Binding of Isaac: Rebirth Wiki

Player[]

Characters[]

Character
Lilith

Keeper
Health Full red heartFull black heartFull black heart Full coin heartFull coin heart
Damage 3.5 (*1.00) 3.5 (*1.20)
Tears Blindfolded
(+0)
+18
Shot Speed Blindfolded
(1)
1
Range Blindfolded
(23.75)
23.75
Speed 1.0 0.85
Luck 0 -2
Starting Pickup(s) None x1 bombs
Needs to be unlocked x1 coins
Needs to be unlocked Store KeyStore Key
Starting Item(s) Incubus
Needs to be unlocked Cambion Conception
Box of Friends
Triple shot
Needs to be unlocked Wooden Nickel

Transformations[]

ID Name Appearance Description
2 Fun Guy Fun Guy

+1 Red Heart Container.

3 Seraphim Seraphim

Grants flight and gives +3 Soul Hearts.

4 Bob Bob

Isaac leaves a trail of green poisonous creep as he walks that deals 6 damage per second.

5 Spun Spun

Gives +2 damage and +0.15 speed, and spawns a random pill upon transformation.

6 Yes Mother? Yes Mother?

Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.

7 Conjoined Conjoined

Adds two tumors that fire diagonally from Isaac's head. -0.3 Damage, -0.3 Tears.

8 Leviathan Leviathan

Grants flight and gives +2 Black Hearts.

9 Oh Crap Oh Crap

Whenever a pile of poop is destroyed, restores half of a red heart.

n/a Super Bum Super Bum

Replaces Bum Friend, Dark Bum, and Key Bum with Super Bum. This bum collects any of the other beggars' pickups, and offers twice the rewards.

Co-op[]

Special Babies

These Babies have special bonuses that will aid the player in some way.

ID Appearance Name Description
27 Black Baby Spawns with an extra black heart.
Black Baby Defeat Mega Satan as Azazel to unlock it.
28 Red Baby Spawns with an extra red heart.
Red Baby Defeat Mega Satan as Magdalene to unlock it.
29 White Baby Gives Isaac an eternal heart when it spawns.
White Baby Defeat Mega Satan as The Lost to unlock it.
30 Blue Baby Spawns with an extra soul heart.
Blue Baby Defeat Mega Satan as ??? to unlock it.
31 Rage Baby Occasionally briefly increases Isaac's damage by 2.
Rage Baby Defeat Mega Satan as Samson to unlock it.
32 Cry Baby Occasionally briefly increases Isaac's tears by 1.
Cry Baby Defeat Mega Satan as Isaac to unlock it.
33 Yellow Baby Occasionally briefly increases Isaac's speed by 0.15.
Yellow Baby Defeat Mega Satan as Eden to unlock it.
34 Long Baby Occasionally briefly increases Isaac's range by 2, shot speed by 0.5, and tear falling speed.
Long Baby Defeat Mega Satan as Lazarus to unlock it.
35 Green Baby Occasionally briefly increases Isaac's luck by 2.
Green Baby Defeat Mega Satan as Cain to unlock it.
36 Lil' Baby Occasionally briefly decreases Isaac's size.
Lil' Baby Defeat Mega Satan as Eve to unlock it.
37 Big Baby Occasionally briefly increases Isaac's size.
Big Baby Defeat Mega Satan as Lilith to unlock it.
38 Brown Baby Occasionally briefly gives Isaac the Butt PennyButt Penny effect.
Brown Baby Defeat Mega Satan as Judas to unlock it.
39 Noose Baby Occasionally briefly gives Isaac the Transcendence effect, granting flight.
Noose Baby Defeat Mega Satan as Keeper to unlock it.
40 Hive Baby Occasionally briefly gives Isaac the Hive Mind effect, doubling the damage dealt by blue spiders and blue flies.
Hive Baby Earn all Hard mode Completion Marks as ??? to unlock it.
41 Buddy Baby Occasionally briefly gives Isaac the Guillotine effect, detaching Isaac's head and increasing damage and tears.
Buddy Baby Earn all Hard mode Completion Marks as Isaac to unlock it.
42 Colorful Baby Upon joining, fully heals Isaac, similar to the rainbow poop effect.
Colorful Baby Earn all Hard mode Completion Marks as Magdalene to unlock it.
43 Whore Baby Occasionally briefly gives Isaac the Whore of Babylon effect, increasing damage and speed.
Whore Baby Earn all Hard mode Completion Marks as Eve to unlock it.
44 Cracked Baby
Cracked Baby Earn all Hard mode Completion Marks as Eden to unlock it.
45 Dripping Baby Occasionally briefly gives Isaac Anemic, increasing range by 5 and causing Isaac to leave a trail of blood that damages enemies.
Dripping Baby Earn all Hard mode Completion Marks as Lazarus to unlock it.
46 Blinding Baby Upon death, activates the effect of XIX - The Sun, fully restoring Isaac's red hearts, deals 100 damage to all enemies in the room, and revealing the map for the current floor.
Blinding Baby Use Blank Card while holding XIX - The SunXIX - The Sun to unlock it.
47 Sucky Baby Has an aura around itself that damages enemies while they are inside, similar to Succubus.
Sucky Baby Earn all Hard mode Completion Marks as Azazel to unlock it.
48 Dark Baby Occasionally provides a brief boost to all of Isaac's stats.
Dark Baby Earn all Hard mode Completion Marks as Lilith to unlock it.
49 Picky Baby Occasionally briefly gives Isaac the Paper ClipPaper Clip effect.
Picky Baby Earn all Hard mode Completion Marks as Cain to unlock it.
50 Revenge Baby Occasionally briefly increases Isaac's damage.
Revenge Baby Earn all Hard mode Completion Marks as Samson to unlock it.
51 Belial Baby Occasionally briefly gives Isaac the The Book of Belial effect, increasing damage.
Belial Baby Earn all Hard mode Completion Marks as Judas to unlock it.
52 Sale Baby Occasionally briefly gives Isaac the Steam Sale effect, halving the prices of all shop items.
Sale Baby Earn all Hard mode Completion Marks as Keeper to unlock it.
53 Goat Head Baby Occasionally briefly gives Isaac the Goat Head effect, guaranteeing that a Devil room or angel room will open if a boss room is completed while the effect is active.
Goat Head Baby Defeat Mom's Heart on Hard mode as Lilith to unlock it.
54 Super Greed Baby Has the Head of the Keeper effect, firing coin tears that have a chance to spawn a coin upon hitting an enemy.
Super Greed Baby Defeat Mom's Heart on Hard mode as Keeper to unlock it.

Normal Babies

These Babies are purely cosmetic and do not have any special behaviors.

ID Appearance Name Description
233 Punkboy Baby A baby dressed as a punk rocker boy.
234 Punkgirl Baby A baby dressed as a punk rocker girl.
235 Computer Baby A baby with a computer for a head.
236 Mask Baby A baby wearing a mask.
237 Gem Baby A baby that looks like it's made of crystal.
238 Shark Baby A baby that looks like a shark.
239 Beret Baby A baby that's wearing a beret.
240 Blisters Baby A baby covered in blisters.
241 Radioactive Baby A sickly green baby.
242 Beast Baby A baby that looks like a beast.
243 Dark Baby A very dark baby.
244 Snail Baby A baby that looks like a snail.
245 Blood Baby A baby that looks like a drop of blood.
246 8 Ball Baby A baby with an 8 ball for a head.
247 Wisp Baby A wispy baby.
248 Cactus Baby A baby that looks like a cactus.
249 Love Eye Baby A pink baby with a heart for an eye.
250 Medusa Baby A baby that resembles Medusa.
251 Nuclear Baby A baby that looks like a mushroom cloud.
252 Purple Baby A strange purple baby.
253 Wizard Baby A baby with a wizard hat.
254 Earth Baby A baby whose head looks like planet Earth.
255 Saturn Baby A baby with a ring around its head.
256 Cloud Baby A baby made of cloud.
257 Tube Baby A baby with a tube connecting both eyes.
258 Rocker Baby A baby dressed as a rock fan.
259 King Baby A baby with a crown.
260 Coat Baby A baby wearing a winter coat.
261 Viking Baby A baby with a Viking helmet.
262 Panda Baby A baby that looks like a panda.
263 Raccoon Baby A baby that looks like a raccoon.
264 Bear Baby A baby that looks like a grizzly bear.
265 Polar Bear Baby A baby that looks like a polar bear.
266 Lovebear Baby A baby that looks like a Care Bear.
267 Hare Baby A baby that looks like a rabbit.
268 Squirrel Baby A baby that looks like a squirrel.
269 Tabby Baby A baby that looks like a cat.
270 Porcupine Baby A baby that looks like a porcupine.
271 Puppy Baby A baby that looks like a puppy.
272 Parrot Baby A baby that looks like a parrot.
273 Chameleon Baby A baby that looks like a Chameleon.
274 Boulder Baby A baby made of rocks.
275 Aqua Baby An aqua-blue baby.
276 Gargoyle Baby A baby that resembles a gargoyle.
277 Spiky Demon Baby A baby that looks like a spiky demon.
278 Red Demon Baby A baby that looks like a red demon.
279 Orange Demon Baby A baby that looks like an orange demon.
280 Eye Demon Baby A baby with an eye for a head.
281 Fang Demon Baby A baby with big fangs.
282 Ghost Baby A baby that looks like a ghost.
283 Arachnid Baby A baby that looks like a spider.
284 Bony Baby A baby that looks like a Bony.
285 Big Tongue Baby A baby with a big tongue.
286 3D Baby A baby wearing 3D glasses.
287 Suit Baby A baby in a nice suit.
288 Butt Baby A baby with a butt for a face.
289 Cupid Baby A baby that looks like Cupid.
290 Heart Baby A baby with a heart-shaped head.
291 Killer Baby A baby that looks like Jason Voorhees from the "Friday the 13th" horror movie series.
292 Lantern Baby A baby that looks like Ash Williams from the Evil Dead series.
293 Banshee Baby A baby that looks like a banshee.
294 Ranger Baby A baby that looks like a Red Power Ranger.
295 Rider Baby A baby that looks like a Kamen Rider.
296 Choco Baby A baby made of chocolate.
297 Woodsman Baby A baby dressed as a hiker.
298 Brunette Baby A baby with brown hair
299 Blonde Baby A baby with blonde hair.
300 Blue Hair Baby A baby with blue hair
301 Bloodied Baby A baby covered in blood.
302 Cheese Baby A baby made of cheese.
303 Pizza Baby A baby made of pizza.
304 Hotdog Baby A baby that is also a hotdog.
305 Nature Baby A naked baby with a leaf.
306 Borg Baby A robotic baby.
307 Corrupted Baby A baby with seems to be covered by an alien life.
308 X Mouth Baby A gagged baby.
309 X Eyed Baby A comically dead baby.
310 Starry Eyed Baby A baby with starry eyes.
311 Surgeon Baby A baby ready for surgery.
312 Sword Baby A baby that's a sword.
313 Monk Baby A baby that's a monk.
314 Disco Baby A funky baby with an afro
315 Puzzle Baby A baby with a "Rubik's Cube" for a head
316 Speaker Baby A baby that has a speaker for a head.
317 Scary Baby A baby that resembles Jeff the Killer.
318 Fireball Baby A fireball with eyes. Possibly a reference to the fire enemy in the Donkey Kong and Mario games.
319 Maw Baby A baby that's just a mouth.
320 Exploding Baby A baby that's a bomb.
321 Cupcake Baby A baby that's also a cupcake.
322 Skinless Baby A baby without skin.
323 Ballerina Baby A baby wearing a tutu.
324 Goblin Baby A baby that resembles a goblin.
325 Cool Goblin Baby A green baby with brown hair and cool shades.
326 Geek Baby A baby with black hair and nerdy glasses.
327 Long Beard Baby A baby with a long beard.
328 Muttonchops Baby A baby with muttonchops.
329 Spartan Baby A baby that resembles King Leonidas from 300.
330 Tortoise Baby A baby that resembles Vectorman from the game Vectorman
331 Slicer Baby A baby that resembles Shredder.
332 Butterfly Baby A baby with butterfly wings.
333 Homeless Baby A baby that resembles a homeless person.
334 Lumberjack Baby A baby that resembles a lumberjack.
335 Cyberspace Baby A baby that resembles something from the Tron universe.
336 Hero Baby A baby that resembles Red from Gunstar Heroes.
337 Boxers Baby A baby that resembles Arthur from Ghosts & Goblins (in his boxers).
338 Wing Helmet Baby A baby that resembles Opa-Opa.
339 X Baby A baby with an X for a head.
340 O Baby A baby with an O for a head.
341 Vomit Baby A baby with vomit coming from its mouth.
342 Merman Baby A baby that resembles Aquaman.
343 Cyborg Baby Might be a reference to a Cyborg from a novel/movie/game?
344 Barbarian Baby A baby that resembles the Barbarian from Diablo.
345 Locust Baby A baby that resembles a locust.
346 Twotone Baby A completely white baby with a black outline.
347 2600 Baby A baby that resembles an Atari 2600 sprite.
348 Fourtone Baby A baby with a minimal colour sprite.
349 Grayscale Baby A baby colored with several shades of gray.
350 Rabbit Baby A baby that resembles Oswald the Lucky Rabbit.
351 Mouse Baby A baby that resembles an old-style Mickey Mouse.
352 Critter Baby A critter that looks white and hairy. Might be a reference to the movie Critters.
353 Blue Robot Baby A baby that resembles Mega Man.
354 Pilot Baby A baby that resembles Jason from Blaster Master.
355 Red Plumber Baby A baby that resembles Mario.
356 Green Plumber Baby A baby that resembles Luigi.
357 Yellow Plumber Baby A baby that resembles Wario.
358 Purple Plumber Baby A baby that resembles Waluigi.
359 Tanooki Baby A baby that's wearing a Tanooki Suit.
360 Mushroom Man Baby A baby that resembles Toad.
361 Mushroom Girl Baby A baby that resembles Toadette.
362 Cannonball Baby A baby that resembles a Chain Chomp.
363 Froggy Baby A baby that's wearing a Frog Suit.
364 Turtle Dragon Baby A baby that resembles Bowser.
365 Shell Suit Baby A baby wearing a Hammer Suit.
366 Fiery Baby A baby wearing a Fire Suit.
367 Mean Mushroom Baby A baby that resembles a Goomba.
368 Arcade Baby A baby that resembles Pac-Man.
369 Scared Ghost Baby A blue ghost with a scared expression.
370 Blue Ghost Baby A baby that resembles Inky.
371 Red Ghost Baby A baby that resembles Blinky.
372 Pink Ghost Baby A baby that resembles Pinky.
373 Orange Ghost Baby A baby that resembles Clyde.
374 Pink Princess Baby A baby that resembles Princess Peach.
375 Yellow Princess Baby A baby that resembles Princess Daisy.
376 Dino Baby A baby that resembles Yoshi.
377 Elf Baby A baby that resembles Link.
378 Dark Elf Baby A baby that resembles Dark Link
379 Dark Knight Baby A baby that resembles a Darknut
380 Octopus Baby A baby that resembles an Octorok.
381 Orange Pig Baby A baby that resembles an orange Moblin.
382 Blue Pig Baby A baby that resembles a blue Moblin.
383 Elf Princess Baby A baby that resembles Princess Zelda.
384 Fishman Baby A baby that resembles a Zora.
385 Fairyman Baby A baby that resembles Tingle.
386 Imp Baby A baby that resembles Midna.
387 Worm Baby A baby that resembles Earthworm Jim.
388 Blue Wrestler Baby A baby that looks like the blue player in Smash TV.
389 Red Wrestler Baby A baby that looks like the red player in Smash TV.
390 Toast Baby A baby that resembles Powdered Toast Man.
391 Roboboy Baby A baby that resembles Astro Boy.
392 Liberty Baby A baby that resembles the Statue of Liberty.
393 Dream Knight Baby A baby that resembles Meta Knight.
394 Cowboy Baby A baby that's wearing a cowboy outfit.
395 Mermaid Baby A baby that resembles Ariel.
396 Plague Baby A baby wearing a plague doctor outfit.
397 Space Soldier Baby A baby that resembles a Warhammer 40k Space Marine.
398 Dark Space Soldier Baby A baby that resembles a Warhammer 40k Chaos Space Marine.
399 Gas Mask Baby A baby that's wearing a gas mask.
400 Tomboy Baby A baby that resembles Sheik from the Legend of Zelda franchise.
401 Corgi Baby A baby that looks like a corgi.
402 Unicorn Baby A baby that looks like a unicorn.
403 Pixie Baby A baby that resembles Tinkerbell.
404 Referee Baby A baby wearing a referee outfit.
405 Deal With It Baby A baby with a goatee and sunglasses.
406 Astronaut Baby A baby that's wearing an astronaut outfit.
407 Blurred Baby A baby with a blur effect across its privates.
408 Censored Baby A baby with a censor bar across its privates.
409 Cool Ghost Baby A baby that resembles the character Shades (Sukezaemon) from Ufouria: The Saga.
410 Gills Baby A baby that resembles the character Gil (Jennifer) from Ufouria: The Saga.
411 Blue Hat Baby A baby that resembles the character Bop-Louie (Hebe) from Ufouria: The Saga.
412 Catsuit Baby A baby that's wearing a cat outfit. Also resembles the character Oh-Chan from Ufouria: The Saga (Japanese version).
413 Pirate Baby A baby that's wearing a pirate outfit.
414 Super Robo Baby A baby that resembles Tekkaman the Space Knight.
415 Lightmage Baby A baby that resembles the white mage class from Final Fantasy.
416 Puncher Baby A baby that resembles the warrior class from Final Fantasy.
417 Holy Knight Baby A baby that resembles the monk class from Final Fantasy.
418 Shadowmage Baby A baby that resembles the black mage class from Final Fantasy.
419 Firemage Baby A baby that resembles the red mage class from Final Fantasy.
420 Priest Baby A baby that's wearing a priest outfit.
421 Zipper Baby A baby with a zipped mouth.
422 Bag Baby A baby with a bag over its head.
423 Sailor Baby A baby that's wearing a sailor outfit.
424 Rich Baby A baby with a top hat and monocle.
425 Toga Baby A baby in an ancient Roman outfit.
426 Knight Baby A baby that resembles a Darknut from The Legend of Zelda.
427 Black Knight Baby A baby that resembles a black Darknut from The Legend of Zelda.



Items[]

95 new items were added in the expansion: 19 activated items and 76 passive items.

Activated Collectibles[]

Name ID Icon Quote Description Quality
Box of Friends 5.100.357
Box of Friends
3 rooms
Double your friends Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Demon Baby for the room instead. 1
D12 5.100.386
D12
3 rooms
Rerolls rocks (except in Repentance) Re-rolls all Rocks and Metal Blocks in the current room into other random obstacles.
(in Repentance) Re-rolls most types of Obstacles in the current room into other random obstacles.
1
D7 5.100.437
D7
3 rooms
Roll again Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room. 1
D8 5.100.406
D8
4 rooms
Reroll stats Re-rolls Isaac's damage, tears, range, and speed. 1
Diplopia 5.100.347
Diplopia
One time use
Double item vision Duplicates all pickups and item pedestals in the room. 3
Friendly Ball 5.100.382
Friendly Ball
2 rooms
Gotta fetch 'em all! Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms. 1
Glass Cannon 5.100.352
Glass Cannon
4 seconds
Be gentle... (except in Repentance) Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
(in Repentance) Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes Broken Glass Cannon.
1
Glowing Hourglass 5.100.422
Glowing Hourglass
Unlimited
Turn back time Rewinds time, putting Isaac back in the previous room and undoing anything that happened in the current room. (in Repentance) Can only be used three times per floor, after which it functions like The Hourglass until the next floor. 3
Jar of Flies 5.100.434
Jar of Flies
Unlimited
Bug catcher Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. 2
Kidney Bean 5.100.421
Kidney Bean
1 room
Love toots! Isaac farts, charming all nearby enemies. 0
Mega Bean 5.100.351
Mega Bean
6 rooms
Giga fart! Petrifies all enemies in the current room for about 1.5 seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing. 1
Mega Blast 5.100.441
Mega Blast
12 rooms
Laser breath Isaac fires a giant laser for approximately 15 seconds. This laser deals massive damage, pushes Isaac backwards, and persists between rooms and floors. 4
Mine Crafter 5.100.427
Mine Crafter
1 room
Booom! Places a Movable TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used again in the same room while the previous TNT barrel is still intact, remotely detonates the TNT. 1
Mom's Box 5.100.439
Mom's Box
4 rooms
What's inside? Increases luck by 1 and doubles the effects of trinkets while held. When used, drops a random trinket on the ground. 2
Placebo 5.100.348
Placebo
Variable
Pill mimic Has the same effect as the Pill currently held by Isaac. (in Repentance) The charge time is based on the power of the pill. 1
Tear Detonator 5.100.383
Tear Detonator
15 seconds
Remote tear detonation! Splits all of Isaac's tears that are currently in the air into 6 tears that fire in all directions, which retain their damage and shot speed. 1
Teleport 2.0 5.100.419
Teleport 2.0
4 rooms
I-Teleport! Teleports Isaac to a room that has not been explored yet. Normal rooms are prioritized over special rooms, and common special rooms take priority over rarer ones. 3
Ventricle Razor 5.100.396
Ventricle Razor
Unlimited
Short cutter Creates up to two portals that remain even if Isaac leaves the room. Upon entering a portal, Isaac is teleported to the other portal. 1
Wooden Nickel 5.100.349
Wooden Nickel
1 room
Flip a coin Has a roughly 50% chance to drop a penny, nickel or dime, and a roughly 50% chance to do nothing. 1

Passive Collectibles[]

Name ID Icon Quote Description Quality
8 Inch Nails 5.100.359 8 Inch Nails Stick it to 'em! +1.5 damage. Replaces Isaac's tears with nails, which have increased knockback. 3
Athame 5.100.408 Athame Call to the void (except in Repentance) When Isaac takes damage, a damaging black ring briefly appears around him. This ring can cause enemies to drop Black Hearts.
(in Repentance) After Isaac kills an enemy, adds a luck-based chance to spawn a damaging black ring around them.
3
Betrayal 5.100.391 Betrayal Turn your enemy (except in Repentance) Charms all enemies in the room when Isaac takes damage.
(in Repentance) Enemies are able to damage each other. If an enemy is damaged by another enemy, they will attack that enemy instead of Isaac.
1
Binky 5.100.438 Binky Tears up Grants one Soul Heart, +0.75 tears and decreases Isaac's size. 3
Black Powder 5.100.420 Black Powder Spin the black circle! Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it. 0
Bomber Boy 5.100.353 Bomber Boy Cross blast + 5 bombs +5 Bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs. 2
Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
Bursting Sack 5.100.377 Bursting Sack Spider love Spider enemies no longer target or deal contact damage to Isaac. 1
Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 1
Car Battery 5.100.356 Car Battery Active power up Causes Isaac's activated item to activate twice on each use. 3
Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 2
Chaos 5.100.402 Chaos !!! Drops 1-6 random pickups on the floor. Causes items to be chosen from random item pools. 3
Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' Battery, gives an active item charge, or petrifies all enemies in the room. 2
Circle of Protection 5.100.423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears. 2
Continuum 5.100.369 Continuum Transcendent tears Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room. 2
Crack Jacks 5.100.354 Crack Jacks HP up. Don't swallow the prize! Grants one full Red Heart container and drops a random trinket. (in Repentance) Heals 1 additional Red Heart. 2
Crown Of Light 5.100.415 Crown Of Light The untainted gain power +2 Soul Hearts. While Isaac has no empty red hearts, grants 2x damage, increased range, and -0.3 shot speed. Regardless of health, the crown deactivates for the current room when Isaac takes damage. 4
Curse of the Tower 5.100.371 Curse of the Tower Embrace chaos Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower. 0
Dead Eye 5.100.373 Dead Eye Accuracy brings power! Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot. 3
Deep Pockets 5.100.416 Deep Pockets More money! (except in Repentance) Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
(in Repentance) Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
2
Eden's Blessing 5.100.381 Eden's Blessing Tears up + your future shines brighter +0.7 tears up. Grants a random item at the start of the next run. 3
Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2
Epiphora 5.100.368 Epiphora Intensifying tears Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount. 1
Evil Eye 5.100.410 Evil Eye Eye shot! Adds a chance to fire a slow-moving eye that fires tears in the same direction as Isaac. The eye is destroyed when it hits an enemy or obstacle. 2
Explosivo 5.100.401 Explosivo Sticky bomb shot! Isaac's tears have a chance to stick to enemies and explode. 3
Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
Fate's Reward 5.100.361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. 2
Friend Zone 5.100.364 Friend Zone Friendly fly Spawns a white attack fly that orbits somewhere between Distant Admiration and Forever Alone, dealing 45 damage per second. 1
Fruit Cake 5.100.418 Fruit Cake Rainbow effects! Isaac's tears gain a random effect that changes every shot. 2
GB Bug 5.100.405 GB Bug Double tap glitch (except in Repentance) Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
(in Repentance) Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
1
Glitter Bombs 5.100.432 Glitter Bombs Prize bombs! +5 Bombs. Bombs have a chance to drop random pickups or charm enemies when they explode. 2
God's Flesh 5.100.398 God's Flesh Shrink shot! Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them. 1
Head of the Keeper 5.100.429 Head of the Keeper Penny tears! Isaac's tears become coins. Hitting an enemy has a 5% chance to drop a Penny. 2
Holy Light 5.100.374 Holy Light Holy death shot Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy. 3
Host Hat 5.100.375 Host Hat Blast resistance A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. 3
Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 1
Incubus 5.100.360 Incubus Dark friend Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. 4
Key Bum 5.100.388 Key Bum He wants your keys! Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return. 0
Kidney Stone 5.100.440 Kidney Stone Matt's kidney stone Isaac is occasionally forced to stop firing and charge an attack that launches a massive piercing, spectral kidney stone and a barrage of tears. (except in Repentance) -0.2 speed, decreases range. 2
Lil Chest 5.100.362 Lil Chest What's in the box? Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. 2
Lil Gurdy 5.100.384 Lil Gurdy A gurd of your own! A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. 1
Lil Loki 5.100.435 Lil Loki 4-way buddy! Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. 1
Lost Fly 5.100.365 Lost Fly Lost protector Spawns a fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. (except in Repentance) It deals 105 damage per second on contact. (in Repentance) It deals 56 damage per second and forces nearby enemies to attack it. 2
Lusty Blood 5.100.411 Lusty Blood Their blood brings rage! Isaac's damage increases for the current room each time he kills an enemy. 3
Marked 5.100.394 Marked Directed tears Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, increases range. 0
Maw Of The Void 5.100.399 Maw Of The Void Consume thy enemy! Isaac can charge and unleash a black ring that rapidly deals damage around him. (except in Repentance) The ring can cause enemies to drop Black Hearts. +1 damage. 3
Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room. 1
Mom's Pearls 5.100.355 Mom's Pearls Range + luck up (except in Repentance) +1.25 range, +0.5 tear falling speed, +1 luck.
(in Repentance) +2.5 range, +1 luck. Grants one Soul Heart.
2
More Options 5.100.414 More Options There's options Two item pedestals are presented in every Treasure RoomTreasure Room. Only one can be taken; the other will disappear. 3
Mr. Dolly 5.100.370 Mr. Dolly Range + tears up (except in Repentance) +0.7 tears, +5.25 range, +0.5 tear falling speed, Spawns a combination of 3 Red Hearts, Soul Hearts or Black Hearts on the floor when picked up.
(in Repentance) +0.7 tears, +2.5 range, spawns 3 random types of Hearts on the floor when picked up.
3
Multidimensional Baby 5.100.431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. 2
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! (except in Repentance) Inflicts fear on all enemies in the room upon taking damage and spawns black friendly Chargers that attack enemies.
(in Repentance) Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly Charger whenever an enemy touches it.
1
Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots. 1
Number Two 5.100.378 Number Two Uh oh... Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes. 2
Obsessed Fan 5.100.426 Obsessed Fan Follows my every move... Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies. 0
Papa Fly 5.100.430 Papa Fly Turret follower Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. 1
Pay To Play 5.100.380 Pay To Play Money talks (except in Repentance) +5 Coins. Most doors require one Penny to open instead of a Key.
(in Repentance) +5 Coins. All locked doors, Locked Chests, and Key Blocks must be opened with one Penny instead of Keys.
2
PJs 5.100.428 PJs You feel cozy Grants 4 Soul Hearts and fully restores Isaac's health. 2
Pupula Duplex 5.100.379 Pupula Duplex Wide shot Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size. 2
Purity 5.100.407 Purity Aura stat boost Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range. 3
Restock 5.100.376 Restock Never ending stores! Causes ShopShops to instantly restock their items when they are bought. (in Repentance) Outside of Greed Mode, the restocked item's cost is increased after each purchase. 2
Rune Bag 5.100.389 Rune Bag Rune generator Spawns a familiar that drops a random rune after clearing enough rooms. 3
Sack Head 5.100.424 Sack Head More sacks! Spawns a Grab Bag on pickup. Coins, Bombs, Keys, cards, runes and batteries have a chance to become Grab Bags. 3
Scatter Bombs 5.100.366 Scatter Bombs We put bombs in your bombs! +5 Bombs. Isaac's bombs explode into 2-4 tiny bombs. 1
Seraphim 5.100.390 Seraphim Sworn friend Spawns an angel familiar who follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. 3
Serpent's Kiss 5.100.393 Serpent's Kiss The kiss of death Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a Black Heart when killed. 2
Spear Of Destiny 5.100.400 Spear Of Destiny Your destiny In addition to tears, Isaac holds a spear in front of him which deals contact damage equal to 2× his tear damage, and occasionally inflicts fear. 1
Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. 1
Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 Bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. (in Repentance) They also leave a long-lasting puddle of slowing white creep. 1
Succubus 5.100.417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5× tear damage multiplier. 3
Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart. 2
Tech X 5.100.395 Tech X Laser ring tears Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring. 4
The Wiz 5.100.358 The Wiz Double wiz shot! Grants spectral tears. Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. 0
Toxic Shock 5.100.350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground. 3
Tractor Beam 5.100.397 Tractor Beam Controlled tears Isaac's tears are bound to a beam emitting in the direction he's firing. (except in Repentance) +0.5 Tears, +5.25 Range, +0.16 Shot Speed. (in Repentance) +1 Fire Rate, +2.5 Range, +0.16 Shot Speed. 3
Zodiac 5.100.392 Zodiac The heavens will change you Gives Isaac a random zodiac item effect that changes every floor. 1

Trinkets[]

29 new trinkets were added in the expansion.

Name ID Icon Quote Description
Black Feather 5.350.80 Black Feather With darkness comes power Increases Isaac's Damage for each 'evil' item or trinket he possesses.
Blasting Cap 5.350.73 Blasting Cap Pop! Pop! Exploding Bombs have a chance to drop another Bomb pickup.
Blind Rage 5.350.81 Blind Rage Blind to damage Increases invincibility time after getting hit.
Blister 5.350.77 Blister Bounce back! Increases knockback of tears.
Bob's Bladder 5.350.71 Bob's Bladder Creepy bombs Leaves a pool of green creep under all Bombs Isaac places, which damages enemies that walk over it.
Brown Cap 5.350.90 Brown Cap Fartoom! Poops explode upon being destroyed.
Child Leash 5.350.89 Child Leash Keep your friends close... Causes familiars to stay closer to each other.
Cracked Dice 5.350.67 Cracked Dice You feel cursed... kinda. Activates the effect of The D6, D8, (in Repentance) D10, D12, or D20 (chosen randomly) whenever Isaac takes damage.
Endless Nameless 5.350.79 Endless Nameless I'm stuck in a loop... Has a 25% chance of creating a duplicate of any pill, card, or rune Isaac uses.
Error 5.350.75 Error Effect not found? Gives a random trinket effect each room.
Faded Polaroid 5.350.69 Faded Polaroid You feel faded Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room. (in Repentance) Can be used to open the Strange Door in The Depths.
Golden Horse Shoe 5.350.82 Golden Horse Shoe Feel lucky? +15% chance for Treasure RoomTreasure Rooms to have two items. Only one item can be taken.
Karma 5.350.85 Karma Karma up Donating to a Donation Machine has a chance to heal Isaac for a full Red Heart or spawn a Beggar. Increases the chance that donating to a Donation Machine will increase Isaac's luck.
Lazy Worm 5.350.66 Lazy Worm Pft Decreases shot speed by 0.5. (except in Repentance) Increases range by 4.
Lil Larva 5.350.86 Lil Larva The poop is moving... Spawns a Blue Fly from every pile of Poop that Isaac destroys.
Louse 5.350.70 Louse Itchy, tasty... Occasionally spawns a Blue Spider.
Mom's Locket 5.350.87 Mom's Locket You feel her love Grants a Half Red Heart each time a Key is used. Converts Half Red Heart pickups into Red Hearts.
NO! 5.350.88 NO! Never again! Prevents active items from being generated, if possible.
Poker Chip 5.350.76 Poker Chip It's double down time! Chests have a 50% chance of paying out with extra pickups and a 50% chance of replacing all of its contents with an Attack Fly.
Rainbow Worm 5.350.64 Rainbow Worm Bleep Bloop Blop Isaac's tears gain a worm effect that changes every 3 seconds.
Rib of Greed 5.350.84 Rib of Greed Feels greedy Prevents Greed and Super Greed from appearing in ShopShops and Secret RoomSecret Rooms, and makes coin drops after clearing rooms more likely.
Safety Scissors 5.350.63 Safety Scissors Fuse Cutter Troll Bombs turn into Bomb pickups before they explode. Mega Troll Bombs turn into Double Bombs before they explode.
Second Hand 5.350.78 Second Hand Extended stat effect time! Increases the time that status effects stay on enemies.
Shiny Rock 5.350.62 Shiny Rock It shines for its brothers Tinted rocks and rocks with Crawl SpaceCrawl Spaces underneath flash white upon entering the room and every 10 seconds afterward.
Store Key 5.350.83 Store Key Stores are open ShopShops can be opened without using Keys.
Stud Finder 5.350.74 Stud Finder The ground below feels hollow... Increases the chance to spawn a Crawl SpaceCrawl Space when a rock is destroyed.
Super Magnet 5.350.68 Super Magnet It Pulls Pulls enemies and pickups towards Isaac.
Tape Worm 5.350.65 Tape Worm Floooooooooop! (except in Repentance) Doubles Isaac's range and halves his tear falling speed.
(in Repentance) +3 range.
Watch Battery 5.350.72 Watch Battery Lil charge Increased chance of Lil' Batteries spawning. Has a chance to add an extra charge to Isaac's activated item upon completing a room.

Pickups[]

Hearts[]

Heart Image Worth Additional Info Unlocked By
Gold Heart Full red heart When a Gold Heart is lost, a few coins will be dropped around you. Gold Heart Complete XXXXXXXXL (challenge #21)

Coins[]

Coin Image Worth Additional Info Unlocked By
Lucky Penny 1

Increases luck by 1 when picked up.

Lucky Pennies Donate 2 Coins to the Greed Donation Machine
Sticky Nickel 5

Will flip upside-down when Isaac tries to collect it. Afterwards, it will get stuck on the ground, unable to be picked up unless blasted off the ground with an explosion.

Sticky Nickels Complete the Boss RushBoss Rush as Keeper

Bombs[]

Bomb Image Worth Additional Info Unlocked By
Gold Bomb

Will not add to the player's bomb count, but when picked up, it will give the player unlimited bombs for the duration of the current floor, even if the current number of bombs is 0.

Gold Bomb Complete Blue Bomber (challenge #23)

Pills[]

ID Pill Effect
28 Needs to be unlocked Percs!

Gives The Wafer effect while in the room. Unlocked by completing Challenge #24: PAY TO PLAY.

29 Needs to be unlocked Addicted!

Makes Isaac take a full heart of damage from all sources for the current room. Unlocked by completing Challenge #24: PAY TO PLAY.

30 Needs to be unlocked Re-Lax

For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: Have a Heart.

31 Needs to be unlocked ???

Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when TAB is held. This effect cannot be negated by Black Candle. Unlocked by completing Challenge #25: Have a Heart.

32 One makes you larger

Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox. These pills contribute to the Stompy transformation.

33 One makes you small

Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.

34 Infested!

Destroys all poop in the room and spawns a single Blue Spider under Isaac and on each destroyed poop.

35 Infested?

Spawns Blue Spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.

36 Power Pill!

Activates an effect similar to The Gamekid.

37 Retro Vision

Briefly pixelates the screen 3 times over 30 seconds.

38 Friends Till The End!

Spawns three blue flies.

Cards[]

Name ID Icon Message Description
Get out of Jail Free Card 5.300.47 Get out of Jail Free Card Open Sesame Upon use, opens all doors in the current room, exactly like Dad's Key.
? Card 5.300.48 ? Card Double active When used, copies the effect of Isaac's currently held activated collectible.

Runes[]

Name ID Icon Message Description
Blank Rune 5.300.40 Blank Rune ??? Grants a random rune effect (except in Repentance) excluding Black Rune. Has a 25% chance to drop another Blank Rune on the ground upon use.

Consumables[]

Name ID Icon Message Description
Dice Shard 5.300.49 Dice Shard D6 + D20 Upon use, invokes the effects of The D6 and the D20 at the same time, re-rolling all item pedestals and pickups in the room.
Emergency Contact 5.300.50 Emergency Contact Help from above When used, will cause two Mom's Hands to come down and grab two random enemies, dealing damage and, if they have 40 or more HP, pinning them to the ground temporarily.

Chests[]

Eternal Chests
  • Eternal Chests are similar in appearance to Gold Chests, except they glow bright blue instead of gold, like a soul heart. They require one key to unlock, but can be reopened a random amount of times, each time requiring another key. They can be found in Angel rooms, in I AM ERROR Rooms and rarely in a normal room. Their loot is similar to Golden Chests, but there is a 25% chance they will drop nothing upon opening. If they contain nothing or an item, they will no longer be able to be reopened.
Spiked Chests
  • Spiked Chests are purple colored chests with spikes protruding from them that will deal damage to Isaac upon opening unless he has the Holy Mantle active, which nullifies the damage, or if found in The Chest/Dark Room, where they are free to open. They can be rarely found upon completing a room or in greed mode shops. Their loot is similar to Brown Chests. Unlike other chests, they do not appear on the minimap.

Sacks[]

Mystery sack
  • Spawns 1-4 random pickups upon touching it. It will not drop any hearts, pills or chests, and they have an increased chance to drop batteries.

Entities[]

Monsters[]

Entity ID Description
Gold Heart
Gold Heart
5.10.7 {{{behavior}}}
Lucky Penny
Lucky Penny
5.20.5 {{{behavior}}}
Sticky Nickel
Sticky Nickel
5.20.6 {{{behavior}}}
Golden Bomb
Golden Bomb
5.40.4 {{{behavior}}}
Spiked Chest
Spiked Chest
5.52 {{{behavior}}}
Eternal Chest
Eternal Chest
5.53 {{{behavior}}}
Grab Bag
Grab Bag
5.69.1 {{{behavior}}}
Flaming Gaper
Flaming Gaper
10.2 Walks towards Isaac, dealing contact damage. Usually turns into a Pacer or Gusher upon death.
Special Shopkeeper
Special Shopkeeper
17.3 {{{behavior}}}
Drowned Hive
Drowned Hive
22.1 Wanders around the room, avoiding Isaac and spawning Drowned Chargers if he gets close. Spawns 0-2 Drowned Chargers upon death.
My Shadow
My Shadow
23.0.1 Charges at enemies when in its line of sight, dealing contact damage. Will always spawn friendly via My Shadow.
Drowned Charger
Drowned Charger
23.1 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Dank Globin
Dank Globin
24.2 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a Spider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.
Drowned Boom Fly
Drowned Boom Fly
25.2 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, explodes and fires four blood shots in the cardinal directions. Also has a chance to spawn a Drowned Charger upon death.
Scarred Double Vis
Scarred Double Vis
39.3 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.
Scarred Guts
Scarred Guts
40.1 Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.
Scarred Para-Bite
Scarred Para-Bite
58.1 Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.
Flaming Fatty
Flaming Fatty
208.2 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away (in Repentance) and spawns a damaging flame. Has a chance to leave behind a damaging flame upon death.
Dank Death's Head
Dank Death's Head
212.1 Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Corn
Corn
217.1 Quickly dashes in random directions, dealing contact damage.
Brownie Corn
Brownie Corn
217.2 Quickly dashes in random directions, dealing contact damage.
Dank Squirt
Dank Squirt
220.1 Dashes towards Isaac and deals contact damage, creating slowing black creep. Spawns 2 Clots upon death.
Black Poop
Black Poop
245.3 {{{behavior}}}
Rag Man's Ragling
Rag Man's Ragling
246.1 Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Dart Fly
Dart Fly
256.0 Flies towards Isaac and attempts to predict his movements. Deals contact damage.
Conjoined Fatty
Conjoined Fatty
257.0 Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty
257.1 Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.
Fat Bat
Fat Bat
258.0 Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.
Imp
Imp
259.0 Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Roundy
Roundy
276.0 Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Black Bony
Black Bony
277.0 Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Black Globin
Black Globin
278.0 Chases Isaac, dealing a full heart of contact damage and launching Spiders towards Isaac whenever it takes damage. Spawns a Spider, a Black Globin's Head, and a Black Globin's Body upon death.
Black Globin's Head
Black Globin's Head
279.0 Slides towards Isaac, leaving a trail of damaging Red Creep.
Black Globin's Body
Black Globin's Body
280.0 Walks aimlessly around the room, occasionally spawning spiders.
Swarm
Swarm
281.0 Follows Isaac in large, tightly-clustered groups and deals contact damage.
Mega Clotty
Mega Clotty
282.0 Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a Clotty or a collapsed Globin. Splits into two Clotties upon death.
Bone Knight
Bone Knight
283.0 Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.
Cyclopia
Cyclopia
284.0 Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.
Red Ghost
Red Ghost
285.0 Disappears, then reappears near Isaac and fires a brimstone laser.
Flesh Death's Head
Flesh Death's Head
286.0 Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
Mom's Dead Hand
Mom's Dead Hand
287.0 Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn Isaac with Mom's laugh.
Dukie
Dukie
288.0 Flies around the room diagonally, occasionally spitting out 1-2 Dart Flies.
Ulcer
Ulcer
289.0 Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.
Meatball
Meatball
290.0 Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.
Pitfall
Pitfall
291.0 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.
Suction Pitfall
Suction Pitfall
291.1 Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Teleport Pitfall
Teleport Pitfall
291.2 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.
Movable TNT
Movable TNT
292.0 {{{behavior}}}
Ultra Greed Coin (Spinner)
Ultra Greed Coin (Spinner)
293.0 Spins around the room, dealing contact damage.
Ultra Greed Coin (Key)
Ultra Greed Coin (Key)
293.1 Spins on itself and opens a golden door around the room if not destroyed, spawning hordes of Greed Gapers.
Ultra Greed Coin (Bomb)
Ultra Greed Coin (Bomb)
293.2 Spins on itself and explodes with a large radius if not destroyed.
Ultra Greed Coin (Heart)
Ultra Greed Coin (Heart)
293.3 Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.
Corn Mine
Corn Mine
295.0 Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.
Hush Fly
Hush Fly
296.0 Gathers with other Hush Flies to form certain patterns. If spawned by Hush, can chase Isaac or orbit Hush. Deals contact damage.
Blue Gaper
Blue Gaper
297.0 Walks towards Isaac, dealing contact damage.
Blue Boil
Blue Boil
298.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Greed Gaper
Greed Gaper
299.0 Walks towards Isaac, dealing contact damage.
Dark Ball
Dark Ball
404.1 Floats towards Isaac, doing contact damage.

Bosses[]

Rag Man Little Horn Dangle Turdlings
The Frail The Stain The Forsaken Brownie
Hush Ultra Greed

Beggars[]

Bomb bum

Bomb Bums are extremely rare, and ask for bombs. Each bomb donated has a chance to have him drop 1-2 bomb pickups or an item from the Bomb Bum Item Pool. After spawning a pedestal item, the Bomb Bum will disappear and can no longer be donated to.

Environment[]

Chapters[]

Burning Basement Flooded Caves
Burning BasementBurning Basement Flooded CavesFlooded Caves
Dank Depths Scarred Womb
Dank DepthsDank Depths Scarred WombScarred Womb
???
??????

Challenges[]

Name Conditions Goal Unlocked by Unlocks
21. XXXXXXXXL

Full red heartFull red heartFull red heart
: yes
: yes
Every floor is the size of an XL WombWomb floor, but does not combine the floors of each chapter.
XXXXXXXXL Defeat Mom Gold Heart Gold Heart
22. SPEED!

Full red heartFull red heartFull red heart
: yes
: yes
Everything is sped up like the Broken Watch effect. After the game timer reaches 16 minutes, Isaac starts taking damage every 10 seconds.
SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
23. Blue Bomber

Full soul heartFull soul heartFull soul heart
Blindfolded
Starts with:
Brother Bobby
Kamikaze!
Pyromaniac
Mr. Mega
: no
: yes
Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
24. PAY TO PLAY

Full red heartFull red heartFull red heart
Starts with:
Money = Power
Sack of Pennies
50 coins
: no
: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
PAY TO PLAY Defeat Isaac as Cain and destroy 10 Tinted Rocks 2 new pills 2 new pills
25. Have a Heart

Full red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Empty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Starts with:
Charm of the Vampire
: yes
: yes
Pennies drop instead of Red Hearts. Many items that restore Red Hearts have no effect.
Have a Heart Defeat Mom 2 new pills 2 new pills
26. I RULE!

Full red heartFull red heartFull red heart
Starts with:
The Boomerang
Key Piece 1
Key Piece 2
The Ladder
Mom's Knife
Trinity Shield
: no
: yes
I RULE! (in Rebirth and Afterbirth) Defeat ??? or The Lamb, defeat Satan as Isaac, and unlock The Negative
(in Afterbirth †) Defeat ??? or The Lamb, and defeat Satan as Isaac
(in Repentance) Defeat Mega Satan and unlock The Negative
Poker Chip Poker Chip
27. BRAINS!

Full soul heartFull soul heartFull soul heart
Blindfolded
Starts with:
3 Bob's Brain
Thunder Thighs
: no
: yes
BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
28. PRIDE DAY!

Full red heartFull red heartFull red heart
Starts with:
3 Dollar Bill
Rainbow Baby
Rainbow WormRainbow Worm
: no
: yes
Cannot drop or replace Rainbow WormRainbow Worm.
PRIDE DAY! Defeat Mom D8 D8
29. Onan's Streak

Full red heart
Starts with:
The Book of Belial
Chocolate Milk
: yes
: yes
Missing a shot deals damage to Judas.
Onan's Streak (in Afterbirth and Afterbirth †) Defeat Mom
(in Repentance) Unlock Judas and It Lives.
Kidney Stone Kidney Stone
30. The Guardian

Full red heartFull red heartFull red heart
Blindfolded
Starts with:
Holy Grail
Isaac's Heart
Punching Bag
Spear Of Destiny
: no
: yes
Isaac's Heart will follow Punching Bag instead of Isaac.
The Guardian Defeat Mom Blank Rune Blank Rune