Binding of Isaac: Rebirth Wiki

The Negative is an unlockable passive item.


  • If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon The Necronomicon effect, damaging all enemies in the room.
  • Allows entrance into the Dark Room Dark Room after beating Satan Satan in Sheol Sheol by touching the chest.
  • Added in Repentance +1 damage.
  • Added in Repentance Opens A Strange Door in Depths Depths II and its variants that leads to Mausoleum Mausoleum/Gehenna Gehenna II.
    • Unlike with the Dark Room entrance, The Negative gets consumed by the door and vanishes from Isaac's inventory.



  • Added in RepentanceA Missing Page A Missing Page / Added in RepentanceMissing Page 2 Missing Page 2: Increases the damage from 40 to 80.
    • A Missing Page + Missing Page 2: The damage increase stacks for a total of 120 damage.

In-game Footage[]


  • The Negative allows access to the Dark Room, which is also the name of a room used to develop photos (Darkroom).
  • A negative is a piece of film with an image imprinted on it and developed, and light can be shone through it to imprint a positive image on photographic paper. A negative has inverted hues and luminosity.
    • Because of the instant nature of Polaroid film versus regular film, however, Polaroids do not have negatives, and a dark room would not be required to develop one, which calls into question its relation to The Polaroid The Polaroid. However, this could probably explain the fact that both items can't be picked up together in a run (unless Forget Me Now Forget Me Now or a 5-pip Dice Room is used).