Binding of Isaac: Rebirth Wiki
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Tick is a trinket.

Effects[ | ]

  • Removes 15% of any enemy's health if they have 60 HP or higher.
  • Gives Isaac one Red HeartRed Heart if he enters an unexplored Boss RoomBoss Room.
  • Once picked up, Tick can't be dropped or replaced with another trinket.

Notes[ | ]

  • Only works on the first stage of multistage bosses.
  • (except in Rebirth)Friendly enemies are also affected by the health removal when above 60 hp.
  • (in Afterbirth and Afterbirth †) This trinket's effect can be multiplied to a maximum of x2 through any combination of multiple copies and Collectible Mom's Box iconMom's Box. This also includes multiplying the healing effect when entering a Boss RoomBoss Room.
  • (in Repentance) This trinket's effect can be stacked via any combination of multiple copies, golden variants, and Collectible Mom's Box iconMom's Box with enough stacks causing any enemy above 60 hp to have the lowest amount of health possible with any amount of damage killing them. This also includes stacking the healing effect when entering a Boss RoomBoss Room. The HP removal stacking effect is equal to 0.85 ^ Number of Tick Instances, with golden trinkets adding on 2 to this.
  • (in Repentance) Has no effect on the Ultra Harbingers. Works on both phases of Dogma.

Synergies[ | ]

  • (in Repentance)Golden Trinket Golden Trinket: The golden version can be freely dropped or replaced by another trinket.
  • (in Afterbirth † and Repentance) Collectible Marbles iconMarbles / Collectible Smelter iconSmelter / Gulp!: Absorbs the trinket, allowing Isaac to pick another trinket up.
  • (except in Rebirth) Match StickMatch Stick: Tick can be removed by picking up Match Stick.
    • Match Stick + Collectible Mom's Purse iconMom's Purse / (in Afterbirth † and Repentance)Collectible Belly Button iconBelly Button: Match Stick can no longer remove Tick, instead moving to the second trinket slot even if Isaac already holds two trinkets.
  • (except in Rebirth)Collectible Mom's Box iconMom's Box: Reduces enemy's health by 30%.

In-game Footage[ | ]

Trivia[ | ]

  • (except in Rebirth) Being able to replace the Tick with Match Stick is a reference to how one can remove a tick that has latched onto their skin in real life with a heated tip of a match stick; however, removing a tick like this can expose oneself to disease-causing bacteria present in the tick. It is also a feature that was carried over from the original The Binding of Isaac, though it's unclear why it wasn't originally added in Rebirth.
  • The Tick is the only trinket that passively changes Isaac's appearance.
  • The Tick bears similarity to a real-life deer tick.
  • This trinket is used in The Host (challenge #18).


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