watch 02:46
The Quarry - The Loop
Do you like this video?
Play Sound

Tooth and Nail is a passive item added in The Binding of Isaac: Repentance.
Effects[]
- Every 6 seconds, Isaac turns to stone and sprouts spikes for 1 second. While Isaac is in this state, he is immune to damage and deals 40 contact damage.
- Isaac flashes white four times before turning to stone on the fourth flash. The first three flashes are accompanied by a "ticking" sound, the final one with the spike extension sound of a mimic chest.
- Unlike
Gnawed Leaf, Isaac can still move and shoot tears.
Notes[]
Blood Donation Machines and
Devil Beggars will still deal damage while Tooth and Nail is active.
- With proper timing,
Curse Rooms can be both entered and exited without taking damage.
- When invincible,
Spiked Chests/
Mimic Chests can be opened without taking damage.
- When under the effects of the Paralysis pill Isaac cannot change into a statue.
Synergies[]
- Contact damage items work great with Tooth and Nail, such as
Aries /
Mom's Heels /
The Virus for extra damage,
Serpent's Kiss for Black Heart generation,
Midas' Touch for coin generation etc.
Damocles: As Isaac is invincible 1/6th of the time, with some luck, Tooth and Nail may save him from the falling sword.
Kamikaze!: Allows usage without taking damage during invincibility.
-
The Lost can use this item to prevent additional damage from occurring after losing the
Holy Mantle (for example, exiting a
Curse Room after being hit), and it does not use up the Holy Mantle's 1-hit protection if it has not been lost.
In-game footage[]
Seeds[]
PC 3T0E WTWQ (Treasure Room adjacent to spawn)
Bugs[]
![]() |
If Tooth and Nail is lost while in the statue form (e.g. through losing its ![]() |
---|
![]() |
Using an active item with no cooldown repeatedly (![]() ![]() |
---|