Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance

The Siren is a boss added in The Binding of Isaac: Repentance that can appear in Mausoleum Mausoleum.


  • If Isaac has any Familiars, The Siren sings, charming up to 3 familiars at a time to assist her and turning their effects against Isaac.
    • Isaac's Familiars when charmed retain most of their behaviors when assisting The Siren but can now deal contact damage and block shots.
    • Charmed Familiars have 60 HP and returned to Isaac when killed.
  • If she has less than 3 charmed shooting Familiars from Isaac, she summons up to orbiting 3 Siren Minions of her own. These Familiars behave identically to 15►Brother Bobby Brother Bobby but with a slower fire rate and can also be killed. She then glides around the room for a few seconds, letting her familiars use their effects against Isaac. If she has any familiars alive after this, she swipes at Isaac, launching all remaining familiars in a cluster in his direction.
    • When the cluster collides with a wall it kills all the Familiars and releases a burst of radial projectiles and a cluster of disorganized projectiles.
      • The amount of projectiles launched during this attack depends on the number of familiars that collided with the wall.
  • Swipes a short distance in Isaac's direction, releasing 5 projectiles.
  • Sinks into the floor becoming invulnerable and chases Isaac, leaving a trail of slowing Black Creep. After reappearing, she swipes at Isaac, shooting a spread of 5 projectiles.
  • Screams, emitting a consistent shockwave around her and spawning 9 pulsating rings of projectiles that expand slowly outwards. These projectiles split into two when far enough.
    • This attack pushes Isaac away like an inverted Gaping Maw.
    • The rings of projectiles have openings towards Isaac's general direction that disappear as the projectiles split.

Upon death, The Siren burns away, leaving behind her skull.



  • Bombing the skull that the Siren leaves behind spawns and unlocks the Forgotten Lullaby Forgotten Lullaby.
    • It only spawns the Forgotten Lullaby Forgotten Lullaby the first time it is bombed.
    • Bombing the skull in subsequent runs treats it as a regular Skull in regards to its drops.
    • Leaving and returning to the room causes the skull to disappear.
  • The Siren can charm Lilith Lilith's Familiars, including her 15►Incubus Incubus, hence making Lilith a difficult character to kill The Siren with. To counter this, either bait The Siren into launching the familiars into the wall and killing them or use bombs/active items to deal damage.
  • Charmed familiars with a charged attack (eg: 12►Lil Brimstone▼3►Lil' Brimstone Lil Brimstone) hold their charge until the Siren launches the familiars.
  • Charmed familiars that are thrown (eg: 15►Bob's Brain Bob's Brain) do not count towards the count of 3 familiars that orbit the Siren but are included in the cluster thrown at the end of the attack.
  • If the Siren has charmed the 15►1up! 1up! or 15►Dead Cat Dead Cat familiars and dies, she will use one of their extra lives to revive herself at respectively full health or 10% of her health.
  • Lasers from charmed 15►Robo-Baby Robo-Baby and 15►Robo-Baby 2.0 Robo-Baby 2.0 do not hurt Isaac.
  • Charmed 15►Abel Abel mirror's The Siren's movements and shoots at her, though these projectiles are dangerous towards Isaac and do not hurt The Siren.
  • Charmed 15►Lil Portal Lil Portal can still collect pickups and create a portal.
  • Charmed 15►Rotten Baby Rotten Baby spawns Attack Flies instead of Blue Flies and 15►Sissy Longlegs Sissy Longlegs spawns Spiders instead of Blue Spiders.
  • Charmed 15►Tinytoma Tinytoma orbits The Siren but still blocks hostile projectiles and turns into friendly Blue Spiders after being destroyed. It will also not return to Isaac when destroyed and will spawn charmed again for The Siren.

Unlockable Achievements[]


  • She is based off of Sirens from Greek mythology, which were dangerous creatures who lured nearby sailors with their enchanting music and singing voices.
  • The Siren is the only boss that can interact with Isaac's collected items.
    • She is also the only boss that can interact with Isaac's familiars.
  • The Siren's ring of tears and sinking in the ground attacks are references to the Gorgun boss from the game Enter the Gungeon. Moreover, both bosses leave behind remains that can be destroyed.


Bug Bug! If The Siren dies on top of a pit, the game crashes because it can not generate the skull.
Bug Bug! If The Siren charms 15►Dead Cat Dead Cat and Isaac dies, the game crashes.

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Chapter 1
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The Void
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