Binding of Isaac: Rebirth Wiki
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Binding of Isaac: Rebirth Wiki
Added in Afterbirth

All of the items in this pool can be found in the gold Treasure Room in Greed Mode. They can also occasionally be found in the Greed Mode Shop.

Activated Collectibles[]

Name ID Icon Weight Description
Anarchist Cookbook 5.100.65
Anarchist Cookbook
3 rooms
1
Spawns six Troll Bombs around the room.
The Bean 5.100.111
The Bean
1 rooms
1
Isaac farts, poisoning any enemy in close range.
Blood Rights 5.100.186
Blood Rights
Unlimited
1
Upon use, takes a full heart of health and deals 40 damage to all enemies in the room.
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
1
Upon use, Isaac holds a poison bomb which can be thrown in the cardinal directions and explodes on impact.
The Book of Belial 5.100.34
The Book of Belial
3 rooms
1
+2 damage for the current room.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Added in Afterbirth Increases the chance by 12.5%.
The Book of Sin 5.100.97
The Book of Sin
4 rooms
1
Spawns a random pickup, pill, card, or trinket.
Book of Revelations 5.100.78
Book of Revelations
6 rooms
1
Gives one Soul Heart, increases the chance for a Devil or Angel Room, and changes the boss of the current floor to a Harbinger if possible.
Box of Friends 5.100.357
Box of Friends
3 rooms
1
Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a 15►Demon Baby Demon Baby for the room instead.
Box of Spiders 5.100.288
Box of Spiders
2 rooms
1
Removed in Repentance Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.
Added in Repentance Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
Dad's Key 5.100.175
Dad's Key
2 rooms
1
Opens all doors in the current room when activated, including doors which require a key to open and entrances to Secret Rooms. Opens the big doors in the first room of both Chest Chest and the Dark Room Dark Room.
Dead Sea Scrolls 5.100.124
Dead Sea Scrolls
2 rooms
1
Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards 5.100.85
Deck of Cards
6 rooms
1
Gives Isaac a random card.
Doctor's Remote 5.100.47
Doctor's Remote
2 rooms
1
Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion.
Flush! 5.100.291
Flush!
4 rooms
1
Turns all non-boss monsters in the room into poop. Instantly kills poop-themed bosses.
Friendly Ball 5.100.382
Friendly Ball
2 rooms
1
Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
The Gamekid 5.100.93
The Gamekid
4 rooms
1
Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed.
Glass Cannon 5.100.352
Glass Cannon
4 seconds
1
Removed in Repentance Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
Added in Repentance Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes 15►Broken Glass Cannon Broken Glass Cannon.
Jar of Flies 5.100.434
Jar of Flies
Unlimited
1
Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar.
Kidney Bean 5.100.421
Kidney Bean
1 rooms
1
Isaac farts, charming all nearby enemies.
Lemon Mishap 5.100.56
Lemon Mishap
2 rooms
1
Creates a tiny pool of yellow creep, damaging enemies that cross it.
Mega Bean 5.100.351
Mega Bean
3 rooms
1
Petrifies all enemies in the current room for a couple of seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing.
Mom's Bottle of Pills 5.100.102
Mom's Bottle of Pills
6 rooms
1
Gives Isaac a random pill.
Mr. Boom 5.100.37
Mr. Boom
2 rooms
1
Places a Mr. Mega bomb that deals 110 damage.
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
1
Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies.
The Necronomicon 5.100.35
The Necronomicon
4 rooms
1
Deals 40 damage to every enemy in the room.
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
1
Gives flight for the current room, while turning Isaac's body into a fast, high damage familiar.
Prayer Card 5.100.146
Prayer Card
6 rooms
1
Gives an Eternal Heart per use.
Remote Detonator 5.100.137
Remote Detonator
Unlimited
1
Bombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs.
Scissors 5.100.325
Scissors
4 rooms
1
Removed in Repentance Turns Isaac's head into a stationary familiar for the current room which fires tears automatically.

Added in Repentance Turns Isaac's head into a stationary familiar for the current room which fires tears automatically, while causing Isaac to shoot a controllable fountain of blood shots.

Tammy's Head 5.100.38
Tammy's Head
1 rooms
1
Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
Tear Detonator 5.100.383
Tear Detonator
16 seconds
1
When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Telepathy for Dummies 5.100.192
Telepathy for Dummies
2 rooms
1
Gives homing tears for the current room. Added in Repentance Also gives +3 range.
Wooden Nickel 5.100.349
Wooden Nickel
1 rooms
1
When used, has a 50% chance to drop one random type of coin (Penny, Nickel, or Dime).
Yum Heart 5.100.45
Yum Heart
4 rooms
1
Restores one Red Heart of Isaac's health.
Added in Afterbirth † Book of the Dead 5.100.545
Book of the Dead
6 rooms
1
Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room.
Added in Afterbirth † Brown Nugget 5.100.504
Brown Nugget
7 seconds
1
Spawns a stationary fly turret that fires tears at nearby enemies.
Added in Afterbirth † Sharp Straw 5.100.507
Sharp Straw
10 seconds
1
Damages all enemies in the room. Has a chance to drop a half red heart Removed in Repentanceor half soul heart if an enemy is hit.
Added in Afterbirth † Sprinkler 5.100.516
Sprinkler
4 rooms
1
Upon use, spawns a sprinkler that rotates and fires tears.
Added in Afterbirth † Telekinesis 5.100.522
Telekinesis
3 seconds
1
Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
Added in Afterbirth † / Removed in Repentance Wait What? 5.100.484
Wait What?
10 seconds
1
Isaac farts, sending out rock waves.
Added in Repentance Decap Attack 5.100.729
Decap Attack
4 seconds
1
Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it.
Added in Repentance Everything Jar 5.100.720
Everything Jar
12 rooms
1
Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects.
Added in Repentance Fortune Cookie 5.100.557
Fortune Cookie
2 rooms
1
Gives Isaac a fortune, soul heart, tarot card, or trinket.
Added in Repentance Free Lemonade 5.100.578
Free Lemonade
4 rooms
1
Creates a large pool of yellow creep beneath Isaac.
Added in Repentance Friend Finder 5.100.687
Friend Finder
4 rooms
1
Spawns a random friendly monster that mimics Isaac's movements and attacks.
Added in Repentance Golden Razor 5.100.555
Golden Razor
Unlimited
1
Spends five coins to increase Isaac's damage by 1.2 for the current room.
Added in Repentance Larynx 5.100.611
Larynx
12 rooms
1
Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage.
Added in Repentance Meat Cleaver 5.100.631
Meat Cleaver
2 rooms
1
Splits all enemies in the room into two smaller versions of themselves with much less health.
Added in Repentance The Scooper 5.100.605
The Scooper
3 rooms
1
Summons a Peeper familiar for the current room, which leaves a trail of red creep.
Added in Repentance Spin to Win 5.100.655
Spin to Win
3 seconds
1
When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held.
Added in Repentance Stitches 5.100.635
Stitches
3 seconds
1
Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.
Added in Repentance Suplex! 5.100.709
Suplex!
6 seconds
1
Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave.
Added in Repentance Yuck Heart 5.100.639
Yuck Heart
6 rooms
1
Gives Isaac a Rotten Heart.
Added in Repentance Esau Jr. 5.100.703
Esau Jr.
1 rooms
0.5
Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
Added in Repentance Eternal D6 5.100.609
Eternal D6
2 rooms
0.5
Rerolls all items in the room. Each item has a chance to disappear instead.
Added in Repentance Gello 5.100.728
Gello
2 rooms
0.5
Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
Added in Repentance Mega Mush 5.100.625
Mega Mush
12 rooms
0.5
Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.
Added in Repentance Plum Flute 5.100.650
Plum Flute
4 rooms
0.5
Summons the boss Baby Plum to fight for Isaac in the current room.
Added in Repentance Keeper's Box 5.100.719
Keeper's Box
4 rooms
0.2
Spawns a random shop item or pickup which can be bought for its normal price.
Added in Repentance Anima Sola 5.100.722
Anima Sola
15 seconds
0.1
Chains down the nearest enemy for 5 seconds, preventing them from acting.
Added in Repentance Spindown Dice 5.100.723
Spindown Dice
6 rooms
0.1
Transforms all items in the room by decreasing their internal ID number.

Passive Collectibles[]

Name ID Icon Weight Description
20/20 5.100.245 20/20
1
Isaac fires two tears at once, one from each eye.
3 Dollar Bill 5.100.191 3 Dollar Bill
1
Removed in Afterbirth Gives Isaac a random tear effect every room.
Added in Afterbirth Gives Isaac a random tear effect every few seconds.
8 Inch Nails 5.100.359 8 Inch Nails
1
+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.
???'s Only Friend 5.100.320 ???'s Only Friend
1
Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys
A Lump of Coal 5.100.132 A Lump of Coal
1
The more distance tears travel, the more damage they will do.
Abel 5.100.188 Abel
1
Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
Anemic 5.100.214 Anemic
1
Increases range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room.
Ankh 5.100.161 Ankh
1
Upon death, the player will respawn as ??? ??? with 3 Soul Hearts.
Anti-Gravity 5.100.222 Anti-Gravity
1
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Aquarius 5.100.308 Aquarius
1
A trail of blue creep is left behind Isaac, which damages enemies.
Aries 5.100.300 Aries
1
+0.25 Speed. Running into enemies while at a high speed will deal damage. Removed in Repentance Does not prevent contact damage.
Ball of Tar 5.100.231 Ball of Tar
1
Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud 5.100.274 Best Bud
1
When hit, spawns a quickly orbiting attack fly similar to 15►Forever Alone Forever Alone for the current room dealing Removed in Repentance75 Added in Repentance150 damage per second.
Betrayal 5.100.391 Betrayal
1
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Big Fan 5.100.279 Big Fan
1
Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies.
Black Lotus 5.100.226 Black Lotus
1
Grants one Red Heart, one Soul Heart, and one Black Heart.
Blood Clot 5.100.254 Blood Clot
1
Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear height.
Blood of the Martyr 5.100.7 Blood of the Martyr
1
Increases damage by 1, and turns Isaac's tears into blood tears.
Bloody Lust 5.100.157 Bloody Lust
1
Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Bob's Brain 5.100.273 Bob's Brain
1
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse 5.100.140 Bob's Curse
1
Gives 5 bombs and grants Isaac's bombs a poison effect.
Bobby-Bomb 5.100.125 Bobby-Bomb
1
+5 bombs. Bombs gain a homing effect, slowly moving towards the nearest enemy.
Bomb Bag 5.100.131 Bomb Bag
1
Spawns a familiar that drops a bomb every 3 rooms.
Bomber Boy 5.100.353 Bomber Boy
1
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs.
Brother Bobby 5.100.8 Brother Bobby
1
A familiar that follows Isaac around shooting normal tears.
Bursting Sack 5.100.377 Bursting Sack
1
Spider enemies no longer target or deal contact damage to Isaac.
Butt Bombs 5.100.209 Butt Bombs
1
+5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
Cain's Other Eye 5.100.319 Cain's Other Eye
1
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Cancer 5.100.301 Cancer
1
Adds 3 Soul Hearts. Grants 15►The Wafer The Wafer effect for the current room after taking damage.
Capricorn 5.100.307 Capricorn
1
Increases health, damage, speed, and range, lowers tear delay, and gives one coin, bomb, and key.
Celtic Cross 5.100.162 Celtic Cross
1
Grants a chance to trigger the 15►Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire 5.100.62 Charm of the Vampire
1
Heals Isaac for half of a Red Heart for every 13 enemies killed. Added in Repentance +0.3 damage.
Chemical Peel 5.100.154 Chemical Peel
1
Tears fired from the left eye have +2 flat damage.
Chocolate Milk 5.100.69 Chocolate Milk
1
Grants charged tears that deal greater damage when fully charged.
The Common Cold 5.100.103 The Common Cold
1
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Continuum 5.100.369 Continuum
1
Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room.
Cricket's Body 5.100.224 Cricket's Body
1
Grants -1 tear delay and reduces range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's.
Cricket's Head 5.100.4 Cricket's Head
1
Increases damage by 0.5, and multiplies it by 1.5x.
Cube of Meat 5.100.73 Cube of Meat
1
Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage.
Cupid's Arrow 5.100.48 Cupid's Arrow
1
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Curse of the Tower 5.100.371 Curse of the Tower
1
Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower XVI - The Tower.
Cursed Eye 5.100.316 Cursed Eye
1
Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
Daddy Longlegs 5.100.170 Daddy Longlegs
1
Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.
Dead Bird 5.100.117 Dead Bird
1
After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second.
Dead Eye 5.100.373 Dead Eye
1
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Dead Onion 5.100.336 Dead Onion
1
Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Deep Pockets 5.100.416 Deep Pockets
1
Removed in Repentance Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Added in Repentance Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
Distant Admiration 5.100.57 Distant Admiration
1
Spawns an attack fly that circles further out than 15►Halo of Flies Halo of Flies, but closer than 15►Forever Alone Forever Alone, dealing 75 damage per second.
Dr. Fetus 5.100.52 Dr. Fetus
1
Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Dry Baby 5.100.265 Dry Baby
1
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering 15►The Necronomicon The Necronomicon effect.
E Coli 5.100.236 E Coli
1
Enemies that touch Isaac are transformed into poop.
Epiphora 5.100.368 Epiphora
1
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Eve's Mascara 5.100.310 Eve's Mascara
1
Doubles damage, halves tears stat, and greatly reduces shot speed.
Evil Eye 5.100.410 Evil Eye
1
While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Explosivo 5.100.401 Explosivo
1
Isaac's tears have a chance to stick to enemies and explode.
Fire Mind 5.100.257 Fire Mind
1
Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever Alone 5.100.128 Forever Alone
1
Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second.
Friend Zone 5.100.364 Friend Zone
1
Spawns a white attack fly that orbits somewhere between 15►Distant Admiration Distant Admiration and 15►Forever Alone Forever Alone, dealing 45 damage per second.
Gemini 5.100.318 Gemini
1
Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second.
Ghost Baby 5.100.163 Ghost Baby
1
Spawns a familiar that follows Isaac around and fires spectral tears.
Glitter Bombs 5.100.432 Glitter Bombs
1
+5 bombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
Gnawed Leaf 5.100.210 Gnawed Leaf
1
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
God's Flesh 5.100.398 God's Flesh
1
Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Guillotine 5.100.206 Guillotine
1
Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay.
Halo of Flies 5.100.10 Halo of Flies
1
Spawns two Pretty Flies that block enemy shots and deal contact damage to flies.
Harlequin Baby 5.100.167 Harlequin Baby
1
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby 5.100.269 Headless Baby
1
Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Host Hat 5.100.375 Host Hat
1
A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Hot Bombs 5.100.256 Hot Bombs
1
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Infamy 5.100.242 Infamy
1
Chance to block projectiles coming from any direction.
Infestation 5.100.148 Infestation
1
Removed in Repentance 1-3 Blue Flies randomly spawn every time Isaac gets hit.
Added in Repentance 2-6 Blue Flies randomly spawn every time Isaac gets hit.
Infestation 2 5.100.234 Infestation 2
1
Spawns allied Blue Spiders from killed enemies.
The Inner Eye 5.100.2 The Inner Eye
1
Grants triple shot but decreases tears.
Ipecac 5.100.149 Ipecac
1
Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar 5.100.201 Iron Bar
1
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Juicy Sack 5.100.266 Juicy Sack
1
Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.
Kidney Stone 5.100.440 Kidney Stone
1
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage.
Lazarus' Rags 5.100.332 Lazarus' Rags
1
Upon dying, resurrect as Lazarus Risen Lazarus Risen in the current room with one heart container and 15►Anemic Anemic.
Leo 5.100.302 Leo
1
Isaac can destroy rocks by walking into them.
Lil Chest 5.100.362 Lil Chest
1
Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room.
Lil Gurdy 5.100.384 Lil Gurdy
1
A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed.
Lil Haunt 5.100.277 Lil Haunt
1
Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear.
Little C.H.A.D. 5.100.96 Little C.H.A.D.
1
Spawns a familiar who drops a Half Red Heart every 3 rooms.
Little Chubby 5.100.88 Little Chubby
1
Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path.
Little Gish 5.100.99 Little Gish
1
Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven 5.100.100 Little Steven
1
Spawns a familiar who follows Isaac around and fires homing tears.
Loki's Horns 5.100.87 Loki's Horns
1
Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact 5.100.213 Lost Contact
1
Isaac's tears can hit and destroy enemy projectiles. -0.16 shot speed.
Lost Fly 5.100.365 Lost Fly
1
Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact.
The Ludovico Technique 5.100.329 The Ludovico Technique
1
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Lusty Blood 5.100.411 Lusty Blood
1
Isaac's damage increases for the current room each time he kills an enemy.
Maggy's Bow 5.100.312 Maggy's Bow
1
Gives one Red Heart container and doubles the healing provided by Red Hearts.
Marked 5.100.394 Marked
1
Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, +3.15 range.
Milk! 5.100.436 Milk!
1
Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room.
Mom's Contacts 5.100.110 Mom's Contacts
1
+0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking.
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow
1
Tears have a chance to charm enemies.
Mom's Eye 5.100.55 Mom's Eye
1
Allows Isaac to fire tears from the back of his head.
Mom's Perfume 5.100.228 Mom's Perfume
1
Adds a chance to shoot fear tears and decreases tear delay by 1.
Monstro's Lung 5.100.229 Monstro's Lung
1
Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Monstro.
Mr. Mega 5.100.106 Mr. Mega
1
Grants 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
The Mulligan 5.100.151 The Mulligan
1
Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy.
Multidimensional Baby 5.100.431 Multidimensional Baby
1
Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
Mutant Spider 5.100.153 Mutant Spider
1
Grants quadruple shot but decreases tears.
My Reflection 5.100.5 My Reflection
1
Gives Isaac's tears a boomerang effect. +1.5 range, +1 tear height, x1.6 shot speed multiplier.
Mysterious Liquid 5.100.317 Mysterious Liquid
1
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery Sack 5.100.271 Mystery Sack
1
Spawns a familiar that drops a Heart, coin, bomb, or key every 5-6 rooms.
Night Light 5.100.425 Night Light
1
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
No. 2 5.100.378 No. 2
1
Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.
Number One 5.100.6 Number One
1
Grants +1.5 tears, but severely reduces range.
Obsessed Fan 5.100.426 Obsessed Fan
1
Spawns a familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Odd Mushroom 5.100.121 Odd Mushroom
1
Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear height, and -0.1 speed.
Odd Mushroom 5.100.120 Odd Mushroom
1
+1.7 tears, +0.3 speed, slightly reduces damage.
Ouija Board 5.100.115 Ouija Board
1
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Papa Fly 5.100.430 Papa Fly
1
Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
The Parasite 5.100.104 The Parasite
1
Isaac's tears split in two when they hit something.
Pay to Play 5.100.380 Pay to Play
1
+5 coins. Turns doors that require a single key into doors which need a coin to enter instead.
The Peeper 5.100.155 The Peeper
1
Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through.
Pisces 5.100.309 Pisces
1
-1 Tear Delay, adds knock-back shots and increases tear size.
Polyphemus 5.100.169 Polyphemus
1
Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage.
Proptosis 5.100.261 Proptosis
1
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag 5.100.281 Punching Bag
1
Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer.
Pupula Duplex 5.100.379 Pupula Duplex
1
Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size.
Purity 5.100.407 Purity
1
Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.
Pyromaniac 5.100.223 Pyromaniac
1
+5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. Added in Repentance Also grants immunity to fire.
Rotten Baby 5.100.268 Rotten Baby
1
Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Rubber Cement 5.100.221 Rubber Cement
1
Tears bounce off walls, enemies, and environmental objects.
Rune Bag 5.100.389 Rune Bag
1
Spawns a familiar that drops a random rune every 5-6 rooms.
Sack of Pennies 5.100.94 Sack of Pennies
1
Spawns a familiar that drops a coin every 2 rooms.
Sacrificial Dagger 5.100.172 Sacrificial Dagger
1
Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots.
Sad Bombs 5.100.220 Sad Bombs
1
+5 Bombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers.
The Sad Onion 5.100.1 The Sad Onion
1
Increases tears by 0.7.
Sagittarius 5.100.306 Sagittarius
1
Increases speed by +0.2 and grants piercing tears.
Samson's Chains 5.100.321 Samson's Chains
1
Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles.
Scapular 5.100.142 Scapular
1
Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.
Scatter Bombs 5.100.366 Scatter Bombs
1
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Scorpio 5.100.305 Scorpio
1
Grants poison tears, which deal damage over time when inflicted.
Serpent's Kiss 5.100.393 Serpent's Kiss
1
Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a black heart when killed.
Sissy Longlegs 5.100.280 Sissy Longlegs
1
Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders.
Sister Maggy 5.100.67 Sister Maggy
1
Spawns a familiar that follows Isaac around shooting normal tears.
Smart Fly 5.100.264 Smart Fly
1
Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second.
SMB Super Fan 5.100.189 SMB Super Fan
1
+1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear height. Fully restores all red hearts.
Soy Milk 5.100.330 Soy Milk
1
Tears are smaller and do much less damage, but fire in very rapid succession.
Spider Bite 5.100.89 Spider Bite
1
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spoon Bender 5.100.3 Spoon Bender
1
Grants Isaac homing tears.
Steam Sale 5.100.64 Steam Sale
1
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Steven 5.100.50 Steven
1
Increases damage by 1.
Sticky Bombs 5.100.367 Sticky Bombs
1
+5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.
Stigmata 5.100.138 Stigmata
1
Increases damage, and adds 1 heart container.
Strange Attractor 5.100.315 Strange Attractor
1
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Taurus 5.100.299 Taurus
1
-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the 15►My Little Unicorn My Little Unicorn effect for 5 seconds.
Tech X 5.100.395 Tech X
1
Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring.
Tech.5 5.100.244 Tech.5
1
Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets.
Technology 5.100.68 Technology
1
Replaces tears with a piercing laser with unlimited range.
Technology 2 5.100.152 Technology 2
1
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Tiny Planet 5.100.233 Tiny Planet
1
Range up and makes shot tears revolve around Isaac until they drop.
Tough Love 5.100.150 Tough Love
1
Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Tractor Beam 5.100.397 Tractor Beam
1
Increases tears, range, and shot speed. Isaac emits a beam from his face that his tears follow along.
Virgo 5.100.303 Virgo
1
Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
The Virus 5.100.13 The Virus
1
Isaac poisons enemies on contact. Removed in Repentance -0.1 speed. Added in Repentance +0.2 speed. Added in Afterbirth / Removed in Repentance Poisoned enemies have a chance to drop a black heart when killed.
The Wafer 5.100.108 The Wafer
1
All sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead.
The Wiz 5.100.358 The Wiz
1
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. Isaac's tears also travel above all obstacles.
Zodiac 5.100.392 Zodiac
1
Gives Isaac a random zodiac item effect that changes every floor.
The Halo 5.100.101 The Halo
Removed in Repentance1
Added in Repentance0.5
Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height.
Magic Mushroom 5.100.12 Magic Mushroom
Removed in Repentance1
Added in Repentance0.5
Makes Isaac bigger. Adds one Red Heart container, +0.3 damage, x1.5 damage multiplier, +5.25 range, and +0.3 speed. Restores all health on pickup.
The Body 5.100.334 The Body
Removed in Repentance1
Added in Repentance0.2
Adds 3 Red Heart containers.
Death's Touch 5.100.237 Death's Touch
Removed in Repentance1
Added in Repentance0.2
+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Holy Light 5.100.374 Holy Light
Removed in Repentance1
Added in Repentance0.2
Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
The Mind 5.100.333 The Mind
Removed in Repentance1
Added in Repentance0.2
Reveals the entire map, including all special rooms and Secret Rooms.
Mom's Knife 5.100.114 Mom's Knife
Removed in Repentance1
Added in Repentance0.2
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
The Soul 5.100.335 The Soul
Removed in Repentance1
Added in Repentance0.2
Grants two Soul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles.
Missing No. 5.100.258 Missing No.
Removed in Repentance1
Added in Repentance0.1
Randomizes all passive items and stats upon pickup and at the start of each succeeding floor.
Removed in Repentance Epic Fetus 5.100.168 Epic Fetus
1
Isaac's tears are replaced with guided missiles, like those used by the 15►Doctor's Remote Doctor's Remote.
Removed in Repentance Godhead 5.100.331 Godhead
1
Grants homing tears with a damaging halo. +0.5 damage, -0.3 tears, +1.2 range, -0.3 shot speed, +0.8 tear height.
Removed in Repentance Judas' Shadow 5.100.311 Judas' Shadow
1
Adds an extra life; upon death, it respawns Isaac as Dark Judas Dark Judas with two Black Hearts.
Removed in Repentance Pyro 5.100.190 Pyro
1
Grants 99 bombs.
Added in Afterbirth † Adrenaline 5.100.493 Adrenaline
1
Increases damage based on how many empty Red Heart containers Isaac has.
Added in Afterbirth † Analog Stick 5.100.465 Analog Stick
1
+0.35 tears up. Allows Isaac to fire tears diagonally.
Added in Afterbirth † Apple! 5.100.443 Apple!
1
Increases tears. Adds a chance to fire a high-damage razor blade.
Added in Afterbirth † Backstabber 5.100.506 Backstabber
1
Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
Added in Afterbirth † Big Chubby 5.100.473 Big Chubby
1
Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.
Added in Afterbirth † Bloodshot Eye 5.100.509 Bloodshot Eye
1
Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
Added in Afterbirth † Bozo 5.100.513 Bozo
1
+0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Added in Afterbirth † Brittle Bones 5.100.549 Brittle Bones
1
Replaces all Red Hearts with 6 empty Bone Hearts. Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Added in Afterbirth † Broken Modem 5.100.514 Broken Modem
1
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Added in Afterbirth † Camo Undies 5.100.497 Camo Undies
1
Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused.
Added in Afterbirth † Compound Fracture 5.100.453 Compound Fracture
1
Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Added in Afterbirth † Cone Head 5.100.457 Cone Head
1
Grants a Soul Heart. Gives Isaac a chance to ignore any damage taken.
Added in Afterbirth † Contagion 5.100.466 Contagion
1
The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Added in Afterbirth † Dead Tooth 5.100.446 Dead Tooth
1
While firing, Isaac gains a green aura that poisons nearby enemies.
Added in Afterbirth † Depression 5.100.469 Depression
1
Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Added in Afterbirth † Dog Tooth 5.100.445 Dog Tooth
1
+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret Rooms or Crawl Spaces.
Added in Afterbirth † Euthanasia 5.100.496 Euthanasia
1
Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Added in Afterbirth † Eye of Greed 5.100.450 Eye of Greed
1
Every 20 tears, Isaac loses 1 coin and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins.
Added in Afterbirth † Finger! 5.100.467 Finger!
1
Spawns a finger familiar that points at enemies, dealing scaling damage.
Added in Afterbirth † Flat Stone 5.100.540 Flat Stone
1
Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area.
Added in Afterbirth † Ghost Pepper 5.100.495 Ghost Pepper
1
Removed in RepentanceGives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Added in RepentanceGives a chance to shoot blue fires alongside tears that become smaller as they travel.
Added in Afterbirth † Glaucoma 5.100.460 Glaucoma
1
Adds a chance to shoot tears that confuse enemies for an extremely long time.
Added in Afterbirth † Mom's Wig 5.100.217 Mom's Wig
1
Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.
Added in Afterbirth † Mongo Baby 5.100.322 Mongo Baby
1
Spawns a familiar that copies the tears of Isaac's other familiars.
Added in Afterbirth † Haemolacria 5.100.531 Haemolacria
1
Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Added in Afterbirth † Hallowed Ground 5.100.543 Hallowed Ground
1
Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots.
Added in Afterbirth † Hushy 5.100.470 Hushy
1
Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving.
Added in Afterbirth † Jacob's Ladder 5.100.494 Jacob's Ladder
1
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Added in Afterbirth † Rainbow Baby 5.100.174 Rainbow Baby
1
Spawns a familiar that follows Isaac around and fires tears with random effects.
Added in Afterbirth † Robo-Baby 5.100.95 Robo-Baby
1
Spawns a familiar that shoots 15►Technology Technology lasers.
Added in Afterbirth † Robo-Baby 2.0 5.100.267 Robo-Baby 2.0
1
Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Added in Afterbirth † Jaw Bone 5.100.548 Jaw Bone
1
Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
Added in Afterbirth † Jumper Cables 5.100.520 Jumper Cables
1
Grants an active item charge every 15 enemies killed.
Added in Afterbirth † Lachryphagy 5.100.532 Lachryphagy
1
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Added in Afterbirth † Large Zit 5.100.502 Large Zit
1
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Added in Afterbirth † Lead Pencil 5.100.444 Lead Pencil
1
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Added in Afterbirth † Leprosy 5.100.525 Leprosy
1
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Added in Afterbirth † Lil Monstro 5.100.471 Lil Monstro
1
Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Added in Afterbirth † Lil Spewer 5.100.537 Lil Spewer
1
Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
Added in Afterbirth † Linger Bean 5.100.447 Linger Bean
1
Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies.
Added in Afterbirth † Little Horn 5.100.503 Little Horn
1
Removed in Repentance Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Added in Repentance Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Added in Afterbirth † Metal Plate 5.100.449 Metal Plate
1
Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
Added in Afterbirth † Mom's Razor 5.100.508 Mom's Razor
1
Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
Added in Afterbirth † Mystery Egg 5.100.539 Mystery Egg
1
Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room.
Added in Afterbirth † Parasitoid 5.100.461 Parasitoid
1
Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.
Added in Afterbirth † Pointy Rib 5.100.544 Pointy Rib
1
Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage.
Added in Afterbirth † Pop! 5.100.529 Pop!
1
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Added in Afterbirth † Shard of Glass 5.100.448 Shard of Glass
1
Upon taking damage, Isaac has a chance to drop a full red heart, Removed in Repentancegain 5 range, and leave a trail of damaging red creep for the current room.
Added in RepentanceTaking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
Added in Afterbirth † Sinus Infection 5.100.459 Sinus Infection
1
Adds a chance to fire a booger that sticks to enemies and deals damage over time.
Added in Afterbirth † Slipped Rib 5.100.542 Slipped Rib
1
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Added in Afterbirth † Sulfuric Acid 5.100.463 Sulfuric Acid
1
+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles.
Added in Afterbirth † Technology Zero 5.100.524 Technology Zero
1
Connects Isaac's tears with electricity that can damage enemies.
Added in Afterbirth † Varicose Veins 5.100.452 Varicose Veins
1
Taking damage releases a ring of 10 high damage tears.
Added in Afterbirth † The Relic 5.100.98 The Relic
Removed in Repentance1
Added in Repentance0.2
Spawns a cross familiar that drops a Soul Heart every 5-6 rooms.
Added in Repentance 120 Volt 5.100.559 120 Volt
1
Repeatedly zaps enemies that are close to Isaac.
Added in Repentance Akeldama 5.100.641 Akeldama
1
While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.
Added in Repentance Almond Milk 5.100.561 Almond Milk
1
Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects.
Added in Repentance Belly Button 5.100.458 Belly Button
1
Drops a random trinket. Grants a second trinket slot.
Added in Repentance Belly Jelly 5.100.690 Belly Jelly
1
Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots.
Added in Repentance Bird Cage 5.100.610 Bird Cage
1
The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to 15►Dead Bird Dead Bird.
Added in Repentance Bird's Eye 5.100.616 Bird's Eye
1
Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Added in Repentance Blood Bombs 5.100.614 Blood Bombs
1
Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any.
Added in Repentance Blood Puppy 5.100.565 Blood Puppy
1
Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal.
Added in Repentance Bloody Gust 5.100.695 Bloody Gust
1
When Isaac takes damage, he gains speed and tears for the rest of the floor.
Added in Repentance Boiled Baby 5.100.607 Boiled Baby
1
Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
Added in Repentance Bone Spurs 5.100.683 Bone Spurs
1
Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them.
Added in Repentance Bot Fly 5.100.629 Bot Fly
1
Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
Added in Repentance Candy Heart 5.100.671 Candy Heart
1
Gives Isaac a permanent stat boost whenever he heals with red heart pickups.
Added in Repentance Cracked Orb 5.100.675 Cracked Orb
1
Unlocks doors and reveals a random room on the map when Isaac takes damage.
Added in Repentance Cube Baby 5.100.652 Cube Baby
1
Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
Added in Repentance Dirty Mind 5.100.576 Dirty Mind
1
Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.
Added in Repentance Empty Heart 5.100.676 Empty Heart
1
If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container.
Added in Repentance Eye Sore 5.100.558 Eye Sore
1
Causes Isaac to occasionally fire extra tears in random directions while shooting.
Added in Repentance Freezer Baby 5.100.608 Freezer Baby
1
Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them.
Added in Repentance Fruity Plum 5.100.649 Fruity Plum
1
Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
Added in Repentance Ghost Bombs 5.100.727 Ghost Bombs
1
+5 bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds.
Added in Repentance Giant Cell 5.100.658 Giant Cell
1
Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies.
Added in Repentance Hemoptysis 5.100.726 Hemoptysis
1
Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him.
Added in Repentance Hypercoagulation 5.100.724 Hypercoagulation
1
After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds.
Added in Repentance IBS 5.100.725 IBS
1
Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies.
Added in Repentance The Intruder 5.100.575 The Intruder
1
A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
Added in Repentance It Hurts 5.100.560 It Hurts
1
Releases a ring of tears and increases tears for the current room when Isaac takes damage.
Added in Repentance Knockout Drops 5.100.637 Knockout Drops
1
Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
Added in Repentance Lil Dumpy 5.100.615 Lil Dumpy
1
Gives Isaac a Dumpy familiar that pushes, confuses, or poisons nearby enemies and flies in a random direction after taking damage.
Added in Repentance Lil Portal 5.100.681 Lil Portal
1
A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room.
Added in Repentance Lodestone 5.100.617 Lodestone
1
Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources.
Added in Repentance Lost Soul 5.100.612 Lost Soul
1
Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items.
Added in Repentance Montezuma's Revenge 5.100.680 Montezuma's Revenge
1
While firing, Isaac charges up a short-ranged 15►Brimstone Brimstone-like diarrhea beam that shoots behind him.
Added in Repentance Mucormycosis 5.100.553 Mucormycosis
1
Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
Added in Repentance Nancy Bombs 5.100.563 Nancy Bombs
1
Gives Isaac +5 bombs and gives his bombs random bomb synergies.
Added in Repentance Playdough Cookie 5.100.570 Playdough Cookie
1
Grants multicolored tears. Each color comes with a different status or tear effect.
Added in Repentance Polydactyly 5.100.454 Polydactyly
1
Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
Added in Repentance Psy Fly 5.100.581 Psy Fly
1
Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears.
Added in Repentance Quints 5.100.661 Quints
1
The first five enemies killed in a room will spawn stationary shooting familiars where they died.
Added in Repentance Rocket in a Jar 5.100.583 Rocket in a Jar
1
+5 bombs. If Isaac is currently moving, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing.
Added in Repentance Rotten Tomato 5.100.618 Rotten Tomato
1
Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies.
Added in Repentance The Swarm 5.100.693 The Swarm
1
Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly.
Added in Repentance Tinytoma 5.100.645 Tinytoma
1
Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders.
Added in Repentance Tooth and Nail 5.100.663 Tooth and Nail
1
Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage.
Added in Repentance Vasculitis 5.100.657 Vasculitis
1
Enemies explode into tears upon death, which inherit the effects of Isaac's tears.
Added in Repentance Worm Friend 5.100.682 Worm Friend
1
Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.
Added in Repentance Astral Projection 5.100.677 Astral Projection
0.5
Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes.
Added in Repentance Keeper's Kin 5.100.717 Keeper's Kin
0.2
Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.
Added in Repentance Keeper's Sack 5.100.716 Keeper's Sack
0.2
Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a key on pickup.
Added in Repentance TMTRAINER 5.100.721 TMTRAINER
0.1
Causes all future items to be "glitched", granting them completely random effects.


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets