Binding of Isaac: Rebirth Wiki
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Binding of Isaac: Rebirth Wiki
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Issues: As this is information relating to newly released content, there may be more information planned to be released by the developers in the following months.

Repentance is a DLC expansion to The Binding of Isaac: Afterbirth † that was released on March 31st, 2021. It costs $15.00 (USD).

For a list of the pre-release blog posts, see The Binding of Isaac: Repentance (Pre-Release).

Features[]

General features revealed include:

  • The fan mod The Binding of Isaac: Antibirth integrated into the game as official content!
  • A new reworked co-op mode, allowing up to four players to play as actual characters instead of babies.
  • 130+ new items (more than 700 items in total and some are from Antibirth)
  • A full alternate path with brand new chapters and two new final bosses and endings (one from Antibirth)
  • 100+ new enemies
  • 25 new bosses
  • 19 new playable characters
  • 10 new challenges
  • 234 new achievements, for a grand total of 637.
  • 5,000+ new room designs

Additions[]

Playable Characters[]

Character Character Bethany appearance.png
Bethany Bethany
Character Jacob and Esau appearance.png
Jacob and Esau Jacob and Esau
Jacob Jacob Esau Esau
Health Stat Icon.png Health Full red heartFull red heartFull red heart Full red heartFull red heartFull red heart Full soul heartFull red heart
Damage Stat Icon.png Damage 3.5 (*1.00) 2.75 (*1.50) 3.75 (*1.00)
Tears Stat Icon.png Tears +0 3.00 2.50
Shot Speed Stat Icon.png Shot Speed 1 1.15 0.85
Range Stat Icon.png Range 6.5 5.00 8.00
Speed Stat Icon.png Speed 1.0 1.00 1.00
Luck Stat Icon.png Luck 0 1.00 -1.00
Starting Item Icon.png Starting Pickups 4 Soul Charges None None
Starting Item Icon.png Starting Item(s) Collectible Book of Virtues icon.pngBook of Virtues None None

There is also a "tainted character" for each existing playable character (including Bethany Bethany and Jacob and Esau Jacob and Esau) which can be unlocked by finding a hidden room on the new stage "Home Home". Because of that, the total number of playable characters in the game is 34.

Items and Trinkets[]

Activated Collectibles[]

Name ID Icon Quote Description Quality
Abyss 5.100.706
Abyss
4 rooms
Come forth from the depths Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. 4
Alabaster Box 5.100.585
Alabaster Box
12 rooms
A sacred offering Spawns three soul hearts and two Angel room items and is consumed. Starts with no charges, and can only be charged by picking up 6 soul hearts. 2
Anima Sola 5.100.722
Anima Sola
15 seconds
Repent Chains down the nearest enemy for 5 seconds, preventing them from acting. 2
Bag of Crafting 5.100.710
Bag of Crafting
Unlimited
Make your destiny Collects and holds up to 8 pickups. Holding the activate button crafts them into a passive item, with the power level based on the quality of pickups used. 3
Berserk! 5.100.704
Berserk!
With damage dealt
Rip and tear Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms. 3
Book of Virtues 5.100.584
Book of Virtues
4 rooms
Spiritual companionship On use, spawns an orbital Wisp familiar that fires spectral tears but can be destroyed. Also becomes a passive item that causes other active items to spawn themed Wisps. 3
Broken Glass Cannon 5.100.474
Broken Glass Cannon
4 rooms
You broke it! Begins with no charges and turns into 15►Glass Cannon Glass Cannon when used. Only acquired by taking damage while holding Glass Cannon. 0
Clear Rune 5.100.263
Clear Rune
Variable
Rune mimic Has the same effect as the rune or soul stone currently held by Isaac. 2
Damocles 5.100.577
Damocles
One time use
A king's fortune... but at what cost? Spawns a sword above Isaac's head, which doubles all item pedestals. After Isaac takes damage, the sword can randomly fall at any point, instantly killing him. 2
Dark Arts 5.100.705
Dark Arts
6 seconds
One with the shadows Makes Isaac invulnerable and intangible for one second. When the effect ends, all enemies Isaac ran through take damage and Isaac temporarily gains +1 damage for each one. 2
Death Certificate 5.100.628
Death Certificate
One time use
Where am I? Takes Isaac to an abandoned and expanded version of Home, which has one copy of every item in the game. After taking an item, Isaac returns to the room he used Death Certificate in. 4
Decap Attack 5.100.729
Decap Attack
4 seconds
Chuck away! Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it. 2
Eraser 5.100.638
Eraser
1 rooms
Erase thy enemy Throws an eraser that instantly kills the first monster it hits, and prevents that monster from spawning for the rest of the run. Can only be used once per floor. 2
Esau Jr. 5.100.703
Esau Jr.
1 rooms
Lost brother Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run. 2
Eternal D6 5.100.609
Eternal D6
2 rooms
??? Rerolls all items in the room. Each item has a chance to disappear instead. 2
Everything Jar 5.100.720
Everything Jar
12 rooms
Anything is possible Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. 2
Flip 5.100.711
Flip
6 rooms
Life and death Switch characters between Tainted Lazarus and Dead Tainted Lazarus. 3
Fortune Cookie 5.100.557
Fortune Cookie
2 rooms
Reusable fortunes Gives Isaac a fortune, soul heart, tarot card, or trinket. 2
Free Lemonade 5.100.578
Free Lemonade
4 rooms
Party time! Creates a large pool of yellow creep beneath Isaac. 2
Friend Finder 5.100.687
Friend Finder
4 rooms
Best friends forever! Spawns a random friendly monster that mimics Isaac's movements and attacks. 3
Gello 5.100.728
Gello
2 rooms
Demonic gestation Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects. 2
Genesis 5.100.622
Genesis
One time use
In the beginning Removes all of Isaac's items and pickups and takes him to a unique bedroom with some pickups and chests and a trapdoor to the next floor. For every item Isaac lost, he gets to take an item from a set of three. 2
Golden Razor 5.100.555
Golden Razor
Unlimited
Pain from gain Spends five coins to increase Isaac's damage by 1.2 for the current room. 2
Hold 5.100.715
Hold
Unlimited
Saved for later Exclusive to Tainted ??? Tainted ???. Allows him to save one poop bomb for later, allowing him to gather more over time. 0
Jar of Wisps 5.100.685
Jar of Wisps
12 rooms
Your faith grows Spawns random wisps that shoot various tears, block shots, and deal contact damage. The number of wisps spawned increases every time the jar is used. 2
Keeper's Box 5.100.719
Keeper's Box
4 rooms
Portable shop Spawns a random shop item or pickup which can be bought for its normal price. 3
Larynx 5.100.611
Larynx
12 rooms
Hear my pain Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage. 2
Lemegeton 5.100.712
Lemegeton
6 rooms
Item summoner Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects. 3
Magic Skin 5.100.642
Magic Skin
6 rooms
All your desires fulfilled Consumes one heart container or two soul hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items. 2
Meat Cleaver 5.100.631
Meat Cleaver
2 rooms
Slice but no dice Splits all enemies in the room into two smaller versions of themselves with much less health. 1
Mega Mush 5.100.625
Mega Mush
12 rooms
I'm a big boy now! Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms. 4
Mom's Bracelet 5.100.604
Mom's Bracelet
Unlimited
Mother's strength Lets Isaac pick up and throw rocks, TNT, poops, and other obstacles. 2
Plum Flute 5.100.650
Plum Flute
4 rooms
Play time! Summons the boss Baby Plum to fight for Isaac in the current room. 2
R Key 5.100.636
R Key
One time use
Time to start over Brings Isaac back to the first floor of a new run, retaining all of his items. 4
Recall 5.100.714
Recall
3 seconds
Come back Retrieves the Forgotten's body from any distance. Only available as the 15►Birthright Birthright effect for Tainted Forgotten Tainted Forgotten. 0
Red Key 5.100.580
Red Key
4 rooms
Explore the other side Creates a new room adjacent to a viable wall, indicated by the outline of a door. These rooms have a chance to be various special rooms. 3
Sharp Key 5.100.623
Sharp Key
Unlimited
Open your enemies Adds 5 keys on pickup. Allows Isaac to throw his keys to deal damage to enemies, destroy obstacles, and open doors. 1
Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Spindown Dice 5.100.723
Spindown Dice
6 rooms
-1 Transforms all items in the room by decreasing their internal ID number. 4
Stitches 5.100.635
Stitches
3 seconds
Bait and switch Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. 1
Sulfur 5.100.556
Sulfur
3 rooms
Temporary demon form Grants 15►Brimstone Brimstone for the current room. 2
Sumptorium 5.100.713
Sumptorium
1 seconds
Return Holding down the fire button converts hearts into familiars that fire tears but can be destroyed. Activating converts the familiars back into hearts. 3
Suplex! 5.100.709
Suplex!
6 seconds
Angel breaker Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave. 3
The Scooper 5.100.605
The Scooper
3 rooms
Plop! Summons a Peeper familiar for the current room, which leaves a trail of red creep. 0
Urn of Souls 5.100.640
Urn of Souls
Unlimited
Unleash their sorrow Spews a stream of damaging flame. Gains Soul Charges each time an enemy dies, which are used to fuel the urn. 3
Vade Retro 5.100.653
Vade Retro
Unlimited
Begone! While held, enemies leave behind ghosts on death. Using the item causes the ghosts to explode, dealing damage to nearby enemies. Stronger enemies leave bigger ghosts. 3
Wavy Cap 5.100.582
Wavy Cap
0.5 seconds
Tears up. A mind changing experience! Increases tears, decreases speed, and distorts the screen. All effects become more pronounced with repeated use, and wear off by clearing rooms. 1
Yuck Heart 5.100.639
Yuck Heart
6 rooms
Gross! Gives Isaac a Rotten Heart. 3

Passive Collectibles[]

Name ID Icon Quote Description Quality
120 Volt 5.100.559 120 Volt Zap! Repeatedly zaps enemies that are close to Isaac. 3
2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear. 2
4.5 Volt 5.100.647 4.5 Volt Beat the juice out of them! Active items don't charge when clearing rooms. Instead, they're charged by dealing damage to enemies. 2
A Bar of Soap 5.100.564 A Bar of Soap Tears + shot speed up Gives Isaac +0.5 Tears and +0.2 Shot Speed. 3
A Pound of Flesh 5.100.672 A Pound of Flesh Blood money Devil deals now cost coins, shop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Act of Contrition 5.100.601 Act of Contrition Tears up, you feel forgiven Increases tears and grants an Eternal Heart. Allows Angel Rooms to appear even if a Devil deal has been taken before. Greatly boosts Devil/Angel Deal chance if Isaac has taken Red Heart damage. 3
Akeldama 5.100.641 Akeldama Spill your guts While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies. 2
Almond Milk 5.100.561 Almond Milk DMG down + tears up + you feel nutty Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects. 1
Astral Projection 5.100.677 Astral Projection The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Azazel's Rage 5.100.699 Azazel's Rage Ancient power Isaac builds rage every time a room is cleared. After four rooms, fires a large 15►Brimstone Brimstone laser when entering the next room. 3
Battery Pack 5.100.603 Battery Pack Instant energy! Recharges Isaac's currently held active item and drops 2-4 batteries. 1
Belly Jelly 5.100.690 Belly Jelly Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 2
Binge Eater 5.100.664 Binge Eater All you can eat +1 red heart container and fully heals Isaac. Item pedestals cycle between their normal items and food, and collecting food grants a temporary damage boost and permanent bonuses to 2 stats. 3
Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to 15►Dead Bird Dead Bird. 1
Bird's Eye 5.100.616 Bird's Eye It burns Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. 2
Birthright 5.100.619 Birthright ??? Has a different effect for each character. 2
Blood Bombs 5.100.614 Blood Bombs Bloody blast + HP up Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any. 1
Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Blood Puppy 5.100.565 Blood Puppy What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal. 2
Bloody Gust 5.100.695 Bloody Gust May your rage bring haste When Isaac takes damage, he gains speed and tears for the rest of the floor. 3
Boiled Baby 5.100.607 Boiled Baby Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
Bone Spurs 5.100.683 Bone Spurs Break your enemies Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them. 2
Booster Pack 5.100.624 Booster Pack Collect them all! Spawns 5 random cards. 1
Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Brimstone Bombs 5.100.646 Brimstone Bombs Demon blast +5 bombs Gives Isaac +5 bombs and causes his bombs to fire 15►Brimstone Brimstone lasers in the cardinal directions upon exploding. 3
C Section 5.100.678 C Section Fetus shots Not fully implemented. 4
Candy Heart 5.100.671 Candy Heart Power of love Gives Isaac a permanent stat boost whenever he heals with red heart pickups. 2
Card Reading 5.100.660 Card Reading A link to your future Spawns two portals that each lead to either the Boss Room, Secret Room, or Treasure Room at the beginning of each floor. 3
Consolation Prize 5.100.644 Consolation Prize +1 to lowest stat Increases Isaac's lowest stat and drops either 3 coins, 1 bomb, or 1 key depending on what Isaac has the least of. 1
Cracked Orb 5.100.675 Cracked Orb Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Dad's Note 5.100.668 Dad's Note ... Begins the sequence to access Home. 0
Dirty Mind 5.100.576 Dirty Mind Filthy friends Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. 2
Divine Intervention 5.100.568 Divine Intervention Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. 2
Dogma 5.100.633 Dogma Ascended Grants flight, +0.1 speed, +2 damage, and the 15►Holy Mantle Holy Mantle effect. Grants enough health to have 6 full hearts, if possible. Automatically given to Isaac after defeating Dogma. 0
Dream Catcher 5.100.566 Dream Catcher Sweet dreams During the transition between floors, Isaac's nightmare shows the floor's Treasure Room item and boss. Grants half a soul heart when entering a new floor. 2
Echo Chamber 5.100.700 Echo Chamber I can see see the future future future When Isaac uses a card, pill, or rune, he also uses a copy of every card/pill/rune he used after picking up Echo Chamber. 2
Empty Heart 5.100.676 Empty Heart It multiplies If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container. 2
Evil Charm 5.100.632 Evil Charm Luck up + you feel protected Increases luck by 2.0. Provides immunity to burn, confusion, fear, and poison. 1
Eye Drops 5.100.600 Eye Drops Tears up Lowers the tear delay in Isaac's left eye, causing his eyes to fire at different rates. 3
Eye of the Occult 5.100.572 Eye of the Occult DMG up + range up + controlled tears Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed. 3
Eye Sore 5.100.558 Eye Sore More eyes Causes Isaac to occasionally fire extra tears in random directions while shooting. 2
False PHD 5.100.654 False PHD Worse pills + evil up Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart. 2
Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Fruity Plum 5.100.649 Fruity Plum Bouncy friend Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. 1
Ghost Bombs 5.100.727 Ghost Bombs Spooky blast +5 bombs +5 bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. 2
Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies. 1
Glitched Crown 5.100.689 Glitched Crown ????? Before being picked up, item pedestals cycle between 5 random items. 4
Guppy's Eye 5.100.665 Guppy's Eye An eye for secrets Shows the contents of Chests, Sacks, and Fire Places before they're opened. 2
Heartbreak 5.100.694 Heartbreak Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Hemoptysis 5.100.726 Hemoptysis Double tap sneeze Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. 3
Hungry Soul 5.100.684 Hungry Soul Out for blood Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. 3
Hypercoagulation 5.100.724 Hypercoagulation Thick blooded After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds. 3
IBS 5.100.725 IBS Your stomach rumbles Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies. 2
Immaculate Heart 5.100.573 Immaculate Heart Halo of tears Adds one red heart container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him. 3
Inner Child 5.100.688 Inner Child Let him free Upon death, Isaac respawns in the current room with half a heart left, a massive size down, and +0.2 speed. 3
Isaac's Tomb 5.100.701 Isaac's Tomb Buried memories Spawns an Old Chest at the start of each floor. 3
It Hurts 5.100.560 It Hurts No it doesn't... Releases a ring of tears and increases tears for the current room when Isaac takes damage. 1
Jupiter 5.100.594 Jupiter You're a gas giant! +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves afterwards. 3
Keeper's Kin 5.100.717 Keeper's Kin Under a rock Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
Keeper's Sack 5.100.716 Keeper's Sack Spending power Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a key on pickup. 3
Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with 15►Knife Piece 2 Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with 15►Knife Piece 1 Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Knockout Drops 5.100.637 Knockout Drops They pack a punch! Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies. 3
Lil Abaddon 5.100.679 Lil Abaddon Abyssal friend Spawns a familiar that charges a miniature 15►Maw of the Void Maw of the Void attack while Isaac shoots. 3
Lil Dumpy 5.100.615 Lil Dumpy Puffy buddy Gives Isaac a Dumpy familiar that pushes, confuses, or poisons nearby enemies and flies in a random direction after taking damage. 0
Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Lodestone 5.100.617 Lodestone Magnetizing tears Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources. 3
Lost Soul 5.100.612 Lost Soul Protect him Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items. 2
Luna 5.100.589 Luna The moon's blessing shines upon you Adds an extra Secret Room and Super Secret Room to each floor. Secret Rooms contain a beam of light that increases tears for the current floor and gives half a soul heart. 2
Mars 5.100.593 Mars Double tap dash Dash by double-tapping the movement key, becoming invulnerable and damaging enemies. There's a short cooldown before Isaac can dash again. 2
Member Card 5.100.602 Member Card Exclusive access! Adds a trapdoor to every shop that leads to a second shop with a unique stock and marked-up prices. 1
Mercurius 5.100.590 Mercurius Speed up + you feel elusive +0.4 speed. Doors stay open after entering a room, even in rooms with enemies. 3
Monstrance 5.100.574 Monstrance Purifying light Isaac gains an aura that deals damage to enemies inside it. 2
Montezuma's Revenge 5.100.680 Montezuma's Revenge Oh no... While firing, Isaac charges up a short-ranged 15►Brimstone Brimstone-like diarrhea beam that shoots behind him. 3
Mucormycosis 5.100.553 Mucormycosis Spore shot Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores. 3
Nancy Bombs 5.100.563 Nancy Bombs Random blast +5 bombs Gives Isaac +5 bombs and gives his bombs random bomb synergies. 1
Neptunus 5.100.597 Neptunus Open the floodgates Isaac's mouth fills with tears over time while not firing, up to a cap. Holding the fire button will release all stored tears in rapid succession. 3
Ocular Rift 5.100.606 Ocular Rift Stare into the abyss Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources. 3
Options? 5.100.670 Options? There might be options If a room gives a reward when cleared, there will be two different rewards to chose from. Taking one causes the other to disappear. 2
Orphan Socks 5.100.571 Orphan Socks Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 soul hearts. 1
Paschal Candle 5.100.567 Paschal Candle Keep the flame burning Gives Isaac a tears bonus based on how many consecutive rooms he's cleared without taking damage. 3
Playdough Cookie 5.100.570 Playdough Cookie Tasty rainbow Grants multicolored tears. Each color comes with a different status or tear effect. 3
Pluto 5.100.598 Pluto Size down Significantly shrinks Isaac, allowing him to squeeze between objects and makes some enemy shots pass over him. Also gives +0.7 tears. 3
Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears. 3
Purgatory 5.100.634 Purgatory Help from beyond While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. 2
Quints 5.100.661 Quints They lurk inside The first five enemies killed in a room will spawn stationary shooting familiars where they died. 1
Red Stew 5.100.621 Red Stew Full HP + temporary DMG up Refills all heart containers. Grants an enormous damage boost that wears off over time. 0
Redemption 5.100.673 Redemption Deliver me from evil Gives Isaac a soul heart and +1 damage if he goes into a Devil Room but doesn't take anything from it. 2
Revelation 5.100.643 Revelation Awaken your faith Grants flight and two soul hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser. 4
Rock Bottom 5.100.562 Rock Bottom It's only up from there Locks Isaac's attributes to their highest values reached. 2
Rocket in a Jar 5.100.583 Rocket in a Jar Rocket propulsion +5 bombs +5 bombs. If Isaac is currently moving, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing. 2
Rotten Tomato 5.100.618 Rotten Tomato Delicious! Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies. 1
Sacred Orb 5.100.691 Sacred Orb Destined for greatness Prevents low-quality items from spawning, greatly increasing the quality of items received from all item pools. 4
Salvation 5.100.696 Salvation Divine protection Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor. 2
Sanguine Bond 5.100.692 Sanguine Bond He awaits your offering Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward. 1
Saturnus 5.100.595 Saturnus Ring of tears Upon entering a room, a circle of tears orbits Isaac. Enemy tears have a chance to be caught in orbit, turning them friendly. 1
Sausage 5.100.669 Sausage All stats up Adds a Red Heart container, and increases speed, damage, tears, range, shot speed, and luck. 3
Sol 5.100.588 Sol Radiant victory Reveals the location of the Boss room. Upon defeating a boss, activates XIX - The Sun, fully recharges Isaac's active item, grants bonus damage and luck for the rest of the floor, and removes curses. 2
Soul Locket 5.100.686 Soul Locket Power of faith Gives Isaac a permanent stat boost whenever he picks up a soul heart. 2
Spirit Shackles 5.100.674 Spirit Shackles Unfinished business On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a soul heart. 3
Spirit Sword 5.100.579 Spirit Sword Divine blade Instead of tears, Isaac swings a sword. Charging does a spin attack and fires a projectile, and a projectile is sometimes fired with normal swings if Isaac has no empty red hearts. 3
Stapler 5.100.708 Stapler DMG up +1 damage. Prevents Isaac from firing tears from one eye, like Cain. 3
Star of Bethlehem 5.100.651 Star of Bethlehem Follow the light Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing tears. 2
Strawman 5.100.667 Strawman A helping hand Spawns Keeper to fight enemies alongside Isaac. If Keeper dies, he spawns blue spiders and Strawman is removed from Isaac's inventory. 2
Supper 5.100.707 Supper HP up Grants one full Red Heart container. Heals 1 additional heart of health. 1
Terra 5.100.592 Terra Born to rock Replaces tears with rocks that deal variable damage, have increased knockback, and can destroy obstacles. 3
The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
The Stairway 5.100.586 The Stairway May you get what you came for Generates a ladder at the start of every floor that leads to a unique Angel Room shop. 3
The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
TMTRAINER 5.100.721 TMTRAINER ZZaZZ ZZdZZiZZmZZhZZ ZZvZZ ZZoZZ ZZ ZZsZZlZZhZZsZZoZZaZZiZZ Causes all future items to be "glitched", granting them completely random effects. 2
Tooth and Nail 5.100.663 Tooth and Nail You feel prickly Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage. 2
Tropicamide 5.100.659 Tropicamide Tear size + range up +1.5 range, Increases tear size. 1
Twisted Pair 5.100.698 Twisted Pair Double trouble! Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. 4
Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. 3
Vanishing Twin 5.100.697 Vanishing Twin He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. 3
Vasculitis 5.100.657 Vasculitis Clogged enemies Enemies explode into tears upon death, which inherit the effects of Isaac's tears. 2
Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 2
Venus 5.100.591 Venus HP up + you feel pretty Adds one red Heart container. Enemies near Isaac become charmed. 1
Voodoo Head 5.100.599 Voodoo Head Extra curse rooms Spawns an additional curse room on each floor. 1
Worm Friend 5.100.682 Worm Friend Clingy buddy Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time. 2


Trinkets[]

Name ID Icon Quote Description
'M 5.350.138 'M t's broken9Reroll your dest Using an activated item rerolls it.
A Lighter 5.350.135 A Lighter Watch the world burn Adds a chance for enemies to burn upon entering a room.
Adoption Papers 5.350.184 Adoption Papers Give them a home Shops can sell familiars, which will always be at a discounted price.
Apollyon's Best Friend 5.350.186 Apollyon's Best Friend Attack buddy Spawns an attack locust familiar which will fly forward while Isaac shoots.
Apple of Sodom 5.350.140 Apple of Sodom It feels empty Picking up red hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing.
Azazel's Stump 5.350.162 Azazel's Stump Unleash your inner demon When clearing a room, adds a chance to turn into Azazel until clearing another.
Beth's Essence 5.350.182 Beth's Essence Virtue's reward Upon entering an Angel Room, spawns 5 wisp orbitals. Giving money to beggars can spawn wisps.
Beth's Faith 5.350.142 Beth's Faith My faith protects me At the beginning of each floor, spawn 4-8 wisps that orbit Isaac and fires tears alongside him.
Blessed Penny 5.350.131 Blessed Penny Wealth of purity Gives a chance to drop a Half Soul Heart when a coin is collected.
Blue Key 5.350.150 Blue Key Look between the rooms Doors can be unlocked without using keys. Opening a door this way brings Isaac to an in-between room that resembles ??? ???, with a few monsters.
Brain Worm 5.350.144 Brain Worm Ding! Tears snap 90 degrees to target enemies that they may have missed.
Broken Glasses 5.350.187 Broken Glasses Double vision? Gives a 33% chance to add a '?' item to Treasure Rooms. Only one item can be taken. The extra items on the alt path are revealed instead.
Broken Padlock 5.350.136 Broken Padlock Bombs are key Locks can be opened with explosions.
Broken Syringe 5.350.132 Broken Syringe Mystery medicine Grants a chance to gain a random syringe effect for the current room.
Charged Penny 5.350.147 Charged Penny Wealth of power Picking up coins has a chance to give an Active Item charge.
Chewed Pen 5.350.130 Chewed Pen It's leaking Adds a chance to fire tears that slow enemies.
Cricket Leg 5.350.185 Cricket Leg Infested Adds a chance to spawn a random locust when killing an enemy.
Crystal Key 5.350.170 Crystal Key Call to the other side Adds a chance to automatically create Red Key rooms after clearing a room.
Cursed Penny 5.350.172 Cursed Penny Wealth of misery Picking up coins teleports Isaac to a random room.
Devil's Crown 5.350.146 Devil's Crown His special customer Treasure Rooms are replaced with unique Red Treasure Rooms, offering a Deal with the Devil in place of an item.
Dice Bag 5.350.154 Dice Bag Bonus roll When Isaac enters a new room, has a chance to give him a Dice item as a consumable for the current room.
Dingle Berry 5.350.163 Dingle Berry Oops! Spawns a Dip Familiar upon clearing a room.
Expansion Pack 5.350.181 Expansion Pack Fun extras Once per room, using an active item triggers another random active item effect.
Flat File 5.350.151 Flat File No more spikes Causes all spikes to retract, making them harmless. Also affects the doors to Curse Rooms.
Forgotten Lullaby 5.350.141 Forgotten Lullaby Sing for your friends Improves the fire rate of Isaac's familiars.
Found Soul 5.350.180 Found Soul Finally! Spawns a familiar that copies Isaac's movements and scales with damage and tears. If it takes damage, it will die and respawn on the next floor.
Friendship Necklace 5.350.148 Friendship Necklace Gather round Causes familiars to orbit Isaac.
Gigante Bean 5.350.134 Gigante Bean Mega farts Increases the size of Isaac's farts.
Gilded Key 5.350.159 Gilded Key Less is more Replaces all new chests, except Mega Chests, with Locked Chests.
Hollow Heart 5.350.168 Hollow Heart A brittle blessing Grants an empty bone heart upon entering a new floor.
Holy Crown 5.350.155 Holy Crown Walk the path of the saint A Treasure Room and Shop appears in the Cathedral Cathedral.
Ice Cube 5.350.188 Ice Cube Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.
Jawbreaker 5.350.129 Jawbreaker Don't chew on it Adds the chance to fire teeth that deal 3.2x damage, similar to 15►Tough Love Tough Love.
Keeper's Bargain 5.350.171 Keeper's Bargain Money talks Devil Deals cost money instead of health.
Kid's Drawing 5.350.169 Kid's Drawing Looks familiar... While held, counts towards the Guppy transformation.
Lil Clot 5.350.176 Lil Clot Mini friend Spawns a clot familiar that mimics Isaac's movements and tears. It dies for the current room after taking too much damage.
Lucky Sack 5.350.160 Lucky Sack Free goodies! Spawns a Grab Bag upon traveling to the next floor.
Modeling Clay 5.350.166 Modeling Clay ??? Grants the effect of a random passive Item each room.
Mom's Lock 5.350.153 Mom's Lock A piece of her love Grants the effects of a random Mom item each room.
Mother's Kiss 5.350.156 Mother's Kiss HP up Grants one heart container.
Myosotis 5.350.137 Myosotis Forget me not... When entering a new floor, up to four uncollected pickups from the previous floor spawn in the starting room.
Nuh Uh! 5.350.165 Nuh Uh! Don't want! Replaces keys and coins that spawn in Chapter 4 and beyond with more useful pickups.
Number Magnet 5.350.174 Number Magnet 6 Increases the chance of earning a Devil Room by 10%, prevents Krampus from spawning, and generates special Devil Room layouts.
Old Capacitor 5.350.143 Old Capacitor Voltage starving Active items don't charge when clearing rooms. Adds a chance to spawn a Lil' Battery when clearing a room, independent of the room's original drop.
Panic Button 5.350.149 Panic Button Push in case of emergency Activates Isaac's active item just before he takes damage.
Perfection 5.350.145 Perfection Luck way up. Don't lose it! +10 Luck. If Isaac takes damage, the trinket is destroyed and its effect is removed.
Polished Bone 5.350.167 Polished Bone Friends from beyond After clearing a room, adds a chance to spawn a friendly Bony.
RC Remote 5.350.179 RC Remote Controllable buddies! Instead of trailing behind Isaac, familiars are directly controlled by the same inputs as Isaac's.
Ring Cap 5.350.164 Ring Cap Twice the bang! Placing a bomb spawns an extra bomb for free.
Short Fuse 5.350.133 Short Fuse Faster explosions Bombs placed by Isaac explode quicker.
Sigil of Baphomet 5.350.189 Sigil of Baphomet Revel in death Grants an invulnerability shield for 1 second after killing an enemy.
Strange Key 5.350.175 Strange Key What could it open? Unlocks the passageway to ??? ??? and the Hush fight, regardless of the run duration. Using 15►Pandora's Box Pandora's Box grants it a special effect, consuming the key.
Swallowed M80 5.350.178 Swallowed M80 Bang! Isaac explodes upon taking damage.
Teardrop Charm 5.350.139 Teardrop Charm It feels lucky Luck-based tear effects have a higher chance of occurring.
Telescope Lens 5.350.152 Telescope Lens Seek the stars Increases the chance for Planetariums to spawn even if one has been visited and allows Planetariums to spawn in Chapter 4.
Temporary Tattoo 5.350.177 Temporary Tattoo You feel braver Spawns a chest after clearing a mob Challenge Room, or an item after clearing a boss Challenge Room.
The Twins 5.350.183 The Twins I'm seeing double... Adds a chance to duplicate one of Isaac's familiars when entering a new room.
Torn Card 5.350.157 Torn Card Death awaits Every 15 shots, Isaac shoots an 15►Ipecac Ipecac + 15►My Reflection My Reflection tear.
Torn Pocket 5.350.158 Torn Pocket A hole in your pocket Upon taking damage, Isaac drops 2 random Pickups from his inventory.
Wicked Crown 5.350.161 Wicked Crown Walk the path of the wicked A Treasure Room and Shop appears in Sheol Sheol.
Your Soul 5.350.173 Your Soul Give it to me Can be used to pay for a Devil deal without losing hearts, and is then consumed.

Pickups[]

Hearts[]

Heart ID Image Worth Additional Info Unlocked By
Rotten Heart 5.10.12
Rotten Heart.png
Rotten heart2.png
Rotten Hearts fill up one whole heart container, or the rightmost Red Heart if all of Isaac's heart containers are full. (It isn't possible to have one-half a Rotten Heart; they are always depleted in one hit.) Each Rotten Heart in Isaac's life bar spawns two Blue Flies upon clearing a room. Rotten Heart Enter the Corpse for the first time

Coins[]

Coin ID Image Worth Additional Info Unlocked By
Golden Penny 5.10.7
Golden Penny.png
1 Spawns another golden penny in a random spot in the same room after being picked up, but has a 5% chance of disappearing instead. Golden Penny Defeat Mega Satan as Tainted Keeper Tainted Keeper

Bombs[]

Bomb ID Image Worth Additional Info Unlocked By
Golden Troll Bomb 4.18
Golden Troll Bomb.png
0 Similar to troll bombs, spawns already ignited and cannot be picked up. However, it explodes endlessly, similar to unlimited bombs of the golden bomb pickup.
Safety Scissors Safety Scissors will turn this into a Golden Bomb before it explodes.
Giga Bombs 5.40.7
Giga Bomb.png
1 Thrown by Bombgaggers and are spawned naturally in some rooms in Ashpit. Explodes and destroys tiles in a diamond shape.
Can be obtained by the player with Safety Scissors Safety Scissors or 15►Everything Jar Everything Jar.
Throwable Bomb 5.41
Throwable Bomb.png
0 Can only be picked up and thrown, explodes in a few seconds after pickup. Spawned only by the Bomb Grimace enemy.

Batteries[]

Battery ID Image Worth Additional Info Unlocked By
Micro Battery 5.90.2
Micro Battery.png
2 Charges. Always Available
Mega Battery 5.90.3
Mega Battery.png
Fully charges the player's Active Item twice. Always available
Golden Battery 5.90.4
Golden Battery.png
Fully charges the player's Active Item. Damages the player for a full heart when picked up, and reappears somewhere else in the floor. Golden Battery Defeat Mega Satan as Tainted Forgotten Tainted Forgotten

Pills[]

Pill effects[]

Pill ID Effect Unlocked By
Shot Speed Down 47 -0.15 shot speed. Always available
Shot Speed Up 48 +0.15 shot speed. Always available
Experimental Pill 49 Increases one attribute and decreases another randomly, with the same power as normal attribute up/down pills. If taken with PHD, it will not reduce an attribute. Always available

Gold Pills[]

Gold Pills (or Golden Pills) can be used multiple times and grant a random pill effect, even from pills not in the pill pool. Every time a Golden Pill is used it has a chance of being consumed. Its Horse Pill variant will make it give only Horse Pill Effects.

Pill ID Image Effect Unlocked by
Gold Pill 5.70.14 Golden Pill icon.png Gives random pill effects and disappears after a random amount of uses. Gold Pill Defeat Mega Satan as Tainted Cain Tainted Cain

Horse Pills[]

Horse Pills appear as larger versions of the standard pills with a more powerful effect, and their effects and appearances are similarly randomly chosen. All items that work with pills work identically with horse pills. A horse pill with a given effect has the same color as the normal pill does. Unlocked by: Horse Pill Defeat Mega Satan as Tainted Eve Tainted Eve

Horse Pill Effect
Bad Gas The poison applies to the entire room.
Bad Trip Two hearts of damage. If Isaac would not survive, the pill becomes Full Health.
Balls of Steel Grants four soul hearts.
Bombs are Key The number of bombs and keys is increased by 50% while swapping.
Explosive Diarrhea Spawns more bombs, boosted with 15►Mr. Mega Mr. Mega and 15►Bobby-Bomb Bobby-Bomb.
Full Health Fully heals and grants 3 soul hearts.
Health Down Removes two heart containers. If this is not possible, the pill becomes Health Up.
Health Up Adds two empty red heart containers.
I Found Pills Isaac's face gets a permanent, very exaggerated expression.
Puberty Isaac gains very fluffy hair covering his entire head and even face.
Pretty Fly Spawns a 15►Big Fan Big Fan instead. There is no upper limit.
Range Down -1.20 range.
Range Up +1.50 range.
Speed Down -0.24 speed.
Speed Up +0.30 speed.
Tears Down -0.56 tears.
Tears Up +0.70 tears.
Luck Down -2 luck.
Luck Up +2 luck.
Telepills Unknown
48 Hour Energy Spawns more batteries.
Hematemesis Spawns more hearts.
Paralysis The effect lasts 4 seconds.
I can see forever! In addition to the normal effect, fully reveals the map like 15►The Mind The Mind.
Pheromones The charm is permanent, turning the enemies friendly.
Amnesia Unknown
Lemon Party The puddle covers nearly the entire room.
R U a Wizard? The effect lasts 60 seconds.
Percs Unknown
Addicted Unknown
Re-Lax The effect lasts much longer, with high speed long enough to cover nearly the entire room.
??? Unknown
One makes you larger Size increases by two steps.
One makes you small Size decreases by two steps.
Infested! Double the number of spiders spawned.
Infested? Double the number of spiders spawned.
Power Pill! In addition to the normal effect, grants Huge Growth Huge Growth for +7 flat damage and +3 range. The Huge Growth bonus persists after the Gamekid wears off.
Retro Vision Lasts 90 seconds, with no breaks.
Friends 'Till The End! Double the number of flies spawned.
X-Lax The pool lasts much longer.
Something's wrong... The pool lasts much longer.
I'm Drowsy... Unknown
I'm Excited!!! Unknown
Gulp! Unknown
Horf! Isaac shoots a small cluster of Horf! tears, with varying power above normal Horf!.
Feels like I'm walking on sunshine! The effect is upgraded to 15►The Gamekid The Gamekid.
Vurp! If the last pill was a normal pill, it becomes a horse pill. No further difference on horse pills themselves.
Shot Speed Down -0.30 shot speed.
Shot Speed Up +0.30 shot speed.
Experimental Pill The two effects are doubled in power.
Gold Pill The random effects are doubled.

Consumables[]

Reversed Cards[]

Name ID Icon Unlock method Message Description
0 - The Fool? 5.300.56 0 - The Fool? The Fool Defeat Ultra Greedier as Tainted Lost Tainted Lost Let go and move on Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Will kill Isaac if he has only soul hearts and all empty red heart containers. Pickups may be spawned as items such as 15►A Quarter A Quarter and 15►Boom! Boom!.
I - The Magician? 5.300.57 I - The Magician? The Magician Defeat Ultra Greedier as Tainted Judas Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like 15►The Soul The Soul but stronger and with a wider area of effect.
II - The High Priestess? 5.300.58 II - The High Priestess? The High Priestess Defeat Ultra Greedier as Tainted Lilith Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding 15►Broken Shovel Broken Shovel.
III - The Empress? 5.300.59 III - The Empress? The Empress Defeat Ultra Greedier as Tainted Eve Tainted Eve May your love bring protection Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene Magdalene's hairstyle. Does not stack.
IV - The Emperor? 5.300.60 IV - The Emperor? The Emperor Defeat Ultra Greedier as Tainted ??? Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor. The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
V - The Hierophant? 5.300.61 V - The Hierophant? The Hierophant Defeat Ultra Greedier as Tainted Bethany Tainted Bethany Two prayers for the forgotten Spawns 2 Bone Hearts.
VI - The Lovers? 5.300.62 VI - The Lovers? The Lovers Defeat Ultra Greedier as Tainted Magdalene Tainted Magdalene May your heart shatter to pieces Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally; no downside for any character who has no health bar; Tainted Keeper Tainted Keeper locked to 1 HP.
VII - The Chariot? 5.300.63 VII - The Chariot? The Chariot Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
VIII - Justice? 5.300.64 VIII - Justice? Justice Complete Cantripped (challenge #43) May your sins come back to torment you Spawns 2 to 4 Golden Chests.
IX - The Hermit? 5.300.65 IX - The Hermit? The Hermit Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
X - Wheel of Fortune? 5.300.66 X - Wheel of Fortune? Wheel of Fortune Defeat Ultra Greedier as Tainted Cain Tainted Cain Throw the dice of fate Invokes a random dice room effect.
XI - Strength? 5.300.67 XI - Strength? Strength Defeat Ultra Greedier as Tainted Samson Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.
XII - The Hanged Man? 5.300.68 XII - The Hanged Man? The Hanged Man Defeat Ultra Greedier as Tainted Keeper Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus, and -0.1 speed. Killed enemies drop random coins.
XIII - Death? 5.300.69 XIII - Death? Death Defeat Ultra Greedier as Tainted Forgotten Tainted Forgotten May life spring forth from the fallen Invokes a 15►Book of the Dead Book of the Dead effect.
XIV - Temperance? 5.300.70 XIV - Temperance? Temperance Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random pills in quick succession.
XV - The Devil? 5.300.71 XV - The Devil? The Devil Defeat Ultra Greedier as Tainted Azazel Tainted Azazel Bask in the light of your mercy Invokes 15►The Bible The Bible (which can kill Mom), and grants Isaac flight and a 15►Seraphim Seraphim familiar for 30 seconds.
XVI - The Tower? 5.300.72 XVI - The Tower? The Tower Defeat Ultra Greedier as Tainted Apollyon Tainted Apollyon Creation brings destruction Spawns 6 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of more than one spawning in one room. The pathways between exits can't be blocked.
XVII - The Stars? 5.300.73 XVII - The Stars? The Stars Defeat Ultra Greedier as Tainted Isaac Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item, including starting items, and spawns 2 random items from the current room's item pool. Doesn't spawn anything if Isaac has no items.
XVIII - The Moon? 5.300.74 XVIII - The Moon? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May you remember lost memories Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.
XIX - The Sun? 5.300.75 XIX - The Sun? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May the darkness swallow all around you Gain 15►Spirit of the Night Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
XX - Judgement? 5.300.76 XX - Judgement? Judgement Defeat Ultra Greedier as Tainted Lazarus Tainted Lazarus May you redeem those found wanting Spawns a Restock Machine.
XXI - The World? 5.300.77 XXI - The World? The World Defeat Ultra Greedier as Tainted Eden Tainted Eden Step into the abyss Spawns a trap door to a crawl space.

Playing Cards[]

Name ID Icon Unlock method Message Description
Queen of Hearts 5.300.79 Queen of Hearts Queen of Hearts Defeat Mega Satan as Tainted Magdalene Tainted Magdalene <3 Spawns 1-20 full red hearts.

Other Cards[]

Name ID Icon Unlock method Message Description
Wild Card 5.300.80 Wild Card Wild Card Defeat Mega Satan as Tainted Eden Tainted Eden Again When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Runes[]

Name ID Icon Unlock method Message Description
Rune Shard 5.300.55 Rune Shard Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Soul Stones[]

Name ID Icon Unlock method Message Description
Soul of Isaac 5.300.81 Soul of Isaac Soul of Isaac Defeat Hush and Boss Rush as Tainted Isaac Tainted Isaac Reroll... or not Rerolls the items in the room like 15►The D6 The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
Soul of Magdalene 5.300.82 Soul of Magdalene Soul of Magdalene Defeat Hush and Boss Rush as Tainted Magdalene Tainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.
Soul of Cain 5.300.83 Soul of Cain Soul of Cain Defeat Hush and Boss Rush as Tainted Cain Tainted Cain Opens the unopenable Opens all doors in the room. Additionally, creates a red room like the 15►Red Key Red Key for every possible red exit. This also destroys the mirror located in Downpour Downpour/Dross Dross II.
Soul of Judas 5.300.84 Soul of Judas Soul of Judas Defeat Hush and Boss Rush as Tainted Judas Tainted Judas Right behind you Stops time for 3 seconds and invokes 15►Dark Arts Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
Soul of ??? 5.300.85 Soul of ??? Soul of ??? Defeat Hush and Boss Rush as Tainted ??? Tainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 15►Butt Bombs Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.
Soul of Eve 5.300.86 Soul of Eve Soul of Eve Defeat Hush and Boss Rush as Tainted Eve Tainted Eve Your very own murder 14 15►Dead Bird Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Soul of Samson 5.300.87 Soul of Samson Soul of Samson Defeat Hush and Boss Rush as Tainted Samson Tainted Samson Slay a thousand Isaac turns berserk (similar to Tainted Samson) for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.
Soul of Azazel 5.300.88 Soul of Azazel Soul of Azazel Defeat Hush and Boss Rush as Tainted Azazel Tainted Azazel Demon rage! Activates 15►Mega Blast Mega Blast for 7.5 seconds.
Soul of Lazarus 5.300.89 Soul of Lazarus Soul of Lazarus Defeat Hush and Boss Rush as Tainted Lazarus Tainted Lazarus Life after death Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, functioning as a minimal extra life.
Soul of Eden 5.300.90 Soul of Eden Soul of Eden Defeat Hush and Boss Rush as Tainted Eden Tainted Eden Embrace chaos Uses 15►The D6 The D6 and 15►D20 D20. The rerolled items use random pools, as if 15►Chaos Chaos were active.
Soul of the Lost 5.300.91 Soul of the Lost Soul of the Lost Defeat Hush and Boss Rush as Tainted Lost Tainted Lost Leave your body behind Isaac "dies" and turns into a ghost (similar to The Lost The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Does not allow you to take devil deals for free. Does not allow you to open the door to Mausoleum for free. The Holy Mantle effect gained from this can be stacked with multiple uses.
Soul of Lilith 5.300.92 Soul of Lilith Soul of Lilith Defeat Hush and Boss Rush as Tainted Lilith Tainted Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except 15►Stitches Stitches. Unique familiars can be received only once. Appropriate familiars count towards Conjoined.
Soul of the Keeper 5.300.93 Soul of the Keeper Soul of the Keeper Defeat Hush and Boss Rush as Tainted Keeper Tainted Keeper $$$ Spawns 1-25 random coins.
Soul of Apollyon 5.300.94 Soul of Apollyon Soul of Apollyon Defeat Hush and Boss Rush as Tainted Apollyon Tainted Apollyon Bringer of calamity Spawns 15 random locusts.
Soul of the Forgotten 5.300.95 Soul of the Forgotten Soul of the Forgotten Defeat Hush and Boss Rush as Tainted Forgotten Tainted Forgotten Skeletal protector Spawns The Forgotten The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his three bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Soul of Bethany 5.300.96 Soul of Bethany Soul of Bethany Defeat Hush and Boss Rush as Tainted Bethany Tainted Bethany Friends from beyond Spawns 6 15►Book of Virtues Book of Virtues wisps with random properties.
Soul of Jacob and Esau 5.300.97 Soul of Jacob and Esau Soul of Jacob and Esau Defeat Hush and Boss Rush as Tainted Jacob Tainted Jacob Bound by blood Spawns Esau Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items the player who spawned him has.

Other[]

Name ID Icon Unlock method Message Description
Cracked Key 5.300.78 Cracked Key Red Key Open the large version of Mom's Box in Home ??? Creates a room adjacent to a viable wall, like 15►Red Key Red Key.

Chests[]

Chest ID Image Additional Info Unlocked By
Old Chest 5.55 Old Chest.png Old Chests are similar in appearance to Golden Chests, but have the color of a normal Chest and a worn-down appearance. They have the same requirements as locked chests. Pulls from the Old Chest item pool.
Wooden Chest 5.56 Wooden Chest.png Wooden Chests appear similar to normal Chests but have an appearance similar to wood. Pulls from the Wooden Chest item pool. Wooden Chest Defeat Mega Satan as Tainted Lazarus Tainted Lazarus
Mega Chest 5.57 Mega Chest.png Mega chests appear similar to Golden Chests but are larger in appearance. Mega Chest Defeat Mega Satan as Tainted Isaac Tainted Isaac
Haunted Chest 5.58 Haunted Chest.png Haunted Chests appear nearly identical to normal Chests until Isaac gets close to them, at which point a Polty picks up the chest and throws it at Isaac, doing half a heart of damage and breaking open the chest. Haunted Chest Defeat Mega Satan as Tainted Lost Tainted Lost
Mom's Chest 5.390 Mom's Chest.png Mom's Chest appears in Home. Mom's chest has no requirements to open. Contains a Red Key upon the first visit. Contains a random Mom-related item or Red Key upon subsequent visits of Home.

Sacks[]

Sack ID Image Additional Info Unlocked By
Black Sack 5.69.2
Black Sack.png
Spawns 2-3 pills, black or bone hearts and/or bombs when collected. Black Sack Defeat Mega Satan as Tainted Judas Tainted Judas

As well, Sacks can spawn in shops for 7 coins.

Monsters[]

Bosses[]

Enemies[]

Entity ID Description
Deep Gaper
Deep Gaper
811.0 Emerges off the floor once all previous enemies have been killed, then proceeds to chase Isaac like a normal Gaper.
Blurb
Blurb
813.0 Walks slowly towards Isaac. After taking some damage or getting close to Isaac, it fires a chaotic burst of tears at him and chases him more quickly.
Crackle
Crackle
87.1 Walks toward Isaac, spitting balls of fire that create lines of fire in the cardinal directions on impact.
Wraith
Wraith
807.0 Walks toward Isaac, dealing contact damage. Can only be seen through its reflection and ripples it leaves in the water as it moves.
Rotten Gaper
Rotten Gaper
10.3 Walks toward Isaac, dealing contact damage. Its behavior varies slightly depending on its facial expression.
Dead Isaac
Dead Isaac
912.20 Summoned by Mother at the bottom of the arena, and walks up towards Mother. Releases a burst of blood shots upon being killed by Mother, while she launches their corpses towards Isaac.
Twitchy
Twitchy
851.0 Alternates between walking towards and rapidly leaping at Isaac.
Level 2 Gaper
Level 2 Gaper
850.0 Walks towards Isaac, dealing contact damage. Splits into a Level 2 Horf and Level 2 Gusher upon death.
Faceless
Faceless
827.0 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots more frequently after taking damage.
Fanatic
Fanatic
832.1 Transformed into from Exorcists. Chases Isaac and occasionally fires two purple, rotating shots.
Exorcist
Exorcist
832.0 Summons The Heretic before transforming into Fanatics.
Dump
Dump
876.0 Slides toward Isaac, leaving a trail of slippery brown creep. After taking enough damage, its head slides off and quickly bounces around the room and its body spews out brown shots until it empties.
Dump Head
Dump Head
876.1 Quickly slides toward Isaac, leaving a trail of slippery brown creep. Can spawn on its own or be created by a Dump after it takes enough damage.
Level 2 Gusher
Level 2 Gusher
850.2 Runs aimlessly around the room, spitting up Small Maggots.
Sub Horf
Sub Horf
812.0 Stationary enemy that spins and fires shots while being moved around or knocked back.
Necro
Necro
828.0 Stationary enemy that summons unlimited-ranged bones to attack Isaac.
Tainted Sub Horf
Tainted Sub Horf
812.1 Will only shoot when hit. Takes heavy knockback and rotates when hit. Shoots a lot faster and has bigger projectiles than its normal variant.
Level 2 Horf
Level 2 Horf
850.1 Slowly floats toward Isaac, spitting Small Maggots at him.
Army Fly
Army Fly
868.0 Chases Isaac, moving along the cardinal directions. Forms a line with other Army Flies in the room. Deals contact damage.
Willo
Willo
808.0 Flies in a circle around Isaac (in formation with other Willos if available), keeping an exact distance away from him. One Willo at a time will occasionally light up and fire a shot at Isaac.
Ultra Famine Fly
Ultra Famine Fly
951.11 Charges at Isaac at a delay. Deals contact damage. Spawned by Ultra Famine.
Ultra Pestilence Fly
Ultra Pestilence Fly
951.21 Flies in swarms around Ultra Pestilence, blocking shots and dealing contact damage.
Fly Bomb
Fly Bomb
819.0 Flies toward Isaac, circling around him as it does. Turn into a tiny bomb upon death.
Eternal Fly Bomb
Eternal Fly Bomb
819.1 Orbits Boom Flies spawned by The Horny Boys. Once its Boom Fly has been killed, turns into a tiny Bomb.
Ink
Ink
61.3 Flies slowly towards Isaac. Fires four tar shots in the ordinal directions and leaves a puddle of slowing black creep upon death.
Tainted Sucker
Tainted Sucker
61.7 Flies slowly towards Isaac. Upon death, fires a radial burst of six blood shots that each also fires a radial burst of six blood shots.
Bulb
Bulb
61.5 Flies in erratic, angled movements toward Isaac if his active item has charges. Drains active item charges instead of dealing damage.
Bloodfly
Bloodfly
61.6 Flies in erratic, angled movements toward Isaac. Fires four blood shots in the cardinal directions upon death.
Tainted Pooter
Tainted Pooter
14.2 Slowly drifts toward Isaac, occasionally firing four blood shots at him that split into two smaller ones when they hit a wall or obstacle.
Mama Fly
Mama Fly
61.4 Wanders aimlessly around the room, occasionally creating Pustules.
Grilled Clotty
Grilled Clotty
15.3 Quickly and randomly wanders around the room, firing four flame shots in the cardinal directions at a slight angle.
Cloggy
Cloggy
872.0 Randomly wanders around the room, firing four curved brown shots in the cardinal directions. These shots alternate between rotating clockwise and counterclockwise with each shot.
Prey
Prey
817.0 Wanders around the room, avoiding Isaac and spawning Small Leeches if he gets close. Spawns 3 Small Leeches upon death.
Fartigan
Fartigan
874.0 Chases Isaac, occasionally coughing up gas. On death, fires an explosive shot that can detonate gas clouds it hits.
Holy Mulligan
Holy Mulligan
22.2 Wanders around the room, avoiding Isaac and spawning Small Angelic Babies if he gets close. Spawns 1-2 Embryos upon death.
Mullighoul
Mullighoul
817.1 Wanders around the room, avoiding Isaac and spawning Willos if he gets close. Spawns 1-2 Willos upon death.
Bouncer
Bouncer
822.0 Wanders around the room, avoiding Isaac. If Isaac stays close to one for long enough, it inflates and starts chasing him, gaining a chance to deflect shots and causing it to explode into lingering blood shots on death.
Tainted Mulligan
Tainted Mulligan
22.3 Wanders around the room, avoiding Isaac and spawning 6 Ring Flies if he gets close. Spawns a plethora of fly enemies upon death.
Danny
Danny
820.0 Walks toward Isaac and spits chaotic bursts of rocks at him, some of which may be Rock Spiders.
Coal Boy
Coal Boy
820.1 Walks toward Isaac and spits hot coals at him, some of which may be Coal Spiders.
Blaster
Blaster
821.0 Slowly wanders around and occasionally shoots Fly Bombs at Isaac.
Small Maggot
Small Maggot
853.0 Slowly crawls toward Isaac, dealing contact damage.
Level 2 Charger
Level 2 Charger
855.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Can slowly change its trajectory while charging.
Carrion Princess
Carrion Princess
23.3 Slowly moves around the room, charging at Isaac when he lines up diagonally with it. Can only be damaged by hitting its tail.
Small Leech
Small Leech
810.0 Chases Isaac continuously, not stopping at walls. Able to swim over gaps.
Elleech
Elleech
855.1 Slowly moves around the room. After Isaac gets in its line of sight, continuously charges at him in the closest cardinal direction.
Blood Puppy
Blood Puppy
802.0 Quickly moves around the room, attacking and charging at other monsters and Isaac when they get in its line of sight.
Tainted Spitty
Tainted Spitty
31.1 Slowly moves around the room, firing chaotic bursts of blood shots in all directions and occasionally spitting a line of blood shots in the direction it's facing. Fires two rotating rings of blood shots upon death.
Cursed Globin
Cursed Globin
24.3 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into 1-2 piles of goo, each of which can be killed and regenerate after a short period of time if not killed quickly. These goo piles have less health the more times the Cursed Globin splits.
Clickety Clack
Clickety Clack
889.0 Walks towards Isaac and turn into a pile of bones when killed. Regenerates a few seconds after killed. Will only despawn if all Clickety Clacks in the room are killed.
Cohort
Cohort
857.0 Acts similarly to Monstro, hopping towards Isaac and can either spit a large projectile towards Isaac that bursts into 8 smaller projectiles or cough up a burst of arcing projectiles and a pile of Globin goo. Spawns 4 piles of Globin goo upon death.
Gasbag
Gasbag
856.0 Occasionally summons Army Flies to chase Isaac. Is surrounded by a ring of toxic gas that hurts Isaac if he stands in it for too long.
Dragon Fly
Dragon Fly
25.3.0 Flies around the room diagonally, dealing contact damage. Upon death, creates four lines of fire in the cardinal directions.
Dragon Fly X
Dragon Fly X
25.3.1 Flies around the room diagonally, dealing contact damage. Upon death, creates four lines of fire in the ordinal directions.
Bone Fly
Bone Fly
25.4 Flies around the room diagonally, dealing contact damage. Fires bones at Isaac if he lines up with it in the cardinal directions. Fires a radial burst of 3 bones upon death.
Sick Boom Fly
Sick Boom Fly
25.5 Flies around the room diagonally, dealing contact damage and trailing poisonous gas. Upon death, explodes into a gas cloud and fires a ring of 6 green shots.
Tainted Boom Fly
Tainted Boom Fly
25.6 Flies around the room diagonally, dealing contact damage. Upon death, sends explosions in a cross-shaped marker across the room.
Hard Host
Hard Host
27.3 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Shortly after raising its head, it slams its head down and fires a rock wave towards Isaac.
Floating Host
Floating Host
859.0 Floats diagonally around the room and is normally invulnerable. When Isaac gets close, reveals a fleshy stem that can be damaged and fires 3 blood shots in an angle at him before hiding its stem again.
Sticky Leaper
Sticky Leaper
34.1 Hops around the room, dealing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while creating a chaotic burst of tar shots in all directions and a puddle of slowing black creep.
Eggy
Eggy
29.2 Hops aimlessly around the room, spawning slowing white creep wherever it hops. Spawns a group of Swarm Spiders upon death.
Tainted Hopper
Tainted Hopper
29.3 Jumps and twirls around the room, shooting 4 rings of projectiles that increase in size with each shot.
Pustule
Pustule
861.0 Slowly increases in size over time, spawning Small Maggots and damaging red creep depending on its size upon death. If it grows to full size, it transforms into a Bloodfly.
Pon
Pon
840.0 Hops around the room, leaving damaging red creep wherever it lands. Upon death, its associated Brainless Knight dies with it.
Gyro
Gyro
824.0 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles as it does.
Grilled Gyro
Grilled Gyro
824.1 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles and creating fires behind itself as it does.
Angelic Baby (small)
Angelic Baby (small)
38.1.1 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere. Can only be spawned by Holy Mulligans.
Wrinkly Baby
Wrinkly Baby
38.3 Lunges towards Isaac at high speed and fires three blood shots in his direction once stopped.
Baby Begotten
Baby Begotten
883.0 Floats toward Isaac, avoiding his shots. After getting close, fires a short 15►Brimstone Brimstone laser in the closest cardinal direction and propels itself away from him.
Unborn
Unborn
860.0 Floats quickly towards Isaac, and occasionally teleports to another position near him.
Vis Versa
Vis Versa
39.4 Randomly wanders around the room. Pauses to charge and fire a homing Brimstone laser when Isaac gets in its line of sight.
Evis
Evis
39.5 Randomly wanders around the room. Launches a string of guts when Isaac gets close to it, which it uses to pull Isaac toward itself.
Slog
Slog
40.2 Attaches itself to a wall or obstacle and rolls around it, charging at Isaac when he is in sight.
Cyst
Cyst
862.0 Attaches itself to a wall or obstacle and rolls around it, regularly firing blood shots at Isaac.
Loose Knight
Loose Knight
41.2 Moves erratically around the room, charges toward Isaac when in line of sight. When its health is depleted, it turns into a Brainless Knight and a Pon.
Brainless Knight
Brainless Knight
41.3 Alternates between running around the room along the cardinal directions and aimlessly walking in circles. Charges at Isaac when in line of sight. Dies when its corresponding Pon dies.
Black Knight
Black Knight
41.4 Moves erratically around the room, charges toward Isaac when in line of sight. Unleashes waves of fire in all cardinal directions upon charging into an obstacle. Shots that hit it from the front are deflected back at Isaac.
Whipper
Whipper
834.0 Runs around the room, sprinting at Isaac when he gets in its line of sight and lashing at him when it gets close.
Snapper
Snapper
834.1 Runs around the room, sprinting at Isaac when he gets in its line of sight and throwing out its whip when he gets in range.
Flagellant
Flagellant
834.2 Runs around the room. When Isaac gets in its line of sight, continuously chases him and lashes its whip, occasionally deflecting Isaac’s shots.
Adult Leech
Adult Leech
854.0 Wanders around the room, quickly charging at Isaac when he lines up diagonally with him and releasing a ring of blood shots upon colliding with a wall. Occasionally burrows into the ground and reappears out of a wall or from above Isaac.
Dead Meat
Dead Meat
57.2 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions that bounce off the walls. Splits into 2 Cysts upon death.
Holy Eye
Holy Eye
60.2 Rapidly summons several beams of light around Isaac every few seconds.
Strider
Strider
814.0 Erratically swims around the room. If it sees Isaac, it chases him, trying to deal contact damage.
Swarm Spider
Swarm Spider
884.0 Very erratically hops toward Isaac in large groups, dealing contact damage.
Rock Spider
Rock Spider
818.0 Slowly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Spider upon death. Turns into a Coal Spider if it touches fire.
Tinted Rock Spider
Tinted Rock Spider
818.1 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Soul Heart upon death. Can only spawn by breaking tinted rocks on Mines or Ashpit.
Coal Spider
Coal Spider
818.2 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a hot coal upon death that blocks shots and deals contact damage, but can be destroyed.
Butt Slicker
Butt Slicker
878.0 Moves erratically around the room unless attached to another Butt Slicker. Grouped Butt Slickers drag themselves towards Isaac, and when an individual is killed they leave black creep, and shoot out black projectiles. The amount of projectiles released and the size of the pool of Black Creep is determined by the amount of Butt Slickers attached.
Mask II + 1/2 Heart
Mask II + 1/2 Heart
92.1 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the ordinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask. If there are more than one 1/2 Heart in the room, they will fire blood shots between each other.
Peeping Fatty
Peeping Fatty
835.0 Has two indestructible eyeballs that are out of their sockets but attached by muscles. Wanders around the room randomly, or toward Isaac if its eyes see him. Occasionally farts and fires a radial burst of 6 blood shots.
Bloaty
Bloaty
879.0 Lumbers around, occasionally spitting green shots and a line of damaging green creep in a random direction.
Bubbles
Bubbles
806.0 Slowly walks towards Isaac, firing back shots upon taking damage. Occasionally farts, which pushes Isaac and adjacent enemies away and creates a chaotic burst of shots. Creates a geyser of water shots upon death.
Shady
Shady
888.0 Walks slowly toward Isaac, occasionally firing a shot that creates shots perpendicular to itself while traveling and splits into a ring of shots upon hitting a wall or obstacle. Also occasionally jumps, creating lines of explosions in the cardinal directions.
Quakey
Quakey
823.0 Walks slowly toward Isaac, occasionally attempting to jump on Isaac, shooting out 8 rock shots when it hits the ground and causing rocks to fall from the ceiling.
Big Bony
Big Bony
830.0 Walks slowly toward Isaac, and will occasionally fire a bone that bounces around the room for a few moments. The bone can be broken if shot enough.
Vis Fatty
Vis Fatty
886.0 Spawns with a Fetal Demon attached to it and slowly walks towards Isaac. Will occasionally fart, briefly pushing the demon away and spawning creep around itself and the demon. If the demon is killed first, the Fatty will shoot out 15►Brimstone Brimstone in the diagonal direction closest to Isaac. It will then fly around the room diagonally, bumping off of walls and tall blocks all while continuously firing 15►Brimstone Brimstone behind it.
Fetal Demon
Fetal Demon
886.1 Usually encountered tethered to Vis Fatties. When tethered it makes short lunges towards Isaac if he gets close. If the Vis Fatty is killed or when encountered alone it will chase Isaac similarly to Gemini's Suture.
Gutted Fatty
Gutted Fatty
831.0 Slowly lumbers around the room, occasionally spawning Festering Guts. Its eyes dislocate as it takes damage, which are invincible and follow the Gutted Fatty but chase Isaac if he gets close to them. Creates a geyser of blood projectiles upon death.
Festering Guts
Festering Guts
831.20 Spawned by Gutted Fatties, Festering Guts randomly slide around the room and occasionally spawn a Charger.
Tainted Faceless
Tainted Faceless
827.1 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots very frequently after taking damage.
Cursed Death's Head
Cursed Death's Head
212.2 Invulnerable enemy that moves diagonally around the room, dealing contact damage. If Isaac enters its purple aura, he will be inflicted with fear and be temporarily unable to shoot. Dies when the room is cleared.
Brimstone Death's Head
Brimstone Death's Head
212.3 Invulnerable enemy that moves diagonally around the room, pausing to fire a 15►Brimstone Brimstone laser when Isaac lines up with it in the cardinal directions. Dies when the room is cleared.
Dusty Death's Head
Dusty Death's Head
887.0 Invulnerable enemy that moves across the room in a waving motion in large quantities. Dies when the room is cleared.
Redskull
Redskull
212.4 Moves diagonally around the room, creating a ring of fire around itself if Isaac gets close to it. Can be killed, but also dies when the room is cleared.
Ultra Death Head
Ultra Death Head
951.42 Invulnerable enemy spawned by Ultra Death that moves across the room in a waving motion in large quantities as a part of one of his attacks. Dies upon the completion of the attack.
Level 2 Willo
Level 2 Willo
838.0 Orbits enemies and shoots tears at Isaac. If the enemy it is orbiting dies, it will orbit another enemy. However, if all enemies are dead, it will chase Isaac, while still occasionally shooting at Isaac.
Migraine
Migraine
869.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Releases multiple Troll Bombs upon death.
Big Corn
Big Corn
217.3 Quickly dashes in random directions, dealing contact damage. Shoots one piece of corn upon death.
Drip
Drip
870.0 Quickly rolls around in diagonal directions, dealing contact damage.
Splurt
Splurt
871.0 Dashes towards Isaac twice and deals contact damage. Spawns 2 Drips upon death.
Hardy
Hardy
826.0 Dashes toward Isaac and deals contact damage creating rock projectiles when it hits a wall/obstacle. It spawns more rock projectiles the more times it crashes into obstacles, dying after doing so a third time.
Revenant
Revenant
841.0 Slowly wanders around the room, stopping to fire a large line of fire at the player.
Quad Revenant
Quad Revenant
841.1 Wanders around the room slowly, stopping to fire lines of flames in the cardinal or ordinal directions, rotating in an attempt to hit Isaac.
Maze Roamer
Maze Roamer
890.0 Wanders around the room and shoots an eyeball at Isaac when he is in sight. Has a clone of itself on the other side of the room that mimics its movement and shots. If one dies, the other starts actively pursuing Isaac.
Holy Bony
Holy Bony
227.1 Wanders around the room, throwing a bone at Isaac when he is in sight. The thrown bone leaves behind a blue flame that deals contact damage, blocks Isaac’s shots, and despawns after some time.
Planetoid
Planetoid
229.1 Moves around the room diagonally, occasionally firing blood shots that orbit itself. Fires more shots and has a chance to send its ring of shots outward upon taking damage.
Poofer
Poofer
892.0 Slowly floats toward Isaac, swells up and fire 6 blood shots in all direction upon taking damage. Explodes upon death, healing nearby enemies and leaving a big puddle of red creep.
Bishop
Bishop
805.0 Shields all enemies in the room, preventing them from taking damage. Fires shots in the cardinal directions when it takes damage.
Goat
Goat
891.0 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines up on either side of it.
Black Goat
Black Goat
891.1 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines upon either side of it. Can also fire thin 15►Brimstone Brimstone lasers in the cardinal directions, along with all other Black Goats in the room.
Cultist
Cultist
885.0 Creates an indestructible, homing Purple Ball at the start of the room and follows it around, occasionally leaving it to revive enemies that have died in the current room.
Blood Cultist
Blood Cultist
885.1 Wanders around the room and fires a line of blood shots and creep if Isaac is on either side of it. Can summons bone traps that temporarily ensnare Isaac if he walks into them.
Soy Creep
Soy Creep
240.1 Slowly crawls along walls to try to line up with Isaac and shoots a stream of shots seemingly affected by 15►Soy Milk Soy Milk.
Tainted Soy Creep
Tainted Soy Creep
240.3 Slowly crawls along walls to try to line up with Isaac and shoots a 4 diagonal streams of 15►Soy Milk Soy Milk shots.
Fire Worm
Fire Worm
825.0 Pops out of the ground in random locations and fires one flame at Isaac.
Tainted Round Worm
Tainted Round Worm
244.2 Pops out of the ground in random locations alongside several tail ends. The head fires a large blood shot that splits into a radial burst of 8 blood shots, while the tail ends shoot normal blood shots.
Tainted Tube Worm
Tainted Tube Worm
244.3 Pops out of the ground in random locations, spitting 4 explosive shots towards Isaac.
Mole
Mole
829.0 Burrows towards Isaac and jumps out the ground to fire 3 blood shots at him.
Tainted Mole
Tainted Mole
829.1 Dig towards Isaac and release a ring of rock waves. Fires 3 blood shots at Isaac 4 times.
Polty
Polty
816.0 Picks up and throws rocks and props at Isaac.
Kineti
Kineti
816.1 Uses telekinesis to pick up and throw rocks and obstacles at Isaac.
Dust
Dust
882.0 Follows Isaac, and is only visible when close to Isaac. Will begin to speed up when they are visible. Teleports away after taking enough damage.
Fly Trap
Fly Trap
873.0 Floats towards Isaac, with 3 Attack Flies circling around it. Coughs up additional Attack Flies and releases gas to launch the Attack Flies outwards.
Poot Mine
Poot Mine
875.0 Creates a gas cloud and propels itself away from Isaac when it gets hit. Explodes on death, detonating all the gas clouds it created.
Bombgagger
Bombgagger
844.0 Spits up a Giga Bomb and runs away from it.
Flesh Maiden
Flesh Maiden
880.0 Vaguely flies towards Isaac in curved swooping motions.
Morningstar
Morningstar
863.0 Floats toward Isaac to deal contact damage while Isaac is moving, gaining speed the longer Isaac continues moving. Stops moving when Isaac stops moving.
Needle
Needle
881.0 Pops out of the ground and lunges towards Isaac, dealing contact damage.
Pasty
Pasty
881.1 Pops out of the ground and lunges toward Isaac, dealing contact damage and firing four shots in the ordinal directions.
Fissure
Fissure
815.0 Jumps out of pits and bounces around the room. Spawns endlessly from pits until room clear. Do not need to be killed to clear room.
Lil Portal
Lil Portal
306.1 Spawns fly and spider enemies until it is destroyed.
Henry
Henry
837.0 Flushes away instantly when Isaac enters the room.
Triple Grimace
Triple Grimace
42.2 Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.
Quake Grimace
Quake Grimace
804.0 Stationary and invulnerable monster that jumps and fires a line of rocks in one direction upon landing.
Bomb Grimace
Bomb Grimace
809.0 Stationary and invulnerable monster that keeps a single Throwable Bomb spawned.
Mockulus
Mockulus
864.0 Rapidly bounces around the room diagonally while Isaac is shooting.
Grudge
Grudge
877.0 Quickly slides towards Isaac when he gets in its line of sight. Cannot be destroyed.
Ball and Chain
Ball and Chain
893.0 Spike balls that rotate at the end of a chain attached to an obstacle. If the obstacle is destroyed, the ball will fly free around the room for a while.
Spikeball
Spikeball
852.0 Spike balls that fly in a line either horizontally or vertically, bouncing off walls and obstacles.
Singe's Ball
Singe's Ball
915.1 Spawned exclusively as apart Singe's boss fight and used in his attacks. They can be pushed around and launched with explosions.
Ultra Death Scythe
Ultra Death Scythe
951.41 Stays stationary for a moment, then travels in straight lines towards Ultra Death.
Siren Minion
Siren Minion
3.220 Spawned in automatically charmed by The Siren. Orbits the boss and fires projectiles towards Isaac.
Siren Helper
Siren Helper
966.0 Spawned in by The Siren and takes the form and control of all of her charmed familiars.
Visage Plasma
Visage Plasma
903.20 Floats in diagonal directions, doing contact damage. Spawned by The Visage and used in its phase 3 attacks.

Champions[]

ID Appearance Effect Drop Rarity Notes
24 Champion Brown.png

Brown

Trails poop behind it as it walks. Nothing Unknown
25 50px

Rainbow

Combines the effects of champion types 0, 2, 5, 10, 11, 13 and 17. A coin, a bomb, a key, a heart, a pill, a card and a trinket. Unknown

Audio[]

  • The Music is once again composed by Ridiculon.
    • Whilst not being in the official release, a fully updated Antibirth soundtrack may be released by Mudeth as a mod.

Environment[]

Chapters[]

Downpour Dross
Downpour Dross
Mines Ashpit
Mines Ashpit
Mausoleum Gehenna
Mausoleum Gehenna
Corpse Home
Corpse Home

Obstacles[]

  • Rocks
    • Spiked Rocks
    • Marked Skulls
    • Buckets
    • Fool's Gold Rocks
  • Poops
    • Giant Poop
    • Charming Poop
  • Fire Places
    • White Fire Place
  • Blocks
    • Pillars
  • Buttons
    • Red Buttons
    • Yellow Buttons
    • Brown Buttons
  • Teleporters

Rooms[]

Challenges[]


Changes[]

The Repentance DLC brings with it many changes to old content in the previous game. For a list of changes, see the V1.06.J787 page.

Video previews[]


Collectible Broken Modem icon.png Version History Collectible Broken Modem icon.png
Rebirth v0.9, v1.0, v1.01, v1.02, v1.031, v1.032, v1.04, v1.041, v1.05 (Hotfix)

Afterbirth
v1.06, v1.06 Hotfix, v1.06.0051, v1.06.0052, v1.06.0059, v1.06.0060, v1.06.0067, v1.06.0076, v1.06.0109

Afterbirth †
v1.06.0180, v1.06.0181, v1.06.0182, v1.06.0183, v1.06.0185, v1.06.0187, v1.06.0188, v1.06.0190, v1.06.0192 (Re-release), v1.06.0193, v1.06.0211
Booster Pack #1 v1.06.J34, v1.06.J39
Booster Pack #2 v1.06.J75, v1.06.J85
Booster Pack #3 v1.06.J99, v1.06.J103, v1.06.J104
Booster Pack #4 v1.06.J113, v1.06.J114, v1.06.J119, v1.06.J127
Booster Pack #5 v1.06.J149, v1.06.J150, v1.06.J168
Repentance v1.06.J787, v1.06.J791, v1.06.J796, v1.06.J813, v1.06.J818, v1.06.J820
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets