The Book of Sin is an unlockable activated item.
Effect[]
- Generates a random pickup, pill, card, or rune.
- This includes
Cracked Key, Dice Shard, and Emergency Contact. - Hearts can be of any type other than Blended Hearts.
- Coins can be of any type, with higher value coins and Lucky Pennies being rarer.
- Bombs and Keys will always be singular (unless Isaac has Bogo Bombs and/or Humbling Bundle).
- This includes
- Each pickup seems to be equally likely, which means that there is around a 1/7 chance to get a particular type of pickup.
- This item belongs to the Bookworm set. Collecting three items from this set will transform Isaac into Bookworm.
This item belongs to the Synergies[]
- Book of Virtues: Spawns the wisp of Yum Heart, Mom's Bottle of Pills, Deck of Cards, Mr. Boom, Portable Slot (Coin wisp, x3), Bob's Rotten Head, Anarchist Cookbook, or Shoop Da Whoop!. Shoop Da Whoop wisps will not fire lasers when Book of Sin is used. The wisp given is independent of the pickup generated.
In-game Footage[]
Trivia[]
- The Book of Sin is a reference to the Seven Deadly Sins. Unlike other Book items, The Book of Sin doesn't appear to be based on a real book or scripture.
Gallery[]
3DS The icon of The Book of Sin as seen on the lower 3DS screen.
Seeds[]
PC 
2YN8 JS3R (
Treasure Room adjacent to spawn)
PC LP12 WXZ1 ( Treasure Room adjacent to spawn)
PC K6RC 1P0T ( Treasure Room adjacent to spawn)
PS4 1V4Q HMXN ( Treasure Room adjacent to spawn)
Vita W4YY DXT4
3DS ZRQY 1Y70 (First floor Treasure Room)
 Books
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 The Binding of Isaac: Rebirth
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