|This article is incomplete. Please help to improve it, or discuss the issue on the talk page.
Issues: Incomplete list of additions and changes.
- 1 Features
- 2 Additions
- 2.1 Player
- 2.2 Items
- 2.3 Trinkets
- 2.4 Pickups
- 2.5 Entities
- 2.6 Environment
- 2.7 Challenges
- 3 Changes
- 4 Gallery
- 5 Trivia
The Binding of Isaac: Afterbirth is the expansion to The Binding of Isaac: Rebirth. The DLC was released on October 30, 2015 and costs $10.99/£7.99. It was released on May 10, 2016 on Xbox One and PS4.
For a list of the pre-release blog posts, see The Binding of Isaac: Afterbirth (Pre-Release).
- Greed Mode: A new game mode with a heavy focus on risk/reward, featuring a new ending and final boss.
- Blue Womb: A new area, featuring a new ending and final boss.
- Daily Runs: Daily seeded runs with online leaderboards.
- Two new characters, Lilith and Keeper.
- 95 new items and 29 new trinkets.
- New pickups, chests, pills, and cards.
- 10 new challenges.
- 4 new alternate chapters: Burning Basement, Flooded Caves, Dank Depths, and Scarred Womb.
- Many new room layouts including tiny rooms, long hallways, and L-shaped rooms.
- New room types like trap rooms, double treasure rooms, and closets.
- New special seeds, along with a seed code combo page.
- An expanded soundtrack.
- An extra HUD option, allowing items picked up to be displayed on-screen.
- 9 new transformations.
- New bosses, along with new variations of bosses introduced in Rebirth.
- New monsters.
- Updated item combo system.
- New achievements.
- New co-op babies.
- An improved collection page that shows item descriptions.
|Damage||3.5 (*1.00)||3.5 (*1.20)|
|Shot Speed|| Blindfolded
|Starting Pickup(s)||None||x1 bombs|
|Starting Item(s)|| Incubus
Box of Friends
Isaac gains a green trail of poisonous creep.
+1 Red Heart container.
Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.
These Babies have special bonuses that will aid the player in some way.
|27||Black Baby||Spawns with an extra black heart.|
Defeat Mega Satan as Azazel to unlock it.
|28||Red Baby||Spawns with an extra red heart.|
Defeat Mega Satan as Magdalene to unlock it.
|29||White Baby||Gives Isaac an eternal heart when it spawns.|
Defeat Mega Satan as The Lost to unlock it.
|30||Blue Baby||Spawns with an extra soul heart.|
Defeat Mega Satan as ??? to unlock it.
|31||Rage Baby||Occasionally briefly increases Isaac's damage.|
Defeat Mega Satan as Samson to unlock it.
|32||Cry Baby||Occasionally briefly increases Isaac's tears.|
Defeat Mega Satan as Isaac to unlock it.
|33||Yellow Baby||Occasionally briefly increases Isaac's speed by 0.15.|
Defeat Mega Satan as Eden to unlock it.
|34||Long Baby||Occasionally briefly increases Isaac's range, shot speed, and tear height.|
Defeat Mega Satan as Lazarus to unlock it.
|35||Green Baby||Occasionally briefly increases Isaac's luck by 2.|
Defeat Mega Satan as Cain to unlock it.
|36||Lil' Baby||Occasionally briefly decreases Isaac's size.|
Defeat Mega Satan as Eve to unlock it.
|37||Big Baby||Occasionally briefly increases Isaac's size.|
Defeat Mega Satan as Lilith to unlock it.
|38||Brown Baby||Occasionally briefly gives Isaac the Butt Penny effect. While it is active, picking up a coin will make Isaac fart, knocking back nearby enemies.|
Defeat Mega Satan as Judas to unlock it.
|39||Noose Baby||Occasionally briefly gives Isaac the Transcendence effect, granting flight.|
Defeat Mega Satan as Keeper to unlock it.
|40||Hive Baby||Occasionally briefly gives Isaac the Hive Mind effect, doubling the damage dealt by blue spiders and blue flies.|
Earn all Hard mode completion marks as ??? to unlock it.
|41||Buddy Baby||Occasionally briefly gives Isaac the Guillotine effect, detaching Isaac's head and increasing damage and tears.|
Earn all Hard mode completion marks as Isaac to unlock it.
|42||Colorful Baby||Upon joining, fully heals Isaac, similar to the rainbow poop effect.|
Earn all Hard mode completion marks as Magdalene to unlock it.
|43||Whore Baby||Occasionally briefly gives Isaac the Whore of Babylon effect, increasing damage and speed.|
Earn all Hard mode completion marks as Eve to unlock it.
Earn all Hard mode completion marks as Eden to unlock it.
|45||Dripping Baby||Occasionally briefly gives Isaac Anemic, increasing range by 5 and causing Isaac to leave a trail of blood that damages enemies.|
Earn all Hard mode completion marks as Lazarus to unlock it.
|46||Blinding Baby||Upon death, activates the effect of XIX - The Sun, fully restoring Isaac's red hearts, deals 100 damage to all enemies in the room, and revealing the map for the current floor.|
Use Blank Card while holding XIX - The Sun to unlock it.
|47||Sucky Baby||Has an aura around itself that damages enemies while they are inside, similar to Succubus.|
Earn all Hard mode completion marks as Azazel to unlock it.
|48||Dark Baby||Occasionally provides a brief boost to all of Isaac's stats.|
Earn all Hard mode completion marks as Lilith to unlock it.
Earn all Hard mode completion marks as Cain to unlock it.
|50||Revenge Baby||Occasionally briefly increases Isaac's damage.|
Earn all Hard mode completion marks as Samson to unlock it.
|51||Belial Baby||Occasionally briefly gives Isaac the The Book of Belial effect, increasing damage.|
Earn all Hard mode completion marks as Judas to unlock it.
|52||Sale Baby||Occasionally briefly gives Isaac the Steam Sale effect, halving the prices of all shop items.|
Earn all Hard mode completion marks as Keeper to unlock it.
|53||Goat Head Baby||Occasionally briefly gives Isaac the Goat Head effect, guaranteeing that a Devil room or angel room will open if a boss room is completed while the effect is active. |
Defeat Mom's Heart on Hard mode as Lilith to unlock it.
|54||Super Greed Baby||Has the Head of the Keeper effect, firing coin tears that have a chance to spawn a coin upon hitting an enemy.|
Defeat Mom's Heart on Hard mode as Keeper to unlock it.
These Babies are purely cosmetic and do not have any special behaviors.
|233||Punkboy Baby||A baby dressed as a punk rocker boy.|
|234||Punkgirl Baby||A baby dressed as a punk rocker girl.|
|235||Computer Baby||A baby with a computer for a head.|
|236||Mask Baby||A baby wearing a mask.|
|237||Gem Baby||A baby that looks like it's made of crystal.|
|238||Shark Baby||A baby that looks like a shark.|
|239||Beret Baby||A baby that's wearing a beret.|
|240||Blisters Baby||A baby covered in blisters.|
|241||Radioactive Baby||A sickly green baby.|
|242||Beast Baby||A baby that looks like a beast.|
|243||Dark Baby||A very dark baby.|
|244||Snail Baby||A baby that looks like a snail.|
|245||Blood Baby||A baby that looks like a drop of blood.|
|246||8 Ball Baby||A baby with an 8 ball for a head.|
|247||Wisp Baby||A wispy baby.|
|248||Cactus Baby||A baby that looks like a cactus.|
|249||Love Eye Baby||A pink baby with a heart for an eye.|
|250||Medusa Baby||A baby that resembles Medusa.|
|251||Nuclear Baby||A baby that looks like a mushroom cloud.|
|252||Purple Baby||A strange purple baby.|
|253||Wizard Baby||A baby with a wizard hat.|
|254||Earth Baby||A baby whose head looks like planet Earth.|
|255||Saturn Baby||A baby with a ring around its head.|
|256||Cloud Baby||A baby made of cloud.|
|257||Tube Baby||A baby with a tube connecting both eyes.|
|258||Rocker Baby||A baby dressed as a rock fan.|
|259||King Baby||A baby with a crown.|
|260||Coat Baby||A baby wearing a winter coat.|
|261||Viking Baby||A baby with a Viking helmet.|
|262||Panda Baby||A baby that looks like a panda.|
|263||Raccoon Baby||A baby that looks like a raccoon.|
|264||Bear Baby||A baby that looks like a grizzly bear.|
|265||Polar Bear Baby||A baby that looks like a polar bear.|
|266||Lovebear Baby||A baby that looks like a Care Bear.|
|267||Hare Baby||A baby that looks like a rabbit.|
|268||Squirrel Baby||A baby that looks like a squirrel.|
|269||Tabby Baby||A baby that looks like a cat.|
|270||Porcupine Baby||A baby that looks like a porcupine.|
|271||Puppy Baby||A baby that looks like a puppy.|
|272||Parrot Baby||A baby that looks like a parrot.|
|273||Chameleon Baby||A baby that looks like a Chameleon.|
|274||Boulder Baby||A baby made of rocks.|
|275||Aqua Baby||An aqua-blue baby.|
|276||Gargoyle Baby||A baby that resembles a gargoyle.|
|277||Spiky Demon Baby||A baby that looks like a spiky demon.|
|278||Red Demon Baby||A baby that looks like a red demon.|
|279||Orange Demon Baby||A baby that looks like an orange demon.|
|280||Eye Demon Baby||A baby with an eye for a head.|
|281||Fang Demon Baby||A baby with big fangs.|
|282||Ghost Baby||A baby that looks like a ghost.|
|283||Arachnid Baby||A baby that looks like a spider.|
|284||Bony Baby||A baby that looks like a Bony.|
|285||Big Tongue Baby||A baby with a big tongue.|
|286||3D Baby||A baby wearing 3D glasses.|
|287||Suit Baby||A baby in a nice suit.|
|288||Butt Baby||A baby with a butt for a face.|
|289||Cupid Baby||A baby that looks like Cupid.|
|290||Heart Baby||A baby with a heart-shaped head.|
|291||Killer Baby||A baby that looks like Jason Voorhees from the "Friday the 13th" horror movie series.|
|292||Lantern Baby||A baby that looks like Ash Williams from the Evil Dead series.|
|293||Banshee Baby||A baby that looks like a banshee.|
|294||Ranger Baby||A baby that looks like a Red Power Ranger.|
|295||Rider Baby||A baby that looks like a Kamen Rider.|
|296||Choco Baby||A baby made of chocolate.|
|297||Woodsman Baby||A baby dressed as a hiker.|
|298||Brunette Baby||A baby with brown hair|
|299||Blonde Baby||A baby with blonde hair.|
|300||Blue Hair Baby||A baby with blue hair|
|301||Bloodied Baby||A baby covered in blood.|
|302||Cheese Baby||A baby made of cheese.|
|303||Pizza Baby||A baby made of pizza.|
|304||Hotdog Baby||A baby that is also a hotdog.|
|305||Nature Baby||A naked baby with a leaf.|
|306||Borg Baby||A robotic baby.|
|307||Corrupted Baby||A baby with seems to be covered by an alien life.|
|308||X Mouth Baby||A gagged baby.|
|309||X Eyed Baby||A comically dead baby.|
|310||Starry Eyed Baby||A baby with starry eyes.|
|311||Surgeon Baby||A baby ready for surgery.|
|312||Sword Baby||A baby that's a sword.|
|313||Monk Baby||A baby that's a monk.|
|314||Disco Baby||A funky baby with an afro|
|315||Puzzle Baby||A baby with a "Rubik's Cube" for a head|
|316||Speaker Baby||A baby that has a speaker for a head.|
|317||Scary Baby||A baby that resembles Jeff the Killer.|
|318||Fireball Baby||A fireball with eyes. Possibly a reference to the fire enemy in the Donkey Kong and Mario games.|
|319||Maw Baby||A baby that's just a mouth.|
|320||Exploding Baby||A baby that's a bomb.|
|321||Cupcake Baby||A baby that's also a cupcake.|
|322||Skinless Baby||A baby without skin.|
|323||Ballerina Baby||A baby wearing a tutu.|
|324||Goblin Baby||A baby that resembles a goblin.|
|325||Cool Goblin Baby||A green baby with brown hair and cool shades.|
|326||Geek Baby||A baby with black hair and nerdy glasses.|
|327||Long Beard Baby||A baby with a long beard.|
|328||Muttonchops Baby||A baby with muttonchops.|
|329||Spartan Baby||A baby that resembles King Leonidas from 300.|
|330||Tortoise Baby||A baby that looks like a tortoise.|
|331||Slicer Baby||A baby that resembles Shredder.|
|332||Butterfly Baby||A baby with butterfly wings.|
|333||Homeless Baby||A baby that resembles a homeless person.|
|334||Lumberjack Baby||A baby that resembles a lumberjack.|
|335||Cyberspace Baby||A baby that resembles something from the Tron universe.|
|336||Hero Baby||A baby that resembles Red from Gunstar Heroes.|
|337||Boxers Baby||A baby that resembles Arthur from Ghosts & Goblins (in his boxers).|
|338||Wing Helmet Baby||A baby that resembles Opa-Opa.|
|339||X Baby||A baby with an X for a head.|
|340||O Baby||A baby with an O for a head.|
|341||Vomit Baby||A baby with vomit coming from its mouth.|
|342||Merman Baby||A baby that resembles Aquaman.|
|343||Cyborg Baby||Might be a reference to a Cyborg from a novel/movie/game?|
|344||Barbarian Baby||A baby that resembles the Barbarian from Diablo.|
|345||Locust Baby||A baby that resembles a locust.|
|346||Twotone Baby||A completely white baby with a black outline.|
|347||2600 Baby||A baby that resembles an Atari 2600 sprite.|
|348||Fourtone Baby||A baby with a minimal colour sprite.|
|349||Grayscale Baby||A baby colored with several shades of gray.|
|350||Rabbit Baby||A baby that resembles Oswald the Lucky Rabbit.|
|351||Mouse Baby||A baby that resembles an old-style Mickey Mouse.|
|352||Critter Baby||A critter that looks white and hairy. Might be a reference to the movie Critters.|
|353||Blue Robot Baby||A baby that resembles Mega Man.|
|354||Pilot Baby||A baby that resembles Jason from Blaster Master.|
|355||Red Plumber Baby||A baby that resembles Mario.|
|356||Green Plumber Baby||A baby that resembles Luigi.|
|357||Yellow Plumber Baby||A baby that resembles Wario.|
|358||Purple Plumber Baby||A baby that resembles Waluigi.|
|359||Tanooki Baby||A baby that's wearing a Tanooki Suit.|
|360||Mushroom Man Baby||A baby that resembles Toad.|
|361||Mushroom Girl Baby||A baby that resembles Toadette.|
|362||Cannonball Baby||A baby that resembles a Chain Chomp.|
|363||Froggy Baby||A baby that's wearing a Frog Suit.|
|364||Turtle Dragon Baby||A baby that resembles Bowser.|
|365||Shell Suit Baby||A baby wearing a Hammer Suit.|
|366||Fiery Baby||A baby wearing a Fire Suit.|
|367||Mean Mushroom Baby||A baby that resembles a Goomba.|
|368||Arcade Baby||A baby that resembles Pac-Man.|
|369||Scared Ghost Baby||A blue ghost with a scared expression.|
|370||Blue Ghost Baby||A baby that resembles Inky.|
|371||Red Ghost Baby||A baby that resembles Blinky.|
|372||Pink Ghost Baby||A baby that resembles Pinky.|
|373||Orange Ghost Baby||A baby that resembles Clyde.|
|374||Pink Princess Baby||A baby that resembles Princess Peach.|
|375||Yellow Princess Baby||A baby that resembles Princess Daisy.|
|376||Dino Baby||A baby that resembles Yoshi.|
|377||Elf Baby||A baby that resembles Link.|
|378||Dark Elf Baby||A baby that resembles Dark Link|
|379||Dark Knight Baby||A baby that resembles a Darknut|
|380||Octopus Baby||A baby that resembles an Octorok.|
|381||Orange Pig Baby||A baby that resembles an orange Moblin.|
|382||Blue Pig Baby||A baby that resembles a blue Moblin.|
|383||Elf Princess Baby||A baby that resembles Princess Zelda.|
|384||Fishman Baby||A baby that resembles a Zora.|
|385||Fairyman Baby||A baby that resembles Tingle.|
|386||Imp Baby||A baby that resembles Midna.|
|387||Worm Baby||A baby that resembles Earthworm Jim.|
|388||Blue Wrestler Baby||A baby that looks like the blue player in Smash TV.|
|389||Red Wrestler Baby||A baby that looks like the red player in Smash TV.|
|390||Toast Baby||A baby that resembles Powdered Toast Man.|
|391||Roboboy Baby||A baby that resembles Astro Boy.|
|392||Liberty Baby||A baby that resembles the Statue of Liberty.|
|393||Dream Knight Baby||A baby that resembles Meta Knight.|
|394||Cowboy Baby||A baby that's wearing a cowboy outfit.|
|395||Mermaid Baby||A baby that resembles Ariel.|
|396||Plague Baby||A baby wearing a plague doctor outfit.|
|397||Space Soldier Baby||A baby that resembles a Warhammer 40k Space Marine.|
|398||Dark Space Soldier Baby||A baby that resembles a Warhammer 40k Chaos Space Marine.|
|399||Gas Mask Baby||A baby that's wearing a gas mask.|
|400||Tomboy Baby||A baby that resembles Sheik from the Legend of Zelda franchise.|
|401||Corgi Baby||A baby that looks like a corgi.|
|402||Unicorn Baby||A baby that looks like a unicorn.|
|403||Pixie Baby||A baby that resembles Tinkerbell.|
|404||Referee Baby||A baby wearing a referee outfit.|
|405||Deal With It Baby||A baby with a goatee and sunglasses.|
|406||Astronaut Baby||A baby that's wearing an astronaut outfit.|
|407||Blurred Baby||A baby with a blur effect across its privates.|
|408||Censored Baby||A baby with a censor bar across its privates.|
|409||Cool Ghost Baby||A baby that resembles the character Shades (Sukezaemon) from Ufouria: The Saga.|
|410||Gills Baby||A baby that resembles the character Gil (Jennifer) from Ufouria: The Saga.|
|411||Blue Hat Baby||A baby that resembles the character Bop-Louie (Hebe) from Ufouria: The Saga.|
|412||Catsuit Baby||A baby that's wearing a cat outfit. Also resembles the character Oh-Chan from Ufouria: The Saga (Japanese version).|
|413||Pirate Baby||A baby that's wearing a pirate outfit.|
|414||Super Robo Baby||A baby that resembles Tekkaman the Space Knight.|
|415||Lightmage Baby||A baby that resembles the white mage class from Final Fantasy.|
|416||Puncher Baby||A baby that resembles the warrior class from Final Fantasy.|
|417||Holy Knight Baby||A baby that resembles the monk class from Final Fantasy.|
|418||Shadowmage Baby||A baby that resembles the black mage class from Final Fantasy.|
|419||Firemage Baby||A baby that resembles the red mage class from Final Fantasy.|
|420||Priest Baby||A baby that's wearing a priest outfit.|
|421||Zipper Baby||A baby with a zipped mouth.|
|422||Bag Baby||A baby with a bag over its head.|
|423||Sailor Baby||A baby that's wearing a sailor outfit.|
|424||Rich Baby||A baby with a top hat and monocle.|
|425||Toga Baby||A baby in an ancient Roman outfit.|
|426||Knight Baby||A baby that resembles a Darknut from The Legend of Zelda.|
|427||Black Knight Baby||A baby that resembles a black Darknut from The Legend of Zelda.|
95 new items were added in the expansion: 19 activated items and 76 passive items.
|Box of Friends||5.100.357||Double your friends||Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Demon Baby for the room instead.||1|
|D12||5.100.386||Rerolls rocks||Re-rolls all rocks in the current room into other random objects, such as bomb rocks, metal blocks, TNT, or poops.||0|
|D7||5.100.437||Roll again||Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.||1|
|D8||5.100.406||Reroll stats||Re-rolls Isaac's damage, tears, range, and speed.||2|
|Diplopia||5.100.347||Double item vision||Duplicates all pickups and item pedestals in the room.||3|
|Friendly Ball||5.100.382||Gotta fetch 'em all!||Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms.||1|
|Glass Cannon||5.100.352||Be gentle...|| Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes Broken Glass Cannon.
|Glowing Hour Glass||5.100.422||Turn back time||When used, this item will rewind time, put Isaac back in the previous room, and undo anything that happened in the current room. Any health, pickups, or items gained or lost will be reset back to the previous state.||1|
|Jar of Flies||5.100.434||Bug catcher||Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar.||2|
|Kidney Bean||5.100.421||Love toots!||Isaac farts, charming all nearby enemies.||0|
|Mega Bean||5.100.351||Giga fart!||Petrifies all enemies in the current room for a couple of seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing.||1|
|Mega Blast||5.100.441||Laser breath||Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.||4|
|Mine Crafter||5.100.427||Booom!||Places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies when used. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT.||1|
|Mom's Box||5.100.439||What's inside?||Passively increases luck by 1 and doubles the effects of trinkets while held. When used, drops a random trinket on the ground.||3|
|Placebo||5.100.348||Pill mimic||When used, copies the effect of the pill Isaac is currently holding without consuming it. Does not copy the effects of cards or runes.||2|
|Tear Detonator||5.100.383||Remote tear detonation!||When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.||1|
|Teleport 2.0||5.100.419||I-Teleport!||Teleports Isaac to a random room that has not been explored yet when used. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the same room.||2|
|Ventricle Razor||5.100.396||Short cutter||Can be used to place an orange portal and a blue portal. Upon entering a portal, Isaac is teleported to the other portal.||1|
|Wooden Nickel||5.100.349||Flip a coin||When used, has a 50% chance to drop one random type of coin (Penny, Nickel, or Dime).||1|
|8 Inch Nails||5.100.359||Stick it to 'em!||+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.||3|
|Athame||5.100.408||Call to the void||When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies.||2|
|Betrayal||5.100.391||Turn your enemy||Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.||0|
|Binky||5.100.438||Tears up||Grants one Soul Heart, +0.75 tears and decreases Isaac's size.||3|
|Black Powder||5.100.420||Spin the black circle!||Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.||1|
|Bomber Boy||5.100.353||Cross blast + 5 bombs||+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs.||2|
|Bumbo||5.100.385||Bumbo want coin!||Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage.||1|
|Bursting Sack||5.100.377||Spider love||Spider enemies no longer target or deal contact damage to Isaac.||1|
|Cambion Conception||5.100.412||Feed them hate||After taking damage a certain amount of times, a permanent demonic familiar spawns.||2|
|Car Battery||5.100.356||Active power up||Causes Isaac's activated item to activate twice on each use.||3|
|Censer||5.100.387||Peace be with you||Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside.||3|
|Chaos||5.100.402||!!!||Drops 1-6 random pickups on the floor. Causes items to be chosen from random item pools.||3|
|Charged Baby||5.100.372||Bbbzzzzzt!||Spawns a familiar that occasionally drops a Lil' Battery, gives an active item charge, or petrifies all enemies in the room.||3|
|Circle of Protection||5.100.423||Protect me from myself||Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears.||1|
|Continuum||5.100.369||Transcendent tears||Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room.||2|
|Crack Jacks||5.100.354||HP up. Don't swallow the prize!||Grants one full Red Heart container and drops a random trinket.||2|
|Crown of Light||5.100.415||The untainted gain power||+2 soul hearts. While Isaac has no empty red hearts, grants 2x damage, +5.25 range, and -0.3 shot speed. Regardless of health, the crown deactivates for the current room when Isaac takes damage.||4|
|Curse of the Tower||5.100.371||Embrace chaos||Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower.||1|
|Dead Eye||5.100.373||Accuracy brings power!||Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.||3|
|Deep Pockets||5.100.416||More money!|| Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
|Eden's Blessing||5.100.381||Tears up + your future shines brighter||+0.7 tears up. Grants a random item at the start of the next run.||3|
|Empty Vessel||5.100.409||I reward an empty vessel||Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds.||2|
|Epiphora||5.100.368||Intensifying tears||Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.||1|
|Evil Eye||5.100.410||Eye shot!||While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.||2|
|Explosivo||5.100.401||Sticky bomb shot!||Isaac's tears have a chance to stick to enemies and explode.||1|
|Farting Baby||5.100.404||He farts!||Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies.||1|
|Fate's Reward||5.100.361||Your fate beside you||A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.||2|
|Friend Zone||5.100.364||Friendly fly||Spawns a white attack fly that orbits somewhere between Distant Admiration and Forever Alone, dealing 45 damage per second.||1|
|Fruit Cake||5.100.418||Rainbow effects!||Isaac's tears gain a random effect that changes every shot.||2|
|GB Bug||5.100.405||Double tap glitch|| Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
|Glitter Bombs||5.100.432||Prize bombs!||+5 bombs. Bombs have a chance to drop random pickups or charm enemies when they explode.||2|
|God's Flesh||5.100.398||Shrink shot!||Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.||1|
|Head of the Keeper||5.100.429||Penny tears!||Isaac's tears become coins and now have a chance to drop Pennies on the floor upon successfully hitting an enemy.||2|
|Holy Light||5.100.374||Holy death shot||Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy.||3|
|Host Hat||5.100.375||Blast resistance||A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions.||3|
|Immaculate Conception||5.100.413||Feed them love||Upon picking up a certain amount of health, spawn a permanent angelic familiar.||1|
|Incubus||5.100.360||Dark friend||Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects.||4|
|Key Bum||5.100.388||He wants your keys!||Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return.||0|
|Kidney Stone||5.100.440||Matt's kidney stone||Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage.||1|
|Lil Chest||5.100.362||What's in the box?||Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room.||2|
|Lil Gurdy||5.100.384||A gurd of your own!||A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed.||1|
|Lil Loki||5.100.435||4-way buddy!||Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern.||1|
|Lost Fly||5.100.365||Lost protector||Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact.||0|
|Lusty Blood||5.100.411||Their blood brings rage!||Isaac's damage increases for the current room each time he kills an enemy.||3|
|Marked||5.100.394||Directed tears||Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, +3.15 range.||0|
|Maw of the Void||5.100.399||Consume thy enemy!||Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. +1 damage, the ring can cause enemies to drop Black Hearts.||4|
|Milk!||5.100.436||Don't cry over it...||Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room.||1|
|Mom's Pearls||5.100.355||Range + luck up||+1.25 range, +0.5 tear height, +1 luck. Grants one Soul Heart.||2|
|More Options||5.100.414||There's options||Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.||3|
|Mr. Dolly||5.100.370||Range + tears up||+0.7 tears, +5.25 range, +0.5 tear height, spawns 3 random types of Hearts on the floor when picked up.||3|
|Multidimensional Baby||5.100.431||ydduB Buddy||Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.||1|
|My Shadow||5.100.433||Me! And my shaaaadow!||Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.||0|
|Night Light||5.100.425||Scared of the dark?||A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.||2|
|No. 2||5.100.378||Uh oh...||Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes.||2|
|Obsessed Fan||5.100.426||Follows my every move...||Spawns a familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.||0|
|Papa Fly||5.100.430||Turret follower||Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies.||1|
|Pay to Play||5.100.380||Money talks||+5 coins. Turns doors that require a single key into doors which need a coin to enter instead.||2|
|PJs||5.100.428||You feel cozy||Grants 4 Soul Hearts and fully restores Isaac's health.||2|
|Pupula Duplex||5.100.379||Wide shot||Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size.||2|
|Purity||5.100.407||Aura stat boost||Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.||2|
|Restock||5.100.376||Never ending stores!||Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.||3|
|Rune Bag||5.100.389||Rune generator||Spawns a familiar that drops a random rune every 5-6 rooms.||3|
|Sack Head||5.100.424||More sacks!||Coins, bombs, keys, cards, runes and batteries have a chance to become sacks.||3|
|Scatter Bombs||5.100.366||We put bombs in your bombs!||Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.||1|
|Seraphim||5.100.390||Sworn friend||Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed.||3|
|Serpent's Kiss||5.100.393||The kiss of death||Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a black heart when killed.||4|
|Spear of Destiny||5.100.400||Your destiny||In addition to tears, Isaac holds a spear in front of him which deals contact damage equal to 2x his tear damage, and occasionally inflicts fear.||1|
|Spider Mod||5.100.403||Mod buddy!||Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room.||1|
|Sticky Bombs||5.100.367||Egg sack bombs!||+5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.||1|
|Succubus||5.100.417||Damage booster||Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.||3|
|Sworn Protector||5.100.363||Protective friend||Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart.||3|
|Tech X||5.100.395||Laser ring tears||Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring.||4|
|The Wiz||5.100.358||Double wiz shot!||Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. Isaac's tears also travel above all obstacles.||1|
|Toxic Shock||5.100.350||Mass poison||Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground.||3|
|Tractor Beam||5.100.397||Controlled tears||Increases tears, range, and shot speed. Isaac emits a beam from his face that his tears follow along.||2|
|Zodiac||5.100.392||The heavens will change you||Gives Isaac a random zodiac item effect that changes every floor.||1|
29 new trinkets were added in the expansion.
|Black Feather||5.350.80||With darkness comes power||Increases Isaac's damage for possessing certain evil items.|
|Blasting Cap||5.350.73||Pop! Pop!||Exploding bombs have a chance to drop another Bomb pickup.|
|Blind Rage||5.350.81||Blind to damage||Increases invincibility time after getting hit.|
|Blister||5.350.77||Bounce back!||Increases knockback of tears.|
|Bob's Bladder||5.350.71||Creepy bombs||Leaves a pool of green creep under all bombs Isaac places, which damages enemies that walk over it.|
|Brown Cap||5.350.90||Fartoom!||Poop explodes upon being destroyed.|
|Child Leash||5.350.89||Keep your friends close...||Causes familiars to stay closer to each other.|
|Cracked Dice||5.350.67||You feel cursed... kinda.||Activates the effect of The D6, D8, D12, or D20 whenever Isaac takes damage.|
|Endless Nameless||5.350.79||I'm stuck in a loop...||Has a 25% chance of creating a duplicate of any pill, card, or rune Isaac uses.|
|Error||5.350.75||Effect not found?||Gives a random trinket effect each room.|
|Faded Polaroid||5.350.69||You feel faded||Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room.|
|Golden Horse Shoe||5.350.82||Feel lucky?||+15% chance for Treasure Rooms to have two items. Only one item can be taken.|
|Karma||5.350.85||Karma up||Donating to a donation machine has a chance to heal Isaac for a full red heart or spawn a beggar. Increases the chance that donating to a Donation Machine will increase Isaac's luck.|
|Lazy Worm||5.350.66||Pft||Increases range by 4 and decreases shot speed by .4.|
|Lil Larva||5.350.86||The poop is moving...||Spawns a Blue Fly from every pile of poop that Isaac destroys.|
|Louse||5.350.70||Itchy, tasty...||Occasionally spawns a Blue Spider.|
|Mom's Locket||5.350.87||You feel her love||Grants half a red heart each time a key is used. Converts half red heart pickups into full red hearts.|
|NO!||5.350.88||Never again!||Prevents active items from being generated, if possible.|
|Poker Chip||5.350.76||It's double down time!||Chests have a 50% chance of paying out with extra pickups and a 50% chance of paying out with nothing or enemies.|
|Rainbow Worm||5.350.64||Bleep Bloop Blop||Isaac's tears gain a worm effect that changes every 3 seconds.|
|Rib of Greed||5.350.84||Feels greedy||Prevents Greed and Super Greed from appearing in shops and secret rooms, and makes coin drops after clearing rooms more likely.|
|Safety Scissors||5.350.63||Fuse Cutter||Troll bombs turn into Bomb pickups before they explode. Mega troll bombs turn into 1+1 free bombs before they explode.|
|Second Hand||5.350.78||Extended stat effect time!||Increases the time that status effects stay on enemies.|
|Shiny Rock||5.350.62||It shines for its brothers||Tinted rocks and rocks with crawl spaces flash white upon entering the room and every 10 seconds afterward.|
|Store Key||5.350.83||Stores are open||Shops can be opened without using keys.|
|Stud Finder||5.350.74||The ground below feels hollow...||Increases the chance to find a Crawl Space.|
|Super Magnet||5.350.68||It Pulls||Pulls enemies and pickups towards Isaac.|
|Tape Worm||5.350.65||Floooooooooop!||Doubles Isaac's range and halves his tear height.|
|Watch Battery||5.350.72||Lil charge||Increased chance of batteries spawning. Has a chance to add an extra charge to Isaac's activated item upon completing a room.|
|Heart||Image||Worth||Additional Info||Unlocked By|
|Gold Heart||When a Gold Heart is lost, a few coins will be dropped around you.||Complete XXXXXXXXL (challenge #21)|
|Coin||Image||Worth||Additional Info||Unlocked By|
Increases luck by 1 when picked up.
|Donate 1 coin to the Greed Donation Machine|
Will flip upside-down when Isaac tries to collect it. Afterwards, it will get stuck on the ground, unable to be picked up unless blasted off the ground with an explosion.
|Complete the Boss Rush as Keeper|
|Bomb||Image||Worth||Additional Info||Unlocked By|
Will not add to the player's bomb count, but when picked up, it will give the player unlimited bombs for the duration of the current floor, even if the current number of bombs is 0.
|Complete Blue Bomber (challenge #23)|
Makes Isaac take a full heart of damage from all sources for the current room. Unlocked by completing Challenge #24: PAY TO PLAY.
For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: Have a Heart.
Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when TAB is held. This effect cannot be negated by Black Candle. Unlocked by completing Challenge #25: Have a Heart.
|32||One makes you larger|
Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox. These pills contribute to the Stompy transformation.
|33||One makes you small|
Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.
Destroys all poop in the room and spawns a single Blue Spider under Isaac and on each destroyed poop.
Spawns Blue Spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.
Activates an effect similar to The Gamekid.
Briefly pixelates the screen 3 times over 30 seconds.
|38||Friends Till The End!|
Spawns three blue flies.
|Get out of Jail Free Card||5.300.47||Open Sesame||Upon use, opens all doors in the current room (including the golden door at The Chest / Dark Room), similar to Dad's Key.|
|? Card||5.300.48||Double active||When used, copies the effect of Isaac's currently held activated collectible.|
|Blank Rune||5.300.40||???||Grants a random rune effect excluding the Black Rune. Has a 25% chance to spawn another Blank Rune upon use.|
|Dice Shard||5.300.49||D6 + D20||Upon use, activates the effects of The D6 and the D20 at the same time.|
|Emergency Contact||5.300.50||Help from above||When used, will cause two Mom's Hands to come down and grab two random enemies.|
- Eternal Chests are similar in appearance to Gold Chests, except they glow bright blue instead of gold, like a soul heart. They require one key to unlock, but can be reopened a random amount of times, each time requiring another key. They can be found in Angel rooms, in I AM ERROR Rooms and rarely in a normal room. Their loot is similar to Golden Chests, but there is a 25% chance they will drop nothing upon opening. If they contain nothing or an item, they will no longer be able to be reopened.
- Spiked Chests are purple colored chests with spikes protruding from them that will deal damage to Isaac upon opening unless he has the Holy Mantle active, which nullifies the damage, or if found in The Chest/Dark Room, where they are free to open. They can be rarely found upon completing a room or in greed mode shops. Their loot is similar to Brown Chests. Unlike other chests, they do not appear on the minimap.
- Spawns 1-4 random pickups upon touching it. It will not drop any hearts, pills or chests, and they have an increased chance to drop batteries.
||10.2||Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or a Pacer#Gusher upon death.|
||22.1||Wanders around the room, avoiding Isaac and spawning Drowned Chargers if he gets close. Spawns 0-2 Drowned Chargers upon death.|
||23.0.1||Charges at enemies when in its line of sight, dealing contact damage. Will always spawn friendly via My Shadow.|
||23.1||Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.|
||24.2||Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a Spider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.|
|Drowned Boom Fly
||25.2||Flies around the room diagonally, dealing contact damage. Upon death, explodes and fires four blood shots in the cardinal directions. Also has a chance to spawn a Drowned Charger upon death.|
|Scarred Double Vis
||39.3||Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.|
||40.1||Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.|
||58.1||Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.|
||208.1||Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away. Has a chance to leave behind a damaging flame upon death.|
|Dank Death's Head
||212.1||Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.|
||217.1||Quickly dashes in random directions, dealing contact damage.|
||217.2||Quickly dashes in random directions, dealing contact damage.|
||220.1||Dashes towards Isaac and deals contact damage, creating slowing black creep. Spawns 2 Clots upon death.|
|Rag Man's Ragling
||246.1||Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.|
||256.0||Flies towards Isaac and attempts to mimic his movements. Deals contact damage.|
||257.0||Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.|
|Blue Conjoined Fatty
||257.1||Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.|
||258.0||Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.|
||259.0||Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.|
||276.0||Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.|
||277.0||Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.|
||278.0||Chases Isaac, dealing a full heart of contact damage and spawning Spiders whenever it takes damage. Spawns a Spider, a Black Globin's Head, and a Black Globin's Body upon death.|
|Black Globin's Head
||279.0||Slides towards Isaac, leaving a trail of damaging Red Creep.|
|Black Globin's Body
||280.0||Walks aimlessly around the room, occasionally spawning spiders.|
||281.0||Follows Isaac in large, tightly-clustered groups and deals contact damage.|
||282.0||Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a Clotty or a collapsed Globin. Splits into two Clotties upon death.|
||283.0||Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.|
||284.0||Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.|
||285.0||Disappears, then reappears near Isaac and fires a brimstone laser.|
|Flesh Death's Head
||286.0||Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.|
|Mom's Dead Hand
||287.0||Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn the player with Mom's laugh.|
||288.0||Flies around the room diagonally, occasionally spitting out 1-2 Dart Flies.|
||289.0||Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.|
||290.0||Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.|
||291.0||Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.|
||291.1||Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.|
||291.2||Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.|
|Ultra Greed Coin (Spinner)
||293.0||Spins around the room, dealing contact damage.|
|Ultra Greed Coin (Key)
||293.1||Spins on itself and opens a golden door around the room if not destroyed, spawning hordes of Greed Gapers.|
|Ultra Greed Coin (Bomb)
||293.2||Spins on itself and explodes with a large radius if not destroyed.|
|Ultra Greed Coin (Heart)
||293.3||Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.|
||295.0||Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.|
||296.0||Gathers with other Hush Flies to form certain patterns. If spawned by Hush, can chase Isaac or orbit Hush. Deals contact damage.|
||297.0||Walks towards Isaac, dealing contact damage.|
||298.0||Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.|
||299.0||Walks towards Isaac, dealing contact damage.|
||404.1||Floats towards Isaac, doing contact damage.|
|Rag Man||Little Horn||Dangle||Turdlings|
|The Frail||The Stain||The Forsaken||Brownie|
Bomb Bums are extremely rare, and ask for bombs. Each bomb donated has a chance to have him drop 1-2 bomb pickups or an item from the Bomb Bum Item Pool. After spawning a pedestal item, the Bomb Bum will disappear and can no longer be donated to.
|Burning Basement||Flooded Caves|
|Dank Depths||Scarred Womb|
|??? (Blue Womb)|
|Defeat Mom||Gold Heart|
|Defeat Mom||Get out of Jail Free Card|
|23. Blue Bomber||
|Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times||Gold Bomb|
|24. PAY TO PLAY||
|Defeat Isaac as Cain||2 new pills|
|25. Have a Heart||
|Defeat Mom||2 new pills|
|26. I RULE!||
| Defeat ??? or The Lamb, and defeat Satan as Isaac
Defeat Mega Satan
|Defeat Isaac 5 times||Stud Finder|
|28. PRIDE DAY!||
|29. Onan's Streak||
|Defeat Mom||Kidney Stone|
|30. The Guardian||
|Defeat Mom||Blank Rune|
- His mini-brimstone's range can be increased with range up items or pills.
- The head deals 3 times Isaac's tear damage as poison over time instead of either 6 or 8 points.
- Increases the chance to open the Devil Room or Angel Room by 12.5% after killing a boss while holding it instead of guaranteeing it.
- Increases chance for a Devil/Angel Room Door to open by 17.5% instead of 35%.
- Knocks back enemy shots.
- The beams have a high chance to directly target enemies.
- Previously held items are removed from the pause menu.
- Reroll an item after defeating The Fallen no longer replace the Devil Room item he drops to a random item from the normal boss item pool.
- Fly enemies are only rerolled into other fly enemies.
- Red flies can't be rerolled anymore (even though enemies can be rerolled into them).
- Floods the whole room with water.
- Flushes all poop-related enemies and bosses away.
- The ladders are covered in water but the walls are not when used inside a crawl space.
- Can no longer be used without red heart containers.
- Has a 50% chance to rotate all beams around the player 90 degrees, similar to Krampus' second Brimstone attack.
- Sprite changed.
- Does not affect if Monstro is in the room the item is used in.
- Knocks back enemy shots.
- Its recharge time is 2 rooms instead of 6 rooms.
- Dark Room can no longer be cleared repeatedly.
- Sprite changed.
- The type of randomized tear changes every 2–3 seconds. The item appears to select two tear effects at once, perhaps staggering the times at which each of those effects changes.
- If a run is quit, and then continued, 3 Dollar Bill will keep tear effects for the current room.
- Shoots tears towards Isaac regardless of which direction Isaac is shooting.
- Blocks enemy shots.
- Bob's Brain is fired directly from where it is located in the chain of familiars behind Isaac, making aiming it slightly more difficult.
- Each copy takes up its own spot on the familiar line, but only the first one launches out. Respawning brains may end up stacking on top of each other.
- Can drop a Golden Bomb.
- Can drop a Golden Bomb.
- Each tear deals Isaac's tear damage.
- The poison hits twice, dealing a total of double Isaac's damage.
- Each bomb deals 5 times the character's normal tear damage instead of 3, plus a flat 30 damage. The flat 30 is not affected by damage multipliers.
- Isaac gives a wide glow lighting up dark areas, such as those under the effects of the Curse of Darkness or the Dark One's attacks.
- Brimstone shots damage the heart.
- Nullifies effects of One Makes You Small pills, One Makes You Larger pills, and other items that decrease the size of Isaac, such as Caffeine Pill.
- Gives a shield to familiar's tears.
- Speed boost is applied immediately.
- Range and tears height buffs are applied immediately.
- If picked up twice in the same run, two knives are fired at once.
- Dies after taking too much damage and then respawns after a long time. Exiting and continuing the run will cause it to reappear right away.
- Dies instantly by enemies' beam-type attacks, such as Uriel's and Gabriel's beam. This also includes enemies' Technology lasers such as Eye and Camillo Jr..
- Reappears instantly each time a familiar or orbital item is picked up.
- The poison hits twice, dealing a total of double Isaac's damage.
- Having multiple Steam Sales reduces all shop prices to 0 coins.
- Causes the Deals with the Devil not to convert the heart-type automatically.
- The slow is only applied after the player is hit.
- Isaac's bombs are magnetically attracted to the player character's tears.
- Each poison hit deals damage equal to Isaac's tear damage instead of 4 or 6 damage.
- Enemies killed after they have been inflicted with this type of poison have a 20% chance to drop Black Hearts.
- Can replace the Tick.
- No longer displays a particular puzzle piece on the last will screen if Isaac dies in a Sacrifice Room while holding it.
- Dying in a Sacrifice Room while holding it unlock The Lost, regardless of the current character.
- If The Lost was already unlocked, Isaac will be revived as The Lost and Missing Poster will be consumed.
- If the player's character is already The Lost, he will be revived in the previous room and Missing Poster will be consumed.
- Can be replaced by Match Stick.
- Troll Bombs are now given a random amount of time before exploding. Before that, they always exploded at a fixed time. This means that if two Troll Bombs spawn at the exact time right next to each other, there's a high chance one Troll Bomb will blow up before the other, sending that Troll Bomb sliding outwards a bit before exploding.
- Only leaves behind bones when killed.
- Double Trouble boss rooms can now contain 2 bosses of different types. Additionally, they can appear as early as chapter 1.
- Possible rewards found in the room include:
- Urns might spawn in the room.
- Killing Key Key Master and Shell Game Beggar no longer apply the 25% bonus.
- Donating to a Beggar until it pays out with an item on the current floor applies a 10% bonus instead of 25%.
- Donating to a Devil Beggar until it pays out with an item on the current floor applies a 10% bonus instead of 25%.
- If this coin flip succeeds, a Devil Room will be generated regardless of the above coin flips.
- "You feel blessed!" fortune in the Sacrifice Room of the current floor applies a bonus:
- If the "You feel blessed!" fortune appeared on the 3rd sacrifice, the chance will be 15%.
- If the "You feel blessed!" fortune appeared on the 5th sacrifice, the chance will be 50%.
- If both "You feel blessed!" fortunes appeared, the chance will be 65%.
- Angel Rooms that spawn after Isaac defeats Mom's Heart or It Lives will be normal Angel Rooms with items or pickups.
- A Troll Bomb can sometimes appear behind the Angel Statue, blowing it up. If the Angel fights have been unlocked, this will begin the boss fight if the player is not careful or quick enough to move the bomb.
- The clean bedroom occasionally has two clean beds instead of one.
- The trapdoor in a dirty bedroom has a chance to lead to a Crawl Space.
- Occasionally, one Rag Man will spawn inside the dirty bedroom.
- There is a chance that there will only be 2 items to choose from. Additionally, items may be trapped behind rocks or spikes. Items may appear in the corners of the room instead of the center.
- All 15 waves are randomized. Each wave spawns two random bosses from the list. Each boss can only appear once per Boss Rush.
- New layouts:
- If a sack spawns for whatever reason, picking it up will start the Boss Rush. The player can still pick up one of the pedestal items.
- Black Market can no longer be accessed in The Chest and The Dark Room, and therefore cannot be used to collect more items.
- The three waves appear in random orders rather than the original orders.
- The payouts only depend on the number of sacrifices made. The number of sacrifices is reset to 0 when the player goes to the next floor.
- Rewards are reworked:
|№ of sacrifices on Current Floor||Chance||Reward|
|67%||"You feel blessed!" (increased chance to receive an Angel Room over a Devil Room for the current floor)
|50%||1 random chest (The type of chest is governed by the same mechanic as room drops. Thus, brown chests are more likely to spawn than any other kind of chest.)|
|5th||33%||3 Pennies (These coins do not have a chance to spawn as a nickel or a dime.)|
|67%||You feel blessed!" (Same conditions as 3rd sacrifice but a stronger modifier.)|
|6th||33%||Teleport to the Devil/Angel Room. (If the floor's Devil/Angel Room has not been entered yet, an Angel Room is guaranteed to spawn — even if you already took a Devil Deal.)|
|67%||1 random chest (The type of chest is governed by the same mechanic as room drops. Thus, brown chests are more likely to spawn than any other kind of chest.)|
|7th||33%||1 random Angel Room pedestal item.|
|67%||1 Soul Heart|
|8th||100%||6 Troll Bombs|
|10th||50%||7 Soul Hearts|
|12th and onwards||50%||Nothing|
|50%||Teleport directly to the Dark Room|
- Losing red hearts due to the spikes will reduce the chance for a Devil Room to appear.
- The amount of luck that the player has does not affect the payout probabilities.
- Angels are normally able to fly over spikes but will take damage from sacrifice room spikes.
- New layouts:
- Can contain 2 Reward Plates.
- There is a small chance when you bomb the Shopkeeper that they can turn into Greed and start attacking you.
- The Dark Room theme contains 4 Nulls and 6 pills or runes instead of 1 Black Heart.
- New themes:
- There's a rare chance that a treasure room might contain two items to choose from, only one of which can be taken.
- Treasure rooms may also contain a Restock Machine, allowing Isaac to re-roll offered items if he has coins or bombs.
- New layouts:
- When not having red hearts in Devil Room, the price of items switches to soul hearts.
- Krampus has a new attack pattern.
- The floor icons on the stage transition sprites are updated; instead of being large rectangles with the unknown ones being grey, the sprites feature a much thinner and more detailed border with the unknown floors being represented by a closed trap door.
- Afterbirth is the placenta and fetal membranes discharged from the uterus after the birth of offspring, which might be why the title screen is bloody.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|