Every 6 seconds, Isaac turns to stone and sprouts spikes for 1 second. While Isaac is in this state, he is immune to damage and deals 40 contact damage.
Isaac flashes white three times before turning to stone on the fourth flash. The first three flashes are accompanied by a "ticking" sound, the final one with the spike extension sound of a mimic chest.
Unlike Gnawed Leaf, Isaac can still move and shoot tears.
Midas' Touch also makes the stone turn a yellowish golden while active. Purely visual, but can help remind the player that they have both items.
Damocles: As Isaac is invincible 1/6th of the time, with some luck, Tooth and Nail may save him from the falling sword.
Kamikaze!: Allows usage without taking damage during invincibility.
The Lost can use this item to prevent additional damage from occurring after losing the Holy Mantle (for example, exiting a Curse Room after being hit), and it does not use up the Holy Mantle's 1-hit protection if it has not been lost.
In-game footage[ | ]
Bugs[ | ]
Bug!
If Tooth and Nail is lost while in the statue form (e.g. through losing its Lemegeton wisp), Isaac will indefinitely remain in the statue form until he leaves the room.
Bug!
Using an active item with no cooldown repeatedly (Mom's Bracelet, Bag of Crafting, etc.) whilst in an invulnerable state will keep Isaac in that state.