Binding of Isaac: Rebirth Wiki
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Binding of Isaac: Rebirth Wiki

Playable Characters[]

Character Character Bethany appearance.png
Bethany Bethany
Character Jacob and Esau appearance.png
Jacob and Esau Jacob and Esau
Jacob Jacob Esau Esau
Health Stat Icon.png Health Full red heartFull red heartFull red heart Full red heartFull red heartFull red heart Full soul heartFull red heart
Damage Stat Icon.png Damage 3.5 (*1.00) 2.75 (*1.50) 3.75 (*1.00)
Tears Stat Icon.png Tears +0 3.00 2.50
Shot Speed Stat Icon.png Shot Speed 1 1.15 0.85
Range Stat Icon.png Range 6.5 5.00 8.00
Speed Stat Icon.png Speed 1.0 1.00 1.00
Luck Stat Icon.png Luck 0 1.00 -1.00
Starting Item Icon.png Starting Pickups 4 Soul Charges None None
Starting Item Icon.png Starting Item(s) Collectible Book of Virtues icon.pngBook of Virtues None None

There is also a "tainted character" for each existing playable character (including Bethany Bethany and Jacob and Esau Jacob and Esau) which can be unlocked by finding a hidden room on the new stage "Home Home". Because of that, the total number of playable characters in the game is 34.

Items and Trinkets[]

Activated Collectibles[]

Name ID Icon Quote Description Added in Repentance Quality
Added in Repentance Abyss 5.100.706
Abyss
4 rooms
Come forth from the depths Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. 4
Added in Repentance Alabaster Box 5.100.585
Alabaster Box
12 rooms
A sacred offering Spawns three soul hearts and two Angel room items and is consumed. Starts with no charges, and can only be charged by picking up 6 soul hearts. 2
Added in Repentance Anima Sola 5.100.722
Anima Sola
15 seconds
Repent Chains down the nearest enemy for 5 seconds, preventing them from acting. 2
Added in Repentance Bag of Crafting 5.100.710
Bag of Crafting
Unlimited
Make your destiny Collects and holds up to 8 pickups. Holding the activate button crafts them into a passive item, with the power level based on the quality of pickups used. 3
Added in Repentance Berserk! 5.100.704
Berserk!
With damage dealt
Rip and tear Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms. 3
Added in Repentance Book of Virtues 5.100.584
Book of Virtues
4 rooms
Spiritual companionship On use, spawns an orbital Wisp familiar that fires spectral tears but can be destroyed. Also becomes a passive item that causes other active items to spawn themed Wisps. 3
Added in Repentance Broken Glass Cannon 5.100.474
Broken Glass Cannon
4 rooms
You broke it! Begins with no charges and turns into 15►Glass Cannon Glass Cannon when used. Only acquired by taking damage while holding Glass Cannon. 0
Added in Repentance Clear Rune 5.100.263
Clear Rune
Variable
Rune mimic Has the same effect as the rune or soul stone currently held by Isaac. 2
Added in Repentance Damocles 5.100.577
Damocles
One time use
A king's fortune... but at what cost? Spawns a sword above Isaac's head, which doubles all item pedestals. After Isaac takes damage, the sword can randomly fall at any point, instantly killing him. 2
Added in Repentance Dark Arts 5.100.705
Dark Arts
6 seconds
One with the shadows Makes Isaac invulnerable and intangible for one second. When the effect ends, all enemies Isaac ran through take damage and Isaac temporarily gains +1 damage for each one. 2
Added in Repentance Death Certificate 5.100.628
Death Certificate
One time use
Where am I? Takes Isaac to an abandoned and expanded version of Home, which has one copy of every item in the game. After taking an item, Isaac returns to the room he used Death Certificate in. 4
Added in Repentance Decap Attack 5.100.729
Decap Attack
4 seconds
Chuck away! Throws Isaac's head, which is still able to fire tears at the spot it lands. Reactivating the item or stepping on the head reattaches it. 2
Added in Repentance Eraser 5.100.638
Eraser
1 rooms
Erase thy enemy Throws an eraser that instantly kills the first monster it hits, and prevents that monster from spawning for the rest of the run. Can only be used once per floor. 2
Added in Repentance Esau Jr. 5.100.703
Esau Jr.
1 rooms
Lost brother Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run. 2
Added in Repentance Eternal D6 5.100.609
Eternal D6
2 rooms
??? Rerolls all items in the room. Each item has a chance to disappear instead. 2
Added in Repentance Everything Jar 5.100.720
Everything Jar
12 rooms
Anything is possible Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. 2
Added in Repentance Flip 5.100.711
Flip
6 rooms
Life and death Switch characters between Tainted Lazarus and Dead Tainted Lazarus. 3
Added in Repentance Fortune Cookie 5.100.557
Fortune Cookie
2 rooms
Reusable fortunes Gives Isaac a fortune, soul heart, tarot card, or trinket. 2
Added in Repentance Free Lemonade 5.100.578
Free Lemonade
4 rooms
Party time! Creates a large pool of yellow creep beneath Isaac. 2
Added in Repentance Friend Finder 5.100.687
Friend Finder
4 rooms
Best friends forever! Spawns a random friendly monster that mimics Isaac's movements and attacks. 3
Added in Repentance Gello 5.100.728
Gello
2 rooms
Demonic gestation Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects. 2
Added in Repentance Genesis 5.100.622
Genesis
One time use
In the beginning Removes all of Isaac's items and pickups and takes him to a unique bedroom with some pickups and chests and a trapdoor to the next floor. For every item Isaac lost, he gets to take an item from a set of three. 2
Added in Repentance Golden Razor 5.100.555
Golden Razor
Unlimited
Pain from gain Spends five coins to increase Isaac's damage by 1.2 for the current room. 2
Added in Repentance Hold 5.100.715
Hold
Unlimited
Saved for later Exclusive to Tainted ??? Tainted ???. Allows him to save one poop bomb for later, allowing him to gather more over time. 0
Added in Repentance Jar of Wisps 5.100.685
Jar of Wisps
12 rooms
Your faith grows Spawns random wisps that shoot various tears, block shots, and deal contact damage. The number of wisps spawned increases every time the jar is used. 2
Added in Repentance Keeper's Box 5.100.719
Keeper's Box
4 rooms
Portable shop Spawns a random shop item or pickup which can be bought for its normal price. 3
Added in Repentance Larynx 5.100.611
Larynx
12 rooms
Hear my pain Isaac shouts, damaging and pushing away nearby enemies. The shout gets stronger the more charges the item has. Can also be charged by taking damage. 2
Added in Repentance Lemegeton 5.100.712
Lemegeton
6 rooms
Item summoner Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects. 3
Added in Repentance Magic Skin 5.100.642
Magic Skin
6 rooms
All your desires fulfilled Consumes one heart container or two soul hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items. 2
Added in Repentance Meat Cleaver 5.100.631
Meat Cleaver
2 rooms
Slice but no dice Splits all enemies in the room into two smaller versions of themselves with much less health. 1
Added in Repentance Mega Mush 5.100.625
Mega Mush
12 rooms
I'm a big boy now! Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms. 4
Added in Repentance Mom's Bracelet 5.100.604
Mom's Bracelet
Unlimited
Mother's strength Lets Isaac pick up and throw rocks, TNT, poops, and other obstacles. 2
Added in Repentance Plum Flute 5.100.650
Plum Flute
4 rooms
Play time! Summons the boss Baby Plum to fight for Isaac in the current room. 2
Added in Repentance R Key 5.100.636
R Key
One time use
Time to start over Brings Isaac back to the first floor of a new run, retaining all of his items. 4
Added in Repentance Recall 5.100.714
Recall
3 seconds
Come back Retrieves the Forgotten's body from any distance. Only available as the 15►Birthright Birthright effect for Tainted Forgotten Tainted Forgotten. 0
Added in Repentance Red Key 5.100.580
Red Key
4 rooms
Explore the other side Creates a new room adjacent to a viable wall, indicated by the outline of a door. These rooms have a chance to be various special rooms. 3
Added in Repentance Sharp Key 5.100.623
Sharp Key
Unlimited
Open your enemies Adds 5 keys on pickup. Allows Isaac to throw his keys to deal damage to enemies, destroy obstacles, and open doors. 1
Added in Repentance Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Added in Repentance Spindown Dice 5.100.723
Spindown Dice
6 rooms
-1 Transforms all items in the room by decreasing their internal ID number. 4
Added in Repentance Stitches 5.100.635
Stitches
3 seconds
Bait and switch Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. 1
Added in Repentance Sulfur 5.100.556
Sulfur
3 rooms
Temporary demon form Grants 15►Brimstone Brimstone for the current room. 2
Added in Repentance Sumptorium 5.100.713
Sumptorium
1 seconds
Return Holding down the fire button converts hearts into familiars that fire tears but can be destroyed. Activating converts the familiars back into hearts. 3
Added in Repentance Suplex! 5.100.709
Suplex!
6 seconds
Angel breaker Isaac dashes forward and picks up the first enemy hit. After a moment, he slams them into the ground to deal damage and create a circular rock wave. 3
Added in Repentance The Scooper 5.100.605
The Scooper
3 rooms
Plop! Summons a Peeper familiar for the current room, which leaves a trail of red creep. 0
Added in Repentance Urn of Souls 5.100.640
Urn of Souls
Unlimited
Unleash their sorrow Spews a stream of damaging flame. Gains Soul Charges each time an enemy dies, which are used to fuel the urn. 3
Added in Repentance Vade Retro 5.100.653
Vade Retro
Unlimited
Begone! While held, enemies leave behind ghosts on death. Using the item causes the ghosts to explode, dealing damage to nearby enemies. Stronger enemies leave bigger ghosts. 3
Added in Repentance Wavy Cap 5.100.582
Wavy Cap
0.5 seconds
Tears up. A mind changing experience! Increases tears, decreases speed, and distorts the screen. All effects become more pronounced with repeated use, and wear off by clearing rooms. 1
Added in Repentance Yuck Heart 5.100.639
Yuck Heart
6 rooms
Gross! Gives Isaac a Rotten Heart. 3

Passive Collectibles[]

Name ID Icon Quote Description Added in Repentance Quality
Added in Repentance 120 Volt 5.100.559 120 Volt Zap! Repeatedly zaps enemies that are close to Isaac. 3
Added in Repentance 2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear. 2
Added in Repentance 4.5 Volt 5.100.647 4.5 Volt Beat the juice out of them! Active items don't charge when clearing rooms. Instead, they're charged by dealing damage to enemies. 2
Added in Repentance A Bar of Soap 5.100.564 A Bar of Soap Tears + shot speed up Gives Isaac +0.5 Tears and +0.2 Shot Speed. 3
Added in Repentance A Pound of Flesh 5.100.672 A Pound of Flesh Blood money Devil deals now cost coins, shop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Added in Repentance Act of Contrition 5.100.601 Act of Contrition Tears up, you feel forgiven Increases tears and grants an Eternal Heart. Allows Angel Rooms to appear even if a Devil deal has been taken before. Greatly boosts Devil/Angel Deal chance if Isaac has taken Red Heart damage. 3
Added in Repentance Akeldama 5.100.641 Akeldama Spill your guts While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies. 2
Added in Repentance Almond Milk 5.100.561 Almond Milk DMG down + tears up + you feel nutty Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects. 1
Added in Repentance Astral Projection 5.100.677 Astral Projection The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Added in Repentance Azazel's Rage 5.100.699 Azazel's Rage Ancient power Isaac builds rage every time a room is cleared. After four rooms, fires a large 15►Brimstone Brimstone laser when entering the next room. 3
Added in Repentance Battery Pack 5.100.603 Battery Pack Instant energy! Recharges Isaac's currently held active item and drops 2-4 batteries. 1
Added in Repentance Belly Jelly 5.100.690 Belly Jelly Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 2
Added in Repentance Binge Eater 5.100.664 Binge Eater All you can eat +1 red heart container and fully heals Isaac. Item pedestals cycle between their normal items and food, and collecting food grants a temporary damage boost and permanent bonuses to 2 stats. 3
Added in Repentance Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to 15►Dead Bird Dead Bird. 1
Added in Repentance Bird's Eye 5.100.616 Bird's Eye It burns Gives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them. 2
Added in Repentance Birthright 5.100.619 Birthright ??? Has a different effect for each character. 2
Added in Repentance Blood Bombs 5.100.614 Blood Bombs Bloody blast + HP up Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any. 1
Added in Repentance Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Added in Repentance Blood Puppy 5.100.565 Blood Puppy What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal. 2
Added in Repentance Bloody Gust 5.100.695 Bloody Gust May your rage bring haste When Isaac takes damage, he gains speed and tears for the rest of the floor. 3
Added in Repentance Boiled Baby 5.100.607 Boiled Baby Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
Added in Repentance Bone Spurs 5.100.683 Bone Spurs Break your enemies Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them. 2
Added in Repentance Booster Pack 5.100.624 Booster Pack Collect them all! Spawns 5 random cards. 1
Added in Repentance Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Added in Repentance Brimstone Bombs 5.100.646 Brimstone Bombs Demon blast +5 bombs Gives Isaac +5 bombs and causes his bombs to fire 15►Brimstone Brimstone lasers in the cardinal directions upon exploding. 3
Added in Repentance C Section 5.100.678 C Section Fetus shots Not fully implemented. 4
Added in Repentance Candy Heart 5.100.671 Candy Heart Power of love Gives Isaac a permanent stat boost whenever he heals with red heart pickups. 2
Added in Repentance Card Reading 5.100.660 Card Reading A link to your future Spawns two portals that each lead to either the Boss Room, Secret Room, or Treasure Room at the beginning of each floor. 3
Added in Repentance Consolation Prize 5.100.644 Consolation Prize +1 to lowest stat Increases Isaac's lowest stat and drops either 3 coins, 1 bomb, or 1 key depending on what Isaac has the least of. 1
Added in Repentance Cracked Orb 5.100.675 Cracked Orb Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Added in Repentance Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Added in Repentance Dad's Note 5.100.668 Dad's Note ... Begins the sequence to access Home. 0
Added in Repentance Dirty Mind 5.100.576 Dirty Mind Filthy friends Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. 2
Added in Repentance Divine Intervention 5.100.568 Divine Intervention Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. 2
Added in Repentance Dogma 5.100.633 Dogma Ascended Grants flight, +0.1 speed, +2 damage, and the 15►Holy Mantle Holy Mantle effect. Grants enough health to have 6 full hearts, if possible. Automatically given to Isaac after defeating Dogma. 0
Added in Repentance Dream Catcher 5.100.566 Dream Catcher Sweet dreams During the transition between floors, Isaac's nightmare shows the floor's Treasure Room item and boss. Grants half a soul heart when entering a new floor. 2
Added in Repentance Echo Chamber 5.100.700 Echo Chamber I can see see the future future future When Isaac uses a card, pill, or rune, he also uses a copy of every card/pill/rune he used after picking up Echo Chamber. 2
Added in Repentance Empty Heart 5.100.676 Empty Heart It multiplies If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container. 2
Added in Repentance Evil Charm 5.100.632 Evil Charm Luck up + you feel protected Increases luck by 2.0. Provides immunity to burn, confusion, fear, and poison. 1
Added in Repentance Eye Drops 5.100.600 Eye Drops Tears up Lowers the tear delay in Isaac's left eye, causing his eyes to fire at different rates. 3
Added in Repentance Eye of the Occult 5.100.572 Eye of the Occult DMG up + range up + controlled tears Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed. 3
Added in Repentance Eye Sore 5.100.558 Eye Sore More eyes Causes Isaac to occasionally fire extra tears in random directions while shooting. 2
Added in Repentance False PHD 5.100.654 False PHD Worse pills + evil up Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart. 2
Added in Repentance Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Added in Repentance Fruity Plum 5.100.649 Fruity Plum Bouncy friend Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. 1
Added in Repentance Ghost Bombs 5.100.727 Ghost Bombs Spooky blast +5 bombs +5 bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. 2
Added in Repentance Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies. 1
Added in Repentance Glitched Crown 5.100.689 Glitched Crown ????? Before being picked up, item pedestals cycle between 5 random items. 4
Added in Repentance Guppy's Eye 5.100.665 Guppy's Eye An eye for secrets Shows the contents of Chests, Sacks, and Fire Places before they're opened. 2
Added in Repentance Heartbreak 5.100.694 Heartbreak Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Added in Repentance Hemoptysis 5.100.726 Hemoptysis Double tap sneeze Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. 3
Added in Repentance Hungry Soul 5.100.684 Hungry Soul Out for blood Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. 3
Added in Repentance Hypercoagulation 5.100.724 Hypercoagulation Thick blooded After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds. 3
Added in Repentance IBS 5.100.725 IBS Your stomach rumbles Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies. 2
Added in Repentance Immaculate Heart 5.100.573 Immaculate Heart Halo of tears Adds one red heart container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him. 3
Added in Repentance Inner Child 5.100.688 Inner Child Let him free Upon death, Isaac respawns in the current room with half a heart left, a massive size down, and +0.2 speed. 3
Added in Repentance Isaac's Tomb 5.100.701 Isaac's Tomb Buried memories Spawns an Old Chest at the start of each floor. 3
Added in Repentance It Hurts 5.100.560 It Hurts No it doesn't... Releases a ring of tears and increases tears for the current room when Isaac takes damage. 1
Added in Repentance Jupiter 5.100.594 Jupiter You're a gas giant! +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves afterwards. 3
Added in Repentance Keeper's Kin 5.100.717 Keeper's Kin Under a rock Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
Added in Repentance Keeper's Sack 5.100.716 Keeper's Sack Spending power Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a key on pickup. 3
Added in Repentance Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with 15►Knife Piece 2 Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Added in Repentance Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with 15►Knife Piece 1 Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Added in Repentance Knockout Drops 5.100.637 Knockout Drops They pack a punch! Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies. 3
Added in Repentance Lil Abaddon 5.100.679 Lil Abaddon Abyssal friend Spawns a familiar that charges a miniature 15►Maw of the Void Maw of the Void attack while Isaac shoots. 3
Added in Repentance Lil Dumpy 5.100.615 Lil Dumpy Puffy buddy Gives Isaac a Dumpy familiar that pushes, confuses, or poisons nearby enemies and flies in a random direction after taking damage. 0
Added in Repentance Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Added in Repentance Lodestone 5.100.617 Lodestone Magnetizing tears Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources. 3
Added in Repentance Lost Soul 5.100.612 Lost Soul Protect him Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items. 2
Added in Repentance Luna 5.100.589 Luna The moon's blessing shines upon you Adds an extra Secret Room and Super Secret Room to each floor. Secret Rooms contain a beam of light that increases tears for the current floor and gives half a soul heart. 2
Added in Repentance Mars 5.100.593 Mars Double tap dash Dash by double-tapping the movement key, becoming invulnerable and damaging enemies. There's a short cooldown before Isaac can dash again. 2
Added in Repentance Member Card 5.100.602 Member Card Exclusive access! Adds a trapdoor to every shop that leads to a second shop with a unique stock and marked-up prices. 1
Added in Repentance Mercurius 5.100.590 Mercurius Speed up + you feel elusive +0.4 speed. Doors stay open after entering a room, even in rooms with enemies. 3
Added in Repentance Monstrance 5.100.574 Monstrance Purifying light Isaac gains an aura that deals damage to enemies inside it. 2
Added in Repentance Montezuma's Revenge 5.100.680 Montezuma's Revenge Oh no... While firing, Isaac charges up a short-ranged 15►Brimstone Brimstone-like diarrhea beam that shoots behind him. 3
Added in Repentance Mucormycosis 5.100.553 Mucormycosis Spore shot Gives Isaac the chance to fire spore tears that stick to enemies and blow up after a few seconds, dealing damage and poisoning nearby enemies and releasing more spores. 3
Added in Repentance Nancy Bombs 5.100.563 Nancy Bombs Random blast +5 bombs Gives Isaac +5 bombs and gives his bombs random bomb synergies. 1
Added in Repentance Neptunus 5.100.597 Neptunus Open the floodgates Isaac's mouth fills with tears over time while not firing, up to a cap. Holding the fire button will release all stored tears in rapid succession. 3
Added in Repentance Ocular Rift 5.100.606 Ocular Rift Stare into the abyss Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources. 3
Added in Repentance Options? 5.100.670 Options? There might be options If a room gives a reward when cleared, there will be two different rewards to chose from. Taking one causes the other to disappear. 2
Added in Repentance Orphan Socks 5.100.571 Orphan Socks Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 soul hearts. 1
Added in Repentance Paschal Candle 5.100.567 Paschal Candle Keep the flame burning Gives Isaac a tears bonus based on how many consecutive rooms he's cleared without taking damage. 3
Added in Repentance Playdough Cookie 5.100.570 Playdough Cookie Tasty rainbow Grants multicolored tears. Each color comes with a different status or tear effect. 3
Added in Repentance Pluto 5.100.598 Pluto Size down Significantly shrinks Isaac, allowing him to squeeze between objects and makes some enemy shots pass over him. Also gives +0.7 tears. 3
Added in Repentance Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears. 3
Added in Repentance Purgatory 5.100.634 Purgatory Help from beyond While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. 2
Added in Repentance Quints 5.100.661 Quints They lurk inside The first five enemies killed in a room will spawn stationary shooting familiars where they died. 1
Added in Repentance Red Stew 5.100.621 Red Stew Full HP + temporary DMG up Refills all heart containers. Grants an enormous damage boost that wears off over time. 0
Added in Repentance Redemption 5.100.673 Redemption Deliver me from evil Gives Isaac a soul heart and +1 damage if he goes into a Devil Room but doesn't take anything from it. 2
Added in Repentance Revelation 5.100.643 Revelation Awaken your faith Grants flight and two soul hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser. 4
Added in Repentance Rock Bottom 5.100.562 Rock Bottom It's only up from there Locks Isaac's attributes to their highest values reached. 2
Added in Repentance Rocket in a Jar 5.100.583 Rocket in a Jar Rocket propulsion +5 bombs +5 bombs. If Isaac is currently moving, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing. 2
Added in Repentance Rotten Tomato 5.100.618 Rotten Tomato Delicious! Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies. 1
Added in Repentance Sacred Orb 5.100.691 Sacred Orb Destined for greatness Prevents low-quality items from spawning, greatly increasing the quality of items received from all item pools. 4
Added in Repentance Salvation 5.100.696 Salvation Divine protection Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor. 2
Added in Repentance Sanguine Bond 5.100.692 Sanguine Bond He awaits your offering Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward. 1
Added in Repentance Saturnus 5.100.595 Saturnus Ring of tears Upon entering a room, a circle of tears orbits Isaac. Enemy tears have a chance to be caught in orbit, turning them friendly. 1
Added in Repentance Sausage 5.100.669 Sausage All stats up Adds a Red Heart container, and increases speed, damage, tears, range, shot speed, and luck. 3
Added in Repentance Sol 5.100.588 Sol Radiant victory Reveals the location of the Boss room. Upon defeating a boss, activates XIX - The Sun, fully recharges Isaac's active item, grants bonus damage and luck for the rest of the floor, and removes curses. 2
Added in Repentance Soul Locket 5.100.686 Soul Locket Power of faith Gives Isaac a permanent stat boost whenever he picks up a soul heart. 2
Added in Repentance Spirit Shackles 5.100.674 Spirit Shackles Unfinished business On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a soul heart. 3
Added in Repentance Spirit Sword 5.100.579 Spirit Sword Divine blade Instead of tears, Isaac swings a sword. Charging does a spin attack and fires a projectile, and a projectile is sometimes fired with normal swings if Isaac has no empty red hearts. 3
Added in Repentance Stapler 5.100.708 Stapler DMG up +1 damage. Prevents Isaac from firing tears from one eye, like Cain. 3
Added in Repentance Star of Bethlehem 5.100.651 Star of Bethlehem Follow the light Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing tears. 2
Added in Repentance Strawman 5.100.667 Strawman A helping hand Spawns Keeper to fight enemies alongside Isaac. If Keeper dies, he spawns blue spiders and Strawman is removed from Isaac's inventory. 2
Added in Repentance Supper 5.100.707 Supper HP up Grants one full Red Heart container. Heals 1 additional heart of health. 1
Added in Repentance Terra 5.100.592 Terra Born to rock Replaces tears with rocks that deal variable damage, have increased knockback, and can destroy obstacles. 3
Added in Repentance The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
Added in Repentance The Stairway 5.100.586 The Stairway May you get what you came for Generates a ladder at the start of every floor that leads to a unique Angel Room shop. 3
Added in Repentance The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Added in Repentance Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Added in Repentance TMTRAINER 5.100.721 TMTRAINER ZZaZZ ZZdZZiZZmZZhZZ ZZvZZ ZZoZZ ZZ ZZsZZlZZhZZsZZoZZaZZiZZ Causes all future items to be "glitched", granting them completely random effects. 2
Added in Repentance Tooth and Nail 5.100.663 Tooth and Nail You feel prickly Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage. 2
Added in Repentance Tropicamide 5.100.659 Tropicamide Tear size + range up +1.5 range, Increases tear size. 1
Added in Repentance Twisted Pair 5.100.698 Twisted Pair Double trouble! Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. 4
Added in Repentance Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. 3
Added in Repentance Vanishing Twin 5.100.697 Vanishing Twin He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. 3
Added in Repentance Vasculitis 5.100.657 Vasculitis Clogged enemies Enemies explode into tears upon death, which inherit the effects of Isaac's tears. 2
Added in Repentance Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 2
Added in Repentance Venus 5.100.591 Venus HP up + you feel pretty Adds one red Heart container. Enemies near Isaac become charmed. 1
Added in Repentance Voodoo Head 5.100.599 Voodoo Head Extra curse rooms Spawns an additional curse room on each floor. 1
Added in Repentance Worm Friend 5.100.682 Worm Friend Clingy buddy Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time. 2


Trinkets[]

Name ID Icon Quote Description
Added in Repentance 'M 5.350.138 'M t's broken9Reroll your dest Using an activated item rerolls it.
Added in Repentance A Lighter 5.350.135 A Lighter Watch the world burn Adds a chance for enemies to burn upon entering a room.
Added in Repentance Adoption Papers 5.350.184 Adoption Papers Give them a home Shops can sell familiars, which will always be at a discounted price.
Added in Repentance Apollyon's Best Friend 5.350.186 Apollyon's Best Friend Attack buddy Spawns an attack locust familiar which will fly forward while Isaac shoots.
Added in Repentance Apple of Sodom 5.350.140 Apple of Sodom It feels empty Picking up red hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing.
Added in Repentance Azazel's Stump 5.350.162 Azazel's Stump Unleash your inner demon When clearing a room, adds a chance to turn into Azazel until clearing another.
Added in Repentance Beth's Essence 5.350.182 Beth's Essence Virtue's reward Upon entering an Angel Room, spawns 5 wisp orbitals. Giving money to beggars can spawn wisps.
Added in Repentance Beth's Faith 5.350.142 Beth's Faith My faith protects me At the beginning of each floor, spawn 4-8 wisps that orbit Isaac and fires tears alongside him.
Added in Repentance Blessed Penny 5.350.131 Blessed Penny Wealth of purity Gives a chance to drop a Half Soul Heart when a coin is collected.
Added in Repentance Blue Key 5.350.150 Blue Key Look between the rooms Doors can be unlocked without using keys. Opening a door this way brings Isaac to an in-between room that resembles ??? ???, with a few monsters.
Added in Repentance Brain Worm 5.350.144 Brain Worm Ding! Tears snap 90 degrees to target enemies that they may have missed.
Added in Repentance Broken Glasses 5.350.187 Broken Glasses Double vision? Gives a 33% chance to add a '?' item to Treasure Rooms. Only one item can be taken. The extra items on the alt path are revealed instead.
Added in Repentance Broken Padlock 5.350.136 Broken Padlock Bombs are key Locks can be opened with explosions.
Added in Repentance Broken Syringe 5.350.132 Broken Syringe Mystery medicine Grants a chance to gain a random syringe effect for the current room.
Added in Repentance Charged Penny 5.350.147 Charged Penny Wealth of power Picking up coins has a chance to give an Active Item charge.
Added in Repentance Chewed Pen 5.350.130 Chewed Pen It's leaking Adds a chance to fire tears that slow enemies.
Added in Repentance Cricket Leg 5.350.185 Cricket Leg Infested Adds a chance to spawn a random locust when killing an enemy.
Added in Repentance Crystal Key 5.350.170 Crystal Key Call to the other side Adds a chance to automatically create Red Key rooms after clearing a room.
Added in Repentance Cursed Penny 5.350.172 Cursed Penny Wealth of misery Picking up coins teleports Isaac to a random room.
Added in Repentance Devil's Crown 5.350.146 Devil's Crown His special customer Treasure Rooms are replaced with unique Red Treasure Rooms, offering a Deal with the Devil in place of an item.
Added in Repentance Dice Bag 5.350.154 Dice Bag Bonus roll When Isaac enters a new room, has a chance to give him a Dice item as a consumable for the current room.
Added in Repentance Dingle Berry 5.350.163 Dingle Berry Oops! Spawns a Dip Familiar upon clearing a room.
Added in Repentance Expansion Pack 5.350.181 Expansion Pack Fun extras Once per room, using an active item triggers another random active item effect.
Added in Repentance Flat File 5.350.151 Flat File No more spikes Causes all spikes to retract, making them harmless. Also affects the doors to Curse Rooms.
Added in Repentance Forgotten Lullaby 5.350.141 Forgotten Lullaby Sing for your friends Improves the fire rate of Isaac's familiars.
Added in Repentance Found Soul 5.350.180 Found Soul Finally! Spawns a familiar that copies Isaac's movements and scales with damage and tears. If it takes damage, it will die and respawn on the next floor.
Added in Repentance Friendship Necklace 5.350.148 Friendship Necklace Gather round Causes familiars to orbit Isaac.
Added in Repentance Gigante Bean 5.350.134 Gigante Bean Mega farts Increases the size of Isaac's farts.
Added in Repentance Gilded Key 5.350.159 Gilded Key Less is more Replaces all new chests, except Mega Chests, with Locked Chests.
Added in Repentance Hollow Heart 5.350.168 Hollow Heart A brittle blessing Grants an empty bone heart upon entering a new floor.
Added in Repentance Holy Crown 5.350.155 Holy Crown Walk the path of the saint A Treasure Room and Shop appears in the Cathedral Cathedral.
Added in Repentance Ice Cube 5.350.188 Ice Cube Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.
Added in Repentance Jawbreaker 5.350.129 Jawbreaker Don't chew on it Adds the chance to fire teeth that deal 3.2x damage, similar to 15►Tough Love Tough Love.
Added in Repentance Keeper's Bargain 5.350.171 Keeper's Bargain Money talks Devil Deals cost money instead of health.
Added in Repentance Kid's Drawing 5.350.169 Kid's Drawing Looks familiar... While held, counts towards the Guppy transformation.
Added in Repentance Lil Clot 5.350.176 Lil Clot Mini friend Spawns a clot familiar that mimics Isaac's movements and tears. It dies for the current room after taking too much damage.
Added in Repentance Lucky Sack 5.350.160 Lucky Sack Free goodies! Spawns a Grab Bag upon traveling to the next floor.
Added in Repentance Modeling Clay 5.350.166 Modeling Clay ??? Grants the effect of a random passive Item each room.
Added in Repentance Mom's Lock 5.350.153 Mom's Lock A piece of her love Grants the effects of a random Mom item each room.
Added in Repentance Mother's Kiss 5.350.156 Mother's Kiss HP up Grants one heart container.
Added in Repentance Myosotis 5.350.137 Myosotis Forget me not... When entering a new floor, up to four uncollected pickups from the previous floor spawn in the starting room.
Added in Repentance Nuh Uh! 5.350.165 Nuh Uh! Don't want! Replaces keys and coins that spawn in Chapter 4 and beyond with more useful pickups.
Added in Repentance Number Magnet 5.350.174 Number Magnet 6 Increases the chance of earning a Devil Room by 10%, prevents Krampus from spawning, and generates special Devil Room layouts.
Added in Repentance Old Capacitor 5.350.143 Old Capacitor Voltage starving Active items don't charge when clearing rooms. Adds a chance to spawn a Lil' Battery when clearing a room, independent of the room's original drop.
Added in Repentance Panic Button 5.350.149 Panic Button Push in case of emergency Activates Isaac's active item just before he takes damage.
Added in Repentance Perfection 5.350.145 Perfection Luck way up. Don't lose it! +10 Luck. If Isaac takes damage, the trinket is destroyed and its effect is removed.
Added in Repentance Polished Bone 5.350.167 Polished Bone Friends from beyond After clearing a room, adds a chance to spawn a friendly Bony.
Added in Repentance RC Remote 5.350.179 RC Remote Controllable buddies! Instead of trailing behind Isaac, familiars are directly controlled by the same inputs as Isaac's.
Added in Repentance Ring Cap 5.350.164 Ring Cap Twice the bang! Placing a bomb spawns an extra bomb for free.
Added in Repentance Short Fuse 5.350.133 Short Fuse Faster explosions Bombs placed by Isaac explode quicker.
Added in Repentance Sigil of Baphomet 5.350.189 Sigil of Baphomet Revel in death Grants an invulnerability shield for 1 second after killing an enemy.
Added in Repentance Strange Key 5.350.175 Strange Key What could it open? Unlocks the passageway to ??? ??? and the Hush fight, regardless of the run duration. Using 15►Pandora's Box Pandora's Box grants it a special effect, consuming the key.
Added in Repentance Swallowed M80 5.350.178 Swallowed M80 Bang! Isaac explodes upon taking damage.
Added in Repentance Teardrop Charm 5.350.139 Teardrop Charm It feels lucky Luck-based tear effects have a higher chance of occurring.
Added in Repentance Telescope Lens 5.350.152 Telescope Lens Seek the stars Increases the chance for Planetariums to spawn even if one has been visited and allows Planetariums to spawn in Chapter 4.
Added in Repentance Temporary Tattoo 5.350.177 Temporary Tattoo You feel braver Spawns a chest after clearing a mob Challenge Room, or an item after clearing a boss Challenge Room.
Added in Repentance The Twins 5.350.183 The Twins I'm seeing double... Adds a chance to duplicate one of Isaac's familiars when entering a new room.
Added in Repentance Torn Card 5.350.157 Torn Card Death awaits Every 15 shots, Isaac shoots an 15►Ipecac Ipecac + 15►My Reflection My Reflection tear.
Added in Repentance Torn Pocket 5.350.158 Torn Pocket A hole in your pocket Upon taking damage, Isaac drops 2 random Pickups from his inventory.
Added in Repentance Wicked Crown 5.350.161 Wicked Crown Walk the path of the wicked A Treasure Room and Shop appears in Sheol Sheol.
Added in Repentance Your Soul 5.350.173 Your Soul Give it to me Can be used to pay for a Devil deal without losing hearts, and is then consumed.

Pickups[]

Hearts[]

Heart ID Image Worth Additional Info Unlocked By
Rotten Heart 5.10.12
Rotten Heart.png
Rotten heart2.png
Rotten Hearts fill up one whole heart container, or the rightmost Red Heart if all of Isaac's heart containers are full. (It isn't possible to have one-half a Rotten Heart; they are always depleted in one hit.) Each Rotten Heart in Isaac's life bar spawns two Blue Flies upon clearing a room. Added in RepentanceRotten Heart Enter the Corpse for the first time

Coins[]

Coin ID Image Worth Additional Info Unlocked By
Golden Penny 5.10.7
Golden Penny.png
1 Spawns another golden penny in a random spot in the same room after being picked up, but has a 5% chance of disappearing instead. Added in RepentanceGolden Penny Defeat Mega Satan as Tainted Keeper Tainted Keeper

Bombs[]

Bomb ID Image Worth Additional Info Unlocked By
Golden Troll Bomb 4.18
Golden Troll Bomb.png
0 Similar to troll bombs, spawns already ignited and cannot be picked up. However, it explodes endlessly, similar to unlimited bombs of the golden bomb pickup.
Added in AfterbirthSafety Scissors Safety Scissors will turn this into a Golden Bomb before it explodes.
Giga Bombs 5.40.7
Giga Bomb.png
1 Thrown by Bombgaggers and are spawned naturally in some rooms in Ashpit. Explodes and destroys tiles in a diamond shape.
Can be obtained by the player with Added in AfterbirthSafety Scissors Safety Scissors or Added in Repentance15►Everything Jar Everything Jar.
Throwable Bomb 5.41
Throwable Bomb.png
0 Can only be picked up and thrown, explodes in a few seconds after pickup. Spawned only by the Bomb Grimace enemy.

Batteries[]

Battery ID Image Worth Additional Info Unlocked By
Micro Battery 5.90.2
Micro Battery.png
2 Charges. Always Available
Mega Battery 5.90.3
Mega Battery.png
Fully charges the player's Active Item twice. Always available
Golden Battery 5.90.4
Golden Battery.png
Fully charges the player's Active Item. Damages the player for a full heart when picked up, and reappears somewhere else in the floor. Added in RepentanceGolden Battery Defeat Mega Satan as Tainted Forgotten Tainted Forgotten

Pills[]

Pill effects[]

Pill ID Effect Unlocked By
Shot Speed Down 47 -0.15 shot speed. Always available
Shot Speed Up 48 +0.15 shot speed. Always available
Experimental Pill 49 Increases one attribute and decreases another randomly, with the same power as normal attribute up/down pills. If taken with PHD, it will not reduce an attribute. Always available

Gold Pills[]

Gold Pills (or Golden Pills) can be used multiple times and grant a random pill effect, even from pills not in the pill pool. Every time a Golden Pill is used it has a chance of being consumed. Its Horse Pill variant will make it give only Horse Pill Effects.

Pill ID Image Effect Unlocked by
Gold Pill 5.70.14 Golden Pill icon.png Gives random pill effects and disappears after a random amount of uses. Added in RepentanceGold Pill Defeat Mega Satan as Tainted Cain Tainted Cain

Horse Pills[]

Horse Pills appear as larger versions of the standard pills with a more powerful effect, and their effects and appearances are similarly randomly chosen. All items that work with pills work identically with horse pills. A horse pill with a given effect has the same color as the normal pill does. Unlocked by: Added in RepentanceHorse Pill Defeat Mega Satan as Tainted Eve Tainted Eve

Horse Pill Effect
Bad Gas The poison applies to the entire room.
Bad Trip Two hearts of damage. If Isaac would not survive, the pill becomes Full Health.
Balls of Steel Grants four soul hearts.
Bombs are Key The number of bombs and keys is increased by 50% while swapping.
Explosive Diarrhea Spawns more bombs, boosted with 15►Mr. Mega Mr. Mega and 15►Bobby-Bomb Bobby-Bomb.
Full Health Fully heals and grants 3 soul hearts.
Health Down Removes two heart containers. If this is not possible, the pill becomes Health Up.
Health Up Adds two empty red heart containers.
I Found Pills Isaac's face gets a permanent, very exaggerated expression.
Puberty Isaac gains very fluffy hair covering his entire head and even face.
Pretty Fly Spawns a 15►Big Fan Big Fan instead. There is no upper limit.
Range Down -1.20 range.
Range Up +1.50 range.
Speed Down -0.24 speed.
Speed Up +0.30 speed.
Tears Down -0.56 tears.
Tears Up +0.70 tears.
Luck Down -2 luck.
Luck Up +2 luck.
Telepills Unknown
48 Hour Energy Spawns more batteries.
Hematemesis Spawns more hearts.
Paralysis The effect lasts 4 seconds.
I can see forever! In addition to the normal effect, fully reveals the map like 15►The Mind The Mind.
Pheromones The charm is permanent, turning the enemies friendly.
Amnesia Unknown
Lemon Party The puddle covers nearly the entire room.
R U a Wizard? The effect lasts 60 seconds.
Percs Unknown
Addicted Unknown
Re-Lax The effect lasts much longer, with high speed long enough to cover nearly the entire room.
??? Unknown
One makes you larger Size increases by two steps.
One makes you small Size decreases by two steps.
Infested! Double the number of spiders spawned.
Infested? Double the number of spiders spawned.
Power Pill! In addition to the normal effect, grants Added in Afterbirth †Huge Growth Huge Growth for +7 flat damage and +3 range. The Huge Growth bonus persists after the Gamekid wears off.
Retro Vision Lasts 90 seconds, with no breaks.
Friends 'Till The End! Double the number of flies spawned.
X-Lax The pool lasts much longer.
Something's wrong... The pool lasts much longer.
I'm Drowsy... Unknown
I'm Excited!!! Unknown
Gulp! Unknown
Horf! Isaac shoots a small cluster of Horf! tears, with varying power above normal Horf!.
Feels like I'm walking on sunshine! The effect is upgraded to 15►The Gamekid The Gamekid.
Vurp! If the last pill was a normal pill, it becomes a horse pill. No further difference on horse pills themselves.
Shot Speed Down -0.30 shot speed.
Shot Speed Up +0.30 shot speed.
Experimental Pill The two effects are doubled in power.
Gold Pill The random effects are doubled.

Consumables[]

Reversed Cards[]

Name ID Icon Unlock method Message Description
Added in Repentance 0 - The Fool? 5.300.56 0 - The Fool? The Fool Defeat Ultra Greedier as Tainted Lost Tainted Lost Let go and move on Drops all hearts and pickups on the floor, leaving Isaac at half a heart. Will kill Isaac if he has only soul hearts and all empty red heart containers. Pickups may be spawned as items such as 15►A Quarter A Quarter and 15►Boom! Boom!.
Added in Repentance I - The Magician? 5.300.57 I - The Magician? The Magician Defeat Ultra Greedier as Tainted Judas Tainted Judas May no harm come to you Grants a repelling blue aura for one minute, like 15►The Soul The Soul but stronger and with a wider area of effect.
Added in Repentance II - The High Priestess? 5.300.58 II - The High Priestess? The High Priestess Defeat Ultra Greedier as Tainted Lilith Tainted Lilith Run Mom's leg starts stomping down repeatedly for one minute, like holding 15►Broken Shovel Broken Shovel.
Added in Repentance III - The Empress? 5.300.59 III - The Empress? The Empress Defeat Ultra Greedier as Tainted Eve Tainted Eve May your love bring protection Grants 2 temporary red heart containers and +1.35 tears for one minute, along with Magdalene Magdalene's hairstyle. Does not stack.
Added in Repentance IV - The Emperor? 5.300.60 IV - The Emperor? The Emperor Defeat Ultra Greedier as Tainted ??? Tainted ??? May you find a worthy opponent Teleports Isaac into an extra Boss Room from the boss pool two floors deeper than the current floor. The boss will drop a reward, but the room has no trapdoor, so Isaac cannot enter the next floor. The room has an exit door, which leads Isaac back to where he used IV - The Emperor?.
Added in Repentance V - The Hierophant? 5.300.61 V - The Hierophant? The Hierophant Defeat Ultra Greedier as Tainted Bethany Tainted Bethany Two prayers for the forgotten Spawns 2 Bone Hearts.
Added in Repentance VI - The Lovers? 5.300.62 VI - The Lovers? The Lovers Defeat Ultra Greedier as Tainted Magdalene Tainted Magdalene May your heart shatter to pieces Spawns a random item from the current room's item pool. Turns 1 red heart container or 2 soul hearts into a broken heart, potentially fatally; no downside for any character who has no health bar; Tainted Keeper Tainted Keeper locked to 1 HP.
Added in Repentance VII - The Chariot? 5.300.63 VII - The Chariot? The Chariot Complete Hot Potato (challenge #42) May nothing walk past you Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
Added in Repentance VIII - Justice? 5.300.64 VIII - Justice? Justice Complete Cantripped (challenge #43) May your sins come back to torment you Spawns 2 to 4 Golden Chests.
Added in Repentance IX - The Hermit? 5.300.65 IX - The Hermit? The Hermit Complete Red Redemption (challenge #44) May you see the value of all things in life "Sells" items and pickups in the room for their usual shop price, spawning a matching amount of coins. Does not affect grab bags. If there is nothing to sell, spawns a penny.
Added in Repentance X - Wheel of Fortune? 5.300.66 X - Wheel of Fortune? Wheel of Fortune Defeat Ultra Greedier as Tainted Cain Tainted Cain Throw the dice of fate Invokes a random dice room effect.
Added in Repentance XI - Strength? 5.300.67 XI - Strength? Strength Defeat Ultra Greedier as Tainted Samson Tainted Samson May you break their resolve All enemies in the room are weakened, becoming slow and take double damage. The effect lasts up to one minute or until the room is left.
Added in Repentance XII - The Hanged Man? 5.300.68 XII - The Hanged Man? The Hanged Man Defeat Ultra Greedier as Tainted Keeper Tainted Keeper May your greed know no bounds Isaac turns visually into Keeper for 30 seconds, with a triple shot, no damage bonus, and -0.1 speed. Killed enemies drop random coins.
Added in Repentance XIII - Death? 5.300.69 XIII - Death? Death Defeat Ultra Greedier as Tainted Forgotten Tainted Forgotten May life spring forth from the fallen Invokes a 15►Book of the Dead Book of the Dead effect.
Added in Repentance XIV - Temperance? 5.300.70 XIV - Temperance? Temperance Complete DELETE THIS (challenge #45) May your hunger be satiated Forces Isaac to eat 5 random pills in quick succession.
Added in Repentance XV - The Devil? 5.300.71 XV - The Devil? The Devil Defeat Ultra Greedier as Tainted Azazel Tainted Azazel Bask in the light of your mercy Invokes 15►The Bible The Bible (which can kill Mom), and grants Isaac flight and a 15►Seraphim Seraphim familiar for 30 seconds.
Added in Repentance XVI - The Tower? 5.300.72 XVI - The Tower? The Tower Defeat Ultra Greedier as Tainted Apollyon Tainted Apollyon Creation brings destruction Spawns 6 clusters of random rocks and other obstacles. Spawned clusters will often contain tinted rocks, with the possibility of more than one spawning in one room. The pathways between exits can't be blocked.
Added in Repentance XVII - The Stars? 5.300.73 XVII - The Stars? The Stars Defeat Ultra Greedier as Tainted Isaac Tainted Isaac May your loss bring fortune Removes Isaac's oldest passive item, including starting items, and spawns 2 random items from the current room's item pool. Doesn't spawn anything if Isaac has no items.
Added in Repentance XVIII - The Moon? 5.300.74 XVIII - The Moon? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May you remember lost memories Teleports the player to the Ultra Secret Room. The pathway back to the normal rooms will be made of red rooms.
Added in Repentance XIX - The Sun? 5.300.75 XIX - The Sun? The Sun and the Moon Defeat Ultra Greedier as Tainted Jacob Tainted Jacob May the darkness swallow all around you Gain 15►Spirit of the Night Spirit of the Night and +1.5 damage for the current level. Turns Isaac's red hearts into bone hearts, but they revert once the effect ends. Also causes Curse of Darkness that cannot be dispelled.
Added in Repentance XX - Judgement? 5.300.76 XX - Judgement? Judgement Defeat Ultra Greedier as Tainted Lazarus Tainted Lazarus May you redeem those found wanting Spawns a Restock Machine.
Added in Repentance XXI - The World? 5.300.77 XXI - The World? The World Defeat Ultra Greedier as Tainted Eden Tainted Eden Step into the abyss Spawns a trap door to a crawl space.

Playing Cards[]

Name ID Icon Unlock method Message Description
Added in Repentance Queen of Hearts 5.300.79 Queen of Hearts Queen of Hearts Defeat Mega Satan as Tainted Magdalene Tainted Magdalene <3 Spawns 1-20 full red hearts.

Other Cards[]

Name ID Icon Unlock method Message Description
Added in Repentance Wild Card 5.300.80 Wild Card Wild Card Defeat Mega Satan as Tainted Eden Tainted Eden Again When used, copies the effect of the most recently used pill, card, rune, soul stone or activated item.

Runes[]

Name ID Icon Unlock method Message Description
Added in Repentance Rune Shard 5.300.55 Rune Shard Always available It still glows faintly Activates a random, weak rune effect: Algiz grants a 3 second shield, Ansuz reveals the map up to 3 rooms away, Berkano gives 1 blue fly and spider, Dagaz gives half a soul heart, Ehwaz makes a trapdoor, Hagalaz destroys some rocks, Jera duplicates one pickup and Perthro rerolls one item.

Soul Stones[]

Name ID Icon Unlock method Message Description
Added in Repentance Soul of Isaac 5.300.81 Soul of Isaac Soul of Isaac Defeat Hush and Boss Rush as Tainted Isaac Tainted Isaac Reroll... or not Rerolls the items in the room like 15►The D6 The D6, but they cycle back to their original form after one second, repeating. If more uses are stacked, an additional item per use will be cycled through.
Added in Repentance Soul of Magdalene 5.300.82 Soul of Magdalene Soul of Magdalene Defeat Hush and Boss Rush as Tainted Magdalene Tainted Magdalene Give me your love! Surrounds Isaac with a bubbling red aura for the current room. All enemies killed drop red half hearts that disappear in 2 seconds.
Added in Repentance Soul of Cain 5.300.83 Soul of Cain Soul of Cain Defeat Hush and Boss Rush as Tainted Cain Tainted Cain Opens the unopenable Opens all doors in the room. Additionally, creates a red room like the 15►Red Key Red Key for every possible red exit. This also destroys the mirror located in Downpour Downpour/Dross Dross II.
Added in Repentance Soul of Judas 5.300.84 Soul of Judas Soul of Judas Defeat Hush and Boss Rush as Tainted Judas Tainted Judas Right behind you Stops time for 3 seconds and invokes 15►Dark Arts Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.
Added in Repentance Soul of ??? 5.300.85 Soul of ??? Soul of ??? Defeat Hush and Boss Rush as Tainted ??? Tainted ??? Chemical warfare Causes 8 poison farts that leave lingering brown creep, then plants a trail of 7 15►Butt Bombs Butt Bombs in quick succession. Standing on the creep gives +1.35 tears and +1 damage.
Added in Repentance Soul of Eve 5.300.86 Soul of Eve Soul of Eve Defeat Hush and Boss Rush as Tainted Eve Tainted Eve Your very own murder 14 15►Dead Bird Dead Bird familiars fly in and attack enemies. They leave after all victims are dead or Isaac leaves the room.
Added in Repentance Soul of Samson 5.300.87 Soul of Samson Soul of Samson Defeat Hush and Boss Rush as Tainted Samson Tainted Samson Slay a thousand Isaac turns berserk (similar to Tainted Samson) for 10 seconds, gaining +0.4 speed, some tears and +3 flat damage along with his melee attack.
Added in Repentance Soul of Azazel 5.300.88 Soul of Azazel Soul of Azazel Defeat Hush and Boss Rush as Tainted Azazel Tainted Azazel Demon rage! Activates 15►Mega Blast Mega Blast for 7.5 seconds.
Added in Repentance Soul of Lazarus 5.300.89 Soul of Lazarus Soul of Lazarus Defeat Hush and Boss Rush as Tainted Lazarus Tainted Lazarus Life after death Isaac dies, and is immediately revived at half a heart remaining in the same room, with some invincibility time. The soul stone is automatically used upon taking fatal damage, functioning as a minimal extra life.
Added in Repentance Soul of Eden 5.300.90 Soul of Eden Soul of Eden Defeat Hush and Boss Rush as Tainted Eden Tainted Eden Embrace chaos Uses 15►The D6 The D6 and 15►D20 D20. The rerolled items use random pools, as if 15►Chaos Chaos were active.
Added in Repentance Soul of the Lost 5.300.91 Soul of the Lost Soul of the Lost Defeat Hush and Boss Rush as Tainted Lost Tainted Lost Leave your body behind Isaac "dies" and turns into a ghost (similar to The Lost The Lost) for the current room, with all The Lost's benefits and weaknesses. He returns to normal upon leaving the room. Does not allow you to take devil deals for free. Does not allow you to open the door to Mausoleum for free. The Holy Mantle effect gained from this can be stacked with multiple uses.
Added in Repentance Soul of Lilith 5.300.92 Soul of Lilith Soul of Lilith Defeat Hush and Boss Rush as Tainted Lilith Tainted Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except 15►Stitches Stitches. Unique familiars can be received only once. Appropriate familiars count towards Conjoined.
Added in Repentance Soul of the Keeper 5.300.93 Soul of the Keeper Soul of the Keeper Defeat Hush and Boss Rush as Tainted Keeper Tainted Keeper $$$ Spawns 1-25 random coins.
Added in Repentance Soul of Apollyon 5.300.94 Soul of Apollyon Soul of Apollyon Defeat Hush and Boss Rush as Tainted Apollyon Tainted Apollyon Bringer of calamity Spawns 15 random locusts.
Added in Repentance Soul of the Forgotten 5.300.95 Soul of the Forgotten Soul of the Forgotten Defeat Hush and Boss Rush as Tainted Forgotten Tainted Forgotten Skeletal protector Spawns The Forgotten The Forgotten as a temporary secondary character, controlled at the same time as Isaac. He dies if his three bone hearts run out, with no further consequence, and disappears when Isaac leaves the room.
Added in Repentance Soul of Bethany 5.300.96 Soul of Bethany Soul of Bethany Defeat Hush and Boss Rush as Tainted Bethany Tainted Bethany Friends from beyond Spawns 6 15►Book of Virtues Book of Virtues wisps with random properties.
Added in Repentance Soul of Jacob and Esau 5.300.97 Soul of Jacob and Esau Soul of Jacob and Esau Defeat Hush and Boss Rush as Tainted Jacob Tainted Jacob Bound by blood Spawns Esau Esau as a temporary secondary character, controlled at the same time as Isaac. He dies if his health runs out, with no further consequence, and disappears when Isaac leaves the room. Esau also has items equal to the number of items the player who spawned him has.

Other[]

Name ID Icon Unlock method Message Description
Added in Repentance Cracked Key 5.300.78 Cracked Key Red Key Open the large version of Mom's Box in Home ??? Creates a room adjacent to a viable wall, like 15►Red Key Red Key.

Chests[]

Chest ID Image Additional Info Unlocked By
Old Chest 5.55 Old Chest.png Old Chests are similar in appearance to Golden Chests, but have the color of a normal Chest and a worn-down appearance. They have the same requirements as locked chests. Pulls from the Old Chest item pool.
Wooden Chest 5.56 Wooden Chest.png Wooden Chests appear similar to normal Chests but have an appearance similar to wood. Pulls from the Wooden Chest item pool. Added in RepentanceWooden Chest Defeat Mega Satan as Tainted Lazarus Tainted Lazarus
Mega Chest 5.57 Mega Chest.png Mega chests appear similar to Golden Chests but are larger in appearance. Added in RepentanceMega Chest Defeat Mega Satan as Tainted Isaac Tainted Isaac
Haunted Chest 5.58 Haunted Chest.png Haunted Chests appear nearly identical to normal Chests until Isaac gets close to them, at which point a Polty picks up the chest and throws it at Isaac, doing half a heart of damage and breaking open the chest. Added in RepentanceHaunted Chest Defeat Mega Satan as Tainted Lost Tainted Lost
Mom's Chest 5.390 Mom's Chest.png Mom's Chest appears in Home. Mom's chest has no requirements to open. Contains a Red Key upon the first visit. Contains a random Mom-related item or Red Key upon subsequent visits of Home.

Sacks[]

Sack ID Image Additional Info Unlocked By
Black Sack 5.69.2
Black Sack.png
Spawns 2-3 pills, black or bone hearts and/or bombs when collected. Added in RepentanceBlack Sack Defeat Mega Satan as Tainted Judas Tainted Judas

As well, Sacks can spawn in shops for 7 coins.

Monsters[]

Bosses[]

Enemies[]

Entity ID Description
Deep Gaper
Deep Gaper
Added in Repentance
811.0 Emerges off the floor once all previous enemies have been killed, then proceeds to chase Isaac like a normal Gaper.
Blurb
Blurb
Added in Repentance
813.0 Walks slowly towards Isaac. After taking some damage or getting close to Isaac, it fires a chaotic burst of tears at him and chases him more quickly.
Crackle
Crackle
Added in Repentance
87.1 Walks toward Isaac, spitting balls of fire that create lines of fire in the cardinal directions on impact.
Wraith
Wraith
Added in Repentance
807.0 Walks toward Isaac, dealing contact damage. Can only be seen through its reflection and ripples it leaves in the water as it moves.
Rotten Gaper
Rotten Gaper
Added in Repentance
10.3 Walks toward Isaac, dealing contact damage. Its behavior varies slightly depending on its facial expression.
Dead Isaac
Dead Isaac
Added in Repentance
912.20 Summoned by Mother at the bottom of the arena, and walks up towards Mother. Releases a burst of blood shots upon being killed by Mother, while she launches their corpses towards Isaac.
Twitchy
Twitchy
Added in Repentance
851.0 Alternates between walking towards and rapidly leaping at Isaac.
Level 2 Gaper
Level 2 Gaper
Added in Repentance
850.0 Walks towards Isaac, dealing contact damage. Splits into a Level 2 Horf and Level 2 Gusher upon death.
Faceless
Faceless
Added in Repentance
827.0 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots more frequently after taking damage.
Fanatic
Fanatic
Added in Repentance
832.1 Transformed into from Exorcists. Chases Isaac and occasionally fires two purple, rotating shots.
Exorcist
Exorcist
Added in Repentance
832.0 Summons The Heretic before transforming into Fanatics.
Dump
Dump
Added in Repentance
876.0 Slides toward Isaac, leaving a trail of slippery brown creep. After taking enough damage, its head slides off and quickly bounces around the room and its body spews out brown shots until it empties.
Dump Head
Dump Head
Added in Repentance
876.1 Quickly slides toward Isaac, leaving a trail of slippery brown creep. Can spawn on its own or be created by a Dump after it takes enough damage.
Level 2 Gusher
Level 2 Gusher
Added in Repentance
850.2 Runs aimlessly around the room, spitting up Small Maggots.
Sub Horf
Sub Horf
Added in Repentance
812.0 Stationary enemy that spins and fires shots while being moved around or knocked back.
Necro
Necro
Added in Repentance
828.0 Stationary enemy that summons unlimited-ranged bones to attack Isaac.
Tainted Sub Horf
Tainted Sub Horf
Added in Repentance
812.1 Will only shoot when hit. Takes heavy knockback and rotates when hit. Shoots a lot faster and has bigger projectiles than its normal variant.
Level 2 Horf
Level 2 Horf
Added in Repentance
850.1 Slowly floats toward Isaac, spitting Small Maggots at him.
Army Fly
Army Fly
Added in Repentance
868.0 Chases Isaac, moving along the cardinal directions. Forms a line with other Army Flies in the room. Deals contact damage.
Willo
Willo
Added in Repentance
808.0 Flies in a circle around Isaac (in formation with other Willos if available), keeping an exact distance away from him. One Willo at a time will occasionally light up and fire a shot at Isaac.
Ultra Famine Fly
Ultra Famine Fly
Added in Repentance
951.11 Charges at Isaac at a delay. Deals contact damage. Spawned by Ultra Famine.
Ultra Pestilence Fly
Ultra Pestilence Fly
Added in Repentance
951.21 Flies in swarms around Ultra Pestilence, blocking shots and dealing contact damage.
Fly Bomb
Fly Bomb
Added in Repentance
819.0 Flies toward Isaac, circling around him as it does. Turn into a tiny bomb upon death.
Eternal Fly Bomb
Eternal Fly Bomb
Added in Repentance
819.1 Orbits Boom Flies spawned by The Horny Boys. Once its Boom Fly has been killed, turns into a tiny Bomb.
Ink
Ink
Added in Repentance
61.3 Flies slowly towards Isaac. Fires four tar shots in the ordinal directions and leaves a puddle of slowing black creep upon death.
Tainted Sucker
Tainted Sucker
Added in Repentance
61.7 Flies slowly towards Isaac. Upon death, fires a radial burst of six blood shots that each also fires a radial burst of six blood shots.
Bulb
Bulb
Added in Repentance
61.5 Flies in erratic, angled movements toward Isaac if his active item has charges. Drains active item charges instead of dealing damage.
Bloodfly
Bloodfly
Added in Repentance
61.6 Flies in erratic, angled movements toward Isaac. Fires four blood shots in the cardinal directions upon death.
Tainted Pooter
Tainted Pooter
Added in Repentance
14.2 Slowly drifts toward Isaac, occasionally firing four blood shots at him that split into two smaller ones when they hit a wall or obstacle.
Mama Fly
Mama Fly
Added in Repentance
61.4 Wanders aimlessly around the room, occasionally creating Pustules.
Grilled Clotty
Grilled Clotty
Added in Repentance
15.3 Quickly and randomly wanders around the room, firing four flame shots in the cardinal directions at a slight angle.
Cloggy
Cloggy
Added in Repentance
872.0 Randomly wanders around the room, firing four curved brown shots in the cardinal directions. These shots alternate between rotating clockwise and counterclockwise with each shot.
Prey
Prey
Added in Repentance
817.0 Wanders around the room, avoiding Isaac and spawning Small Leeches if he gets close. Spawns 3 Small Leeches upon death.
Fartigan
Fartigan
Added in Repentance
874.0 Chases Isaac, occasionally coughing up gas. On death, fires an explosive shot that can detonate gas clouds it hits.
Holy Mulligan
Holy Mulligan
Added in Repentance
22.2 Wanders around the room, avoiding Isaac and spawning Small Angelic Babies if he gets close. Spawns 1-2 Embryos upon death.
Mullighoul
Mullighoul
Added in Repentance
817.1 Wanders around the room, avoiding Isaac and spawning Willos if he gets close. Spawns 1-2 Willos upon death.
Bouncer
Bouncer
Added in Repentance
822.0 Wanders around the room, avoiding Isaac. If Isaac stays close to one for long enough, it inflates and starts chasing him, gaining a chance to deflect shots and causing it to explode into lingering blood shots on death.
Tainted Mulligan
Tainted Mulligan
Added in Repentance
22.3 Wanders around the room, avoiding Isaac and spawning 6 Ring Flies if he gets close. Spawns a plethora of fly enemies upon death.
Danny
Danny
Added in Repentance
820.0 Walks toward Isaac and spits chaotic bursts of rocks at him, some of which may be Rock Spiders.
Coal Boy
Coal Boy
Added in Repentance
820.1 Walks toward Isaac and spits hot coals at him, some of which may be Coal Spiders.
Blaster
Blaster
Added in Repentance
821.0 Slowly wanders around and occasionally shoots Fly Bombs at Isaac.
Small Maggot
Small Maggot
Added in Repentance
853.0 Slowly crawls toward Isaac, dealing contact damage.
Level 2 Charger
Level 2 Charger
Added in Repentance
855.0 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Can slowly change its trajectory while charging.
Carrion Princess
Carrion Princess
Added in Repentance
23.3 Slowly moves around the room, charging at Isaac when he lines up diagonally with it. Can only be damaged by hitting its tail.
Small Leech
Small Leech
Added in Repentance
810.0 Chases Isaac continuously, not stopping at walls. Able to swim over gaps.
Elleech
Elleech
Added in Repentance
855.1 Slowly moves around the room. After Isaac gets in its line of sight, continuously charges at him in the closest cardinal direction.
Blood Puppy
Blood Puppy
Added in Repentance
802.0 Quickly moves around the room, attacking and charging at other monsters and Isaac when they get in its line of sight.
Tainted Spitty
Tainted Spitty
Added in Repentance
31.1 Slowly moves around the room, firing chaotic bursts of blood shots in all directions and occasionally spitting a line of blood shots in the direction it's facing. Fires two rotating rings of blood shots upon death.
Cursed Globin
Cursed Globin
Added in Repentance
24.3 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into 1-2 piles of goo, each of which can be killed and regenerate after a short period of time if not killed quickly. These goo piles have less health the more times the Cursed Globin splits.
Clickety Clack
Clickety Clack
Added in Repentance
889.0 Walks towards Isaac and turn into a pile of bones when killed. Regenerates a few seconds after killed. Will only despawn if all Clickety Clacks in the room are killed.
Cohort
Cohort
Added in Repentance
857.0 Acts similarly to Monstro, hopping towards Isaac and can either spit a large projectile towards Isaac that bursts into 8 smaller projectiles or cough up a burst of arcing projectiles and a pile of Globin goo. Spawns 4 piles of Globin goo upon death.
Gasbag
Gasbag
Added in Repentance
856.0 Occasionally summons Army Flies to chase Isaac. Is surrounded by a ring of toxic gas that hurts Isaac if he stands in it for too long.
Dragon Fly
Dragon Fly
Added in Repentance
25.3.0 Flies around the room diagonally, dealing contact damage. Upon death, creates four lines of fire in the cardinal directions.
Dragon Fly X
Dragon Fly X
Added in Repentance
25.3.1 Flies around the room diagonally, dealing contact damage. Upon death, creates four lines of fire in the ordinal directions.
Bone Fly
Bone Fly
Added in Repentance
25.4 Flies around the room diagonally, dealing contact damage. Fires bones at Isaac if he lines up with it in the cardinal directions. Fires a radial burst of 3 bones upon death.
Sick Boom Fly
Sick Boom Fly
Added in Repentance
25.5 Flies around the room diagonally, dealing contact damage and trailing poisonous gas. Upon death, explodes into a gas cloud and fires a ring of 6 green shots.
Tainted Boom Fly
Tainted Boom Fly
Added in Repentance
25.6 Flies around the room diagonally, dealing contact damage. Upon death, sends explosions in a cross-shaped marker across the room.
Hard Host
Hard Host
Added in Repentance
27.3 Stationary enemy that is normally invulnerable. Raises its head up when Isaac gets close, revealing a fleshy stem that can be damaged. Shortly after raising its head, it slams its head down and fires a rock wave towards Isaac.
Floating Host
Floating Host
Added in Repentance
859.0 Floats diagonally around the room and is normally invulnerable. When Isaac gets close, reveals a fleshy stem that can be damaged and fires 3 blood shots in an angle at him before hiding its stem again.
Sticky Leaper
Sticky Leaper
Added in Repentance
34.1 Hops around the room, dealing contact damage. Occasionally jumps high into the air, dropping down onto Isaac's position while creating a chaotic burst of tar shots in all directions and a puddle of slowing black creep.
Eggy
Eggy
Added in Repentance
29.2 Hops aimlessly around the room, spawning slowing white creep wherever it hops. Spawns a group of Swarm Spiders upon death.
Tainted Hopper
Tainted Hopper
Added in Repentance
29.3 Jumps and twirls around the room, shooting 4 rings of projectiles that increase in size with each shot.
Pustule
Pustule
Added in Repentance
861.0 Slowly increases in size over time, spawning Small Maggots and damaging red creep depending on its size upon death. If it grows to full size, it transforms into a Bloodfly.
Pon
Pon
Added in Repentance
840.0 Hops around the room, leaving damaging red creep wherever it lands. Upon death, its associated Brainless Knight dies with it.
Gyro
Gyro
Added in Repentance
824.0 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles as it does.
Grilled Gyro
Grilled Gyro
Added in Repentance
824.1 Rolls around like a wheel. Charges at Isaac when he is in line of sight, bouncing off of walls and obstacles and creating fires behind itself as it does.
Angelic Baby (small)
Angelic Baby (small)
Added in Repentance
38.1.1 Slowly floats towards Isaac and fires a blood shot at him. Occasionally teleports and reappears elsewhere. Can only be spawned by Holy Mulligans.
Wrinkly Baby
Wrinkly Baby
Added in Repentance
38.3 Lunges towards Isaac at high speed and fires three blood shots in his direction once stopped.
Baby Begotten
Baby Begotten
Added in Repentance
883.0 Floats toward Isaac, avoiding his shots. After getting close, fires a short 15►Brimstone Brimstone laser in the closest cardinal direction and propels itself away from him.
Unborn
Unborn
Added in Repentance
860.0 Floats quickly towards Isaac, and occasionally teleports to another position near him.
Vis Versa
Vis Versa
Added in Repentance
39.4 Randomly wanders around the room. Pauses to charge and fire a homing Brimstone laser when Isaac gets in its line of sight.
Evis
Evis
Added in Repentance
39.5 Randomly wanders around the room. Launches a string of guts when Isaac gets close to it, which it uses to pull Isaac toward itself.
Slog
Slog
Added in Repentance
40.2 Attaches itself to a wall or obstacle and rolls around it, charging at Isaac when he is in sight.
Cyst
Cyst
Added in Repentance
862.0 Attaches itself to a wall or obstacle and rolls around it, regularly firing blood shots at Isaac.
Loose Knight
Loose Knight
Added in Repentance
41.2 Moves erratically around the room, charges toward Isaac when in line of sight. When its health is depleted, it turns into a Brainless Knight and a Pon.
Brainless Knight
Brainless Knight
Added in Repentance
41.3 Alternates between running around the room along the cardinal directions and aimlessly walking in circles. Charges at Isaac when in line of sight. Dies when its corresponding Pon dies.
Black Knight
Black Knight
Added in Repentance
41.4 Moves erratically around the room, charges toward Isaac when in line of sight. Unleashes waves of fire in all cardinal directions upon charging into an obstacle. Shots that hit it from the front are deflected back at Isaac.
Whipper
Whipper
Added in Repentance
834.0 Runs around the room, sprinting at Isaac when he gets in its line of sight and lashing at him when it gets close.
Snapper
Snapper
Added in Repentance
834.1 Runs around the room, sprinting at Isaac when he gets in its line of sight and throwing out its whip when he gets in range.
Flagellant
Flagellant
Added in Repentance
834.2 Runs around the room. When Isaac gets in its line of sight, continuously chases him and lashes its whip, occasionally deflecting Isaac’s shots.
Adult Leech
Adult Leech
Added in Repentance
854.0 Wanders around the room, quickly charging at Isaac when he lines up diagonally with him and releasing a ring of blood shots upon colliding with a wall. Occasionally burrows into the ground and reappears out of a wall or from above Isaac.
Dead Meat
Dead Meat
Added in Repentance
57.2 Slowly moves around the room, occasionally hopping and firing 8 large blood shots in all directions that bounce off the walls. Splits into 2 Cysts upon death.
Holy Eye
Holy Eye
Added in Repentance
60.2 Rapidly summons several beams of light around Isaac every few seconds.
Strider
Strider
Added in Repentance
814.0 Erratically swims around the room. If it sees Isaac, it chases him, trying to deal contact damage.
Swarm Spider
Swarm Spider
Added in Repentance
884.0 Very erratically hops toward Isaac in large groups, dealing contact damage.
Rock Spider
Rock Spider
Added in Repentance
818.0 Slowly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Spider upon death. Turns into a Coal Spider if it touches fire.
Tinted Rock Spider
Tinted Rock Spider
Added in Repentance
818.1 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a Soul Heart upon death. Can only spawn by breaking tinted rocks on Mines or Ashpit.
Coal Spider
Coal Spider
Added in Repentance
818.2 Quickly crawls around the room. If it sees Isaac, it crawls at him, trying to deal contact damage. Turns into a hot coal upon death that blocks shots and deals contact damage, but can be destroyed.
Butt Slicker
Butt Slicker
Added in Repentance
878.0 Moves erratically around the room unless attached to another Butt Slicker. Grouped Butt Slickers drag themselves towards Isaac, and when an individual is killed they leave black creep, and shoot out black projectiles. The amount of projectiles released and the size of the pool of Black Creep is determined by the amount of Butt Slickers attached.
Mask II + 1/2 Heart
Mask II + 1/2 Heart
Added in Repentance
92.1 The Mask is invulnerable and moves around erratically, charging at Isaac when he lines up with it. The Heart avoids Isaac and fires 4 blood shots in the ordinal directions when Isaac gets near. Killing the Heart will automatically kill the Mask. If there are more than one 1/2 Heart in the room, they will fire blood shots between each other.
Peeping Fatty
Peeping Fatty
Added in Repentance
835.0 Has two indestructible eyeballs that are out of their sockets but attached by muscles. Wanders around the room randomly, or toward Isaac if its eyes see him. Occasionally farts and fires a radial burst of 6 blood shots.
Bloaty
Bloaty
Added in Repentance
879.0 Lumbers around, occasionally spitting green shots and a line of damaging green creep in a random direction.
Bubbles
Bubbles
Added in Repentance
806.0 Slowly walks towards Isaac, firing back shots upon taking damage. Occasionally farts, which pushes Isaac and adjacent enemies away and creates a chaotic burst of shots. Creates a geyser of water shots upon death.
Shady
Shady
Added in Repentance
888.0 Walks slowly toward Isaac, occasionally firing a shot that creates shots perpendicular to itself while traveling and splits into a ring of shots upon hitting a wall or obstacle. Also occasionally jumps, creating lines of explosions in the cardinal directions.
Quakey
Quakey
Added in Repentance
823.0 Walks slowly toward Isaac, occasionally attempting to jump on Isaac, shooting out 8 rock shots when it hits the ground and causing rocks to fall from the ceiling.
Big Bony
Big Bony
Added in Repentance
830.0 Walks slowly toward Isaac, and will occasionally fire a bone that bounces around the room for a few moments. The bone can be broken if shot enough.
Vis Fatty
Vis Fatty
Added in Repentance
886.0 Spawns with a Fetal Demon attached to it and slowly walks towards Isaac. Will occasionally fart, briefly pushing the demon away and spawning creep around itself and the demon. If the demon is killed first, the Fatty will shoot out 15►Brimstone Brimstone in the diagonal direction closest to Isaac. It will then fly around the room diagonally, bumping off of walls and tall blocks all while continuously firing 15►Brimstone Brimstone behind it.
Fetal Demon
Fetal Demon
Added in Repentance
886.1 Usually encountered tethered to Vis Fatties. When tethered it makes short lunges towards Isaac if he gets close. If the Vis Fatty is killed or when encountered alone it will chase Isaac similarly to Gemini's Suture.
Gutted Fatty
Gutted Fatty
Added in Repentance
831.0 Slowly lumbers around the room, occasionally spawning Festering Guts. Its eyes dislocate as it takes damage, which are invincible and follow the Gutted Fatty but chase Isaac if he gets close to them. Creates a geyser of blood projectiles upon death.
Festering Guts
Festering Guts
Added in Repentance
831.20 Spawned by Gutted Fatties, Festering Guts randomly slide around the room and occasionally spawn a Charger.
Tainted Faceless
Tainted Faceless
Added in Repentance
827.1 Wanders around the room, rarely firing a radial burst of six shots. Chases Isaac and fires shots very frequently after taking damage.
Cursed Death's Head
Cursed Death's Head
Added in Repentance
212.2 Invulnerable enemy that moves diagonally around the room, dealing contact damage. If Isaac enters its purple aura, he will be inflicted with fear and be temporarily unable to shoot. Dies when the room is cleared.
Brimstone Death's Head
Brimstone Death's Head
Added in Repentance
212.3 Invulnerable enemy that moves diagonally around the room, pausing to fire a 15►Brimstone Brimstone laser when Isaac lines up with it in the cardinal directions. Dies when the room is cleared.
Dusty Death's Head
Dusty Death's Head
Added in Repentance
887.0 Invulnerable enemy that moves across the room in a waving motion in large quantities. Dies when the room is cleared.
Redskull
Redskull
Added in Repentance
212.4 Moves diagonally around the room, creating a ring of fire around itself if Isaac gets close to it. Can be killed, but also dies when the room is cleared.
Ultra Death Head
Ultra Death Head
Added in Repentance
951.42 Invulnerable enemy spawned by Ultra Death that moves across the room in a waving motion in large quantities as a part of one of his attacks. Dies upon the completion of the attack.
Level 2 Willo
Level 2 Willo
Added in Repentance
838.0 Orbits enemies and shoots tears at Isaac. If the enemy it is orbiting dies, it will orbit another enemy. However, if all enemies are dead, it will chase Isaac, while still occasionally shooting at Isaac.
Migraine
Migraine
Added in Repentance
869.0 Crawls around the room erratically, following Isaac and dealing contact damage. Can jump small distances. Releases multiple Troll Bombs upon death.
Big Corn
Big Corn
Added in Repentance
217.3 Quickly dashes in random directions, dealing contact damage. Shoots one piece of corn upon death.
Drip
Drip
Added in Repentance
870.0 Quickly rolls around in diagonal directions, dealing contact damage.
Splurt
Splurt
Added in Repentance
871.0 Dashes towards Isaac twice and deals contact damage. Spawns 2 Drips upon death.
Hardy
Hardy
Added in Repentance
826.0 Dashes toward Isaac and deals contact damage creating rock projectiles when it hits a wall/obstacle. It spawns more rock projectiles the more times it crashes into obstacles, dying after doing so a third time.
Revenant
Revenant
Added in Repentance
841.0 Slowly wanders around the room, stopping to fire a large line of fire at the player.
Quad Revenant
Quad Revenant
Added in Repentance
841.1 Wanders around the room slowly, stopping to fire lines of flames in the cardinal or ordinal directions, rotating in an attempt to hit Isaac.
Maze Roamer
Maze Roamer
Added in Repentance
890.0 Wanders around the room and shoots an eyeball at Isaac when he is in sight. Has a clone of itself on the other side of the room that mimics its movement and shots. If one dies, the other starts actively pursuing Isaac.
Holy Bony
Holy Bony
Added in Repentance
227.1 Wanders around the room, throwing a bone at Isaac when he is in sight. The thrown bone leaves behind a blue flame that deals contact damage, blocks Isaac’s shots, and despawns after some time.
Planetoid
Planetoid
Added in Repentance
229.1 Moves around the room diagonally, occasionally firing blood shots that orbit itself. Fires more shots and has a chance to send its ring of shots outward upon taking damage.
Poofer
Poofer
Added in Repentance
892.0 Slowly floats toward Isaac, swells up and fire 6 blood shots in all direction upon taking damage. Explodes upon death, healing nearby enemies and leaving a big puddle of red creep.
Bishop
Bishop
Added in Repentance
805.0 Shields all enemies in the room, preventing them from taking damage. Fires shots in the cardinal directions when it takes damage.
Goat
Goat
Added in Repentance
891.0 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines up on either side of it.
Black Goat
Black Goat
Added in Repentance
891.1 Wanders around the room. Occasionally moves toward Isaac, either firing blood shots at him or charging if he lines upon either side of it. Can also fire thin 15►Brimstone Brimstone lasers in the cardinal directions, along with all other Black Goats in the room.
Cultist
Cultist
Added in Repentance
885.0 Creates an indestructible, homing Purple Ball at the start of the room and follows it around, occasionally leaving it to revive enemies that have died in the current room.
Blood Cultist
Blood Cultist
Added in Repentance
885.1 Wanders around the room and fires a line of blood shots and creep if Isaac is on either side of it. Can summons bone traps that temporarily ensnare Isaac if he walks into them.
Soy Creep
Soy Creep
Added in Repentance
240.1 Slowly crawls along walls to try to line up with Isaac and shoots a stream of shots seemingly affected by 15►Soy Milk Soy Milk.
Tainted Soy Creep
Tainted Soy Creep
Added in Repentance
240.3 Slowly crawls along walls to try to line up with Isaac and shoots a 4 diagonal streams of 15►Soy Milk Soy Milk shots.
Fire Worm
Fire Worm
Added in Repentance
825.0 Pops out of the ground in random locations and fires one flame at Isaac.
Tainted Round Worm
Tainted Round Worm
Added in Repentance
244.2 Pops out of the ground in random locations alongside several tail ends. The head fires a large blood shot that splits into a radial burst of 8 blood shots, while the tail ends shoot normal blood shots.
Tainted Tube Worm
Tainted Tube Worm
Added in Repentance
244.3 Pops out of the ground in random locations, spitting 4 explosive shots towards Isaac.
Mole
Mole
Added in Repentance
829.0 Burrows towards Isaac and jumps out the ground to fire 3 blood shots at him.
Tainted Mole
Tainted Mole
Added in Repentance
829.1 Dig towards Isaac and release a ring of rock waves. Fires 3 blood shots at Isaac 4 times.
Polty
Polty
Added in Repentance
816.0 Picks up and throws rocks and props at Isaac.
Kineti
Kineti
Added in Repentance
816.1 Uses telekinesis to pick up and throw rocks and obstacles at Isaac.
Dust
Dust
Added in Repentance
882.0 Follows Isaac, and is only visible when close to Isaac. Will begin to speed up when they are visible. Teleports away after taking enough damage.
Fly Trap
Fly Trap
Added in Repentance
873.0 Floats towards Isaac, with 3 Attack Flies circling around it. Coughs up additional Attack Flies and releases gas to launch the Attack Flies outwards.
Poot Mine
Poot Mine
Added in Repentance
875.0 Creates a gas cloud and propels itself away from Isaac when it gets hit. Explodes on death, detonating all the gas clouds it created.
Bombgagger
Bombgagger
Added in Repentance
844.0 Spits up a Giga Bomb and runs away from it.
Flesh Maiden
Flesh Maiden
Added in Repentance
880.0 Vaguely flies towards Isaac in curved swooping motions.
Morningstar
Morningstar
Added in Repentance
863.0 Floats toward Isaac to deal contact damage while Isaac is moving, gaining speed the longer Isaac continues moving. Stops moving when Isaac stops moving.
Needle
Needle
Added in Repentance
881.0 Pops out of the ground and lunges towards Isaac, dealing contact damage.
Pasty
Pasty
Added in Repentance
881.1 Pops out of the ground and lunges toward Isaac, dealing contact damage and firing four shots in the ordinal directions.
Fissure
Fissure
Added in Repentance
815.0 Jumps out of pits and bounces around the room. Spawns endlessly from pits until room clear. Do not need to be killed to clear room.
Lil Portal
Lil Portal
Added in Repentance
306.1 Spawns fly and spider enemies until it is destroyed.
Henry
Henry
Added in Repentance
837.0 Flushes away instantly when Isaac enters the room.
Triple Grimace
Triple Grimace
Added in Repentance
42.2 Stationary and invulnerable monster that occasionally fires a triple shot at Isaac. Stops firing when room is cleared.
Quake Grimace
Quake Grimace
Added in Repentance
804.0 Stationary and invulnerable monster that jumps and fires a line of rocks in one direction upon landing.
Bomb Grimace
Bomb Grimace
Added in Repentance
809.0 Stationary and invulnerable monster that keeps a single Throwable Bomb spawned.
Mockulus
Mockulus
Added in Repentance
864.0 Rapidly bounces around the room diagonally while Isaac is shooting.
Grudge
Grudge
Added in Repentance
877.0 Quickly slides towards Isaac when he gets in its line of sight. Cannot be destroyed.
Ball and Chain
Ball and Chain
Added in Repentance
893.0 Spike balls that rotate at the end of a chain attached to an obstacle. If the obstacle is destroyed, the ball will fly free around the room for a while.
Spikeball
Spikeball
Added in Repentance
852.0 Spike balls that fly in a line either horizontally or vertically, bouncing off walls and obstacles.
Singe's Ball
Singe's Ball
Added in Repentance
915.1 Spawned exclusively as apart Singe's boss fight and used in his attacks. They can be pushed around and launched with explosions.
Ultra Death Scythe
Ultra Death Scythe
Added in Repentance
951.41 Stays stationary for a moment, then travels in straight lines towards Ultra Death.
Siren Minion
Siren Minion
Added in Repentance
3.220 Spawned in automatically charmed by The Siren. Orbits the boss and fires projectiles towards Isaac.
Siren Helper
Siren Helper
Added in Repentance
966.0 Spawned in by The Siren and takes the form and control of all of her charmed familiars.
Visage Plasma
Visage Plasma
Added in Repentance
903.20 Floats in diagonal directions, doing contact damage. Spawned by The Visage and used in its phase 3 attacks.

Champions[]

ID Appearance Effect Drop Rarity Notes
24 Champion Brown.png

Brown

Trails poop behind it as it walks. Nothing Unknown
25 50px

Rainbow

Combines the effects of champion types 0, 2, 5, 10, 11, 13 and 17. A coin, a bomb, a key, a heart, a pill, a card and a trinket. Unknown

Audio[]

  • The Music is once again composed by Ridiculon.
    • Whilst not being in the official release, a fully updated Antibirth soundtrack may be released by Mudeth as a mod.

Environment[]

Chapters[]

Downpour Dross
Downpour Dross
Mines Ashpit
Mines Ashpit
Mausoleum Gehenna
Mausoleum Gehenna
Corpse Home
Corpse Home

Obstacles[]

  • Rocks
    • Spiked Rocks
    • Marked Skulls
    • Buckets
    • Fool's Gold Rocks
  • Poops
    • Giant Poop
    • Charming Poop
  • Fire Places
    • White Fire Place
  • Blocks
    • Pillars
  • Buttons
    • Red Buttons
    • Yellow Buttons
    • Brown Buttons
  • Teleporters

Rooms[]

Challenges[]