Binding of Isaac: Rebirth Wiki

The Common Cold is a passive item.


  • Adds a chance to shoot poison tears, dealing damage over time when inflicted.
    • Removed in Afterbirth The poison randomly hits either 2 or 3 times, dealing a total of 4 or 6 damage.
    • Added in Afterbirth The poison hits 3 times, dealing a total of 3x Isaac's damage.
    • Added in Repentance The poison hits 2 times, dealing a total of 2x Isaac's damage.


  • The chance for a tear to be poisoned depends on the luck stat. The activation rate is equal to 1/(4 - (Luck / 4)). At base luck (0), the chance is 25%, maxing out at 100% at 12 luck.
    • Due to how this formula works, increases in activation rate are only seen with every 4 points of luck, as this formula rounds down after dividing Isaac's luck by 4.



  • Ipecac Ipecac/Scorpio Scorpio: Overrides The Common Cold.
  • Added in Afterbirth / Removed in RepentanceSerpent's Kiss Serpent's Kiss: Both poison effects work, but poison caused by Common Cold will not cause Black Heart Black Heart drops. There is no way to tell which poison is applied.
  • Pinky Eye Pinky Eye: Activation rates are individually applied to each tear, effectively allowing for higher amounts of poison tears. However at 12 Luck, the trinket will not do anything for Isaac as The Common Cold is guaranteed to make every tear poisoned at that point.

In-game Footage[]


  • In the original The Binding of Isaac, this item also belonged to the Devil Room pool.


PC ANX3 VC3V (Treasure Room adjacent to spawn)

PC Hard mode only Added in Afterbirth MPLX AJVP (Treasure Room adjacent to spawn; Curse of the Labyrinth)

Switch Normal mode only KWFP J9MK (First Floor Treasure Room; East from Start)