The Host

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The   Host
Isaac
Full red heartFull red heartFull red heart
Table dividing line 1.png
Challenge Number
18
Starting Items
15►The Mulligan The Mulligan
15►Spiderbaby Spiderbaby
Trinket:
Tick Tick
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Goal
Boss Mom.png

The Host is Challenge #18, starting with the items 15►Spiderbaby Spiderbaby, 15►The Mulligan The Mulligan, and the Tick Tick. The goal is to defeat Mom. This Challenge is unlocked by default.

Difficulty[edit | edit source]

Strategy[edit | edit source]

  • Shops can sell Mom's Purse, which will allow a second trinket.
  • Shops can also sell 15►Hive Mind Hive Mind, which will make blue flies and blue spiders bigger and stronger.
  • Shops can also sell Smelter, which will allow the tick to be smelted and new trinkets to be picked up.

Reward[edit | edit source]

Trivia[edit | edit source]

  • A host is an organism that is infected by a parasite, which explains why Isaac has items and trinkets relating to parasites.
  • This challenge is similar to the 'Lord of the Flies' challenge in the original game.


MainPageChallenges.png Challenges MainPageChallenges.png

Rebirth
1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
8. Cat Got Your Tongue 9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards
15. Slow Roll 16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
Afterbirth
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
Repentance
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
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