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The designs of these items appear to be that of Triquetra, a Christian symbol of the Trinity.
The item's description, along with those of The Soul and The Body, are references to the three attributes commonly ascribed to God in Christian theology: omniscience, omnipotence, and omnipresence. For The Mind, it is omniscience, the ability to "know all".
This item might be referencing Solomon from the Bible, who became unhappy with life after gaining preposterous wisdom - which is why Isaac might look so done with everything in the item sprite.
The Mind's icon under the minimap overrides the icons of other mapping effects.
Blue Map, 
The Lost Unlocks 
Satan Unlocks 
The Binding of Isaac: Rebirth
