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Issues: As this is information relating to newly released content, there may be more information planned to be released by the developers in the following months.

Repentance is a DLC expansion to The Binding of Isaac: Afterbirth † that was released on March 31st, 2021. It costs $15.00.

For a list of the pre-release blog posts, see The Binding of Isaac: Repentance (Pre-Release).

Features

General features revealed include:

  • The fan mod The Binding of Isaac: Antibirth integrated into the game as official content!
  • A new reworked co-op mode, allowing up to four players to play as actual characters instead of babies.
  • 130+ new items (more than 700 items in total and some are from Antibirth)
  • A full alternate path with brand new chapters and two new final bosses and endings (one from Antibirth)
  • 100+ new enemies
  • 25 new bosses
  • 19 new playable characters
  • 10 new challenges
  • 234 new achievements, for a grand total of 637.
  • 5,000+ new room designs

Additions

Playable Characters

Character Character Bethany appearance.png
Character Bethany icon.png Bethany
Character Jacob and Esau appearance.png
Character Jacob and Esau icon.png Jacob and Esau
Character Jacob icon.png Jacob Character Esau icon.png Esau
Health Stat Icon.png Health HUD heart red full.png HUD heart red full.png HUD heart red full.png HUD heart red full.png HUD heart red full.png HUD heart red full.png HUD heart soul full.png HUD heart red full.png
Damage Stat Icon.png Damage 3.5 (*1.00) 2.75 (*1.50) 3.75 (*1.00)
Tears Stat Icon.png Tears +0 3.00 2.50
Shot Speed Stat Icon.png Shot Speed 1 1.15 0.85
Range Stat Icon.png Range 6.5 5.00 8.00
Speed Stat Icon.png Speed 1.0 1.00 1.00
Luck Stat Icon.png Luck 0 1.00 -1.00
Starting Item Icon.png Starting Pickups 4 Soul Charges None None
Starting Item Icon.png Starting Item(s) Collectible Book of Virtues icon.pngBook of Virtues None None
There is also a "tainted character" for each existing playable character (including Character Bethany icon.png Bethany and Character Jacob and Esau icon.png Jacob and Esau) which can be unlocked by finding a hidden room on the new stage "Home". Because of that, the total number of playable characters in the game is 34.

Items and Trinkets

Activated Collectibles

Name ID Icon Quote Description Quality
Abyss 5.100.706 Come forth from the depths Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. 4
Alabaster Box 5.100.585 A sacred offering Spawns three soul hearts and two Angel room items and is consumed. Starts with no charges, and can only be charged by picking up 6 soul hearts. 2
Anima Sola 5.100.722 Repent Chains down the nearest enemy for 5 seconds, preventing them from acting. 2
Bag of Crafting 5.100.710 Make your destiny Collects and holds up to 8 pickups. Holding the activate button crafts them into a passive item, with the power level based on the quality of pickups used. 3
Berserk! 5.100.704 Rip and tear Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms. 3
Book of Virtues 5.100.584 Spiritual companionship On use, spawns an orbital Wisp familiar that fires spectral tears but can be destroyed. Also becomes a passive item that causes other active items to spawn themed Wisps. 3
Broken Glass Cannon 5.100.474 You broke it! Begins with no charges and turns into Collectible Glass Cannon icon.png Glass Cannon when used. Only acquired by taking damage while holding Glass Cannon. 0
Clear Rune 5.100.263 Rune mimic Has the same effect as the rune or soul stone currently held by Isaac. 2
Damocles 5.100.577 A king's fortune... but at what cost? Spawns a sword above Isaac's head, which doubles all item pedestals. After Isaac takes damage, the sword can randomly fall at any point, instantly killing him. 2
Dark Arts 5.100.705 One with the shadows Makes Isaac invulnerable and intangible for one second. When the effect ends, all enemies Isaac ran through take damage and Isaac temporarily gains +1 damage for each one. 2
Death Certificate 5.100.628 Where am I? Takes Isaac to an abandoned and expanded version of Home, which has one copy of every item in the game. After taking an item, Isaac returns to the room he used Death Certificate in. 4
Decap Attack 5.100.729 Chuck away! Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it. 2
Eraser 5.100.638 Erase thy enemy Throws an eraser that instantly kills the first monster it hits, and prevents that monster from spawning for the rest of the run. Can only be used once per floor. 2
Esau Jr. 5.100.703 Lost brother Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run. 2
Eternal D6 5.100.609 ??? Rerolls all items in the room. Each item has a chance to disappear instead. 2
Everything Jar 5.100.720 Anything is possible Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. 2
Flip 5.100.711 Life and death Switch characters between Tainted Lazarus and Dead Tainted Lazarus. 3
Fortune Cookie 5.100.557 Reusable fortunes Gives Isaac a fortune, soul heart, tarot card, or trinket. 2
Free Lemonade 5.100.578 Party time! Creates a large pool of yellow creep beneath Isaac. 2
Friend Finder 5.100.687 Best friends forever! Spawns a random friendly monster that mimics Isaac's movements and attacks. 3
Gello 5.100.728 Demonic gestation Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects. 2
Genesis 5.100.622 In the beginning Removes all of Isaac's items and pickups and takes him to a unique bedroom with some pickups and chests and a trapdoor to the next floor. For every item Isaac lost, he gets to take an item from a set of three. 2
Golden Razor 5.100.555 Pain from gain Spends five coins to increase Isaac's damage by 1.2 for the current room. 2
Hold 5.100.715 Saved for later Exclusive to Character Tainted ??? icon.png Tainted ???. Allows him to save one poop bomb for later, allowing him to gather more over time. 0
Jar of Wisps 5.100.685 Your faith grows Spawns random wisps that shoot various tears, block shots, and deal contact damage. The number of wisps spawned increases every time the jar is used. 2
Keeper's Box 5.100.719 Portable shop Spawns a random shop item or pickup which can be bought for its normal price. 3
Larynx 5.100.611 Hear my pain Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage. 2
Lemegeton 5.100.712 Item summoner Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects. 3
Magic Skin 5.100.642 All your desires fulfilled Consumes one heart container or two soul hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items. 2
Meat Cleaver 5.100.631 Slice but no dice Splits all enemies in the room into two smaller versions of themselves with much less health. 1
Mega Mush 5.100.625 I'm a big boy now! Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms. 4
Mom's Bracelet 5.100.604 Mother's strength Lets Isaac pick up and throw rocks, TNT, poops, and other obstacles. 2
Plum Flute 5.100.650 Play time! Summons the boss Baby Plum to fight for Isaac in the current room. 2
R Key 5.100.636 Time to start over Brings Isaac back to the first floor of a new run, retaining all of his items. 4
Recall 5.100.714 Come back Retrieves the Forgotten's body from any distance. Only available as the Collectible Birthright icon.png Birthright effect for Character Tainted Forgotten icon.png Tainted Forgotten. 0
Red Key 5.100.580 Explore the other side Creates a new room adjacent to a viable wall, indicated by the outline of a door. These rooms have a chance to be various special rooms. 3
Sharp Key 5.100.623 Open your enemies Adds 5 keys on pickup. Allows Isaac to throw his keys to deal damage to enemies, destroy obstacles, and open doors. 1
Spin to Win 5.100.655 Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Spindown Dice 5.100.723 -1 Transforms all items in the room by decreasing their internal ID number. 4
Stitches 5.100.635 Bait and switch Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. 1
Sulfur 5.100.556 Temporary demon form Grants Collectible Brimstone icon.png Brimstone for the current room. 2
Sumptorium 5.100.713 Return Holding down the fire button converts hearts into familiars that fire tears but can be destroyed. Activating converts the familiars back into hearts. 3
Suplex! 5.100.709 Angel breaker Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave. 3
The Scooper 5.100.605 Plop! Summons a Peeper familiar for the current room, which leaves a trail of red creep. 0
Urn of Souls 5.100.640 Unleash their sorrow Spews a stream of damaging flame. Gains Soul Charges each time an enemy dies, which are used to fuel the urn. 3
Vade Retro 5.100.653 Begone! While held, enemies leave behind ghosts on death. Using the item causes the ghosts to explode, dealing damage to nearby enemies. Stronger enemies leave bigger ghosts. 3
Wavy Cap 5.100.582 Tears up. A mind changing experience! Increases tears, decreases speed, and distorts the screen. All effects become more pronounced with repeated use, and wear off by clearing rooms. 1
Yuck Heart 5.100.639 Gross! Gives Isaac a Rotten Heart. 3

Passive Collectibles

Name ID Icon Quote Description Quality
120 Volt 5.100.559 Collectible 120 Volt icon.png Zap! Repeatedly zaps enemies that are close to Isaac. 3
2Spooky 5.100.554 Collectible 2Spooky icon.png 4me Enemies near Isaac are afflicted with fear. 2
4.5 Volt 5.100.647 Collectible 4.5 Volt icon.png Beat the juice out of them! Active items don't charge when clearing rooms. Instead, they're charged by dealing damage to enemies. 2
A Bar of Soap 5.100.564 Collectible A Bar of Soap icon.png Tears + shot speed up Gives Isaac +0.5 Tears and +0.2 Shot Speed. 3
A Pound of Flesh 5.100.672 Collectible A Pound of Flesh icon.png Blood money Devil deals now cost coins, shop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Act of Contrition 5.100.601 Collectible Act of Contrition icon.png Tears up, you feel forgiven Increases tears and grants an Eternal Heart. Allows Angel Rooms to appear even if a Devil deal has been taken before. Greatly boosts Devil/Angel Deal chance if Isaac has taken Red Heart damage. 3
Akeldama 5.100.641 Collectible Akeldama icon.png Spill your guts While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies. 2
Almond Milk 5.100.561 Collectible Almond Milk icon.png DMG down + tears up + you feel nutty Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects. 1
Astral Projection 5.100.677 Collectible Astral Projection icon.png The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Azazel's Rage 5.100.699 Collectible Azazel's Rage icon.png Ancient power Isaac builds rage every time a room is cleared. After four rooms, fires a large Collectible Brimstone icon.png Brimstone laser when entering the next room. 3
Battery Pack 5.100.603 Collectible Battery Pack icon.png Instant energy! Recharges Isaac's currently held active item and drops 2-4 batteries. 1
Belly Jelly 5.100.690 Collectible Belly Jelly icon.png Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit and enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 2
Binge Eater 5.100.664 Collectible Binge Eater icon.png All you can eat +1 red heart container and fully heals Isaac. Item pedestals cycle between their normal items and food, and collecting food grants a temporary damage boost and permanent bonuses to 2 stats. 3
Bird Cage 5.100.610 Collectible Bird Cage icon.png Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Collectible Dead Bird icon.png Dead Bird. 1
Bird's Eye 5.100.616 Collectible Bird's Eye icon.png It burns Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. 2
Birthright 5.100.619 Collectible Birthright icon.png ??? Has a different effect for each character. 2
Blood Bombs 5.100.614 Collectible Blood Bombs icon.png Bloody blast + HP up Grants a Red Heart container and restore 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any. 1
Blood Oath 5.100.569 Collectible Blood Oath icon.png Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Blood Puppy 5.100.565 Collectible Blood Puppy icon.png What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal. 2
Bloody Gust 5.100.695 Collectible Bloody Gust icon.png May your rage bring haste When Isaac takes damage, he gains speed and tears for the rest of the floor. 3
Boiled Baby 5.100.607 Collectible Boiled Baby icon.png Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
Bone Spurs 5.100.683 Collectible Bone Spurs icon.png Break your enemies Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them. 2
Booster Pack 5.100.624 Collectible Booster Pack icon.png Collect them all! Spawns 5 random cards. 1
Bot Fly 5.100.629 Collectible Bot Fly icon.png Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Brimstone Bombs 5.100.646 Collectible Brimstone Bombs icon.png Demon blast +5 bombs Gives Isaac +5 bombs and causes his bombs to fire Collectible Brimstone icon.png Brimstone lasers in the cardinal directions upon exploding. 3
C Section 5.100.678 Collectible C Section icon.png Fetus shots Not fully implemented. 4
Candy Heart 5.100.671 Collectible Candy Heart icon.png Power of love Gives Isaac a permanent stat boost whenever he heals with red heart pickups. 2
Card Reading 5.100.660 Collectible Card Reading icon.png A link to your future Spawns two portals that each lead to either the Boss Room, Secret Room, or Treasure Room at the beginning of each floor. 3
Consolation Prize 5.100.644 Collectible Consolation Prize icon.png +1 to lowest stat Increases Isaac's lowest stat and drops either 3 coins, 1 bomb, or 1 key depending on what Isaac has the least of. 1
Cracked Orb 5.100.675 Collectible Cracked Orb icon.png Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Cube Baby 5.100.652 Collectible Cube Baby icon.png Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Dad's Note 5.100.668 Collectible Dad's Note icon.png ... Begins the sequence to access Home. 0
Dirty Mind 5.100.576 Collectible Dirty Mind icon.png Filthy friends Destroying poop spawns friendly Dips that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. 2
Divine Intervention 5.100.568 Collectible Divine Intervention icon.png Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. 2
Dogma 5.100.633 Collectible Dogma icon.png Ascended Grants flight, +0.1 speed, +2 damage, and the Collectible Holy Mantle icon.png Holy Mantle effect. Grants enough health to have 6 full hearts, if possible. Automatically given to Isaac after defeating Dogma. 0
Dream Catcher 5.100.566 Collectible Dream Catcher icon.png Sweet dreams During the transition between floors, Isaac's nightmare shows the floor's Treasure Room item and boss. Grants half a soul heart when entering a new floor. 2
Echo Chamber 5.100.700 Collectible Echo Chamber icon.png I can see see the future future future When Isaac uses a card, pill, or rune, he also uses a copy of every card/pill/rune he used after picking up Echo Chamber. 2
Empty Heart 5.100.676 Collectible Empty Heart icon.png It multiplies If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container. 2
Evil Charm 5.100.632 Collectible Evil Charm icon.png Luck up + you feel protected Increases luck by 2.0. Provides immunity to burn, confusion, fear, and poison. 1
Eye Drops 5.100.600 Collectible Eye Drops icon.png Tears up Lowers the tear delay in Isaac's left eye, causing his eyes to fire at different rates. 3
Eye of the Occult 5.100.572 Collectible Eye of the Occult icon.png DMG up + range up + controlled tears Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed. 3
Eye Sore 5.100.558 Collectible Eye Sore icon.png More eyes Causes Isaac to occasionally extra fire tears in random directions while shooting. 2
False PHD 5.100.654 Collectible False PHD icon.png Worse pills + evil up Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart. 2
Freezer Baby 5.100.608 Collectible Freezer Baby icon.png Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Fruity Plum 5.100.649 Collectible Fruity Plum icon.png Bouncy friend Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. 1
Ghost Bombs 5.100.727 Collectible Ghost Bombs icon.png Spooky blast +5 bombs +5 bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. 2
Giant Cell 5.100.658 Collectible Giant Cell icon.png Micro friends Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies. 1
Glitched Crown 5.100.689 Collectible Glitched Crown icon.png ????? Before being picked up, item pedestals cycle between 5 random items. 4
Guppy's Eye 5.100.665 Collectible Guppy's Eye icon.png An eye for secrets Shows the contents of Chests, Sacks, and Fire Places before they're opened. 2
Heartbreak 5.100.694 Collectible Heartbreak icon.png Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Hemoptysis 5.100.726 Collectible Hemoptysis icon.png Double tap sneeze Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. 3
Hungry Soul 5.100.684 Collectible Hungry Soul icon.png Out for blood Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. 3
Hypercoagulation 5.100.724 Collectible Hypercoagulation icon.png Thick blooded After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds. 3
IBS 5.100.725 Collectible IBS icon.png Your stomach rumbles Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies. 2
Immaculate Heart 5.100.573 Collectible Immaculate Heart icon.png Halo of tears Adds one red heart container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him. 3
Inner Child 5.100.688 Collectible Inner Child icon.png Let him free Upon death, Isaac respawns in the current room with half a heart left, a massive size down, and +0.2 speed. 3
Isaac's Tomb 5.100.701 Collectible Isaac's Tomb icon.png Buried memories Spawns an Old Chest at the start of each floor. 3
It Hurts 5.100.560 Collectible It Hurts icon.png No it doesn't... Releases a ring of tears and increases tears for the current room when Isaac takes damage. 1
Jupiter 5.100.594 Collectible Jupiter icon.png You're a gas giant! +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves afterwards. 3
Keeper's Kin 5.100.717 Collectible Keeper's Kin icon.png Under a rock Rocks and props spawn spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
Keeper's Sack 5.100.716 Collectible Keeper's Sack icon.png Spending power Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a key on pickup. 3
Knife Piece 1 5.100.626 Collectible Knife Piece 1 icon.png ??? Combined with Collectible Knife Piece 2 icon.png Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Stage Corpse icon.png Corpse. 0
Knife Piece 2 5.100.627 Collectible Knife Piece 2 icon.png ??? Combined with Collectible Knife Piece 1 icon.png Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Stage Corpse icon.png Corpse. 0
Knockout Drops 5.100.637 Collectible Knockout Drops icon.png They pack a punch! Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies. 3
Lil Abaddon 5.100.679 Collectible Lil Abaddon icon.png Abyssal friend Spawns a familiar that charges a miniature Collectible Maw of the Void icon.png Maw of the Void attack while Isaac shoots. 3
Lil Dumpy 5.100.615 Collectible Lil Dumpy icon.png Puffy buddy Gives Isaac a Dumpy familiar that pushes, confuses, or poisons nearby enemies and flies in a random direction after taking damage. 0
Lil Portal 5.100.681 Collectible Lil Portal icon.png It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Lodestone 5.100.617 Collectible Lodestone icon.png Magnetizing tears Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources. 3
Lost Soul 5.100.612 Collectible Lost Soul icon.png Protect him Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items. 2
Luna 5.100.589 Collectible Luna icon.png The moon's blessing shines upon you Adds an extra Secret Room and Super Secret Room to each floor. Secret Rooms contain a beam of light that increases tears for the current floor and give soul hearts. 2
Mars 5.100.593 Collectible Mars icon.png Double tap dash Dash by double-tapping the movement key, becoming invulnerable and damaging enemies. There's a short cooldown before Isaac can dash again. 2
Member Card 5.100.602 Collectible Member Card icon.png Exclusive access! Adds a trapdoor to every shop that leads to a second shop with a unique stock and marked-up prices. 1
Mercurius 5.100.590 Collectible Mercurius icon.png Speed up + you feel elusive +0.4 speed. Doors stay open after entering a room, even in rooms with enemies. 3
Monstrance 5.100.574 Collectible Monstrance icon.png Purifying light Isaac gains an aura that deals damage to enemies inside it. 2
Montezuma's Revenge 5.100.680 Collectible Montezuma's Revenge icon.png Oh no... While firing, Isaac charges up a short-ranged Collectible Brimstone icon.png Brimstone-like diarrhea beam that shoots behind him. 3
Mucormycosis 5.100.553 Collectible Mucormycosis icon.png Spore shot Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores. 3
Nancy Bombs 5.100.563 Collectible Nancy Bombs icon.png Random blast +5 bombs Gives Isaac +5 bombs and gives his bombs random bomb synergies. 1
Neptunus 5.100.597 Collectible Neptunus icon.png Open the floodgates Isaac's mouth fills with tears over time while not firing, up to a cap. Holding the fire button will release all stored tears in rapid succession. 3
Ocular Rift 5.100.606 Collectible Ocular Rift icon.png Stare into the abyss Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources. 3
Options? 5.100.670 Collectible Options? icon.png There might be options If a room gives a reward when cleared, there will be two different rewards to chose from. Taking one causes the other to disappear. 2
Orphan Socks 5.100.571 Collectible Orphan Socks icon.png Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 soul hearts. 1
Paschal Candle 5.100.567 Collectible Paschal Candle icon.png Keep the flame burning Gives Isaac a tears bonus based on how many consecutive rooms he's cleared without taking damage. 3
Playdough Cookie 5.100.570 Collectible Playdough Cookie icon.png Tasty rainbow Grants multicolored tears. Each color comes with a different status or tear effect. 3
Pluto 5.100.598 Collectible Pluto icon.png Size down Significantly shrinks Isaac, allowing him to squeeze between objects and makes some enemy shots pass over him. Also gives +0.7 tears. 3
Psy Fly 5.100.581 Collectible Psy Fly icon.png Flamboyant protector Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears. 3
Purgatory 5.100.634 Collectible Purgatory icon.png Help from beyond While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. 2
Quints 5.100.661 Collectible Quints icon.png They lurk inside Killing enemies spawns a stationary shooting familiar where they died for the current room. 1
Red Stew 5.100.621 Collectible Red Stew icon.png Full HP + temporary DMG up Refills all heart containers. Grants an enormous damage boost that wears off over time. 0
Redemption 5.100.673 Collectible Redemption icon.png Deliver me from evil Gives Isaac a soul heart and +1 damage if he goes into a Devil Room but doesn't take anything from it. 2
Revelation 5.100.643 Collectible Revelation icon.png Awaken your faith Grants flight and two soul hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser. 4
Rock Bottom 5.100.562 Collectible Rock Bottom icon.png It's only up from there Locks Isaac's attributes to their highest values reached. 2
Rocket in a Jar 5.100.583 Collectible Rocket in a Jar icon.png Rocket propulsion +5 bombs +5 bombs. If Isaac is currently moving, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing. 2
Rotten Tomato 5.100.618 Collectible Rotten Tomato icon.png Delicious! Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies. 1
Sacred Orb 5.100.691 Collectible Sacred Orb icon.png Destined for greatness Prevents low-quality items from spawning, greatly increasing the quality of items received from all items pools. 4
Salvation 5.100.696 Collectible Salvation icon.png Divine protection Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor. 2
Sanguine Bond 5.100.692 Collectible Sanguine Bond icon.png He awaits your offering Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward. 1
Saturnus 5.100.595 Collectible Saturnus icon.png Ring of tears Upon entering a room, a circle of tears orbits Isaac. Enemy tears have a chance to be caught in orbit, turning them friendly. 1
Sausage 5.100.669 Collectible Sausage icon.png All stats up Adds a Red Heart container, and increases speed, damage, tears, range, shot speed, and luck. 3
Sol 5.100.588 Collectible Sol icon.png Radiant victory Reveals the location of the Boss room. Upon defeating a boss, activates XIX - The Sun, fully recharges Isaac's active item, grants bonus damage and luck for the rest of the floor, and removes curses. 2
Soul Locket 5.100.686 Collectible Soul Locket icon.png Power of faith Gives Isaac a permanent stat boost whenever he picks up a soul heart. 2
Spirit Shackles 5.100.674 Collectible Spirit Shackles icon.png Unfinished business On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a soul heart. 3
Spirit Sword 5.100.579 Collectible Spirit Sword icon.png Divine blade Instead of tears, Isaac swings a sword. Charging does a spin attack and fires a projectile, and a projectile is sometimes fired with normal swings if Isaac has no empty red hearts. 3
Stapler 5.100.708 Collectible Stapler icon.png DMG up +1 damage. Prevents Isaac from firing tears from one eye, like Cain. 3
Star of Bethlehem 5.100.651 Collectible Star of Bethlehem icon.png Follow the light Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing. 2
Strawman 5.100.667 Collectible Strawman icon.png A helping hand Spawns Keeper to fight enemies alongside Isaac. If Keeper dies, he spawns blue spiders and Strawman is removed from Isaac's inventory. 2
Supper 5.100.707 Collectible Supper icon.png HP up Grants one full Red Heart container. Heals 1 additional heart of health. 1
Terra 5.100.592 Collectible Terra icon.png Born to rock Replaces tears with rocks that deal variable damage, have increased knockback, and can destroy obstacles. 3
The Intruder 5.100.575 Collectible The Intruder icon.png Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
The Stairway 5.100.586 Collectible The Stairway icon.png May you get what you came for Generates a ladder at the start of every floor that leads to a unique Angel Room shop. 3
The Swarm 5.100.693 Collectible The Swarm icon.png Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Tinytoma 5.100.645 Collectible Tinytoma icon.png Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
TMTRAINER 5.100.721 Collectible TMTRAINER icon.png ZZaZZ ZZdZZiZZmZZhZZ ZZvZZ ZZoZZ ZZ ZZsZZlZZhZZsZZoZZaZZiZZ Causes all future items to be "glitched", granting them completely random effects. 2
Tooth and Nail 5.100.663 Collectible Tooth and Nail icon.png You feel prickly Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage. 2
Tropicamide 5.100.659 Collectible Tropicamide icon.png Tear size + range up +1.5 range, Increases tear size. 1
Twisted Pair 5.100.698 Collectible Twisted Pair icon.png Double trouble! Gives Isaac two familiars that stand by Isaac's side and fire tears that use Isaac's tears, range, shot speed, and tear effects and scale with Isaac's damage. 4
Uranus 5.100.596 Collectible Uranus icon.png Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. 3
Vanishing Twin 5.100.697 Collectible Vanishing Twin icon.png He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. 3
Vasculitis 5.100.657 Collectible Vasculitis icon.png Clogged enemies Enemies explode into tears upon death, which inherit the effects of Isaac's tears. 2
Vengeful Spirit 5.100.702 Collectible Vengeful Spirit icon.png Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 2
Venus 5.100.591 Collectible Venus icon.png HP up + you feel pretty Adds one red Heart container. Enemies near Isaac become charmed. 1
Voodoo Head 5.100.599 Collectible Voodoo Head icon.png Extra curse rooms Spawns an additional curse room on each floor. 1
Worm Friend 5.100.682 Collectible Worm Friend icon.png Clingy buddy Gives Isaac a nerve ending familiar that burrows out of the ground to grab and deal damage to enemies over time. 2

Trinkets

Name ID Icon Quote Description
'M 5.350.138 Trinket 'M icon.png t's broken9Reroll your dest Using an activated item rerolls it.
A Lighter 5.350.135 Trinket A Lighter icon.png Watch the world burn Adds a chance for enemies to burn upon entering a room.
Adoption Papers 5.350.184 Trinket Adoption Papers icon.png Give them a home Shops can sell familiars, which will always be at a discounted price.
Apollyon's Best Friend 5.350.186 Trinket Apollyon's Best Friend icon.png Attack buddy Spawns an attack locust familiar which will fly forward while Isaac shoots.
Apple of Sodom 5.350.140 Trinket Apple of Sodom icon.png It feels empty Picking up red hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing.
Azazel's Stump 5.350.162 Trinket Azazel's Stump icon.png Unleash your inner demon When clearing a room, adds a chance to turn into Azazel until clearing another.
Beth's Essence 5.350.182 Trinket Beth's Essence icon.png Virtue's reward Upon entering an Angel Room, spawns 5 wisp orbitals. Giving money to beggars can spawn wisps.
Beth's Faith 5.350.142 Trinket Beth's Faith icon.png My faith protects me At the beginning of each floor, spawn 4-8 wisps that orbit Isaac and fires tears alongside him.
Blessed Penny 5.350.131 Trinket Blessed Penny icon.png Wealth of purity Gives a chance to drop a Half Soul Heart when a coin is collected.
Blue Key 5.350.150 Trinket Blue Key icon.png Look between the rooms Doors can be unlocked without using keys. Opening a door this way brings Isaac to an in-between room that resembles Stage Blue Womb icon.png ???, with a few monsters.
Brain Worm 5.350.144 Trinket Brain Worm icon.png Ding! Tears snap 90 degrees to target enemies that they may have missed.
Broken Glasses 5.350.187 Trinket Broken Glasses icon.png Double vision? Gives a 33% chance to add a '?' item to Treasure Rooms. Only one item can be taken. The extra items on the alt path are revealed instead.
Broken Padlock 5.350.136 Trinket Broken Padlock icon.png Bombs are key Locks can be opened with explosions.
Broken Syringe 5.350.132 Trinket Broken Syringe icon.png Mystery medicine Grants a chance to gain a random syringe effect for the current room.
Charged Penny 5.350.147 Trinket Charged Penny icon.png Wealth of power Picking up coins has a chance to give an Active Item charge.
Chewed Pen 5.350.130 Trinket Chewed Pen icon.png It's leaking Adds a chance to fire tears that slow enemies.
Cricket Leg 5.350.185 Trinket Cricket Leg icon.png Infested Adds a chance to spawn a random locust when killing an enemy.
Crystal Key 5.350.170 Trinket Crystal Key icon.png Call to the other side Adds a chance to automatically create Red Key rooms after clearing a room.
Cursed Penny 5.350.172 Trinket Cursed Penny icon.png Wealth of misery Picking up coins teleports Isaac to a random room.
Devil's Crown 5.350.146 Trinket Devil's Crown icon.png His special customer Treasure Rooms are replaced with unique Red Treasure Rooms, offering a Deal with the Devil in place of an item.
Dice Bag 5.350.154 Trinket Dice Bag icon.png Bonus roll When Isaac enters a new room, has a chance to give him a Dice item as a consumable for the current room.
Dingle Berry 5.350.163 Trinket Dingle Berry icon.png Oops! Spawns a friendly Dip upon clearing a room.
Expansion Pack 5.350.181 Trinket Expansion Pack icon.png Fun extras Once per room, using an active item triggers another random active item effect.
Flat File 5.350.151 Trinket Flat File icon.png No more spikes Causes all spikes to retract, making them harmless. Also affects the doors to Curse Rooms.
Forgotten Lullaby 5.350.141 Trinket Forgotten Lullaby icon.png Sing for your friends Improves the fire rate of Isaac's familiars.
Found Soul 5.350.180 Trinket Found Soul icon.png Finally! Spawns a familiar that copies Isaac's movements and scales with damage and tears. If it takes damage, it will die and respawn on the next floor.
Friendship Necklace 5.350.148 Trinket Friendship Necklace icon.png Gather round Causes familiars to orbit Isaac.
Gigante Bean 5.350.134 Trinket Gigante Bean icon.png Mega farts Increases the size of Isaac's farts.
Gilded Key 5.350.159 Trinket Gilded Key icon.png Less is more Replaces all new chests, except Mega Chests, with Locked Chests.
Hollow Heart 5.350.168 Trinket Hollow Heart icon.png A brittle blessing Grants an empty bone heart upon entering a new floor.
Holy Crown 5.350.155 Trinket Holy Crown icon.png Walk the path of the saint A Treasure Room and Shop appears in the Stage Cathedral icon.png Cathedral.
Ice Cube 5.350.188 Trinket Ice Cube icon.png Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.
Jawbreaker 5.350.129 Trinket Jawbreaker icon.png Don't chew on it Adds the chance to fire teeth that deal 3.2x damage, similar to Collectible Tough Love icon.png Tough Love.
Keeper's Bargain 5.350.171 Trinket Keeper's Bargain icon.png Money talks Devil Deals cost money instead of health.
Kid's Drawing 5.350.169 Trinket Kid's Drawing icon.png Looks familiar... While held, counts towards the Guppy transformation.
Lil Clot 5.350.176 Trinket Lil Clot icon.png Mini friend Spawns a clot familiar that mimics Isaac's movements and tears. It dies for the current room after taking too much damage.
Lucky Sack 5.350.160 Trinket Lucky Sack icon.png Free goodies! Spawns a Grab Bag upon traveling to the next floor.
Modeling Clay 5.350.166 Trinket Modeling Clay icon.png ??? Grants the effect of a random passive Item each room.
Mom's Lock 5.350.153 Trinket Mom's Lock icon.png A piece of her love Grants the effects of a random Mom item each room.
Mother's Kiss 5.350.156 Trinket Mother's Kiss icon.png HP up Grants one heart container.
Myosotis 5.350.137 Trinket Myosotis icon.png Forget me not... When entering a new floor, up to four uncollected pickups from the previous floor spawn in the starting room.
Nuh Uh! 5.350.165 Trinket Nuh Uh! icon.png Don't want! Replaces keys and coins that spawn in Chapter 4 and beyond with more useful pickups.
Number Magnet 5.350.174 Trinket Number Magnet icon.png 6 Increases the chance of earning a Devil Room by 10%.
Old Capacitor 5.350.143 Trinket Old Capacitor icon.png Voltage starving Active items don't charge when clearing rooms. Adds a chance to spawn a Lil' Battery when clearing a room, independent of the room's original drop.
Panic Button 5.350.149 Trinket Panic Button icon.png Push in case of emergency Activates Isaac's active item just before he takes damage.
Perfection 5.350.145 Trinket Perfection icon.png Luck way up. Don't lose it! +10 Luck. If Isaac takes damage, the trinket is destroyed and its effect is removed.
Polished Bone 5.350.167 Trinket Polished Bone icon.png Friends from beyond After clearing a room, adds a chance to spawn a friendly Bony.
RC Remote 5.350.179 Trinket RC Remote icon.png Controllable buddies! Instead of trailing behind Isaac, familiars are directly controlled by the same inputs as Isaac's.
Ring Cap 5.350.164 Trinket Ring Cap icon.png Twice the bang! Placing a bomb spawns an extra bomb for free.
Short Fuse 5.350.133 Trinket Short Fuse icon.png Faster explosions Bombs placed by Isaac explode more quickly.
Sigil of Baphomet 5.350.189 Trinket Sigil of Baphomet icon.png Revel in death Grants an invulnerability shield for 1 second after killing an enemy.
Strange Key 5.350.175 Trinket Strange Key icon.png What could it open? Unlocks the passageway to Stage Blue Womb icon.png ??? and the Hush fight, regardless of the run duration. Using Collectible Pandora's Box icon.png Pandora's Box grants it a special effect, consuming the key.
Swallowed M80 5.350.178 Trinket Swallowed M80 icon.png Bang! Isaac explodes upon taking damage.
Teardrop Charm 5.350.139 Trinket Teardrop Charm icon.png It feels lucky Luck-based tear effects have a higher chance of occurring.
Telescope Lens 5.350.152 Trinket Telescope Lens icon.png Seek the stars Increases the chance for Planetariums to spawn even if one has been visited and allows Planetariums to spawn in Chapter 4.
Temporary Tattoo 5.350.177 Trinket Temporary Tattoo icon.png You feel braver Spawns a chest after clearing a mob Challenge Room, or an item after clearing a boss Challenge Room.
The Twins 5.350.183 Trinket The Twins icon.png I'm seeing double... Adds a chance to duplicate one of Isaac's familiars when entering a new room.
Torn Card 5.350.157 Trinket Torn Card icon.png Death awaits Every 15 shots, Isaac shoots an Collectible Ipecac icon.png Ipecac + Collectible My Reflection icon.png My Reflection tear.
Torn Pocket 5.350.158 Trinket Torn Pocket icon.png A hole in your pocket Upon taking damage, Isaac drops 2 random Pickups from his inventory.
Wicked Crown 5.350.161 Trinket Wicked Crown icon.png Walk the path of the wicked A Treasure Room and Shop appears in Stage Sheol icon.png Sheol.
Your Soul 5.350.173 Trinket Your Soul icon.png Give it to me Can be used to pay for a Devil deal without losing hearts, and is then consumed.

Pickups

Hearts

Heart ID Image Worth Additional Info Unlocked By
Rotten Heart 5.10.12 Rotten Heart.png Rotten heart2.png Rotten Hearts fill up one whole heart container, or the rightmost Red Heart if all of Isaac's heart containers are full. (It isn't possible to have one-half a Rotten Heart; they are always depleted in one hit.) Each Rotten Heart in Isaac's life bar spawns two Blue Flies upon clearing a room. Achievement Rotten Heart icon.png Enter the Corpse for the first time

Coins

Coin ID Image Worth Additional Info Unlocked By
Golden Penny 5.10.7 Golden Penny.png 1 Spawns another golden penny in a random spot in the same room after being picked up, but has a 5% chance of disappearing instead. Achievement Golden Penny icon.png Defeat Mega Satan as Character Tainted Keeper icon.png Tainted Keeper

Bombs

Bomb ID Image Worth Additional Info Unlocked By
Golden Troll Bomb 4.18 Golden Troll Bomb.png 0 Similar to troll bombs, spawns already ignited and cannot be picked up. However, it explodes endlessly, similar to unlimited bombs of the golden bomb pickup.
Trinket Safety Scissors icon.png Safety Scissors will turn this into a Golden Bomb before it explodes.
Giga Bombs 5.40.7 Giga Bomb.png 1 Thrown by Bombgaggers and are spawned naturally in some rooms in Ashpit. Explodes and destroys tiles in a diamond shape.
Can be obtained by the player with Trinket Safety Scissors icon.png Safety Scissors or Collectible Everything Jar icon.png Everything Jar.
Throwable Bomb 5.41 Throwable Bomb.png 0 Can only be picked up and thrown, explodes in a few seconds after pickup. Spawned only by the Bomb Grimace enemy.

Batteries

Battery ID Image Worth Additional Info Unlocked By
Micro Battery 5.90.2 Micro Battery.png 2 Charges. Always Available
Mega Battery 5.90.3 Mega Battery.png Fully charges the player's Active Item twice. Always available
Golden Battery 5.90.4 Golden Battery.png Fully charges the player's Active Item. Damages the player for a full heart when picked up, and reappears somewhere else in the floor. Achievement Golden Battery icon.png Defeat Mega Satan as Character Tainted Forgotten icon.png Tainted Forgotten

Pills

Pill effects

Pill ID Effect Unlocked By
Shot Speed Down 47 -0.15 shot speed. Always available
Shot Speed Up 48 +0.15 shot speed. Always available
Experimental Pill 49 Increases one attribute and decreases another randomly, with the same power as normal attribute up/down pills. If taken with PHD, it will not reduce an attribute. Always available

Gold Pills

Gold Pills (or Golden Pills) can be used multiple times and grant a random pill effect, even from pills not in the pill pool. Every time a Golden Pill is used it has a chance of being consumed. Its Horse Pill variant will make it give only Horse Pill Effects.

Pill ID Image Effect Unlocked by
Gold Pill 5.70.14 Golden Pill icon.png Gives random pill effects and disappears after a random amount of uses. Achievement Gold Pill icon.png Defeat Mega Satan as Character Tainted Cain icon.png Tainted Cain

Horse Pills

Horse Pills appear as larger versions of the standard pills with a more powerful effect, and their effects and appearances are similarly randomly chosen. All items that work with pills work identically with horse pills. A horse pill with a given effect has the same color as the normal pill does. Unlocked by: Achievement Horse Pill icon.png Defeat Mega Satan as Character Tainted Eve icon.png Tainted Eve

Horse Pill Effect
Bad Gas The poison applies to the entire room.
Bad Trip Two hearts of damage. If Isaac would not survive, the pill becomes Full Health.
Balls of Steel Grants four soul hearts.
Bombs are Key The number of bombs and keys is increased by 50% while swapping.
Explosive Diarrhea Spawns more bombs, boosted with Collectible Mr. Mega icon.png Mr. Mega and Collectible Bobby-Bomb icon.png Bobby-Bomb.
Full Health Fully heals and grants 3 soul hearts.
Health Down Removes two heart containers. If this is not possible, the pill becomes Health Up.
Health Up Adds two empty red heart containers.
I Found Pills Isaac's face gets a permanent, very exaggerated expression.
Puberty Isaac gains very fluffy hair covering his entire head and even face.
Pretty Fly Spawns a Collectible Big Fan icon.png Big Fan instead. There is no upper limit.
Range Down -1.20 range.
Range Up +1.50 range.
Speed Down -0.24 speed.
Speed Up +0.30 speed.
Tears Down -0.56 tears.
Tears Up +0.70 tears.
Luck Down -2 luck.
Luck Up +2 luck.
Telepills Unknown
48 Hour Energy Spawns more batteries.
Hematemesis Spawns more hearts.
Paralysis The effect lasts 4 seconds.
I can see forever! In addition to the normal effect, fully reveals the map like Collectible The Mind icon.png The Mind.
Pheromones The charm is permanent, turning the enemies friendly.
Amnesia Unknown
Lemon Party The puddle covers nearly the entire room.
R U a Wizard? The effect lasts 60 seconds.
Percs Unknown
Addicted Unknown
Re-Lax The effect lasts much longer, with high speed long enough to cover nearly the entire room.
??? Unknown
One makes you larger Size increases by two steps.
One makes you small Size decreases by two steps.
Infested! Double the number of spiders spawned.
Infested? Double the number of spiders spawned.
Power Pill! In addition to the normal effect, grants Pickup Huge Growth icon.png Huge Growth for +7 flat damage and +3 range. The Huge Growth bonus persists after the Gamekid wears off.
Retro Vision Lasts 90 seconds, with no breaks.
Friends 'Till The End! Double the number of flies spawned.
X-Lax The pool lasts much longer.
Something's wrong... The pool lasts much longer.
I'm Drowsy... Unknown
I'm Excited!!! Unknown
Gulp! Unknown
Horf! Isaac shoots a small cluster of Horf! tears, with varying power above normal Horf!.
Feels like I'm walking on sunshine! The effect is upgraded to Collectible The Gamekid icon.png The Gamekid.
Vurp! If the last pill was a normal pill, it becomes a horse pill. No further difference on horse pills themselves.
Shot Speed Down -0.30 shot speed.
Shot Speed Up +0.30 shot speed.
Experimental Pill The two effects are doubled in power.
Gold Pill The random effects are doubled.

Consumables

Reversed Cards

Name ID Icon Unlock method Message Description
0 - The Fool? 5.300.56 Pickup 0 - The Fool? icon.png Achievement The Fool icon.png Defeat Ultra Greedier as Character Tainted Lost icon.png Tainted Lost Let go and move on Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Pickups may be spawned as items such as Collectible A Quarter icon.png A Quarter and Collectible Boom! icon.png Boom!.
I - The Magician? 5.300.57 Pickup I - The Magician? icon.png Achievement The Magician icon.png Defeat Ultra Greedier as Character Tainted Judas icon.png Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like Collectible The Soul icon.png The Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 Pickup II - The High Priestess? icon.png Achievement The High Priestess icon.png Defeat Ultra Greedier as Character Tainted Lilith icon.png Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding Collectible Broken Shovel 1 icon.png Broken Shovel.
III - The Empress? 5.300.59 Pickup III - The Empress? icon.png Achievement The Empress icon.png Defeat Ultra Greedier as Character Tainted Eve icon.png Tainted Eve May your love bring protection Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene's hairstyle. Does not stack.
IV - The Emperor? 5.300.60 Pickup IV - The Emperor? icon.png Achievement The Emperor icon.png Defeat Ultra Greedier as Character Tainted ??? icon.png Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor. The boss will drop a reward, but the room has no trapdoor so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
V - The Hierophant? 5.300.61 Pickup V - The Hierophant? icon.png Achievement The Hierophant icon.png Defeat Ultra Greedier as Character Tainted Bethany icon.png Tainted Bethany Two prayers for the forgotten Spawns 2 Bone Hearts.
VI - The Lovers? 5.300.62 Pickup VI - The Lovers? icon.png Achievement The Lovers icon.png Defeat Ultra Greedier as Character Tainted Magdalene icon.png Tainted Magdalene May your heart shatter to pieces Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally; no downside for any character who has no health bar; Tainted Keeper locked to 1 HP.
VII - The Chariot? 5.300.63 Pickup VII - The Chariot? icon.png Achievement The Chariot icon.png Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
VIII - Justice? 5.300.64 Pickup VIII - Justice? icon.png Achievement Justice icon.png Complete Cantripped (challenge #43) May your sins come back to torment you Spawns 2 to 4 Golden Chests.
IX - The Hermit? 5.300.65 Pickup IX - The Hermit? icon.png Achievement The Hermit icon.png Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
X - Wheel of Fortune? 5.300.66 Pickup X - Wheel of Fortune? icon.png Achievement Wheel of Fortune icon.png Defeat Ultra Greedier as Character Tainted Cain icon.png Tainted Cain Throw the dice of fate Invokes a random dice room effect.
XI - Strength? 5.300.67 Pickup XI - Strength? icon.png Achievement Strength icon.png Defeat Ultra Greedier as Character Tainted Samson icon.png Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.
XII - The Hanged Man? 5.300.68 Pickup XII - The Hanged Man? icon.png Achievement The Hanged Man icon.png Defeat Ultra Greedier as Character Tainted Keeper icon.png Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus and -0.1 speed. Killed enemies drop random coins.
XIII - Death? 5.300.69 Pickup XIII - Death? icon.png Achievement Death icon.png Defeat Ultra Greedier as Character Tainted Forgotten icon.png Tainted Forgotten May life spring forth from the fallen Invokes a Collectible Book of the Dead icon.png Book of the Dead effect.
XIV - Temperance? 5.300.70 Pickup XIV - Temperance? icon.png Achievement Temperance icon.png Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random pills in quick succession.
XV - The Devil? 5.300.71 Pickup XV - The Devil? icon.png Achievement The Devil icon.png Defeat Ultra Greedier as Character Tainted Azazel icon.png Tainted Azazel Bask in the light of your mercy Invokes Collectible The Bible icon.png The Bible (which can kill Mom), and grants Isaac flight and a Collectible Seraphim icon.png Seraphim familiar for 30 seconds.
XVI - The Tower? 5.300.72 Pickup XVI - The Tower? icon.png Achievement The Tower icon.png Defeat Ultra Greedier as Character Tainted Apollyon icon.png Tainted Apollyon Creation brings destruction Spawns 6 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 Pickup XVII - The Stars? icon.png Achievement The Stars icon.png Defeat Ultra Greedier as Character Tainted Isaac icon.png Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item, including starting items, and spawns 2 random items from the current room's item pool. Doesn't spawn anything if Isaac has no items.
XVIII - The Moon? 5.300.74 Pickup XVIII - The Moon? icon.png Achievement The Sun and the Moon icon.png Defeat Ultra Greedier as Character Tainted Jacob icon.png Tainted Jacob May you remember lost memories Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.
XIX - The Sun? 5.300.75 Pickup XIX - The Sun? icon.png Achievement The Sun and the Moon icon.png Defeat Ultra Greedier as Character Tainted Jacob icon.png Tainted Jacob May the darkness swallow all around you Gain Collectible Spirit of the Night icon.png Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 Pickup XX - Judgement? icon.png Achievement Judgement icon.png Defeat Ultra Greedier as Character Tainted Lazarus icon.png Tainted Lazarus May you redeem those found wanting Spawns a Restock Machine.
XXI - The World? 5.300.77 Pickup XXI - The World? icon.png Achievement The World icon.png Defeat Ultra Greedier as Character Tainted Eden icon.png Tainted Eden Step into the abyss Spawns a trap door to a crawl space.

Playing Cards

Name ID Icon Unlock method Message Description
Queen of Hearts 5.300.79 Pickup Queen of Hearts icon.png Achievement Queen of Hearts icon.png Defeat Mega Satan as Character Tainted Magdalene icon.png Tainted Magdalene <3 Spawns 1-16 full red hearts.

Other Cards

Name ID Icon Unlock method Message Description
Wild Card 5.300.80 Pickup Wild Card icon.png Achievement Wild Card icon.png Defeat Mega Satan as Character Tainted Eden icon.png Tainted Eden Again When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Runes

Name ID Icon Unlock method Message Description
Rune Shard 5.300.55 Pickup Rune Shard icon.png Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Soul Stones

Name ID Icon Unlock method Message Description
Soul of Isaac 5.300.81 Pickup Soul of Isaac icon.png Achievement Soul of Isaac icon.png Defeat Hush and Boss Rush as Character Tainted Isaac icon.png Tainted Isaac Reroll... or not Rerolls the items in the room like Collectible The D6 icon.png The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
Soul of Magdalene 5.300.82 Pickup Soul of Magdalene icon.png Achievement Soul of Magdalene icon.png Defeat Hush and Boss Rush as Character Tainted Magdalene icon.png Tainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Pickup Soul of Cain icon.png Achievement Soul of Cain icon.png Defeat Hush and Boss Rush as Character Tainted Cain icon.png Tainted Cain Opens the unopenable Opens all doors in the room. Additionally, creates a red room like the Collectible Red Key icon.png Red Key for every possible red exit.
Soul of Judas 5.300.84 Pickup Soul of Judas icon.png Achievement Soul of Judas icon.png Defeat Hush and Boss Rush as Character Tainted Judas icon.png Tainted Judas Right behind you Stops time for 3 seconds and invokes Collectible Dark Arts icon.png Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
Soul of ??? 5.300.85 Pickup Soul of ??? icon.png Achievement Soul of ??? icon.png Defeat Hush and Boss Rush as Character Tainted ??? icon.png Tainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 Collectible Butt Bombs icon.png Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.
Soul of Eve 5.300.86 Pickup Soul of Eve icon.png Achievement Soul of Eve icon.png Defeat Hush and Boss Rush as Character Tainted Eve icon.png Tainted Eve Your very own murder 14 Collectible Dead Bird icon.png Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Pickup Soul of Samson icon.png Achievement Soul of Samson icon.png Defeat Hush and Boss Rush as Character Tainted Samson icon.png Tainted Samson Slay a thousand Isaac turns berserk (similar to Tainted Samson) for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.
Soul of Azazel 5.300.88 Pickup Soul of Azazel icon.png Achievement Soul of Azazel icon.png Defeat Hush and Boss Rush as Character Tainted Azazel icon.png Tainted Azazel Demon rage! Activates Collectible Mega Blast icon.png Mega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Pickup Soul of Lazarus icon.png Achievement Soul of Lazarus icon.png Defeat Hush and Boss Rush as Character Tainted Lazarus icon.png Tainted Lazarus Life after death Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, functioning as a minimal extra life.
Soul of Eden 5.300.90 Pickup Soul of Eden icon.png Achievement Soul of Eden icon.png Defeat Hush and Boss Rush as Character Tainted Eden icon.png Tainted Eden Embrace chaos Uses Collectible The D6 icon.png The D6 and Collectible D20 icon.png D20. The rerolled items use random pools, as if Collectible Chaos icon.png Chaos were active.
Soul of the Lost 5.300.91 Pickup Soul of the Lost icon.png Achievement Soul of the Lost icon.png Defeat Hush and Boss Rush as Character Tainted Lost icon.png Tainted Lost Leave your body behind Isaac "dies" and turns into a ghost (similar to Character The Lost icon.png The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Does not allow you to take devil deals for free. Does not allow you to open the door to Mausoleum for free. The Holy Mantle effect gained from this can be stacked with multiple uses.
Soul of Lilith 5.300.92 Pickup Soul of Lilith icon.png Achievement Soul of Lilith icon.png Defeat Hush and Boss Rush as Character Tainted Lilith icon.png Tainted Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except Collectible Stitches icon.png Stitches. Unique familiars can be received only once.
Soul of the Keeper 5.300.93 Pickup Soul of the Keeper icon.png Achievement Soul of the Keeper icon.png Defeat Hush and Boss Rush as Character Tainted Keeper icon.png Tainted Keeper $$$ Spawns ~2-25 random coins.
Soul of Apollyon 5.300.94 Pickup Soul of Apollyon icon.png Achievement Soul of Apollyon icon.png Defeat Hush and Boss Rush as Character Tainted Apollyon icon.png Tainted Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Pickup Soul of the Forgotten icon.png Achievement Soul of the Forgotten icon.png Defeat Hush and Boss Rush as Character Tainted Forgotten icon.png Tainted Forgotten Skeletal protector Spawns Character The Forgotten icon.png The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his three bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Soul of Bethany 5.300.96 Pickup Soul of Bethany icon.png Achievement Soul of Bethany icon.png Defeat Hush and Boss Rush as Character Tainted Bethany icon.png Tainted Bethany Friends from beyond Spawns 6 Collectible Book of Virtues icon.png Book of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Pickup Soul of Jacob and Esau icon.png Achievement Soul of Jacob and Esau icon.png Defeat Hush and Boss Rush as Character Tainted Jacob icon.png Tainted Jacob Bound by blood Spawns Character Esau icon.png Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items the player who spawned him has.

Other

Name ID Icon Unlock method Message Description
Cracked Key 5.300.78 Pickup Cracked Key icon.png Achievement Red Key icon.png Open the large version of Mom's Box in Home ??? Creates a room adjacent to a viable wall, like Collectible Red Key icon.png Red Key.

Chests

Chest ID Image Additional Info Unlocked By
Old Chest 5.55 Old Chest.png Old Chests are similar in appearance to Golden Chests, but have the color of a normal Chest and a worn-down appearance. They have the same requirements as locked chests. Pulls from the Old Chest item pool.
Wooden Chest 5.56 Wooden Chest.png Wooden Chests appear similar to normal Chests but have an appearance similar to wood. Pulls from the Wooden Chest item pool. Achievement Wooden Chest icon.png Defeat Mega Satan as Character Tainted Lazarus icon.png Tainted Lazarus
Mega Chest 5.57 Mega Chest.png Mega chests appear similar to Golden Chests but are larger in appearance. Achievement Mega Chest icon.png Defeat Mega Satan as Character Tainted Isaac icon.png Tainted Isaac
Haunted Chest 5.58 Haunted Chest.png Haunted Chests appear nearly identical to normal Chests until Isaac gets close to them, at which point a Polty picks up the chest and throws it at Isaac, doing half a heart of damage and breaking open the chest. Achievement Haunted Chest icon.png Defeat Mega Satan as Character Tainted Lost icon.png Tainted Lost
Mom's Chest 5.390 Mom's Chest.png Mom's Chest appears in Home. Mom's chest has no requirements to open. Contains a Red Key upon the first visit. Contains a random Mom-related item or Red Key upon subsequent visits of Home.

Sacks

Sack ID Image Additional Info Unlocked By
Black Sack 5.69.2 Black Sack.png Spawns 2-3 pills, black or bone hearts and/or bombs when collected. Achievement Black Sack icon.png Defeat Mega Satan as Character Tainted Judas icon.png Tainted Judas

As well, Sacks can spawn in shops for 7 coins.

Monsters

Bosses

Enemies

Entity ID Description
Deep Gaper
Deep Gaper.png
811.0 Emerges off the floor once all previous enemies have been killed, then proceeds to chase Isaac like a normal Gaper.
Blurb
Blurb.png
813.0 Walks slowly towards Isaac. After taking some damage or getting close to Isaac, it fires a chaotic burst of tears at him and chases him more quickly.
Crackle
Crackle.png
87.1 Walks toward Isaac, spitting balls of fire that create lines of fire in the cardinal directions on impact.
Wraith
Wraith.png
807.0 Walks toward Isaac, dealing contact damage. Can only be seen through its reflection and ripples it leaves in the water as it moves.
Rotten Gaper
Rotten Gaper.png
10.3 Walks toward Isaac, dealing contact damage. Its behavior varies slightly depending on its facial expression.
Dead Isaac
Dead Isaac.png
912.20 Summoned by Mother at the bottom of the arena, and walks up towards Mother. Releases a burst of blood shots upon being killed by Mother, while she launches their corpses towards Isaac.
Twitchy
Twitchy.png
851.0 Alternates between walking towards and rapidly leaping at Isaac.
Level 2 Gaper
Level 2 Gaper.png
850.0 Walks towards Isaac, dealing contact damage. Splits into a Level 2 Horf and Level 2 Gusher upon death.
Faceless
Faceless.png
827.0 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots more frequently after taking damage.
Fanatic
Fanatic.png
832.1 Transformed into from Exorcists. Chases Isaac and occasionally fires two purple, rotating shots.
Exorcist
Exorcist.png
832.0 Summons The Heretic before transforming into Fanatics.
Dump
Dump.png
876.0 Slides toward Isaac, leaving a trail of slippery brown creep. After taking enough damage, its head slides off and quickly bounces around the room and its body spews out brown shots until it empties.
Dump Head
Dump Head.png
876.1 Quickly slides toward Isaac, leaving a trail of slippery brown creep. Can spawn on its own or be created by a Dump after it takes enough damage.
Level 2 Gusher
Level 2 Gusher.png
850.2 Runs aimlessly around the room, spitting up Small Maggots.
Sub Horf
Sub Horf.png
812.0 Stationary enemy that spins and fires shots while being moved around or knocked back.
Necro
Necro.png
828.0 Stationary enemy that summons unlimited-ranged bones to attack Isaac.
Tainted Sub Horf
Tainted Sub Horf.png
812.1 Will only shoot when hit. Takes heavy knockback and rotates when hit. Shoots a lot faster and has bigger projectiles than its normal variant.
Level 2 Horf
Level 2 Horf.png
850.1 Slowly floats toward Isaac, spitting Small Maggots at him.
Army Fly
Army Fly.png
868.0 Chases Isaac, moving along the cardinal directions. Forms a line with other Army Flies in the room. Deals contact damage.
Willo
Willo.png
808.0 Flies in a circle around Isaac (in formation with other Willos if available), keeping an exact distance away from him. One Willo at a time will occasionally light up and fire a shot at Isaac.
Ultra Famine Fly
Ultra Famine Fly.png
951.11 Charges at Isaac at a delay. Deals contact damage. Spawned by Ultra Famine.
Ultra Pestilence Fly
Ultra Pestilence Fly.png
951.21 Flies in swarms around Ultra Pestilence, blocking shots and dealing contact damage. Can be launched in a ball during the boss' second phase.
Fly Bomb
Fly Bomb.png
819.0 Flies toward Isaac, circling around him as it does. Turn into a tiny bomb upon death.
Eternal Fly Bomb
Eternal Fly Bomb.png
819.1 Orbits Boom Flies spawned by The Horny Boys. Once its Boom Fly has been killed, turns into a tiny Bomb.
Ink
Ink.png
61.3 Flies slowly towards Isaac. Fires four tar shots in the ordinal directions and leaves a puddle of slowing black creep upon death.
Tainted Sucker
Tainted Sucker.png
61.7 Flies slowly towards Isaac. Upon death, fires a radial burst of six blood shots that each also fires a radial burst of six blood shots.
Bulb
Bulb.png
61.5 Flies in erratic, angled movements toward Isaac if his active item has charges. Drains active item charges instead of dealing damage.
Bloodfly
Bloodfly.png
61.6 Flies in erratic, angled movements toward Isaac. Fires four blood shots in the cardinal directions upon death.
Tainted Pooter
Tainted Pooter.png
14.2 Slowly drifts toward Isaac, occasionally firing four blood shots at him that split into two smaller ones when they hit a wall or obstacle.
Mama Fly
Mama Fly.png
61.4 Wanders aimlessly around the room, occasionally creating Pustules.
Grilled Clotty
Grilled Clotty.png
15.3 Quickly and randomly wanders around the room, firing four flame shots in the cardinal directions at a slight angle.
Cloggy
Cloggy.png
872.0 Randomly wanders around the room, firing four curved brown shots in the cardinal directions. These shots alternate between rotating clockwise and counterclockwise with each shot.
Prey
Prey.png
817.0 Wanders around the room, avoiding Isaac and spawning Small Leeches if he gets close. Spawns 3 Small Leeches upon death.
Fartigan
Fartigan.png
874.0 Chases Isaac, occasionally coughing up gas. On death, fires an explosive shot that can detonate gas clouds it hits.
Holy Mulligan
Holy Mulligan.png
22.2 Wanders around the room, avoiding Isaac and spawning Small Angelic Babies if he gets close. Spawns 1-2 Embryos upon death.
Mullighoul
Mullighoul.png
817.1 Wanders around the room, avoiding Isaac and spawning Willos if he gets close. Spawns 1-2 Willos upon death.
Bouncer
Bouncer.png
822.0 Wanders around the room, avoiding Isaac. If Isaac stays close to one for long enough, it inflates and starts chasing him, gaining a chance to deflect shots and causing it to explode into lingering blood shots on death.
Tainted Mulligan
Tainted Mulligan.png
22.3 Wanders around the room, avoiding Isaac and spawning 6 Ring Flies if he gets close. Spawns a plethora of fly enemies upon death.
Danny
Danny.png
820.0 Walks toward Isaac and spits chaotic bursts of rocks at him, some of which may be Rock Spiders.
Coal Boy
Coal Boy.png
820.1 Walks toward Isaac and spits hot coals at him, some of which may be Coal Spiders.
Blaster
Blaster.png
821.0 Slowly wanders around and occasionally shoots Fly Bombs at Isaac.
Small Maggot
Small Maggot.png
853.0 Slowly crawls toward Isaac, dealing contact damage.
Level 2 Charger
Level 2 Charger.png
855.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Can slowly change its trajectory while charging.
Carrion Princess
Carrion Princess.png
23.3 Slowly moves around the room, charging at Isaac when he lines up diagonally with it. Can only be damaged by hitting its tail.
Small Leech
Small Leech.png
810.0 Chases Isaac continuously, not stopping at walls. Able to swim over gaps.
Elleech
Elleech.png
855.1 Slowly moves around the room. After Isaac gets in its line of sight, continuously charges at him in the closest cardinal direction.
Blood Puppy
Familiar bloodpuppy level2.png
802.0 Quickly moves around the room, attacking and charging at other monsters and Isaac when they get in its line of sight.
Tainted Spitty
Tainted Spitty.png
31.1 Slowly moves around the room, firing chaotic bursts of blood shots in all directions and occasionally spitting a line of blood shots in the direction it's facing. Fires two rotating rings of blood shots upon death.
Cursed Globin
Cursed Globin.png
278.1 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into 1-2 piles of goo, each of which can be killed and regenerate after a short period of time if not killed quickly. These goo piles have less health the more times the Cursed Globin splits.
Clickety Clack
Clickety Clack.png
889.0 Walks towards Isaac and turn into a pile of bones when killed. Regenerates a few seconds after killed. Will only despawn if all Clickety Clacks in the room are killed.
Cohort
Cohort.png
857.0 Acts similarly to Monstro, hopping towards Isaac and using one of two projectile patterns. Spawns four Globins upon death.
Gasbag
Gasbag.png
856.0 Occasionally summons Army Flies to chase Isaac. Is surrounded by a ring of toxic gas that hurts Isaac if he stands in it for too long.
Dragon Fly
Dragon Fly.png
25.3.0 Flies around the room diagonally, dealing contact damage. Upon death, creates four lines of fire in the cardinal directions.
Dragon Fly X
Dragon Fly X.png
25.3.1 Flies around the room diagonally, dealing contact damage. Upon death, creates four lines of fire in the ordinal directions.
Bone Fly
Bone Fly.png
25.4 Flies around the room diagonally, dealing contact damage. Fires bones at Isaac if he lines up with it in the cardinal directions. Fires a radial burst of 3 bones upon death.
Sick Boom Fly
Sick Boom Fly.png
25.5 Flies around the room diagonally, dealing contact damage and trailing poisonous gas. Upon death, explodes into a gas cloud and fires a ring of 6 green shots.
Tainted Boom Fly
Tainted Boom Fly.png
25.6 Flies around the room diagonally, dealing contact damage. Upon death, sends explosions in a cross-shaped marker across the room.
Hard Host
Hard Host.png
27.3 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Shortly after raising its head, it slams its head down and fires a rock wave towards Isaac.
Floating Host
Floating Host.png
859.0 Floats diagonally around the room and is normally invulnerable. When Isaac gets close, reveals a fleshy stem that can be damaged and fires 3 blood shots in an angle at him before hiding its stem again.
Sticky Leaper
Sticky Leaper.png
34.1 Hops around the room, dealing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while creating a chaotic burst of tar shots in all directions and a puddle of slowing black creep.
Eggy
Eggy.png
29.2 Hops aimlessly around the room, spawning slowing white creep wherever it hops. Spawns a group of Swarm Spiders upon death.
Tainted Hopper
Tainted Hopper.png
29.3 Jumps and twirls around the room, shooting 4 rings of projectiles that increase in size with each shot.
Pustule
Pustule.png
861.0 Slowly increases in size over time, spawning Small Maggots and damaging red creep depending on its size upon death. If it grows to full size, it transforms into a Bloodfly.
Pon
Pon.png
840.0 Hops around the room, leaving damaging red creep wherever it lands. Upon death, its associated Brainless Knight dies with it.
Gyro
Gyro.png
824.0 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles as it does.
Grilled Gyro
Grilled Gyro.png
824.1 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles and creating fires behind itself as it does.
Angelic Baby (small)
Angelic Baby (small).png
38.1.1 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere. Can only be spawned by Holy Mulligans.
Wrinkly Baby
Wrinkly Baby.png
38.3 Lunges towards Isaac at high speed and fires three blood shots in his direction once stopped.
Baby Begotten
Baby Begotten.png
883.0 Floats toward Isaac, avoiding his shots. After getting close, fires a short Collectible Brimstone icon.png Brimstone laser in the closest cardinal direction and propels itself away from him.
Unborn
Unborn.png
860.0 Floats quickly towards Isaac, and occasionally teleports to another position near him.
Vis Versa
Vis Versa.png
39.4 Randomly wanders around the room. Pauses to charge and fire a homing Brimstone laser when Isaac gets in its line of sight.
Evis
Evis.png
39.5 Randomly wanders around the room. Launches a string of guts when Isaac gets close to it, which it uses to pull Isaac toward itself.
Slog
Slog.png
40.2 Attaches itself to a wall or obstacle and rolls around it, charging at Isaac when he is in sight.
Cyst
Cyst.png
862.0 Attaches itself to a wall or obstacle and rolls around it, regularly firing blood shots at Isaac.
Loose Knight
Loose Knight.png
41.2 Moves erratically around the room, charges toward Isaac when in line of sight. When its health is depleted, it turns into a Brainless Knight and a Pon.
Brainless Knight
Brainless Knight.png
41.3 Alternates between running around the room along the cardinal directions and aimlessly walking in circles. Charges at Isaac when in line of sight. Dies when its corresponding Pon dies.
Black Knight
Black Knight.png
41.4 Moves erratically around the room, charges toward Isaac when in line of sight. Unleashes waves of fire in all cardinal directions upon charging into an obstacle. Shots that hit it from the front are deflected back at Isaac.
Whipper
Whipper.png
834.0 Runs around the room, sprinting at Isaac when he gets in its line of sight and lashing at him when it gets close.
Snapper
Snapper.png
834.1 Runs around the room, sprinting at Isaac when he gets in its line of sight and throwing out its whip when he gets in range.
Flagellant
Flagellant.png
834.2 Runs around the room. When Isaac gets in its line of sight, continuously chases him and lashes its whip, occasionally deflecting Isaac’s shots.
Adult Leech
Adult Leech.png
854.0 Wanders around the room, quickly charging at Isaac when he lines up diagonally with him and releasing a ring of blood shots upon colliding with a wall. Occasionally burrows into the ground and reappears out of a wall or from above Isaac.
Dead Meat
Dead Meat.png
57.2 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions that bounce off the walls. Splits into 2 Cysts upon death.
Holy Eye
Holy Eye.png
60.2 Rapidly summons several beams of light around Isaac every few seconds.
Strider
Strider.png
814.0 Erratically swims around the room. If it sees Isaac, it chases him, trying to deal contact damage.
Swarm Spider
Swarm Spider.png
884.0 Very erratically hops toward Isaac in large groups, dealing contact damage.
Rock Spider
Rock Spider.png
818.0 Slowly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Spider upon death. Turns into a Coal Spider if it touches fire.
Tinted Rock Spider
Tinted Rock Spider.png
818.1 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Soul Heart upon death. Can only spawn by breaking tinted rocks on Mines or Ashpit.
Coal Spider
Coal Spider.png
818.2 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a hot coal upon death that blocks shots and deals contact damage, but can be destroyed.
Butt Slicker
Butt Slicker.png
878.0 Moves erratically around the room unless attached to another Butt Slicker. Grouped Butt Slickers drag themselves towards Isaac, and when an individual is killed they leave black creep, and shoot out black projectiles. The amount of projectiles released and the size of the pool of Black Creep is determined by the amount of Butt Slickers attached.
Mask II + 1/2 Heart
Mask Heart II.png
92.1 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the ordinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask. If there are more than one 1/2 Heart in the room, they will fire blood shots between each other.
Peeping Fatty
Peeping Fatty.png
835.0 Has two indestructible eyeballs that are out of their sockets but attacked by muscles. Wanders around the room randomly, or toward Isaac if its eyes see him. Occasionally farts and fires a radial burst of 6 blood shots.
Bloaty
Bloaty.png
879.0 Lumbers around, occasionally spitting green shots and a line of damaging green creep in a random direction.
Bubbles
Bubbles.png
806.0 Slowly walks towards Isaac, firing back shots upon taking damage. Occasionally farts, which pushes Isaac and adjacent enemies away and creates a chaotic burst of shots. Creates a geyser of water shots upon death.
Shady
Shady.png
888.0 Slowly walks toward Isaac, occasionally firing a shot that creates shots perpendicular to itself while traveling and splits into a ring of shots upon hitting a wall or obstacle. Also occasionally jumps, creating lines of explosions in the cardinal directions.
Quakey
Quakey.png
823.0 Attempts to jump on Isaac, shooting out 8 rock shots when it hits the ground.
Big Bony
Big Bony.png
830.0 Walks slowly toward Isaac, and will occasionally fire a bone that bounces around the room for a few moments. The bone can be broken if shot enough.
Vis Fatty
Vis Fatty.png
886.0 Spawns with a Fetal Demon attached to it and slowly walks towards Isaac. Will occasionally fart, briefly pushing the demon away and spawning creep around itself and the demon. If the Fatty is killed first, the demon will chase the player similarly to Gemini's Suture. If the demon is killed first, the Fatty will shoot out Collectible Brimstone icon.png Brimstone in the diagonal direction closest to Isaac. It will then fly around the room diagonally, bumping off of walls and tall blocks all while continuously firing brimstone behind it.
Fetal Demon
Fetal Demon.png
886.1 Behave like Gemini's Suture. Usually seen attached to Vis Fatties.
Gutted Fatty
Gutted Fatty.png
831.0 Slowly lumbers around the room, occasionally spawning Festering Guts. Its eyes dislocate as it takes damage, which are invincible and follow the Gutted Fatty but chase Isaac if he gets close to them. Creates a geyser of blood projectiles upon death.
Festering Guts
Festering Guts.png
831.20 Spawned by Gutted Fatties, Festering Guts randomly slide around the room and occasionally spawn a Charger.
Tainted Faceless
Tainted Faceless.png
827.1 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots very frequently after taking damage.
Cursed Death's Head
Cursed Death's Head.png
212.2 Invulnerable enemy that moves diagonally around the room, dealing contact damage. If Isaac enters its purple aura, he will be inflicted with fear and be temporarily unable to shoot. Dies when the room is cleared.
Brimstone Death's Head
Brimstone Death's Head.png
212.3 Invulnerable enemy that moves diagonally around the room, pausing to fire a Collectible Brimstone icon.png Brimstone laser when Isaac lines up with it in the cardinal directions. Dies when the room is cleared.
Dusty Death's Head
Dusty Death's Head.png
887.0 Invulnerable enemy that moves across the room in a waving motion in large quantities. Dies when the room is cleared.
Redskull
Redskull.png
212.4 Moves diagonally around the room, creating a ring of fire around itself if Isaac gets close to it. Can be killed, but also dies when the room is cleared.
Ultra Death Head
Ultra Death Head.png
951.42 Invulnerable enemy spawned by Ultra Death that moves across the room in a waving motion in large quantities as a part of one of his attacks. Dies upon the completion of the attack.
Level 2 Willo
Level 2 Willo.png
838.0 Orbits enemies and shoots tears at Isaac. If the enemy it is orbiting dies, it will orbit another enemy. However, if all enemies are dead, it will chase Isaac, while still occasionally shooting at Isaac.
Migraine
Migraine.png
869.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Releases multiple Troll Bombs upon death.
Big Corn
Big Corn.png
217.3 Quickly dashes in random directions, dealing contact damage. Shoots one piece of corn upon death.
Drip
Drip.png
870.0 Quickly rolls around in diagonal directions, dealing contact damage.
Splurt
Splurt.png
871.0 Dashes towards Isaac twice and deals contact damage. Spawns 2 Drips upon death.
Hardy
Hardy.png
826.0 Dashes toward Isaac and deals contact damage creating rock projectiles when it hits a wall/obstacle. It spawns more rock projectiles the more times it crashes into obstacles, dying after doing so a third time.
Revenant
Revenant.png
841.0 Slowly wanders around the room, stopping to fire a large line of fire at the player.
Quad Revenant
Quad Revenant.png
841.1 Wanders around the room slowly, stopping to fire lines of flames in the cardinal or ordinal directions, rotating in an attempt to hit Isaac.
Maze Roamer
Maze Roamer.png
890.0 Wanders around the room and shoots an eyeball at Isaac when he is in sight. Has a clone of itself on the other side of the room that mimics its movement and shots. If one dies, the other starts actively pursuing Isaac.
Holy Bony
Holy Bony.png
227.1 Wanders around the room, throwing a bone at Isaac when he is in sight. The thrown bone leaves behind a blue flame that deals contact damage, blocks Isaac’s shots, and despawns after some time.
Planetoid
Planetoid.png
229.1 Moves around the room diagonally, occasionally firing blood shots that orbit itself. Fires more shots and has a chance to send its ring of shots outward upon taking damage.
Poofer
Poofer.png
892.0 Slowly floats toward Isaac, swells up and fire 6 blood shots in all direction upon taking damage. Explodes upon death, healing nearby enemies and leaving a big puddle of red creep.
Bishop
Bishop.png
805.0 Shields all enemies in the room, preventing them from taking damage. Fires shots in the cardinal directions when it takes damage.
Goat
Goat.png
891.0 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines up on either side of it.
Black Goat
Black Goat.png
891.1 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines upon either side of it. Can also fire Collectible Brimstone icon.png Brimstone lasers in the cardinal directions, along with all other Black Goats in the room.
Cultist
Cultist.png
885.0 Creates an indestructible, homing Purple Ball at the start of the room and follows it around, occasionally leaving it to revive enemies that have died in the current room.
Blood Cultist
Blood Cultist.png
885.1 Wanders around the room and fires a line of blood shots and creep if Isaac is on either side of it. Can summons bone traps that temporarily ensnare Isaac if he walks into them.
Soy Creep
Soy Creep.png
240.1 Slowly crawls along walls to try to line up with Isaac and shoots a stream of shots seemingly affected by Collectible Soy Milk icon.png Soy Milk.
Tainted Soy Creep
Tainted Soy Creep.png
240.3 Slowly crawls along walls to try to line up with Isaac and shoots a 4 diagonal streams of Collectible Soy Milk icon.png Soy Milk shots.
Fire Worm
Fire Worm.png
825.0 Pops out of the ground in random locations and fires one flame at Isaac.
Tainted Round Worm
Tainted Round Worm.png
244.2 Pops out of the ground in random locations alongside several tail ends. The head fires a large blood shot that splits into a radial burst of 8 blood shots, while the tail ends shoot normal blood shots.
Tainted Tube Worm
Tainted Tube Worm.png
244.3 Pops out of the ground in random locations, spitting 4 explosive shots towards Isaac.
Mole
Mole.png
829.0 Burrows towards Isaac and jumps out the ground to fire 3 blood shots at him.
Tainted Mole
Tainted Mole.png
829.1 Dig towards Isaac and release a ring of rock waves. Fires 3 blood shots at Isaac 4 times.
Polty
Polty.png
816.0 Picks up and throws rocks and props at Isaac.
Kineti
Kineti.png
816.1 Uses telekinesis to pick up and throw rocks and obstacles at Isaac.
Dust
Dust.png
882.0 Follows Isaac, and is only visible when close to Isaac. Will begin to speed up when they are visible. Teleports away after taking enough damage.
Fly Trap
Fly Trap.png
873.0 Floats towards Isaac, with 3 Attack Flies circling around it. Coughs up additional Attack Flies and releases gas to launch the Attack Flies outwards.
Poot Mine
Poot Mine.png
875.0 Creates a gas cloud and propels itself away from Isaac when it gets hit. Explodes on death, detonating all the gas clouds it created.
Bombgagger
Bombgagger.png
844.0 Spits up a Giga Bomb and runs away from it.
Flesh Maiden
Flesh Maiden.png
880.0 Vaguely flies towards Isaac in curved swooping motions.
Morningstar
Morningstar.png
863.0 Floats toward Isaac to deal contact damage while Isaac is moving, gaining speed the longer Isaac continues moving. Stops moving when Isaac stops moving.
Needle
Needle.png
881.0 Pops out of the ground and lunges towards Isaac, dealing contact damage.
Pasty
Pasty.png
881.1 Pops out of the ground and lunges toward Isaac, dealing contact damage and firing four shots in the ordinal directions.
Fissure
Fissure.png
815.0 Jumps out of pits and bounces around the room. Spawns endlessly from pits until room clear. Do not need to be killed to clear room.
Lil Portal
Lil Portal.png
306.1 Spawns fly and spider enemies until it is destroyed.
Henry
Henry.png
837.0 Flushes away instantly when Isaac enters the room.
Triple Grimace
Triple Grimace.png
42.2 Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.
Quake Grimace
Quake Grimace.png
804.0 Stationary and invulnerable monster that jumps and fires a line of rocks in one direction upon landing.
Bomb Grimace
Bomb Grimace.png
809.0 Stationary and invulnerable monster that keeps a single Throwable Bomb spawned.
Mockulus
Mockulus.png
864.0 Rapidly bounces around the room diagonally while Isaac is shooting.
Grudge
Grudge.png
877.0 Quickly slides towards Isaac when he gets in its line of sight. Cannot be destroyed.
Ball and Chain
Ball and Chain.png
893.0 Spike balls that rotate at the end of a chain attached to an obstacle. If the obstacle is destroyed, the ball will fly free around the room for a while.
Spikeball
Spikeball.png
852.0 Spike balls that fly in a line either horizontally or vertically, bouncing off walls and obstacles.
Singe's Ball
Singe's Ball.png
915.1 Spike balls that fly in a line either horizontally or vertically, bouncing off walls and obstacles.
Ultra Death Scythe
Ultra Death Scythe.png
951.41 Stays stationary for a moment, then travels in straight lines towards Ultra Death.
Siren Minion
Siren Minion.png
3.220 Spawned in automatically charmed by The Siren. Orbits the boss and fires projectiles towards Isaac.
Siren Helper
Siren Helper.png
966.0 Spawned in by The Siren and takes the form and control of all of her charmed familiars.
Visage Plasma
Visage Plasma.png
903.20 Floats in diagonal directions, doing contact damage. Spawned by The Visage and used in its phase 3 attacks.

Champions

ID Appearance Effect Drop Rarity Notes
24 Champion Brown.png

Brown

Trails poop behind it as it walks. Nothing Unknown
25

Rainbow

Combines the effects of champion types 0, 2, 5, 10, 11, 13 and 17. A coin, a bomb, a key, a heart, a pill, a card and a trinket. Unknown

Audio

  • The Music is once again composed by Ridiculon.
    • Whilst not being in the official release, a fully updated Antibirth soundtrack may be released by Mudeth as a mod.

Environment

Chapters

Stage Downpour room.png
Downpour
Stage Dross room.png
Dross
Downpour Dross
Stage Mines room.png
Mines
Stage Ashpit room.png
Ashpit
Mines Ashpit
Stage Mausoleum room.png
Mausoleum
Stage Gehenna room.png
Gehenna
Mausoleum Gehenna
Stage Corpse room.png
Corpse
Stage Home room.png
Home
Corpse Home

Obstacles

  • Rocks
    • Spiked Rocks
    • Marked Skulls
    • Buckets
    • Fool's Gold Rocks
  • Poops
    • Giant Poop
    • Charming Poop
  • Fire Places
    • White Fire Place
  • Blocks
    • Pillars
  • Buttons
    • Red Buttons
    • Yellow Buttons
    • Brown Buttons
  • Teleporters

Rooms

Challenges

Changes

The Repentance DLC brings with it many changes to old content in the previous game. For a list of changes, see the V1.06.J787 page.

Video previews


Collectible Broken Modem icon.png Version History Collectible Broken Modem icon.png
Rebirth v0.9, v1.0, v1.01, v1.02, v1.031, v1.032, v1.04, v1.041, v1.05 (Hotfix)

Afterbirth
v1.06, v1.06 Hotfix, v1.06.0051, v1.06.0052, v1.06.0059, v1.06.0060, v1.06.0067, v1.06.0076, v1.06.0109

Afterbirth †
v1.06.0180, v1.06.0181, v1.06.0182, v1.06.0183, v1.06.0185, v1.06.0187, v1.06.0188, v1.06.0190, v1.06.0192 (Re-release), v1.06.0193, v1.06.0211
Booster Pack #1 v1.06.J34, v1.06.J39
Booster Pack #2 v1.06.J75, v1.06.J85
Booster Pack #3 v1.06.J99, v1.06.J103, v1.06.J104
Booster Pack #4 v1.06.J113, v1.06.J114, v1.06.J119, v1.06.J127
Booster Pack #5 v1.06.J149, v1.06.J150, v1.06.J168
Repentance v1.06.J787, v1.06.J791, v1.06.J796, v1.06.J813, v1.06.J818, v1.06.J820
SmallIsaac.png The Binding of Isaac: Rebirth SmallIsaac.png
MainPageAchievements.png Achievements MainPageAttributes.png Attributes MainPageBosses.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters
Character Isaac appearance.png Characters MainPageBabies.png Co-op MainPageItems Small.png Items Collectible Isaac's Tears icon.png Item pools MainPageMonsters.png Monsters MainPageObjects.png Objects
Red Heart.png Pickups BlueBlue.png Pills MainPageRooms.png Rooms MainPageSeeds2.png Seeds Transformation Guppy appearance.png Transformations Trinket The Left Hand icon.png Trinkets
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