Binding of Isaac: Rebirth Wiki

The Host is Challenge #18, starting with the items Spiderbaby, The Mulligan, and the TickTick. The goal is to defeat Mom. This Challenge is unlocked by default.

Difficulty[]

  • The lack of Item room isn't as well compensated by the starting items when compared to the other challenges. Isaac also doesn't start with an active item.

Strategy[]

  • ShopShops can sell Mom's Purse, allowing a second trinket or Smelter allowing the tick to be smelted and new trinkets to be picked up.
  • Shops can also sell Hive Mind, which will make blue flies and blue spiders bigger and stronger.
  • Isaac starts with one item each for the (in Afterbirth † and Repentance) Spider BabySpider Baby transformation and the BeelzebubBeelzebub transformation, meaning only two more items from each set will grant Isaac special abilities. While the lack of treasure rooms somewhat limits the possibility of completing either transformation, it is still possible:
    • Hive Mind counts for (in Repentance) both transformations ((except in Repentance) just the Beelzebub transformation), and is in the Shop pool.
    • The only other shop item that's in the Spider Baby set is (except in Rebirth) Spider Mod.
    • (except in Rebirth) Sticky Bombs from (except in Rebirth) Bomb Bum is the only other possible item for the set that appears outside the Treasure Room pool.
    • For the Beelzebub set, the only other item in the Shop pool is (except in Rebirth) Jar of Flies, which synergizes well with Hive Mind.
    • (in Repentance) Plum Flute, another Beelzebub set item, can be easily acquired by not attacking (in Repentance) Baby Plum for about 30 seconds.
    • Skatole, another Beelzebub set item, can be won from Shell Games, which are likely to spawn in ArcadeArcades.
    • Key Masters have more than a dozen fly items that contribute to the Beelzebub set that they could pay out with.
  • Isaac still produces flies when firing at lowered Hosts, so it is possible to farm flies off of them.

Reward[]

Trivia[]

  • A host is an organism that is infected by a parasite, which explains why Isaac has items and trinkets relating to parasites.
  • This challenge is similar to the 'Lord of the Flies' challenge in the original game.