The Family Man is Challenge #19. Isaac is blindfolded and must instead rely on familiars to do damage. The goal is to defeat Isaac. Isaac starts with Brother Bobby, Sister Maggy, Dad's Key, BFFS! and Rotten Baby.
Isaac also starts with the Conjoined transformation due to the familiars the player starts with, making the challenge more difficult. This is because the Conjoined transformation decreases your damage, which the blue flies from Rotten Baby rely on.
Both Brother Bobby and Sister Maggy have been buffed, making this challenge markedly easier: Brother Bobby now has a higher fire rate; while Sister Maggy has an increased damage of 6 (with BFFS! a respectable 12)
- Dad's Key allows the player to enter secret rooms and shops without using bombs or keys. Saving and obtaining extra pickups via Dad's Key can be leveraged for items from Beggars and Arcade machines to offset the challenge's lack of treasure rooms.
- Also, Dad's Key can be used to exit the Boss Rush without having to fight any bosses, granting a free item if the Boss Rush is reached in time.
- Gaining flight will allow Isaac to stay safely out of range while the familiars deal damage.
- Damage from blue flies scales with Isaac's damage, allowing more damage into the late game. Several items can help achieve this.
- Sacrificial Dagger is extremely useful, because with BFFS! it deals 30 damage per tick, making it extremely useful against bosses. However, this does not apply to Spear of Destiny.
- Getting this combined with invincibility such as Rune of Algiz will allow a guaranteed kill on bosses.
- Additional damage-dealing familiars can be leveraged against enemies.
- Lil Brimstone is particularly useful for its significant damage, unlimited range, and attacks that pierce obstacles and enemies.
- ???'s Only Friend can also deal high damage and can be controlled to attack enemies anywhere in the room.
- Bob's Brain can be tricky to use effectively but offers a tremendous boost to damage.
- Damage-dealing active items, such as The Candle, Red Candle, or The Boomerang also offer a reliable amount of damage, and are all obtainable from the Shop.
- Defensive orbitals block projectiles and some can be used to deal damage. Using Slot Machines is a relatively reliable method to get 2-3 defensive flies.
- Re-rolling Isaac's Items with a Dice Room, the D4, the D100, or Missing No. is not recommended as it can leave Isaac without means of dealing damage.
- Most of Lilith's unlockable items will make the challenge easier:
- Incubus enables Isaac to fire as Lilith does, and also benefits from the Conjoined transformation.
- Box of Friends doubles familiars, and therefore allows Isaac to double his tear output.
- Cambion Conception and Immaculate Conception are reliable methods of generating new familiars.
- Succubus can deal high amounts of damage and help clear rooms.
- Baby-Bender gives all familiar's tears homing ability.
- Both Pause and Camo Undies, when combined with Rotten Baby allows Isaac to snipe enemies from safety.
|1. Pitch Black||2. High Brow||3. Head Trauma||4. Darkness Falls||5. The Tank|
|6. Solar System||7. Suicide King||8. Cat Got Your Tongue||9. Demo Man||10. Cursed!|
|11. Glass Cannon||12. When Life Gives You Lemons||13. Beans!||14. It's in the Cards||15. Slow Roll|
|16. Computer Savvy||17. Waka Waka||18. The Host||19. The Family Man||20. Purist|
|21. XXXXXXXXL||22. SPEED!||23. Blue Bomber||24. PAY TO PLAY||25. Have a Heart|
|26. I RULE!||27. BRAINS!||28. PRIDE DAY!||29. Onan's Streak||30. The Guardian|
|31. Backasswards||32. Aprils Fool||33. Pokey Mans||34. Ultra Hard||35. Pong|
|36. Scat Man||37. Bloody Mary||38. Baptism by Fire||39. Isaac's Awakening||40. Seeing Double|
|41. Pica Run||42. Hot Potato||43. Cantripped!||44. Red Redemption||45. DELETE THIS|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|