Binding of Isaac: Rebirth Wiki
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(in Repentance)

The Siren is a boss added in The Binding of Isaac: Repentance that can appear in the MausoleumMausoleum.

Behavior[ | ]

  • If Isaac has any Familiars, The Siren sings, charming up to 3 familiars at a time to assist her and turning their effects against Isaac.
    • Isaac's Familiars when charmed retain most of their behaviors when assisting The Siren but can now deal contact damage and block shots.
    • Charmed Familiars have 60 HP and return to Isaac when killed.
  • If she has less than 3 charmed shooting Familiars from Isaac, she summons up to orbiting 3 Siren MinionSiren Minions of her own. These Familiars behave identically to Collectible Brother Bobby iconBrother Bobby but with a slower fire rate and can also be killed. She then glides around the room for a few seconds, letting her familiars use their effects against Isaac. If she has any familiars alive after this, she swipes at Isaac, launching all remaining familiars in a cluster in his direction.
    • When the cluster collides with a wall it kills all the Familiars and releases a burst of radial projectiles and a cluster of disorganized projectiles.
      • The amount of projectiles launched during this attack depends on the number of familiars that collided with the wall.
  • Swipes a short distance in Isaac's direction, releasing 5 projectiles.
  • Sinks into the floor becoming invulnerable and chases Isaac, leaving a trail of slowing Black Creep. After reappearing, she swipes at Isaac, shooting a spread of 5 projectiles.
  • Screams, emitting a consistent shockwave around her and spawning 9 pulsating rings of projectiles that expand outwards.
    • This attack pushes Isaac away like an inverted Gaping MawGaping Maw.
    • The rings of projectiles have openings towards Isaac's general direction.

Upon death, The Siren burns away, leaving behind her skull.

Gallery[ | ]

Notes[ | ]

  • Bombing the skull that the Siren leaves behind spawns and unlocks the Forgotten LullabyForgotten Lullaby.
    • It only spawns the Forgotten LullabyForgotten Lullaby the first time it is bombed.
    • Bombing the skull in subsequent runs treats it as a regular Skull in regards to its drops.
    • Leaving and returning to the room causes the skull to disappear.
  • The Siren can charm Character Lilith iconLilith's Familiars, including her Collectible Incubus iconIncubus, hence making Lilith a difficult character to kill The Siren with. To counter this, either bait The Siren into launching the familiars into the wall and killing them or use bombs/active items to deal damage.
  • Charmed familiars with a charged attack (eg: Collectible Lil Brimstone iconLil Brimstone) hold their charge until the Siren launches the familiars.
  • Charmed familiars that are thrown (eg: Collectible Bob's Brain iconBob's Brain) do not count towards the count of 3 familiars that orbit the Siren but are included in the cluster thrown at the end of the attack.
  • Lasers from charmed Collectible Robo-Baby iconRobo-Baby and Collectible Robo-Baby 2.0 iconRobo-Baby 2.0 do not hurt Isaac.
  • Charmed Collectible Abel iconAbel mirror's The Siren's movements and shoots at her, though these projectiles are dangerous towards Isaac and do not hurt The Siren.
  • Charmed Collectible Lil Portal iconLil Portal can still collect pickups and create a portal.
  • Charmed Collectible Paschal Candle iconPaschal Candle will still grant a tears buff while charmed.
  • Charmed Collectible Rotten Baby iconRotten Baby spawns Attack FlyAttack Flies instead of Blue Flies and Collectible Sissy Longlegs iconSissy Longlegs spawns SpiderSpiders instead of Blue Spiders.
  • Charmed Collectible Tinytoma iconTinytoma orbits The Siren but still blocks hostile projectiles and turns into friendly Blue Spiders after being destroyed. It will also not return to Isaac when destroyed and will spawn charmed again for The Siren.
  • Temporary familiars and Collectible King Baby iconKing Baby cannot be charmed.

Unlockable Achievements[ | ]

Trivia[ | ]

  • The Siren originates from the Antibirth mod. Compared to the version in Repentance, two features were cut: one was a musical note projectile attack that reversed your controls, and the other was a revival mechanic that occured when The Siren charmed an extra life familiar like Collectible 1up! icon1up! or Collectible Dead Cat iconDead Cat.
  • She is based off of Sirens from Greek mythology, which were dangerous creatures who lured nearby sailors with their enchanting music and singing voices.
  • The Siren is the only boss that can interact with Isaac's collected items or familiars.
  • The Siren's ring of tears and sinking in the ground attacks are references to the Gorgun boss from the game Enter the Gungeon. Moreover, both bosses leave behind remains that can be destroyed.
  • The Siren is voiced by Carla Kihlstedt, also known to be the voice of Boss Mom ingameMom.


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