The Virus

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The   Virus
Item icon
Item altar
"Poison touch"
Table dividing line 1.png
Item ID
5.100.13
Character Appearance
Character appearance
Table dividing line 2.png
Table dividing line 3.png
Collection Grid
Removed in Afterbirth(page 1, column 3, row 2)
Added in Afterbirth(page 1, column 13, row 1)

The Virus is a passive item.

Effects[edit | edit source]

  • Inflicts poison on enemies who make contact with Isaac.
    • Added in Repentance Enemies take 12 damage upon contact with Isaac.
    • Removed in Repentance The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
      • Added in Afterbirth / Removed in Repentance Each poison hit deals damage equal to Isaac's tear damage.
      • Added in Afterbirth † / Removed in Repentance The poison hits a total of 6 times against normal enemies and 3 times against bosses. The effect can only be applied to bosses roughly every 6 seconds.
    • Added in Repentance The poison lasts for 6-7 ticks and deals damage equal to (0.2*HeartContainers^2) + 2, where HeartContainers is the total number of heart containers and bone hearts Isaac has.
  • Added in Afterbirth / Removed in Repentance Enemies who are killed after they have been inflicted with this type of poison have a 20% chance to drop Black Hearts.
    • Added in Repentance It is no longer possible for enemies who are inflicted with this type of poison to drop black hearts
  • Removed in Repentance -0.1 speed down (Removed in Afterbirth not applied until the next time Isaac's speed stat is updated).
  • Added in Repentance +0.2 speed up.
  • Added in Afterbirth This item belongs to the Spun set. Collecting three items from this set will transform Isaac into a buff berserker.

Notes[edit | edit source]

  • Removed in Repentance The black heart is only dropped if the poison was caused by The Virus. The item's effect doesn't extend to poison tears.
  • Removed in Repentance If an enemy doesn't do contact damage, The Virus can safely be applied to it for more chances at black hearts. Black flies, Mulligans, and Hosts are the most common enemies this can be applied to.
    • Removed in Repentance With 15►Skatole Skatole, Hives and Swarmers will constantly spawn normal Flies, meaning they can be endless sources of Black Hearts.
    • Removed in Afterbirth † Although Stonies and Shopkeepers can't be visibly poisoned, they still can drop Black Hearts if destroyed after being touched.
  • Enemies won't start taking poison damage if they are pushing up against Isaac; The Virus will be constantly trying to apply poison and refreshing the ticks where poison damage would occur.
    • Removed in Repentance 15►Gnawed Leaf Gnawed Leaf and The Virus can still work if Isaac has a short-range orbital such as 15►Cube of Meat Cube of Meat or 15►Ball of Bandages Ball of Bandages, as it will kill enemies pushing against Isaac that are not taking poison damage while still dropping Black Hearts.

Synergies[edit | edit source]

Interactions[edit | edit source]

  • Removed in Repentance 15►Odd Mushroom Odd Mushroom: The speed down from the Virus does not stack with the Odd Mushroom; if both are collected, only a total of -0.1 applies.

In-game Footage[edit | edit source]

Unlockable Achievements[edit | edit source]

Trivia[edit | edit source]

  • Upon picking up The Virus, Isaac looks very similar to Lust, which is fitting since Lust also drops The Virus.
    • As such, The Virus may be a reference to an STI.

Seeds[edit | edit source]

PC 26ND Z11A (Treasure Room adjacent to spawn)

PC 1389 DNH1 (Treasure Room adjacent to spawn)

PC Added in Afterbirth † Normal and hard modes only FKVG 36FZ (Lust fight right of spawn)

PC Added in Repentance A643 V2FE (Treasure Room adjacent to spawn)

PS4 913D J63B (First floor Treasure Room)

3DS TKYD 8DRA (Treasure Room adjacent to spawn)

Switch Greedier mode only FEKK E8JS (First Golden Treasure Room)


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