The Book of Sin is an unlockable activated item.
Effect[ | ]
- On use, spawns a random coin, heart, bomb, key, battery, pill or card near Isaac.
This item belongs to the Bookworm set. Collecting three items from this set will transform Isaac into Bookworm.
This item belongs to the 
Notes[ | ]
- Hearts are proportionally more likely to be generated, with Red Hearts, Soul Hearts and Black Hearts each having a 1/9 chance of being chosen, the other 6/9 being distributed among the other categories.
- Each category has a 1/7 chance of being chosen.
- The card category includes runes, Dice Shard, Emergency Contact and Cracked Key.
- The heart category has the following distribution:
Hearts are proportionally more likely to be generated, with 
Each category has a 1/7 chance of being chosen.
Type Chance Red Heart48.3% Soul Heart16.1% Black Heart16.1% Bone Heart6.4% Rotten Heart6.4% Eternal Heart3.2% Gold Heart3.2%
- Half Red Hearts, Half Soul Hearts and Blended Hearts cannot be generated.
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- Coins can be of any type, with higher value coins, including Lucky Pennies, and Sticky Nickels, being rarer.
- Bombs and Keys will always be singular (unless Isaac has BOGO Bombs and/or Humbleing Bundle).
- The Book of Sin cannot generate a Micro Battery.
Synergies[ | ]
- Book of Virtues: Grants a random wisp based on one of the Seven Deadly Sins. The wisp spawned isn't linked to the pickup dropped.
- Pride: a blue bomb wisp in the middle ring. When destroyed, a small homing bomb that deals normal troll bomb damage is spawned.
- Greed: 3 yellow coin wisps in the outer ring. Their tears may petrify enemies like Midas' Touch.
- Wrath: an orange bomb wisp in the middle ring, which fire flaming tears. They drop troll bombs when continuously firing, and leave a bomb pickup when they die.
- Envy: a white face-like wisp in the outer ring.
- Lust: a randomly colored pill wisp in the inner ring, with effects that are the same as Mom's Bottle of Pills wisps.
- Gluttony: a heart wisp in the middle ring, with effects that are the same as Yum Heart wisps.
- Sloth: a Bob's Head wisp in the middle ring. Their tears travel in an arc like Ipecac but don't always explode on impact. There is a small chance for an exploding tear.
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In-game Footage[ | ]
Trivia[ | ]
- The Book of Sin is a reference to the Seven Deadly Sins. Unlike other Book items, The Book of Sin doesn't appear to be based on a real book or scripture.
Gallery[ | ]
3DS The icon of The Book of Sin as seen on the lower 3DS screen.
 Books
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| Items |
 The Binding of Isaac: Rebirth
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