Treasure Room (Greed Mode Item Pool)

Item Pool
Normal/Hard	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar
	Devil Beggar	Key Master	Bomb Bum	Planetarium	Crane Game	Rotten Beggar	Battery Bum	Old Chest	Wooden Chest	Mom's Chest	Baby Shop
Greed Greedier	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest

All of the items in this pool can be found in the gold Treasure Room in Greed Mode. They can also occasionally be found in the Greed Mode Shop.

Activated Collectibles

Name	ID	Icon	Weight	Description
Anarchist Cookbook	5.100.65		1	Spawns six Troll Bombs around the room.
The Bean	5.100.111		1	Isaac farts, poisoning any enemy in close range.
Blood Rights	5.100.186		1	Upon use, takes a full heart of health and deals 40 damage to all enemies in the room.
Bob's Rotten Head	5.100.42		1	Upon use, Isaac holds a poison bomb which can be thrown in the cardinal directions and explodes on impact.
The Book of Belial	5.100.34		1	+2 damage for the current room. Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Increases the chance by 12.5%.
The Book of Sin	5.100.97		1	Spawns a random pickup, pill, card, or trinket.
Book of Revelations	5.100.78		1	Gives one Soul Heart, increases the chance for a Devil or Angel Room, and changes the boss of the current floor to a Harbinger if possible.
Box of Friends	5.100.357		1	Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Demon Baby for the room instead.
Box of Spiders	5.100.288		1	Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies. Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
Dad's Key	5.100.175		1	Opens all doors in the current room when activated, including doors which require a key to open and entrances to Secret Rooms. Opens the big doors in the first room of both Chest and the Dark Room.
Dead Sea Scrolls	5.100.124		1	Triggers the effect of a random activated item from a list of possible options (not every activated item is included).
Deck of Cards	5.100.85		1	Gives Isaac a random card.
Doctor's Remote	5.100.47		1	Creates a crosshair on the ground that can be aimed with tear controls. A missile strikes the spot after 2 seconds, creating a heavy damage explosion.
Flush!	5.100.291		1	Turns all non-boss monsters in the room into poop. Instantly kills poop-themed bosses.
Friendly Ball	5.100.382		1	Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.
The Gamekid	5.100.93		1	Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed.
Glass Cannon	5.100.352		1	Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart. Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes Broken Glass Cannon.
Jar of Flies	5.100.434		1	Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar.
Kidney Bean	5.100.421		1	Isaac farts, charming all nearby enemies.
Lemon Mishap	5.100.56		1	Creates a tiny pool of yellow creep, damaging enemies that cross it.
Mega Bean	5.100.351		1	Petrifies all enemies in the current room for a couple of seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing.
Mom's Bottle of Pills	5.100.102		1	Gives Isaac a random pill.
Mr. Boom	5.100.37		1	Places a Mr. Mega bomb that deals 110 damage.
My Little Unicorn	5.100.77		1	Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies.
The Necronomicon	5.100.35		1	Deals 40 damage to every enemy in the room.
The Pinking Shears	5.100.107		1	Gives flight for the current room, while turning Isaac's body into a fast, high damage familiar.
Prayer Card	5.100.146		1	Gives an Eternal Heart per use.
Remote Detonator	5.100.137		1	Bombs placed by Isaac only explode when Remote Detonator is used. Gives 5 bombs.
Scissors	5.100.325		1	Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. Turns Isaac's head into a stationary familiar for the current room which fires tears automatically, while causing Isaac to shoot a controllable fountain of blood shots.
Tammy's Head	5.100.38		1	Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.
Tear Detonator	5.100.383		1	When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Telepathy for Dummies	5.100.192		1	Gives homing tears for the current room. Also gives +3 range.
Wooden Nickel	5.100.349		1	When used, has a 50% chance to drop one random type of coin (Penny, Nickel, or Dime).
Yum Heart	5.100.45		1	Restores one Red Heart of Isaac's health.
Book of the Dead	5.100.545		1	Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room.
Brown Nugget	5.100.504		1	Spawns a stationary fly turret that fires tears at nearby enemies.
Sharp Straw	5.100.507		1	Damages all enemies in the room. Has a chance to drop a half red heart or half soul heart if an enemy is hit.
Sprinkler	5.100.516		1	Upon use, spawns a sprinkler that rotates and fires tears.
Telekinesis	5.100.522		1	Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
Wait What?	5.100.484		1	Isaac farts, sending out rock waves.
Decap Attack	5.100.729		1	Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it.
Everything Jar	5.100.720		1	Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects.
Fortune Cookie	5.100.557		1	Gives Isaac a fortune, soul heart, tarot card, or trinket.
Free Lemonade	5.100.578		1	Creates a large pool of yellow creep beneath Isaac.
Friend Finder	5.100.687		1	Spawns a random friendly monster that mimics Isaac's movements and attacks.
Golden Razor	5.100.555		1	Spends five coins to increase Isaac's damage by 1.2 for the current room.
Larynx	5.100.611		1	Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage.
Meat Cleaver	5.100.631		1	Splits all enemies in the room into two smaller versions of themselves with much less health.
The Scooper	5.100.605		1	Summons a Peeper familiar for the current room, which leaves a trail of red creep.
Spin to Win	5.100.655		1	When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held.
Stitches	5.100.635		1	Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.
Suplex!	5.100.709		1	Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave.
Yuck Heart	5.100.639		1	Gives Isaac a Rotten Heart.
Esau Jr.	5.100.703		0.5	Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
Eternal D6	5.100.609		0.5	Rerolls all items in the room. Each item has a chance to disappear instead.
Gello	5.100.728		0.5	Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
Mega Mush	5.100.625		0.5	Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.
Plum Flute	5.100.650		0.5	Summons the boss Baby Plum to fight for Isaac in the current room.
Keeper's Box	5.100.719		0.2	Spawns a random shop item or pickup which can be bought for its normal price.
Anima Sola	5.100.722		0.1	Chains down the nearest enemy for 5 seconds, preventing them from acting.
Spindown Dice	5.100.723		0.1	Transforms all items in the room by decreasing their internal ID number.

Passive Collectibles

Name	ID	Icon	Weight	Description
20/20	5.100.245		1	Isaac fires two tears at once, one from each eye.
3 Dollar Bill	5.100.191		1	Gives Isaac a random tear effect every room. Gives Isaac a random tear effect every few seconds.
8 Inch Nails	5.100.359		1	+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.
???'s Only Friend	5.100.320		1	Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys
A Lump of Coal	5.100.132		1	The more distance tears travel, the more damage they will do.
Abel	5.100.188		1	Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
Anemic	5.100.214		1	Increases range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room.
Ankh	5.100.161		1	Upon death, the player will respawn as ??? with 3 Soul Hearts.
Anti-Gravity	5.100.222		1	-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Aquarius	5.100.308		1	A trail of blue creep is left behind Isaac, which damages enemies.
Aries	5.100.300		1	+0.25 Speed. Running into enemies while at a high speed will deal damage. Does not prevent contact damage.
Ball of Tar	5.100.231		1	Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed.
Best Bud	5.100.274		1	When hit, spawns a quickly orbiting attack fly similar to Forever Alone for the current room dealing 75 150 damage per second.
Betrayal	5.100.391		1	Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Big Fan	5.100.279		1	Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies.
Black Lotus	5.100.226		1	Grants one Red Heart, one Soul Heart, and one Black Heart.
Blood Clot	5.100.254		1	Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear height.
Blood of the Martyr	5.100.7		1	Increases damage by 1, and turns Isaac's tears into blood tears.
Bloody Lust	5.100.157		1	Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Bob's Brain	5.100.273		1	Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Bob's Curse	5.100.140		1	Gives 5 bombs and grants Isaac's bombs a poison effect.
Bobby-Bomb	5.100.125		1	+5 bombs. Bombs gain a homing effect, slowly moving towards the nearest enemy.
Bomb Bag	5.100.131		1	Spawns a familiar that drops a bomb every 3 rooms.
Bomber Boy	5.100.353		1	+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs.
Brother Bobby	5.100.8		1	A familiar that follows Isaac around shooting normal tears.
Bursting Sack	5.100.377		1	Spider enemies no longer target or deal contact damage to Isaac.
Butt Bombs	5.100.209		1	+5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies.
Cain's Other Eye	5.100.319		1	Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac.
Cancer	5.100.301		1	Adds 3 Soul Hearts. Grants The Wafer effect for the current room after taking damage.
Capricorn	5.100.307		1	Increases health, damage, speed, and range, lowers tear delay, and gives one coin, bomb, and key.
Celtic Cross	5.100.162		1	Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
Charm of the Vampire	5.100.62		1	Heals Isaac for half of a Red Heart for every 13 enemies killed. +0.3 damage.
Chemical Peel	5.100.154		1	Tears fired from the left eye have +2 flat damage.
Chocolate Milk	5.100.69		1	Grants charged tears that deal greater damage when fully charged.
The Common Cold	5.100.103		1	Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Continuum	5.100.369		1	Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room.
Cricket's Body	5.100.224		1	Grants -1 tear delay and reduces range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's.
Cricket's Head	5.100.4		1	Increases damage by 0.5, and multiplies it by 1.5x.
Cube of Meat	5.100.73		1	Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage.
Cupid's Arrow	5.100.48		1	Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Curse of the Tower	5.100.371		1	Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower.
Cursed Eye	5.100.316		1	Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room.
Daddy Longlegs	5.100.170		1	Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.
Dead Bird	5.100.117		1	After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second.
Dead Eye	5.100.373		1	Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Dead Onion	5.100.336		1	Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed.
Deep Pockets	5.100.416		1	Allows Isaac to carry two cards or pills (or a combination of both) at the same time. Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
Distant Admiration	5.100.57		1	Spawns an attack fly that circles further out than Halo of Flies, but closer than Forever Alone, dealing 75 damage per second.
Dr. Fetus	5.100.52		1	Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired.
Dry Baby	5.100.265		1	Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
E Coli	5.100.236		1	Enemies that touch Isaac are transformed into poop.
Epiphora	5.100.368		1	Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Eve's Mascara	5.100.310		1	Doubles damage, halves tears stat, and greatly reduces shot speed.
Evil Eye	5.100.410		1	While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.
Explosivo	5.100.401		1	Isaac's tears have a chance to stick to enemies and explode.
Fire Mind	5.100.257		1	Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.
Forever Alone	5.100.128		1	Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second.
Friend Zone	5.100.364		1	Spawns a white attack fly that orbits somewhere between Distant Admiration and Forever Alone, dealing 45 damage per second.
Gemini	5.100.318		1	Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second.
Ghost Baby	5.100.163		1	Spawns a familiar that follows Isaac around and fires spectral tears.
Glitter Bombs	5.100.432		1	+5 bombs. Bombs have a chance to drop random pickups or charm enemies when they explode.
Gnawed Leaf	5.100.210		1	After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
God's Flesh	5.100.398		1	Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Guillotine	5.100.206		1	Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay.
Halo of Flies	5.100.10		1	Spawns two Pretty Flies that block enemy shots and deal contact damage to flies.
Harlequin Baby	5.100.167		1	Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Headless Baby	5.100.269		1	Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Host Hat	5.100.375		1	A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.
Hot Bombs	5.100.256		1	Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Infamy	5.100.242		1	Chance to block projectiles coming from any direction.
Infestation	5.100.148		1	1-3 Blue Flies randomly spawn every time Isaac gets hit. 2-6 Blue Flies randomly spawn every time Isaac gets hit.
Infestation 2	5.100.234		1	Spawns allied Blue Spiders from killed enemies.
The Inner Eye	5.100.2		1	Grants triple shot but decreases tears.
Ipecac	5.100.149		1	Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.
Iron Bar	5.100.201		1	Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Juicy Sack	5.100.266		1	Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.
Kidney Stone	5.100.440		1	Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage.
Lazarus' Rags	5.100.332		1	Upon dying, resurrect as Lazarus Risen in the current room with one heart container and Anemic.
Leo	5.100.302		1	Isaac can destroy rocks by walking into them.
Lil Chest	5.100.362		1	Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room.
Lil Gurdy	5.100.384		1	A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed.
Lil Haunt	5.100.277		1	Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear.
Little C.H.A.D.	5.100.96		1	Spawns a familiar who drops a Half Red Heart every 3 rooms.
Little Chubby	5.100.88		1	Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path.
Little Gish	5.100.99		1	Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed.
Little Steven	5.100.100		1	Spawns a familiar who follows Isaac around and fires homing tears.
Loki's Horns	5.100.87		1	Gives a random chance for projectiles to fire in all 4 cardinal directions.
Lost Contact	5.100.213		1	Isaac's tears can hit and destroy enemy projectiles. -0.16 shot speed.
Lost Fly	5.100.365		1	Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact.
The Ludovico Technique	5.100.329		1	Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Lusty Blood	5.100.411		1	Isaac's damage increases for the current room each time he kills an enemy.
Maggy's Bow	5.100.312		1	Gives one Red Heart container and doubles the healing provided by Red Hearts.
Marked	5.100.394		1	Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, +3.15 range.
Milk!	5.100.436		1	Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room.
Mom's Contacts	5.100.110		1	+0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking.
Mom's Eyeshadow	5.100.200		1	Tears have a chance to charm enemies.
Mom's Eye	5.100.55		1	Allows Isaac to fire tears from the back of his head.
Mom's Perfume	5.100.228		1	Adds a chance to shoot fear tears and decreases tear delay by 1.
Monstro's Lung	5.100.229		1	Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Monstro.
Mr. Mega	5.100.106		1	Grants 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
The Mulligan	5.100.151		1	Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy.
Multidimensional Baby	5.100.431		1	Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
Mutant Spider	5.100.153		1	Grants quadruple shot but decreases tears.
My Reflection	5.100.5		1	Gives Isaac's tears a boomerang effect. +1.5 range, +1 tear height, x1.6 shot speed multiplier.
Mysterious Liquid	5.100.317		1	Tears leave a small, short lasting pool of creep on impact or when their range is depleted.
Mystery Sack	5.100.271		1	Spawns a familiar that drops a Heart, coin, bomb, or key every 5-6 rooms.
Night Light	5.100.425		1	A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
No. 2	5.100.378		1	Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.
Number One	5.100.6		1	Grants +1.5 tears, but severely reduces range.
Obsessed Fan	5.100.426		1	Spawns a familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Odd Mushroom	5.100.121		1	Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear height, and -0.1 speed.
Odd Mushroom	5.100.120		1	+1.7 tears, +0.3 speed, slightly reduces damage.
Ouija Board	5.100.115		1	Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Papa Fly	5.100.430		1	Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.
The Parasite	5.100.104		1	Isaac's tears split in two when they hit something.
Pay to Play	5.100.380		1	+5 coins. Turns doors that require a single key into doors which need a coin to enter instead.
The Peeper	5.100.155		1	Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through.
Pisces	5.100.309		1	-1 Tear Delay, adds knock-back shots and increases tear size.
Polyphemus	5.100.169		1	Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage.
Proptosis	5.100.261		1	Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Punching Bag	5.100.281		1	Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer.
Pupula Duplex	5.100.379		1	Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size.
Purity	5.100.407		1	Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.
Pyromaniac	5.100.223		1	+5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. Also grants immunity to fire.
Rotten Baby	5.100.268		1	Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Rubber Cement	5.100.221		1	Tears bounce off walls, enemies, and environmental objects.
Rune Bag	5.100.389		1	Spawns a familiar that drops a random rune every 5-6 rooms.
Sack of Pennies	5.100.94		1	Spawns a familiar that drops a coin every 2 rooms.
Sacrificial Dagger	5.100.172		1	Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots.
Sad Bombs	5.100.220		1	+5 Bombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers.
The Sad Onion	5.100.1		1	Increases tears by 0.7.
Sagittarius	5.100.306		1	Increases speed by +0.2 and grants piercing tears.
Samson's Chains	5.100.321		1	Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles.
Scapular	5.100.142		1	Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart.
Scatter Bombs	5.100.366		1	Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Scorpio	5.100.305		1	Grants poison tears, which deal damage over time when inflicted.
Serpent's Kiss	5.100.393		1	Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a black heart when killed.
Sissy Longlegs	5.100.280		1	Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders.
Sister Maggy	5.100.67		1	Spawns a familiar that follows Isaac around shooting normal tears.
Smart Fly	5.100.264		1	Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second.
SMB Super Fan	5.100.189		1	+1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear height. Fully restores all red hearts.
Soy Milk	5.100.330		1	Tears are smaller and do much less damage, but fire in very rapid succession.
Spider Bite	5.100.89		1	Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spoon Bender	5.100.3		1	Grants Isaac homing tears.
Steam Sale	5.100.64		1	Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Steven	5.100.50		1	Increases damage by 1.
Sticky Bombs	5.100.367		1	+5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.
Stigmata	5.100.138		1	Increases damage, and adds 1 heart container.
Strange Attractor	5.100.315		1	Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Taurus	5.100.299		1	-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn effect for 5 seconds.
Tech X	5.100.395		1	Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring.
Tech.5	5.100.244		1	Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets.
Technology	5.100.68		1	Replaces tears with a piercing laser with unlimited range.
Technology 2	5.100.152		1	Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Tiny Planet	5.100.233		1	Range up and makes shot tears revolve around Isaac until they drop.
Tough Love	5.100.150		1	Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Tractor Beam	5.100.397		1	Increases tears, range, and shot speed. Isaac emits a beam from his face that his tears follow along.
Virgo	5.100.303		1	Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
The Virus	5.100.13		1	Isaac poisons enemies on contact. -0.1 speed. +0.2 speed. Poisoned enemies have a chance to drop a black heart when killed.
The Wafer	5.100.108		1	All sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead.
The Wiz	5.100.358		1	Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. Isaac's tears also travel above all obstacles.
Zodiac	5.100.392		1	Gives Isaac a random zodiac item effect that changes every floor.
The Halo	5.100.101		1 0.5	Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height.
Magic Mushroom	5.100.12		1 0.5	Makes Isaac bigger. Adds one Red Heart container, +0.3 damage, x1.5 damage multiplier, +5.25 range, and +0.3 speed. Restores all health on pickup.
The Body	5.100.334		1 0.2	Adds 3 Red Heart containers.
Death's Touch	5.100.237		1 0.2	+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Holy Light	5.100.374		1 0.2	Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.
The Mind	5.100.333		1 0.2	Reveals the entire map, including all special rooms and Secret Rooms.
Mom's Knife	5.100.114		1 0.2	Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
The Soul	5.100.335		1 0.2	Grants two Soul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles.
Missing No.	5.100.258		1 0.1	Randomizes all passive items and stats upon pickup and at the start of each succeeding floor.
Epic Fetus	5.100.168		1	Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote.
Godhead	5.100.331		1	Grants homing tears with a damaging halo. +0.5 damage, -0.3 tears, +1.2 range, -0.3 shot speed, +0.8 tear height.
Judas' Shadow	5.100.311		1	Adds an extra life; upon death, it respawns Isaac as Dark Judas with two Black Hearts.
Pyro	5.100.190		1	Grants 99 bombs.
Adrenaline	5.100.493		1	Increases damage based on how many empty Red Heart containers Isaac has.
Analog Stick	5.100.465		1	+0.35 tears up. Allows Isaac to fire tears diagonally.
Apple!	5.100.443		1	Increases tears. Adds a chance to fire a high-damage razor blade.
Backstabber	5.100.506		1	Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac.
Big Chubby	5.100.473		1	Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact.
Bloodshot Eye	5.100.509		1	Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds.
Bozo	5.100.513		1	+0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Brittle Bones	5.100.549		1	Replaces all Red Hearts with 6 empty Bone Hearts. Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up.
Broken Modem	5.100.514		1	Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Camo Undies	5.100.497		1	Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused.
Compound Fracture	5.100.453		1	Increases range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle.
Cone Head	5.100.457		1	Grants a Soul Heart. Gives Isaac a chance to ignore any damage taken.
Contagion	5.100.466		1	The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Dead Tooth	5.100.446		1	While firing, Isaac gains a green aura that poisons nearby enemies.
Depression	5.100.469		1	Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Dog Tooth	5.100.445		1	+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret Rooms or Crawl Spaces.
Euthanasia	5.100.496		1	Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Eye of Greed	5.100.450		1	Every 20 tears, Isaac loses 1 coin and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins.
Finger!	5.100.467		1	Spawns a finger familiar that points at enemies, dealing scaling damage.
Flat Stone	5.100.540		1	Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area.
Ghost Pepper	5.100.495		1	Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. Gives a chance to shoot blue fires alongside tears that become smaller as they travel.
Glaucoma	5.100.460		1	Adds a chance to shoot tears that confuse enemies for an extremely long time.
Mom's Wig	5.100.217		1	Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart.
Mongo Baby	5.100.322		1	Spawns a familiar that copies the tears of Isaac's other familiars.
Haemolacria	5.100.531		1	Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.
Hallowed Ground	5.100.543		1	Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots.
Hushy	5.100.470		1	Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving.
Jacob's Ladder	5.100.494		1	Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Rainbow Baby	5.100.174		1	Spawns a familiar that follows Isaac around and fires tears with random effects.
Robo-Baby	5.100.95		1	Spawns a familiar that shoots Technology lasers.
Robo-Baby 2.0	5.100.267		1	Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Jaw Bone	5.100.548		1	Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups.
Jumper Cables	5.100.520		1	Grants an active item charge every 15 enemies killed.
Lachryphagy	5.100.532		1	Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Large Zit	5.100.502		1	Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Lead Pencil	5.100.444		1	After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Leprosy	5.100.525		1	Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Lil Monstro	5.100.471		1	Spawns a familiar that fires clusters of tears. Must be charged before shooting.
Lil Spewer	5.100.537		1	Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type.
Linger Bean	5.100.447		1	Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies.
Little Horn	5.100.503		1	Adds a chance to fire a piercing tear that instantly kills any enemy that it touches. Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Metal Plate	5.100.449		1	Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears.
Mom's Razor	5.100.508		1	Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
Mystery Egg	5.100.539		1	Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room.
Parasitoid	5.100.461		1	Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.
Pointy Rib	5.100.544		1	Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage.
Pop!	5.100.529		1	Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Shard of Glass	5.100.448		1	Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room. Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart.
Sinus Infection	5.100.459		1	Adds a chance to fire a booger that sticks to enemies and deals damage over time.
Slipped Rib	5.100.542		1	Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Sulfuric Acid	5.100.463		1	+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles.
Technology Zero	5.100.524		1	Connects Isaac's tears with electricity that can damage enemies.
Varicose Veins	5.100.452		1	Taking damage releases a ring of 10 high damage tears.
The Relic	5.100.98		1 0.2	Spawns a cross familiar that drops a Soul Heart every 5-6 rooms.
120 Volt	5.100.559		1	Repeatedly zaps enemies that are close to Isaac.
Akeldama	5.100.641		1	While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies.
Almond Milk	5.100.561		1	Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects.
Belly Button	5.100.458		1	Drops a random trinket. Grants a second trinket slot.
Belly Jelly	5.100.690		1	Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots.
Bird Cage	5.100.610		1	The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird.
Bird's Eye	5.100.616		1	Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Blood Bombs	5.100.614		1	Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any.
Blood Puppy	5.100.565		1	Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal.
Bloody Gust	5.100.695		1	When Isaac takes damage, he gains speed and tears for the rest of the floor.
Boiled Baby	5.100.607		1	Gives Isaac a familiar that fires chaotic bursts of tears in all directions.
Bone Spurs	5.100.683		1	Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them.
Bot Fly	5.100.629		1	Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles.
Candy Heart	5.100.671		1	Gives Isaac a permanent stat boost whenever he heals with red heart pickups.
Cracked Orb	5.100.675		1	Unlocks doors and reveals a random room on the map when Isaac takes damage.
Cube Baby	5.100.652		1	Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills.
Dirty Mind	5.100.576		1	Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects.
Empty Heart	5.100.676		1	If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container.
Eye Sore	5.100.558		1	Causes Isaac to occasionally fire extra tears in random directions while shooting.
Freezer Baby	5.100.608		1	Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them.
Fruity Plum	5.100.649		1	Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels.
Ghost Bombs	5.100.727		1	+5 bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds.
Giant Cell	5.100.658		1	Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies.
Hemoptysis	5.100.726		1	Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him.
Hypercoagulation	5.100.724		1	After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds.
IBS	5.100.725		1	Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies.
The Intruder	5.100.575		1	A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.
It Hurts	5.100.560		1	Releases a ring of tears and increases tears for the current room when Isaac takes damage.
Knockout Drops	5.100.637		1	Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies.
Lil Dumpy	5.100.615		1	Gives Isaac a Dumpy familiar that pushes, confuses, or poisons nearby enemies and flies in a random direction after taking damage.
Lil Portal	5.100.681		1	A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room.
Lodestone	5.100.617		1	Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources.
Lost Soul	5.100.612		1	Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items.
Montezuma's Revenge	5.100.680		1	While firing, Isaac charges up a short-ranged Brimstone-like diarrhea beam that shoots behind him.
Mucormycosis	5.100.553		1	Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores.
Nancy Bombs	5.100.563		1	Gives Isaac +5 bombs and gives his bombs random bomb synergies.
Playdough Cookie	5.100.570		1	Grants multicolored tears. Each color comes with a different status or tear effect.
Polydactyly	5.100.454		1	Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill.
Psy Fly	5.100.581		1	Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears.
Quints	5.100.661		1	The first five enemies killed in a room will spawn stationary shooting familiars where they died.
Rocket in a Jar	5.100.583		1	+5 bombs. If Isaac is currently moving, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing.
Rotten Tomato	5.100.618		1	Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies.
The Swarm	5.100.693		1	Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly.
Tinytoma	5.100.645		1	Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders.
Tooth and Nail	5.100.663		1	Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage.
Vasculitis	5.100.657		1	Enemies explode into tears upon death, which inherit the effects of Isaac's tears.
Worm Friend	5.100.682		1	Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time.
Astral Projection	5.100.677		0.5	Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes.
Keeper's Kin	5.100.717		0.2	Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.
Keeper's Sack	5.100.716		0.2	Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a key on pickup.
TMTRAINER	5.100.721		0.1	Causes all future items to be "glitched", granting them completely random effects.