sacrificial Dagger
1
Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact.
Sad Bombs 5.100.220 Sad Bombs
1
+5 Bombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers.
The Sad Onion 5.100.1 The Sad Onion
1
Increases tears by 0.7.
Sagittarius 5.100.306 Sagittarius
1
Increases speed by +0.2 and grants piercing tears.
Samson's Chains 5.100.321 Samson's Chains
1
Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles.
Scapular 5.100.142 Scapular
1
Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.
Scorpio 5.100.305 Scorpio
1
Grants poison tears, which deal damage over time when inflicted.
Sissy Longlegs 5.100.280 Sissy Longlegs
1
Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders.
Sister Maggy 5.100.67 Sister Maggy
1
Spawns a familiar that follows Isaac around shooting normal tears.
Smart Fly 5.100.264 Smart Fly
1
Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second.
Soy Milk 5.100.330 Soy Milk
1
Tears are smaller and do much less damage, but fire in very rapid succession.
Speed Ball 5.100.143 Speed Ball
1
+0.3 speed, +0.2 shot speed.
Spelunker Hat 5.100.91 Spelunker Hat
1
Reveals type of adjacent rooms, including location for Secret Rooms and Super Secret Rooms.
Spider Bite 5.100.89 Spider Bite
1
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spiderbaby 5.100.211 Spiderbaby
1
Removed in Repentance When hit, spawns 1-2 Blue Spiders.
Added in Repentance When hit, spawns 3-5 Blue Spiders.
Spoon Bender 5.100.3 Spoon Bender
1
Grants Isaac homing tears.
Stem Cells 5.100.176 Stem Cells
1
Grants one full Red Heart container and +0.16 shot speed.
Stigmata 5.100.138 Stigmata
1
Increases damage, and adds 1 heart container.
Strange Attractor 5.100.315 Strange Attractor
1
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Super Bandage 5.100.92 Super Bandage
1
Grants one full Red Heart container and 2 Soul Hearts.
Taurus 5.100.299 Taurus
1
-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the 15►My Little Unicorn My Little Unicorn effect for 5 seconds.
Tech.5 5.100.244 Tech.5
1
Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets.
Technology 2 5.100.152 Technology 2
1
Decreases Removed in Repentance damage and replaces the tears fired from Isaac's right eye with a rapidly firing and piercing laser.
Added in Repentance Reduces the tears of Isaac's left eye; damage is unaffected.
Technology 5.100.68 Technology
1
Replaces tears with a piercing laser with unlimited range.
Thunder Thighs 5.100.314 Thunder Thighs
1
Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed.
Tiny Planet 5.100.233 Tiny Planet
1
Range up and makes shot tears revolve around Isaac until they drop.
Tough Love 5.100.150 Tough Love
1
Adds a chance to shoot a tooth instead of a tear, which deals x3.2 Isaac's damage.
Virgo 5.100.303 Virgo
1
Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
The Virus 5.100.13 The Virus
1
Isaac poisons enemies on contact. Removed in Repentance -0.1 speed. Added in Repentance +0.2 speed. Added in Afterbirth / Removed in Repentance Poisoned enemies have a chance to drop a black heart when killed.
The Wafer 5.100.108 The Wafer
1
All sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead.
X-Ray Vision 5.100.76 X-Ray Vision
1
Reveals and opens all Secret Room and Super Secret Room entrances.
The Halo 5.100.101 The Halo
Removed in Repentance1
Added in Repentance0.5
Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height.
Magic Mushroom 5.100.12 Magic Mushroom
Removed in Repentance1
Added in Repentance0.5
Makes Isaac bigger. Adds one Red Heart container, +0.3 damage, x1.5 damage multiplier, +5.25 range, and +0.3 speed. Restores all health on pickup.
The Body 5.100.334 The Body
Removed in Repentance1
Added in Repentance0.2
Adds 3 Red Heart Containers.
Death's Touch 5.100.237 Death's Touch
Removed in Repentance1
Added in Repentance0.2
+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Holy Mantle 5.100.313 Holy Mantle
Removed in Repentance1
Added in Repentance0.2
Upon entering a room, grants a shield that negates the first damage taken.
The Mind 5.100.333 The Mind
Removed in Repentance1
Added in Repentance0.2
Reveals the entire map, including all special rooms and Secret Rooms.
Mom's Knife 5.100.114 Mom's Knife
Removed in Repentance1
Added in Repentance0.2
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
The Relic 5.100.98 The Relic
Removed in Repentance1
Added in Repentance0.2
Spawns a cross familiar that drops a Soul Heart every 5-6 rooms.
The Soul 5.100.335 The Soul
Removed in Repentance1
Added in Repentance0.2
Grants two Soul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles.
Pyro 5.100.190 Pyro
Removed in Repentance1
Added in Repentance0.2
Grants 99 Bombs.
Pyromaniac 5.100.223 Pyromaniac
Removed in Repentance1
Added in Repentance0.2
+5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. Added in Repentance Also grants immunity to fire.
Removed in Repentance A Quarter 5.100.74 A Quarter
1
Gives Isaac 25 coins.
Removed in Repentance Epic Fetus 5.100.168 Epic Fetus
1
Isaac's tears are replaced with guided missiles, like those used by the 15►Doctor's Remote Doctor's Remote.
Removed in Repentance Judas' Shadow 5.100.311 Judas' Shadow
1
Upon death, respawns Isaac as Dark Judas Dark Judas with two Black Hearts in the most recent non-hostile room.
Added in Afterbirth 8 Inch Nails 5.100.359 8 Inch Nails
1
+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.
Added in Afterbirth Betrayal 5.100.391 Betrayal
1
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Added in Afterbirth Bomber Boy 5.100.353 Bomber Boy
1
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs.
Added in Afterbirth Bumbo 5.100.385 Bumbo
1
Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage.
Added in Afterbirth Bursting Sack 5.100.377 Bursting Sack
1
Spider enemies no longer target or deal contact damage to Isaac.
Added in Afterbirth Continuum 5.100.369 Continuum
1
Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room.
Added in Afterbirth Curse of the Tower 5.100.371 Curse of the Tower
1
Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower XVI - The Tower.
Added in Afterbirth Dead Eye 5.100.373 Dead Eye
1
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Added in Afterbirth Eden's Blessing 5.100.381 Eden's Blessing
1
+0.7 tears up. Grants a random item at the start of the next run.
Added in Afterbirth Epiphora 5.100.368 Epiphora
1
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Added in Afterbirth Evil Eye 5.100.410 Evil Eye
1
Adds a chance to fire a slow-moving eye that fires tears in the same direction as Isaac. The eye will be destroyed if it hits an enemy or obstacle.
Added in Afterbirth Explosivo 5.100.401 Explosivo
1
Isaac's tears have a chance to stick to enemies and explode.
Added in Afterbirth Farting Baby 5.100.404 Farting Baby
1
Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies.
Added in Afterbirth Fate's Reward 5.100.361 Fate's Reward
1
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Added in Afterbirth Friend Zone 5.100.364 Friend Zone
1
Spawns a white attack fly that orbits somewhere between 15►Distant Admiration Distant Admiration and 15►Forever Alone Forever Alone, dealing 45 damage per second.
Added in Afterbirth Fruit Cake 5.100.418 Fruit Cake
1
Isaac's tears gain a random effect that changes every shot.
Added in Afterbirth GB Bug 5.100.405 GB Bug
1
Removed in Repentance Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
Added in Repentance Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
Added in Afterbirth Glitter Bombs 5.100.432 Glitter Bombs
1
+5 bombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
Added in Afterbirth God's Flesh 5.100.398 God's Flesh
1
Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Added in Afterbirth Host Hat 5.100.375 Host Hat
1
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Added in Afterbirth Key Bum 5.100.388 Key Bum
1
Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return.
Added in Afterbirth Kidney Stone 5.100.440 Kidney Stone
1
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage.
Added in Afterbirth Lil Chest 5.100.362 Lil Chest
1
Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room.
Added in Afterbirth Lil Gurdy 5.100.384 Lil Gurdy
1
A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed.
Added in Afterbirth Lil Loki 5.100.435 Lil Loki
1
Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern.
Added in Afterbirth Lost Fly 5.100.365 Lost Fly
1
Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact.
Added in Afterbirth Lusty Blood 5.100.411 Lusty Blood
1
Isaac's damage increases for the current room each time he kills an enemy.
Added in Afterbirth Marked 5.100.394 Marked
1
Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, +3.15 range.
Added in Afterbirth Milk! 5.100.436 Milk!
1
Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room.
Added in Afterbirth Multidimensional Baby 5.100.431 Multidimensional Baby
1
Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
Added in Afterbirth No. 2 5.100.378 No. 2
1
Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.
Added in Afterbirth Obsessed Fan 5.100.426 Obsessed Fan
1
Spawns a familiar that follows Isaac's movements on a 3 second delay and deals 30 contact damage per second to enemies.
Added in Repentance The fly follows Isaac on a 0.66 second delay.
Added in Afterbirth Papa Fly 5.100.430 Papa Fly
1
Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
Added in Afterbirth Pupula Duplex 5.100.379 Pupula Duplex
1
Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size.
Added in Afterbirth Purity 5.100.407 Purity
1
Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.
Added in Afterbirth Rune Bag 5.100.389 Rune Bag
1
Spawns a familiar that drops a random rune every Removed in Repentance 5-6 (Added in Repentance 7-8) rooms.
Added in Afterbirth Scatter Bombs 5.100.366 Scatter Bombs
1
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Added in Afterbirth Seraphim 5.100.390 Seraphim
1
Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed.
Added in Afterbirth Serpent's Kiss 5.100.393 Serpent's Kiss
1
Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a black heart when killed.
Added in Afterbirth Sticky Bombs 5.100.367 Sticky Bombs
1
+5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.
Added in Afterbirth Tech X 5.100.395 Tech X
1
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring.
Added in Afterbirth Toxic Shock 5.100.350 Toxic Shock
1
Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground.
Added in Afterbirth Tractor Beam 5.100.397 Tractor Beam
1
Increases Tears, Range, and Shot Speed. Isaac emits a beam from his face that his tears are bound to.
Added in Afterbirth The Wiz 5.100.358 The Wiz
1
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. Isaac's tears also travel above all obstacles.
Added in Afterbirth Zodiac 5.100.392 Zodiac
1
Gives Isaac a random zodiac item effect that changes every floor.
Added in Afterbirth Holy Light 5.100.374 Holy Light
Removed in Repentance1
Added in Repentance0.2
Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
Added in Afterbirth † Acid Baby 5.100.491 Acid Baby
1
Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned.
Added in Afterbirth † Adrenaline 5.100.493 Adrenaline
1
Increases damage based on how many empty Red Heart containers Isaac has.
Added in Afterbirth † Analog Stick 5.100.465 Analog Stick
1
+0.35 tears up. Allows Isaac to fire tears diagonally.
Added in Afterbirth † Angry Fly 5.100.511 Angry Fly
1
Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with.
Added in Afterbirth † Apple! 5.100.443 Apple!
1
Increases tears. Adds a chance to fire a high-damage razor blade.
Added in Afterbirth † Backstabber 5.100.506 Backstabber
1
Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
Added in Afterbirth † Big Chubby 5.100.473 Big Chubby
1
Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.
Added in Afterbirth † Bloodshot Eye 5.100.509 Bloodshot Eye
1
Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
Added in Afterbirth † Bozo 5.100.513 Bozo
1
+0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Added in Afterbirth † Brittle Bones 5.100.549 Brittle Bones
1
Replaces all Red Hearts with 6 empty Bone Hearts. Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Added in Afterbirth † Camo Undies 5.100.497 Camo Undies
1
Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused.
Added in Afterbirth † Compound Fracture 5.100.453 Compound Fracture
1
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Added in Afterbirth † Cone Head 5.100.457 Cone Head
1
Grants a Soul Heart. Gives Isaac a chance to ignore any damage taken.
Added in Afterbirth † Contagion 5.100.466 Contagion
1
The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Added in Afterbirth † Dead Tooth 5.100.446 Dead Tooth
1
While firing, Isaac gains a green aura that poisons nearby enemies.
Added in Afterbirth † Depression 5.100.469 Depression
1
Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Added in Afterbirth † Dog Tooth 5.100.445 Dog Tooth
1
+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret Rooms or Crawl Spaces.
Added in Afterbirth † Euthanasia 5.100.496 Euthanasia
1
Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Added in Afterbirth † Fast Bombs 5.100.517 Fast Bombs
1
Grants 7 bombs and allows bombs to be placed rapidly.
Added in Afterbirth † Finger! 5.100.467 Finger!
1
Spawns a finger familiar that points at enemies, dealing scaling damage.
Added in Afterbirth † Flat Stone 5.100.540 Flat Stone
1
Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area.
Added in Afterbirth † Ghost Pepper 5.100.495 Ghost Pepper
1
Removed in RepentanceGives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Added in RepentanceGives a chance to shoot blue fires alongside tears that become smaller as they travel.
Added in Afterbirth † Glaucoma 5.100.460 Glaucoma
1
Adds a chance to shoot tears that confuse enemies for an extremely long time.
Added in Afterbirth † Haemolacria 5.100.531 Haemolacria
1
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Added in Afterbirth † Hallowed Ground 5.100.543 Hallowed Ground
1
Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots.
Added in Afterbirth † Hushy 5.100.470 Hushy
1
Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving.
Added in Afterbirth † Jacob's Ladder 5.100.494 Jacob's Ladder
1
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Added in Afterbirth † Jaw Bone 5.100.548 Jaw Bone
1
Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
Added in Afterbirth † Lachryphagy 5.100.532 Lachryphagy
1
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Added in Afterbirth † Large Zit 5.100.502 Large Zit
1
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Added in Afterbirth † Lead Pencil 5.100.444 Lead Pencil
1
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Added in Afterbirth † Leprosy 5.100.525 Leprosy
1
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Added in Afterbirth † Lil Monstro 5.100.471 Lil Monstro
1
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Added in Afterbirth † Lil Spewer 5.100.537 Lil Spewer
1
Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
Added in Afterbirth † Linger Bean 5.100.447 Linger Bean
1
Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies.
Added in Afterbirth † Metal Plate 5.100.449 Metal Plate
1
Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
Added in Afterbirth † Mom's Razor 5.100.508 Mom's Razor
1
Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
Added in Afterbirth † Mystery Egg 5.100.539 Mystery Egg
1
Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room.
Added in Afterbirth † Parasitoid 5.100.461 Parasitoid
1
Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.
Added in Afterbirth † Pointy Rib 5.100.544 Pointy Rib
1
Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage.
Added in Afterbirth † Pop! 5.100.529 Pop!
1
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Added in Afterbirth † Shard of Glass 5.100.448 Shard of Glass
1
Removed in Repentance Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Added in Repentance Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
Added in Afterbirth † Sinus Infection 5.100.459 Sinus Infection
1
Adds a chance to fire a booger that sticks to enemies and deals damage over time.
Added in Afterbirth † Slipped Rib 5.100.542 Slipped Rib
1
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Added in Afterbirth † Sulfuric Acid 5.100.463 Sulfuric Acid
1
+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles.
Added in Afterbirth † Technology Zero 5.100.524 Technology Zero
1
Connects Isaac's tears with electricity that can damage enemies.
Added in Afterbirth † Varicose Veins 5.100.452 Varicose Veins
1
Taking damage releases a ring of 10 high damage tears.
Added in Afterbirth † YO LISTEN! 5.100.492 YO LISTEN!
1
+1 luck. Spawns a fairy familiar that points out Secret Rooms, Crawl Space entrances, and tinted rocks.
Added in Repentance 120 Volt 5.100.559 120 Volt
1
Repeatedly zaps enemies that are close to Isaac.
Added in Repentance Akeldama 5.100.641 Akeldama
1
While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.
Added in Repentance Almond Milk 5.100.561 Almond Milk
1
Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects.
Added in Repentance Belly Button 5.100.458 Belly Button
1
Drops a random trinket. Grants a second trinket slot.
Added in Repentance Belly Jelly 5.100.690 Belly Jelly
1
Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots.
Added in Repentance Bird Cage 5.100.610 Bird Cage
1
The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to 15►Dead Bird Dead Bird.
Added in Repentance Bird's Eye 5.100.616 Bird's Eye
1
Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Added in Repentance Blood Bombs 5.100.614 Blood Bombs
1
Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any.
Added in Repentance Blood Puppy 5.100.565 Blood Puppy
1
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Attacking it returns it to normal.
Added in Repentance Bloody Gust 5.100.695 Bloody Gust
1
When Isaac takes damage, he gains speed and tears for the rest of the floor.
Added in Repentance Boiled Baby 5.100.607 Boiled Baby
1
Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
Added in Repentance Bone Spurs 5.100.683 Bone Spurs
1
Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them.
Added in Repentance Bot Fly 5.100.629 Bot Fly
1
Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
Added in Repentance Candy Heart 5.100.671 Candy Heart
1
Gives Isaac a permanent stat boost whenever he heals with red heart pickups.
Added in Repentance Cracked Orb 5.100.675 Cracked Orb
1
Unlocks doors and reveals a random room on the map when Isaac takes damage.
Added in Repentance Cube Baby 5.100.652 Cube Baby
1
Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
Added in Repentance Dirty Mind 5.100.576 Dirty Mind
1
Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.
Added in Repentance Empty Heart 5.100.676 Empty Heart
1
If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container.
Added in Repentance Eye Sore 5.100.558 Eye Sore
1
Causes Isaac to occasionally fire extra tears in random directions while shooting.
Added in Repentance Freezer Baby 5.100.608 Freezer Baby
1
Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them.
Added in Repentance Fruity Plum 5.100.649 Fruity Plum
1
Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
Added in Repentance Ghost Bombs 5.100.727 Ghost Bombs
1
+5 bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds.
Added in Repentance Giant Cell 5.100.658 Giant Cell
1
Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies.
Added in Repentance Hemoptysis 5.100.726 Hemoptysis
1
Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him.
Added in Repentance Hypercoagulation 5.100.724 Hypercoagulation
1
After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds.
Added in Repentance IBS 5.100.725 IBS
1
Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies.
Added in Repentance It Hurts 5.100.560 It Hurts
1
Releases a ring of tears and increases tears for the current room when Isaac takes damage.
Added in Repentance Keeper's Kin 5.100.717 Keeper's Kin
1
Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.
Added in Repentance Knockout Drops 5.100.637 Knockout Drops
1
Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
Added in Repentance Lil Dumpy 5.100.615 Lil Dumpy
1
Gives Isaac a Dumpy familiar that pushes, confuses, or poisons nearby enemies and flies in a random direction after taking damage.
Added in Repentance Lil Portal 5.100.681 Lil Portal
1
A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room.
Added in Repentance Lodestone 5.100.617 Lodestone
1
Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources.
Added in Repentance Lost Soul 5.100.612 Lost Soul
1
Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Hearts, Eternal Hearts, or an item.
Added in Repentance Montezuma's Revenge 5.100.680 Montezuma's Revenge
1
While firing, Isaac charges up a short-ranged 15►Brimstone Brimstone-like diarrhea beam that shoots behind him.
Added in Repentance Mucormycosis 5.100.553 Mucormycosis
1
Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
Added in Repentance Nancy Bombs 5.100.563 Nancy Bombs
1
Gives Isaac +5 bombs and gives his bombs random bomb synergies.
Added in Repentance Playdough Cookie 5.100.570 Playdough Cookie
1
Grants multicolored tears. Each color comes with a different status or tear effect.
Added in Repentance Polydactyly 5.100.454 Polydactyly
1
Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
Added in Repentance Psy Fly 5.100.581 Psy Fly
1
Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears that deal 2 damage. Turns some Fly enemies into friendly Blue Flies if it touches them while deflecting shots.
Added in Repentance Quints 5.100.661 Quints
1
The first five enemies killed in a room will spawn stationary shooting familiars where they died.
Added in Repentance Rocket in a Jar 5.100.583 Rocket in a Jar
1
+5 bombs. If Isaac is currently moving, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing.
Added in Repentance Rotten Tomato 5.100.618 Rotten Tomato
1
Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies.
Added in Repentance The Intruder 5.100.575 The Intruder
1
A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
Added in Repentance The Swarm 5.100.693 The Swarm
1
Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly.
Added in Repentance Tinytoma 5.100.645 Tinytoma
1
Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders.
Added in Repentance Tooth and Nail 5.100.663 Tooth and Nail
1
Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage.
Added in Repentance Vasculitis 5.100.657 Vasculitis
1
Enemies explode into tears upon death, which inherit the effects of Isaac's tears.
Added in Repentance Worm Friend 5.100.682 Worm Friend
1
Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.
Added in Repentance Astral Projection 5.100.677 Astral Projection
0.2
Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes.
Added in Repentance Skeleton Key 5.100.17 Skeleton Key
0.1
Gives Isaac 99 Keys.


Advertisement