The Common Cold is a passive item.


  • Adds a chance to shoot poison tears, dealing damage over time when inflicted.
  • Dlc na indicator.png The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
    • Dlc a indicator.png The poison hits twice, dealing a total of double Isaac's damage.


  • The chance for a tear to be poisoned depends on the luck stat. The activation rate is equal to 1/(4 - (Luck / 4)). At base luck (0), the chance is 25%, maxing out at 100% at 12 luck.
    • Due to how this formula works, increases in activation rate are only seen with every 4 points of luck, as this formula rounds down after dividing Isaac's luck by 4.



  • Collectible Ipecac icon.png Ipecac/ Collectible Scorpio icon.png Scorpio: Overrides The Common Cold.
  • Dlc a indicator.png Collectible Serpent's Kiss icon.png Serpent's Kiss: Both poison effects work, but poison caused by Common Cold will not cause black heart drops. There is no way to tell which poison is applied.
  • Trinket Pinky Eye icon.png Pinky Eye: Activation rates are individually applied to each tear, effectively allowing for higher amounts of poison tears. However at 12 Luck, the trinket will not do anything for Isaac as The Common Cold is guaranteed to make every tear poisoned at that point.

In-game Footage


  • In the original Binding of Isaac, this item also belonged to the Devil Room pool.


PC ANX3 VC3V (Treasure Room adjacent to spawn)

PC HardIndicator.png Dlc a indicator.png MPLX AJVP (Treasure Room adjacent to spawn; Curse of the Labyrinth)

Switch NormalIndicator.png KWFP J9MK (First Floor Treasure Room; East from Start)


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