Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth

Toxic Shock is a passive item added in The Binding of Isaac: Afterbirth.


  • Upon entering a room, all enemies are poisoned, dealing double Isaac's tear damage and also creating a green fog for the first few seconds of the room.
  • Killing enemies leaves a small, short-lasting pool of green creep on the ground.
    • The creep deals 1 damage per tick or 30 damage per second.


  • High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless.
  • Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Flies spawned from a Mulligan dying.
  • Enemies that spawn with some form of invulnerability such as Hosts, Wizoobs, or Added in Repentance Needles are not affected by this item.
  • The poison effect only activates upon entering a room and not at the start of a wave. In Boss Rush and most of Greed mode, the item will not poison enemies.
  • If Toxic Shock is picked up in the middle of a room with enemies, the mass poison will occur immediately.

In-game Footage[]



PC 0DMW R92S (First floor Treasure Room)

PC Hard mode only MS6L 43MM (First floor Treasure Room)

PC Normal and hard modes only E3ER VEGE (First floor Treasure Room)

PC Added in Repentance KXBC NCBR (First floor Treasure Room)

Switch Added in Afterbirth † 7YV6 DDJ1 (Treasure Room adjacent to spawn)