Binding of Isaac: Rebirth Wiki
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(in Afterbirth)

The Binding of Isaac: Afterbirth is the expansion to The Binding of Isaac: Rebirth. The DLC was released on October 30, 2015 and costs $10.99/£7.99. It was released on May 10, 2016 on Xbox One and PS4.

For a list of the pre-release blog posts, see The Binding of Isaac: Afterbirth (Pre-Release).

Features[ | ]

Additions[ | ]

Player[ | ]

Characters[ | ]

Character Lilith App
Lilith
Keeper App
Keeper
Health Stat Icon Health Full red heartFull black heartFull black heart Full coin heartFull coin heart
Damage Stat Icon Damage 3.5 (*1.00) 3.5 (*1.20)
Tears Stat Icon Tears BlindfoldedBlindfolded
(+0)
+18
Shot Speed Stat Icon Shot Speed BlindfoldedBlindfolded
(1)
1
Range Stat Icon Range BlindfoldedBlindfolded
(23.75)
23.75
Speed Stat Icon Speed 1.0 0.85
Luck Stat Icon Luck 0 -2
Starting Item Icon Starting Pickup(s) None x1 bombs
Needs to be unlocked x1 coins
Needs to be unlocked Store KeyStore Key
Starting Item Icon Starting Item(s) Collectible Incubus Afterbirth iconIncubus
Needs to be unlocked Collectible Cambion Conception Afterbirth iconCambion Conception
Collectible Box of Friends iconBox of Friends
Triple shot
Needs to be unlocked Collectible Wooden Nickel iconWooden Nickel

Transformations[ | ]

ID Name Appearance Description
2 Fun Guy Fun Guy

+1 Red Heart Container.

3 Seraphim Seraphim

Grants flight and gives +3 Soul HeartSoul Hearts.

4 Bob Bob

Isaac leaves a trail of green poisonous creep as he walks that deals 6 damage per second.

5 Spun Spun

Gives +2 damage and +0.15 speed, and spawns a random pill upon transformation.

6 Yes Mother? Yes Mother?

Isaac gains a stationary knife that trails directly behind him. It synergizes like Collectible Mom's Knife iconMom's Knife would.

7 Conjoined Conjoined

Adds two tumors that fire diagonally from Isaac's head. -0.3 Damage, -0.3 Tears.

8 Leviathan Leviathan

Grants flight and gives +2 Black HeartBlack Hearts.

9 Oh Crap Oh Crap

Whenever a pile of poop is destroyed, restores half of a red heart.

n/a Super Bum Super Bum

Replaces Collectible Bum Friend iconBum Friend, Collectible Dark Bum iconDark Bum, and Collectible Key Bum iconKey Bum with Super Bum. This bum collects any of the other beggars' pickups, and offers twice the rewards.

Co-op[ | ]

Special Babies

These Babies have special bonuses that will aid the player in some way.

ID Appearance Name Description
27 027 baby black Black Baby Spawns with an extra black heart.
Black Baby Defeat Mega Satan as Character Azazel iconAzazel to unlock it.
28 028 baby red Red Baby Spawns with an extra red heart.
Red Baby Defeat Mega Satan as Character Magdalene iconMagdalene to unlock it.
29 029 baby white White Baby Gives Isaac an eternal heart when it spawns.
White Baby Defeat Mega Satan as Character The Lost iconThe Lost to unlock it.
30 030 baby blue Blue Baby Spawns with an extra soul heart.
Blue Baby Defeat Mega Satan as Character ??? (Character) icon??? to unlock it.
31 031 baby rage Rage Baby Occasionally briefly increases Isaac's damage by 2.
Rage Baby Defeat Mega Satan as Character Samson iconSamson to unlock it.
32 032 baby cry Cry Baby Occasionally briefly increases Isaac's tears by 1.
Cry Baby Defeat Mega Satan as Character Isaac iconIsaac to unlock it.
33 033 baby yellow Yellow Baby Occasionally briefly increases Isaac's speed by 0.15.
Yellow Baby Defeat Mega Satan as Character Eden iconEden to unlock it.
34 034 baby long Long Baby Occasionally briefly increases Isaac's range by 2, shot speed by 0.5, and tear falling speed.
Long Baby Defeat Mega Satan as Character Lazarus iconLazarus to unlock it.
35 035 baby green Green Baby Occasionally briefly increases Isaac's luck by 2.
Green Baby Defeat Mega Satan as Character Cain iconCain to unlock it.
36 036 baby lil Lil' Baby Occasionally briefly decreases Isaac's size.
Lil' Baby Defeat Mega Satan as Character Eve iconEve to unlock it.
37 037 baby big Big Baby Occasionally briefly increases Isaac's size.
Big Baby Defeat Mega Satan as Character Lilith iconLilith to unlock it.
38 038 baby brown Brown Baby Occasionally briefly gives Isaac the Butt PennyButt Penny effect.
Brown Baby Defeat Mega Satan as Character Judas iconJudas to unlock it.
39 039 baby noose Noose Baby Occasionally briefly gives Isaac the Collectible Transcendence iconTranscendence effect, granting flight.
Noose Baby Defeat Mega Satan as Character Keeper iconKeeper to unlock it.
40 040 baby hive Hive Baby Occasionally briefly gives Isaac the Collectible Hive Mind iconHive Mind effect, doubling the damage dealt by blue spiders and blue flies.
Hive Baby Earn all Hard mode Completion Marks as Character ??? (Character) icon??? to unlock it.
41 041 baby buddy Buddy Baby Occasionally briefly gives Isaac the Collectible Guillotine iconGuillotine effect, detaching Isaac's head and increasing damage and tears.
Buddy Baby Earn all Hard mode Completion Marks as Character Isaac iconIsaac to unlock it.
42 042 baby colorful Colorful Baby Upon joining, fully heals Isaac, similar to the rainbow poop effect.
Colorful Baby Earn all Hard mode Completion Marks as Character Magdalene iconMagdalene to unlock it.
43 043 baby whore Whore Baby Occasionally briefly gives Isaac the Collectible Whore of Babylon iconWhore of Babylon effect, increasing damage and speed.
Whore Baby Earn all Hard mode Completion Marks as Character Eve iconEve to unlock it.
44 044 baby cracked Cracked Baby
Cracked Baby Earn all Hard mode Completion Marks as Character Eden iconEden to unlock it.
45 045 baby dripping Dripping Baby Occasionally briefly gives Isaac Collectible Anemic iconAnemic, increasing range by 5 and causing Isaac to leave a trail of blood that damages enemies.
Dripping Baby Earn all Hard mode Completion Marks as Character Lazarus iconLazarus to unlock it.
46 046 baby blinding Blinding Baby Upon death, activates the effect of XIX - The Sun, fully restoring Isaac's red hearts, deals 100 damage to all enemies in the room, and revealing the map for the current floor.
Blinding Baby Use Collectible Blank Card iconBlank Card while holding XIX - The SunXIX - The Sun to unlock it.
47 047 baby sucky Sucky Baby Has an aura around itself that damages enemies while they are inside, similar to Collectible Succubus iconSuccubus.
Sucky Baby Earn all Hard mode Completion Marks as Character Azazel iconAzazel to unlock it.
48 048 baby dark Dark Baby Occasionally provides a brief boost to all of Isaac's stats.
Dark Baby Earn all Hard mode Completion Marks as Character Lilith iconLilith to unlock it.
49 049 baby picky Picky Baby Occasionally briefly gives Isaac the Paper ClipPaper Clip effect.
Picky Baby Earn all Hard mode Completion Marks as Character Cain iconCain to unlock it.
50 050 baby revenge Revenge Baby Occasionally briefly increases Isaac's damage.
Revenge Baby Earn all Hard mode Completion Marks as Character Samson iconSamson to unlock it.
51 051 baby belial Belial Baby Occasionally briefly gives Isaac the Collectible The Book of Belial iconThe Book of Belial effect, increasing damage.
Belial Baby Earn all Hard mode Completion Marks as Character Judas iconJudas to unlock it.
52 052 baby sale Sale Baby Occasionally briefly gives Isaac the Collectible Steam Sale iconSteam Sale effect, halving the prices of all shop items.
Sale Baby Earn all Hard mode Completion Marks as Character Keeper iconKeeper to unlock it.
53 053 baby goatbaby Goat Head Baby Occasionally briefly gives Isaac the Collectible Goat Head iconGoat Head effect, guaranteeing that a Devil room or angel room will open if a boss room is completed while the effect is active.
Goat Head Baby Defeat Mom's Heart on Hard mode as Character Lilith iconLilith to unlock it.
54 054 baby supergreedbaby Super Greed Baby Has the Head of the Keeper effect, firing coin tears that have a chance to spawn a coin upon hitting an enemy.
Super Greed Baby Defeat Mom's Heart on Hard mode as Character Keeper iconKeeper to unlock it.

Normal Babies

These Babies are purely cosmetic and do not have any special behaviors.

ID Appearance Name Description
233 233 baby punkboy Punkboy Baby A baby dressed as a punk rocker boy.
234 234 baby punkgirl Punkgirl Baby A baby dressed as a punk rocker girl.
235 235 baby computer Computer Baby A baby with a computer for a head.
236 236 baby mask Mask Baby A baby wearing a mask.
237 237 baby gem Gem Baby A baby that looks like it's made of crystal.
238 238 baby shark Shark Baby A baby that looks like a shark.
239 239 baby beret Beret Baby A baby that's wearing a beret.
240 240 baby blisters Blisters Baby A baby covered in blisters.
241 241 baby radioactive Radioactive Baby A sickly green baby.
242 242 baby beast Beast Baby A baby that looks like a beast.
243 243 baby dark Dark Baby A very dark baby.
244 244 baby snail Snail Baby A baby that looks like a snail.
245 245 baby blood Blood Baby A baby that looks like a drop of blood.
246 246 baby 8ball 8 Ball Baby A baby with an 8 ball for a head.
247 247 baby wisp Wisp Baby A wispy baby.
248 248 baby cactus Cactus Baby A baby that looks like a cactus.
249 249 baby loveeye Love Eye Baby A pink baby with a heart for an eye.
250 250 baby medusa Medusa Baby A baby that resembles Medusa.
251 251 baby nuclear Nuclear Baby A baby that looks like a mushroom cloud.
252 252 baby purple Purple Baby A strange purple baby.
253 253 baby wizard Wizard Baby A baby with a wizard hat.
254 254 baby earth Earth Baby A baby whose head looks like planet Earth.
255 255 baby saturn Saturn Baby A baby with a ring around its head.
256 256 baby cloud Cloud Baby A baby made of cloud.
257 257 baby tube Tube Baby A baby with a tube connecting both eyes.
258 258 baby rocker Rocker Baby A baby dressed as a rock fan.
259 259 baby king King Baby A baby with a crown.
260 260 baby coat Coat Baby A baby wearing a winter coat.
261 261 baby viking Viking Baby A baby with a Viking helmet.
262 262 baby panda Panda Baby A baby that looks like a panda.
263 263 baby raccoon Raccoon Baby A baby that looks like a raccoon.
264 264 baby bear Bear Baby A baby that looks like a grizzly bear.
265 265 baby polarbear Polar Bear Baby A baby that looks like a polar bear.
266 266 baby lovebear Lovebear Baby A baby that looks like a Care Bear.
267 267 baby hare Hare Baby A baby that looks like a rabbit.
268 268 baby squirrel Squirrel Baby A baby that looks like a squirrel.
269 269 baby tabby Tabby Baby A baby that looks like a cat.
270 270 baby porcupine Porcupine Baby A baby that looks like a porcupine.
271 271 baby puppy Puppy Baby A baby that looks like a puppy.
272 272 baby parrot Parrot Baby A baby that looks like a parrot.
273 273 baby chameleon Chameleon Baby A baby that looks like a Chameleon.
274 274 baby boulder Boulder Baby A baby made of rocks.
275 275 baby aqua Aqua Baby An aqua-blue baby.
276 276 baby gargoyle Gargoyle Baby A baby that resembles a gargoyle.
277 277 baby spikydemon Spiky Demon Baby A baby that looks like a spiky demon.
278 278 baby reddemon Red Demon Baby A baby that looks like a red demon.
279 279 baby orangedemon Orange Demon Baby A baby that looks like an orange demon.
280 280 baby eyedemon Eye Demon Baby A baby with an eye for a head.
281 281 baby fangdemon Fang Demon Baby A baby with big fangs.
282 282 baby ghost Ghost Baby A baby that looks like a ghost.
283 283 baby arachnid Arachnid Baby A baby that looks like a spider.
284 284 baby bony Bony Baby A baby that looks like a Bony.
285 285 baby bigtongue Big Tongue Baby A baby with a big tongue.
286 286 baby 3d 3D Baby A baby wearing 3D glasses.
287 287 baby suit Suit Baby A baby in a nice suit.
288 288 baby butt Butt Baby A baby with a butt for a face.
289 289 baby cupid Cupid Baby A baby that looks like Cupid.
290 290 baby heart Heart Baby A baby with a heart-shaped head.
291 291 baby killer Killer Baby A baby that looks like Jason Voorhees from the "Friday the 13th" horror movie series.
292 292 baby lantern Lantern Baby A baby that looks like Ash Williams from the Evil Dead series.
293 293 baby banshee Banshee Baby A baby that looks like a banshee.
294 294 baby ranger Ranger Baby A baby that looks like a Red Power Ranger.
295 295 baby rider Rider Baby A baby that looks like a Kamen Rider.
296 296 baby choco Choco Baby A baby made of chocolate.
297 297 baby woodsman Woodsman Baby A baby dressed as a hiker.
298 298 baby brunette Brunette Baby A baby with brown hair
299 299 baby blonde Blonde Baby A baby with blonde hair.
300 300 baby bluehair Blue Hair Baby A baby with blue hair
301 301 baby bloodied Bloodied Baby A baby covered in blood.
302 302 baby cheese Cheese Baby A baby made of cheese.
303 303 baby pizza Pizza Baby A baby made of pizza.
304 304 baby hotdog Hotdog Baby A baby that is also a hotdog.
305 305 baby hotdog Nature Baby A naked baby with a leaf.
306 306 baby borg Borg Baby A robotic baby.
307 307 baby corrupted Corrupted Baby A baby with seems to be covered by an alien life.
308 308 baby xmouth X Mouth Baby A gagged baby.
309 309 baby xeyes X Eyed Baby A comically dead baby.
310 310 baby stareyes Starry Eyed Baby A baby with starry eyes.
311 311 baby surgeon Surgeon Baby A baby ready for surgery.
312 312 baby sword Sword Baby A baby that's a sword.
313 313 baby monk Monk Baby A baby that's a monk.
314 314 baby disco Disco Baby A funky baby with an afro
315 315 baby puzzle Puzzle Baby A baby with a "Rubik's Cube" for a head
316 316 baby speaker Speaker Baby A baby that has a speaker for a head.
317 317 baby scary Scary Baby A baby that resembles Jeff the Killer.
318 318 baby fireball Fireball Baby A fireball with eyes. Possibly a reference to the fire enemy in the Donkey Kong and Mario games.
319 319 baby maw Maw Baby A baby that's just a mouth.
320 320 baby exploding Exploding Baby A baby that's a bomb.
321 321 baby cupcake Cupcake Baby A baby that's also a cupcake.
322 322 baby skinless Skinless Baby A baby without skin.
323 323 baby ballerina Ballerina Baby A baby wearing a tutu.
324 324 baby goblin Goblin Baby A baby that resembles a goblin.
325 325 baby coolgoblin Cool Goblin Baby A green baby with brown hair and cool shades.
326 326 baby geek Geek Baby A baby with black hair and nerdy glasses.
327 327 baby longbeard Long Beard Baby A baby with a long beard.
328 328 baby muttonchops Muttonchops Baby A baby with muttonchops.
329 329 baby spartan Spartan Baby A baby that resembles King Leonidas from 300.
330 330 baby tortoise Tortoise Baby A baby that resembles Vectorman from the game Vectorman
331 331 baby slicer Slicer Baby A baby that resembles Shredder.
332 332 baby butterfly Butterfly Baby A baby with butterfly wings.
333 333 baby homeless Homeless Baby A baby that resembles a homeless person.
334 334 baby lumberjack Lumberjack Baby A baby that resembles a lumberjack.
335 335 baby cyberspace Cyberspace Baby A baby that resembles something from the Tron universe.
336 336 baby hero Hero Baby A baby that resembles Red from Gunstar Heroes.
337 337 baby boxers Boxers Baby A baby that resembles Arthur from Ghosts & Goblins (in his boxers).
338 338 baby winghelmet Wing Helmet Baby A baby that resembles Opa-Opa.
339 339 baby x X Baby A baby with an X for a head.
340 340 baby o O Baby A baby with an O for a head.
341 341 baby vomit Vomit Baby A baby with vomit coming from its mouth.
342 342 baby merman Merman Baby A baby that resembles Aquaman.
343 343 baby cyborg Cyborg Baby Might be a reference to a Cyborg from a novel/movie/game?
344 344 baby barbarian Barbarian Baby A baby that resembles the Barbarian from Diablo.
345 345 baby locust Locust Baby A baby that resembles a locust.
346 346 baby twotone Twotone Baby A completely white baby with a black outline.
347 347 baby 2600 2600 Baby A baby that resembles an Atari 2600 sprite.
348 348 baby fourtone Fourtone Baby A baby with a minimal colour sprite.
349 349 baby grayscale Grayscale Baby A baby colored with several shades of gray.
350 350 baby rabbit Rabbit Baby A baby that resembles Oswald the Lucky Rabbit.
351 351 baby mouse Mouse Baby A baby that resembles an old-style Mickey Mouse.
352 352 baby critter Critter Baby A critter that looks white and hairy. Might be a reference to the movie Critters.
353 353 baby bluerobot Blue Robot Baby A baby that resembles Mega Man.
354 354 baby pilot Pilot Baby A baby that resembles Jason from Blaster Master.
355 355 baby redplumber Red Plumber Baby A baby that resembles Mario.
356 356 baby greenplumber Green Plumber Baby A baby that resembles Luigi.
357 357 baby yellowplumber Yellow Plumber Baby A baby that resembles Wario.
358 358 baby purpleplumber Purple Plumber Baby A baby that resembles Waluigi.
359 359 baby tanooki Tanooki Baby A baby that's wearing a Tanooki Suit.
360 360 baby mushroomman Mushroom Man Baby A baby that resembles Toad.
361 361 baby mushroomgirl Mushroom Girl Baby A baby that resembles Toadette.
362 362 baby cannonball Cannonball Baby A baby that resembles a Chain Chomp.
363 363 baby froggy Froggy Baby A baby that's wearing a Frog Suit.
364 364 baby turtledragon Turtle Dragon Baby A baby that resembles Bowser.
365 365 baby shellsuit Shell Suit Baby A baby wearing a Hammer Suit.
366 366 baby fiery Fiery Baby A baby wearing a Fire Suit.
367 367 baby meanmushroom Mean Mushroom Baby A baby that resembles a Goomba.
368 368 baby arcade Arcade Baby A baby that resembles Pac-Man.
369 369 baby scaredghost Scared Ghost Baby A blue ghost with a scared expression.
370 370 baby blueghost Blue Ghost Baby A baby that resembles Inky.
371 371 baby redghost Red Ghost Baby A baby that resembles Blinky.
372 372 baby pinkghost Pink Ghost Baby A baby that resembles Pinky.
373 373 baby orangeghost Orange Ghost Baby A baby that resembles Clyde.
374 374 baby pinkprincess Pink Princess Baby A baby that resembles Princess Peach.
375 375 baby yellowprincess Yellow Princess Baby A baby that resembles Princess Daisy.
376 376 baby dino Dino Baby A baby that resembles Yoshi.
377 377 baby elf Elf Baby A baby that resembles Link.
378 378 baby darkelf Dark Elf Baby A baby that resembles Dark Link
379 379 baby darkknight Dark Knight Baby A baby that resembles a Darknut
380 380 baby octopus Octopus Baby A baby that resembles an Octorok.
381 381 baby orangepig Orange Pig Baby A baby that resembles an orange Moblin.
382 382 baby bluepig Blue Pig Baby A baby that resembles a blue Moblin.
383 383 baby elfprincess Elf Princess Baby A baby that resembles Princess Zelda.
384 384 baby fishman Fishman Baby A baby that resembles a Zora.
385 385 baby fairyman Fairyman Baby A baby that resembles Tingle.
386 386 baby imp Imp Baby A baby that resembles Midna.
387 387 baby worm Worm Baby A baby that resembles Earthworm Jim.
388 388 baby bluewrestler Blue Wrestler Baby A baby that looks like the blue player in Smash TV.
389 389 baby redwrestler Red Wrestler Baby A baby that looks like the red player in Smash TV.
390 390 baby toast Toast Baby A baby that resembles Powdered Toast Man.
391 391 baby roboboy Roboboy Baby A baby that resembles Astro Boy.
392 392 baby liberty Liberty Baby A baby that resembles the Statue of Liberty.
393 393 baby dreamknight Dream Knight Baby A baby that resembles Meta Knight.
394 394 baby cowboy Cowboy Baby A baby that's wearing a cowboy outfit.
395 395 baby mermaid Mermaid Baby A baby that resembles Ariel.
396 396 baby plague Plague Baby A baby wearing a plague doctor outfit.
397 397 baby spacesoldier Space Soldier Baby A baby that resembles a Warhammer 40k Space Marine.
398 398 baby darkspacesoldier Dark Space Soldier Baby A baby that resembles a Warhammer 40k Chaos Space Marine.
399 399 baby gasmask Gas Mask Baby A baby that's wearing a gas mask.
400 400 baby tomboy Tomboy Baby A baby that resembles Sheik from the Legend of Zelda franchise.
401 401 baby corgi Corgi Baby A baby that looks like a corgi.
402 402 baby unicorn Unicorn Baby A baby that looks like a unicorn.
403 403 baby pixie Pixie Baby A baby that resembles Tinkerbell.
404 404 baby referee Referee Baby A baby wearing a referee outfit.
405 405 baby dealwithit Deal With It Baby A baby with a goatee and sunglasses.
406 406 baby astronaut Astronaut Baby A baby that's wearing an astronaut outfit.
407 407 baby blurred Blurred Baby A baby with a blur effect across its privates.
408 408 baby censored Censored Baby A baby with a censor bar across its privates.
409 409 baby coolghost Cool Ghost Baby A baby that resembles the character Shades (Sukezaemon) from Ufouria: The Saga.
410 410 baby gills Gills Baby A baby that resembles the character Gil (Jennifer) from Ufouria: The Saga.
411 411 baby bluehat Blue Hat Baby A baby that resembles the character Bop-Louie (Hebe) from Ufouria: The Saga.
412 412 baby catsuit Catsuit Baby A baby that's wearing a cat outfit. Also resembles the character Oh-Chan from Ufouria: The Saga (Japanese version).
413 413 baby pirate Pirate Baby A baby that's wearing a pirate outfit.
414 414 baby superrobo Super Robo Baby A baby that resembles Tekkaman the Space Knight.
415 415 baby lightmage Lightmage Baby A baby that resembles the white mage class from Final Fantasy.
416 416 baby puncher Puncher Baby A baby that resembles the warrior class from Final Fantasy.
417 417 baby holyknight Holy Knight Baby A baby that resembles the monk class from Final Fantasy.
418 418 baby shadowmage Shadowmage Baby A baby that resembles the black mage class from Final Fantasy.
419 419 baby firemage Firemage Baby A baby that resembles the red mage class from Final Fantasy.
420 420 baby priest Priest Baby A baby that's wearing a priest outfit.
421 421 baby zipper Zipper Baby A baby with a zipped mouth.
422 422 baby bag Bag Baby A baby with a bag over its head.
423 423 baby sailor Sailor Baby A baby that's wearing a sailor outfit.
424 424 baby rich Rich Baby A baby with a top hat and monocle.
425 425 baby toga Toga Baby A baby in an ancient Roman outfit.
426 426 baby knight Knight Baby A baby that resembles a Darknut from The Legend of Zelda.
427 427 baby blackknight Black Knight Baby A baby that resembles a black Darknut from The Legend of Zelda.



Items[ | ]

95 new items were added in the expansion: 19 activated items and 76 passive items.

Activated Collectibles[ | ]

Name ID Icon Quote Description Quality
Box of Friends 5.100.357
Box of Friends
3 rooms
Double your friends Duplicates all of Isaac's familiars for the current room. If Isaac has no familiars, spawns a Collectible Demon Baby iconDemon Baby for the room instead. 1
D12 5.100.386
D12
3 rooms
Rerolls rocks (except in Repentance) Re-rolls all Rocks and Metal Blocks in the current room into other random obstacles.
(in Repentance) Re-rolls most types of Obstacles in the current room into other random obstacles.
1
D7 5.100.437
D7
3 rooms
Roll again Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room. 1
D8 5.100.406
D8
4 rooms
Reroll stats Re-rolls Isaac's damage, tears, range, and speed. 2
Diplopia 5.100.347
Diplopia
One time use
Double item vision Duplicates all pickups and item pedestals in the room. 3
Friendly Ball 5.100.382
Friendly Ball
2 rooms
Gotta fetch 'em all! Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms. 1
Glass Cannon 5.100.352
Glass Cannon
4 seconds
Be gentle... (except in Repentance) Fires a high-damage piercing spectral tear, but lowers Isaac's health to half a heart.
(in Repentance) Fires a high-damage piercing spectral tear. If Isaac takes damage while holding this, he takes extra damage and it becomes Collectible Broken Glass Cannon iconBroken Glass Cannon.
1
Glowing Hourglass 5.100.422
Glowing Hourglass
Unlimited
Turn back time Rewinds time, putting Isaac back in the previous room and undoing anything that happened in the current room. (in Repentance) Can only be used three times per floor, after which it functions like Collectible The Hourglass iconThe Hourglass until the next floor. 3
Jar of Flies 5.100.434
Jar of Flies
Unlimited
Bug catcher Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. 2
Kidney Bean 5.100.421
Kidney Bean
1 room
Love toots! Isaac farts, charming all nearby enemies. 1
Mega Bean 5.100.351
Mega Bean
3 rooms
Giga fart! Petrifies all enemies in the current room for about 1.5 seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing. 1
Mega Blast 5.100.441
Mega Blast
12 rooms
Laser breath Upon use, Isaac fires a laser similar to the one used by Mega Satan Head ingameMega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active. 4
Mine Crafter 5.100.427
Mine Crafter
1 room
Booom! Places a Movable TNTMovable TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used again in the same room while the previous TNT barrel is still intact, remotely detonates the TNT. 1
Mom's Box 5.100.439
Mom's Box
4 rooms
What's inside? Increases luck by 1 and doubles the effects of trinkets while held. When used, drops a random trinket on the ground. 2
Placebo 5.100.348
Placebo
Variable
Pill mimic Has the same effect as the Pill currently held by Isaac. (in Repentance) The charge time is based on the power of the pill. 2
Tear Detonator 5.100.383
Tear Detonator
15 seconds
Remote tear detonation! Splits all of Isaac's tears that are currently in the air into 6 tears that fire in all directions, which retain their damage and shot speed. 1
Teleport 2.0 5.100.419
Teleport 2
4 rooms
I-Teleport! Teleports Isaac to a room that has not been explored yet. Normal rooms are prioritized over special rooms, and common special rooms take priority over rarer ones. 3
Ventricle Razor 5.100.396
Ventricle Razor
Unlimited
Short cutter Creates up to two portals that remain even if Isaac leaves the room. Upon entering a portal, Isaac is teleported to the other portal. 1
Wooden Nickel 5.100.349
Wooden Nickel
1 room
Flip a coin When used, has a roughly 50% chance to drop a penny, nickel or dime. 1

Passive Collectibles[ | ]

Name ID Icon Quote Description Quality
8 Inch Nails 5.100.359 8 Inch Nails Stick it to 'em! +1.5 damage. Replaces Isaac's tears with nails, which have increased knockback. 3
Athame 5.100.408 Athame Call to the void (except in Repentance) When Isaac takes damage, a damaging black ring briefly appears around him. This ring can cause enemies to drop Black HeartBlack Hearts.
(in Repentance) After Isaac kills an enemy, adds a luck-based chance to spawn a damaging black ring around them.
3
Betrayal 5.100.391 Betrayal Turn your enemy (except in Repentance) Charms all enemies in the room when Isaac takes damage.
(in Repentance) Enemies are able to damage each other. If an enemy is damaged by another enemy, they will attack that enemy instead of Isaac.
1
Binky 5.100.438 Binky Tears up Grants one Soul HeartSoul Heart, +0.75 tears and decreases Isaac's size. 3
Black Powder 5.100.420 Black Powder Spin the black circle! Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it. 1
Bomber Boy 5.100.353 Bomber Boy Cross blast + 5 bombs +5 BombBombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll BombTroll Bombs. 2
Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
Bursting Sack 5.100.377 Bursting Sack Spider love Spider enemies no longer target or deal contact damage to Isaac. 1
Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 2
Car Battery 5.100.356 Car Battery Active power up Causes Isaac's activated item to activate twice on each use. 3
Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
Chaos 5.100.402 Chaos !!! Drops 1-6 random pickups on the floor. Causes items to be chosen from random item pools. 3
Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' BatteryLil' Battery, gives an active item charge, or petrifies all enemies in the room. 3
Circle of Protection 5.100.423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears. 2
Continuum 5.100.369 Continuum Transcendent tears Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room. 2
Crack Jacks 5.100.354 Crack Jacks HP up. Don't swallow the prize! Grants one full Red Heart container and drops a random trinket. (in Repentance) Heals 1 additional Red HeartRed Heart. 2
Crown Of Light 5.100.415 Crown Of Light The untainted gain power +2 Soul HeartSoul Hearts. While Isaac has no empty red hearts, grants 2x damage, increased range, and -0.3 shot speed. Regardless of health, the crown deactivates for the current room when Isaac takes damage. 4
Curse of the Tower 5.100.371 Curse of the Tower Embrace chaos Upon taking damage, spawns six Troll BombTroll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower. 0
Dead Eye 5.100.373 Dead Eye Accuracy brings power! Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot. 3
Deep Pockets 5.100.416 Deep Pockets More money! (except in Repentance) Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
(in Repentance) Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
2
Eden's Blessing 5.100.381 Eden's Blessing Tears up + your future shines brighter +0.7 tears up. Grants a random item at the start of the next run. 3
Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black HeartBlack Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2
Epiphora 5.100.368 Epiphora Intensifying tears Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount. 2
Evil Eye 5.100.410 Evil Eye Eye shot! Adds a chance to fire a slow-moving eye that fires tears in the same direction as Isaac. The eye is destroyed when it hits an enemy or obstacle. 2
Explosivo 5.100.401 Explosivo Sticky bomb shot! Isaac's tears have a chance to stick to enemies and explode. 3
Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
Fate's Reward 5.100.361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. 2
Friend Zone 5.100.364 Friend Zone Friendly fly Spawns a white attack fly that orbits somewhere between Collectible Distant Admiration iconDistant Admiration and Collectible Forever Alone iconForever Alone, dealing 45 damage per second. 1
Fruit Cake 5.100.418 Fruit Cake Rainbow effects! Isaac's tears gain a random effect that changes every shot. 2
GB Bug 5.100.405 GB Bug Double tap glitch (except in Repentance) Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
(in Repentance) Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
1
Glitter Bombs 5.100.432 Glitter Bombs Prize bombs! +5 BombBombs. Bombs have a chance to drop random pickups or charm enemies when they explode. 2
God's Flesh 5.100.398 God's Flesh Shrink shot! Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them. 1
Head of the Keeper 5.100.429 Head of the Keeper Penny tears! Isaac's tears become coins and now have a chance to drop Pennies on the floor upon successfully hitting an enemy. 2
Holy Light 5.100.374 Holy Light Holy death shot Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy. 3
Host Hat 5.100.375 Host Hat Blast resistance A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. 3
Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 1
Incubus 5.100.360 Incubus Dark friend Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. 4
Key Bum 5.100.388 Key Bum He wants your keys! Spawns a familiar that follows Isaac and collects KeyKeys for himself, giving random ChestChests in return. 0
Kidney Stone 5.100.440 Kidney Stone Matt's kidney stone Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage. 2
Lil Chest 5.100.362 Lil Chest What's in the box? Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. 2
Lil Gurdy 5.100.384 Lil Gurdy A gurd of your own! A Boss Gurdy Jr. ingameGurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. 2
Lil Loki 5.100.435 Lil Loki 4-way buddy! Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. 1
Lost Fly 5.100.365 Lost Fly Lost protector Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. (except in Repentance) It deals 105 damage per second on contact. (in Repentance) It deals 56 damage per second and forces nearby enemies to attack it. 2
Lusty Blood 5.100.411 Lusty Blood Their blood brings rage! Isaac's damage increases for the current room each time he kills an enemy. 3
Marked 5.100.394 Marked Directed tears Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, increases range. 1
Maw Of The Void 5.100.399 Maw Of The Void Consume thy enemy! Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. (except in Repentance) +1 damage, the ring can cause enemies to drop Black HeartBlack Hearts. 3
Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room. 1
Mom's Pearls 5.100.355 Mom's Pearls Range + luck up (except in Repentance) +1.25 range, +0.5 tear falling speed, +1 luck.
(in Repentance) +2.5 range, +1 luck. Grants one Soul HeartSoul Heart.
2
More Options 5.100.414 More Options There's options Two item pedestals are presented in every Treasure RoomTreasure Room. Only one can be taken; the other will disappear. 3
Mr. Dolly 5.100.370 Mr Range + tears up (except in Repentance) +0.7 tears, +5.25 range, +0.5 tear falling speed, Spawns a combination of 3 Red HeartRed Hearts, Soul HeartSoul Hearts or Black HeartBlack Hearts on the floor when picked up.
(in Repentance) +0.7 tears, +2.5 range, spawns 3 random types of Red HeartHearts on the floor when picked up.
3
Multidimensional Baby 5.100.431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. 2
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! (except in Repentance) Inflicts fear on all enemies in the room upon taking damage and spawns black friendly ChargerChargers that attack enemies.
(in Repentance)Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly ChargerCharger whenever an enemy touches it.
2
Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots. 1
Number Two 5.100.378 Number Two Uh oh... Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes. 2
Obsessed Fan 5.100.426 Obsessed Fan Follows my every move... Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies. 0
Papa Fly 5.100.430 Papa Fly Turret follower Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. 1
Pay To Play 5.100.380 Pay To Play Money talks (except in Repentance) +5 PennyCoins. Most doors require one PennyPenny to open instead of a KeyKey.
(in Repentance) +5 PennyCoins. All locked doors, Locked ChestLocked Chests, and Key Blocks must be opened with one PennyPenny instead of KeyKeys.
2
PJs 5.100.428 PJs You feel cozy Grants 4 Soul HeartSoul Hearts and fully restores Isaac's health. 2
Pupula Duplex 5.100.379 Pupula Duplex Wide shot Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size. 2
Purity 5.100.407 Purity Aura stat boost Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range. 3
Restock 5.100.376 Restock Never ending stores! Causes ShopShops to instantly restock their items when they are bought. (in Repentance) Outside of Greed Mode, the restocked item's cost is increased after each purchase. 2
Rune Bag 5.100.389 Rune Bag Rune generator Spawns a familiar that drops a random rune after clearing enough rooms. 3
Sack Head 5.100.424 Sack Head More sacks! Spawns a Grab BagGrab Bag on pickup. PennyCoins, BombBombs, KeyKeys, cards, runes and batteries have a chance to become Grab BagGrab Bags. 3
Scatter Bombs 5.100.366 Scatter Bombs We put bombs in your bombs! +5 BombBombs. Isaac's bombs explode into 2-4 tiny bombs. 1
Seraphim 5.100.390 Seraphim Sworn friend Spawns an angel familiar who follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. 3
Serpent's Kiss 5.100.393 Serpent's Kiss The kiss of death Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a Black HeartBlack Heart when killed. 2
Spear Of Destiny 5.100.400 Spear Of Destiny Your destiny In addition to tears, Isaac holds a spear in front of him which deals contact damage equal to 2x his tear damage, and occasionally inflicts fear. 2
Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' BatteryLil' Battery/Blue spider upon clearing a room. 1
Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 BombBombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. (in Repentance) They also leave a long-lasting puddle of slowing white creep. 2
Succubus 5.100.417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. 3
Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal HeartEternal Heart. 3
Tech X 5.100.395 Tech X Laser ring tears Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring. 4
The Wiz 5.100.358 The Wiz Double wiz shot! Grants spectral tears. Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. 0
Toxic Shock 5.100.350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground. 3
Tractor Beam 5.100.397 Tractor Beam Controlled tears Isaac's tears are bound to a beam emitting in the direction he's firing. (except in Repentance) +0.5 Tears, +5.25 Range, +0.16 Shot Speed. (in Repentance) +1 Fire Rate, +2.5 Range, +0.16 Shot Speed. 3
Zodiac 5.100.392 Zodiac The heavens will change you Gives Isaac a random zodiac item effect that changes every floor. 1

Trinkets[ | ]

29 new trinkets were added in the expansion.

Name ID Icon Quote Description
Black Feather 5.350.80 Black Feather With darkness comes power Increases Isaac's Damage for each 'evil' item or trinket he possesses.
Blasting Cap 5.350.73 Blasting Cap Pop! Pop! Exploding BombBombs have a chance to drop another Bomb pickup.
Blind Rage 5.350.81 Blind Rage Blind to damage Increases invincibility time after getting hit.
Blister 5.350.77 Blister Bounce back! Increases knockback of tears.
Bob's Bladder 5.350.71 Bob's Bladder Creepy bombs Leaves a pool of green creep under all BombBombs Isaac places, which damages enemies that walk over it.
Brown Cap 5.350.90 Brown Cap Fartoom! PoopPoops explode upon being destroyed.
Child Leash 5.350.89 Child Leash Keep your friends close... Causes familiars to stay closer to each other.
Cracked Dice 5.350.67 Cracked Dice You feel cursed... kinda. Activates the effect of Collectible The D6 iconThe D6, Collectible D8 iconD8, (in Repentance)Collectible D10 iconD10, Collectible D12 iconD12, or Collectible D20 iconD20 (chosen randomly) whenever Isaac takes damage.
Endless Nameless 5.350.79 Endless Nameless I'm stuck in a loop... Has a 25% chance of creating a duplicate of any pill, card, or rune Isaac uses.
Error 5.350.75 Error Effect not found? Gives a random trinket effect each room.
Faded Polaroid 5.350.69 Faded Polaroid You feel faded Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room. (in Repentance) Can be used to open the Strange Door in The Depths.
Golden Horse Shoe 5.350.82 Golden Horse Shoe Feel lucky? +15% chance for Treasure RoomTreasure Rooms to have two items. Only one item can be taken.
Karma 5.350.85 Karma Karma up Donating to a Donation MachineDonation Machine has a chance to heal Isaac for a full Red HeartRed Heart or spawn a BeggarBeggar. Increases the chance that donating to a Donation Machine will increase Isaac's luck.
Lazy Worm 5.350.66 Lazy Worm Pft Decreases shot speed by 0.5. (except in Repentance) Increases range by 4.
Lil Larva 5.350.86 Lil Larva The poop is moving... Spawns a Blue Fly from every pile of PoopPoop that Isaac destroys.
Louse 5.350.70 Louse Itchy, tasty... Occasionally spawns a Blue Spider.
Mom's Locket 5.350.87 Mom's Locket You feel her love Grants a Half Red HeartHalf Red Heart each time a KeyKey is used. Converts Half Red HeartHalf Red Heart pickups into Red HeartRed Hearts.
NO! 5.350.88 NO! Never again! Prevents active items from being generated, if possible.
Poker Chip 5.350.76 Poker Chip It's double down time! Chests have a 50% chance of paying out with extra pickups and a 50% chance of replacing all of its contents with an Attack FlyAttack Fly.
Rainbow Worm 5.350.64 Rainbow Worm Bleep Bloop Blop Isaac's tears gain a worm effect that changes every 3 seconds.
Rib of Greed 5.350.84 Rib of Greed Feels greedy Prevents GreedGreed and Super GreedSuper Greed from appearing in ShopShops and Secret RoomSecret Rooms, and makes coin drops after clearing rooms more likely.
Safety Scissors 5.350.63 Safety Scissors Fuse Cutter Troll BombTroll Bombs turn into BombBomb pickups before they explode. Mega Troll BombMega Troll Bombs turn into Double BombDouble Bombs before they explode.
Second Hand 5.350.78 Second Hand Extended stat effect time! Increases the time that status effects stay on enemies.
Shiny Rock 5.350.62 Shiny Rock It shines for its brothers Tinted rocks and rocks with Crawl SpaceCrawl Spaces underneath flash white upon entering the room and every 10 seconds afterward.
Store Key 5.350.83 Store Key Stores are open ShopShops can be opened without using KeyKeys.
Stud Finder 5.350.74 Stud Finder The ground below feels hollow... Increases the chance to spawn a Crawl SpaceCrawl Space when a rock is destroyed.
Super Magnet 5.350.68 Super Magnet It Pulls Pulls enemies and pickups towards Isaac.
Tape Worm 5.350.65 Tape Worm Floooooooooop! (except in Repentance) Doubles Isaac's range and halves his tear falling speed.
(in Repentance) +3 range.
Watch Battery 5.350.72 Watch Battery Lil charge Increased chance of Lil' BatteryLil' Batteries spawning. Has a chance to add an extra charge to Isaac's activated item upon completing a room.

Pickups[ | ]

Hearts[ | ]

Heart Image Worth Additional Info Unlocked By
Gold Heart GoldHeart Full red heart When a Gold Heart is lost, a few coins will be dropped around you. Gold Heart Complete XXXXXXXXL (challenge #21)

Coins[ | ]

Coin Image Worth Additional Info Unlocked By
Lucky Penny LuckyPenny 1

Increases luck by 1 when picked up.

Lucky Pennies Donate 2 Coins to the Greed Donation MachineGreed Donation Machine
Sticky Nickel Nickel 5

Will flip upside-down when Isaac tries to collect it. Afterwards, it will get stuck on the ground, unable to be picked up unless blasted off the ground with an explosion.

Sticky Nickels Complete the Boss RushBoss Rush as Character Keeper iconKeeper

Bombs[ | ]

Bomb Image Worth Additional Info Unlocked By
Gold Bomb Gold Bomb

Will not add to the player's bomb count, but when picked up, it will give the player unlimited bombs for the duration of the current floor, even if the current number of bombs is 0.

Gold Bomb Complete Blue Bomber (challenge #23)

Pills[ | ]

ID Pill Effect
28 Needs to be unlocked Percs!

Gives Collectible The Wafer iconThe Wafer effect while in the room. Unlocked by completing Challenge #24: PAY TO PLAY.

29 Needs to be unlocked Addicted!

Makes Isaac take a full heart of damage from all sources for the current room. Unlocked by completing Challenge #24: PAY TO PLAY.

30 Needs to be unlocked Re-Lax

For a short time, poop spawns wherever Isaac moves, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: Have a Heart.

31 Needs to be unlocked ???

Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when TAB is held. This effect cannot be negated by Collectible Black Candle iconBlack Candle. Unlocked by completing Challenge #25: Have a Heart.

32 One makes you larger

Increases Isaac's size and decreases the pitch of his voice. This effect does not increase the size of Isaac's hitbox. These pills contribute to the Stompy transformation.

33 One makes you small

Decreases Isaac's size and increases the pitch of his voice. This effect decreases the size of Isaac's hitbox.

34 Infested!

Destroys all poop in the room and spawns a single Blue Spider under Isaac and on each destroyed poop.

35 Infested?

Spawns Blue Spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders.

36 Power Pill!

Activates an effect similar to Collectible The Gamekid Rebirth iconThe Gamekid.

37 Retro Vision

Briefly pixelates the screen 3 times over 30 seconds.

38 Friends Till The End!

Spawns three blue flies.

Cards[ | ]

Name ID Icon Message Description
Get out of Jail Free Card 5.300.47 Get out of Jail Free Card Open Sesame Upon use, opens all doors in the current room, exactly like Collectible Dad's Key iconDad's Key.
? Card 5.300.48 ? Card Double active When used, copies the effect of Isaac's currently held activated collectible.

Runes[ | ]

Name ID Icon Message Description
Blank Rune 5.300.40 Blank Rune ??? Grants a random rune effect (except in Repentance) excluding Black Rune. Has a 25% chance to drop another Blank Rune on the ground upon use.

Consumables[ | ]

Name ID Icon Message Description
Dice Shard 5.300.49 Dice Shard D6 + D20 Upon use, invokes the effects of Collectible The D6 iconThe D6 and the Collectible D20 iconD20 at the same time, re-rolling all item pedestals and pickups in the room.
Emergency Contact 5.300.50 Emergency Contact Help from above When used, will cause two Mom's HandMom's Hands to come down and grab two random enemies, dealing damage and, if they have 40 or more HP, pinning them to the ground temporarily.

Chests[ | ]

AngelChest Eternal Chests
  • Eternal Chests are similar in appearance to Gold Chests, except they glow bright blue instead of gold, like a soul heart. They require one key to unlock, but can be reopened a random amount of times, each time requiring another key. They can be found in Angel rooms, in I AM ERROR Rooms and rarely in a normal room. Their loot is similar to Golden Chests, but there is a 25% chance they will drop nothing upon opening. If they contain nothing or an item, they will no longer be able to be reopened.
SpikedChest Spiked Chests
  • Spiked Chests are purple colored chests with spikes protruding from them that will deal damage to Isaac upon opening unless he has the Holy Mantle active, which nullifies the damage, or if found in The Chest/Dark Room, where they are free to open. They can be rarely found upon completing a room or in greed mode shops. Their loot is similar to Brown Chests. Unlike other chests, they do not appear on the minimap.

Sacks[ | ]

MysteryBag Mystery sack
  • Spawns 1-4 random pickups upon touching it. It will not drop any hearts, pills or chests, and they have an increased chance to drop batteries.

Entities[ | ]

Monsters[ | ]

Entity ID Description
Gold Heart
Gold Heart
5.10.7 {{{behavior}}}
Lucky Penny
Lucky Penny
5.20.5 {{{behavior}}}
Sticky Nickel
Sticky Nickel
5.20.6 {{{behavior}}}
Golden Bomb
Golden Bomb
5.40.4 {{{behavior}}}
Spiked Chest
Spiked Chest
5.52 {{{behavior}}}
Eternal Chest
Eternal Chest
5.53 {{{behavior}}}
Grab Bag
Grab Bag
5.69.1 {{{behavior}}}
Flaming Gaper
Flaming Gaper
10.2 Walks towards Isaac, dealing contact damage. Usually turns into a PacerPacer or GusherGusher upon death.
Special Shopkeeper
Special Shopkeeper
17.3 {{{behavior}}}
Drowned Hive
Drowned Hive
22.1 Wanders around the room, avoiding Isaac and spawning Drowned ChargerDrowned Chargers if he gets close. Spawns 0-2 Drowned Chargers upon death.
My Shadow
My Shadow
23.0.1 Charges at enemies when in its line of sight, dealing contact damage. Will always spawn friendly via Collectible My Shadow iconMy Shadow.
Drowned Charger
Drowned Charger
23.1 Slowly moves around the room, charging at Isaac when he gets in its line of sight. Explodes into four blood shots in the ordinal directions upon death.
Dank Globin
Dank Globin
24.2 Chases Isaac, dealing a full heart of contact damage. Upon taking enough damage, it collapses into a pile of goo, spawns a SpiderSpider, and leaves a puddle of slowing Black Creep. Will regenerate after a short time if not killed quickly. Leaves another puddle of Black Creep upon death.
Drowned Boom Fly
Drowned Boom Fly
25.2 Flies across the room in straight diagonal lines, dealing contact damage. Upon death, explodes and fires four blood shots in the cardinal directions. Also has a chance to spawn a Drowned ChargerDrowned Charger upon death.
Scarred Double Vis
Scarred Double Vis
39.3 Randomly wanders around the room. Pauses to charge and fire a Brimstone laser which fires from all four cardinal sides when Isaac gets in its line of sight.
Scarred Guts
Scarred Guts
40.1 Attaches itself to a wall or obstacle and rolls around it, leaving a trail of damaging Red Creep.
Scarred Para-Bite
Scarred Para-Bite
58.1 Moves towards Isaac, dealing contact damage and firing a short-range blood shot at him. Can burrow underground and reappear elsewhere.
Flaming Fatty
Flaming Fatty
208.2 Slowly walks towards Isaac. Occasionally farts, which pushes Isaac and adjacent enemies away (in Repentance) and spawns a damaging flame. Has a chance to leave behind a damaging flame upon death.
Dank Death's Head
Dank Death's Head
212.1 Moves diagonally around the room, dealing contact damage. Needs to be killed to complete the room.
Corn
Corn
217.1 Quickly dashes in random directions, dealing contact damage.
Brownie Corn
Brownie Corn
217.2 Quickly dashes in random directions, dealing contact damage.
Dank Squirt
Dank Squirt
220.1 Dashes towards Isaac and deals contact damage, creating slowing black creep. Spawns 2 Clots upon death.
Black Poop
Black Poop
245.3 {{{behavior}}}
Rag Man's Ragling
Rag Man's Ragling
246.1 Quickly leaps towards Isaac and deals contact damage. Randomly shoots two purple shots that orbit around it.
Dart Fly
Dart Fly
256.0 Flies towards Isaac and attempts to predict his movements. Deals contact damage.
Conjoined Fatty
Conjoined Fatty
257.0 Slowly walks towards Isaac. Occasionally pauses to fart out a line of damaging Green Creep towards Isaac. Chance to turn into a regular Fatty upon death.
Blue Conjoined Fatty
Blue Conjoined Fatty
257.1 Slowly walks towards Isaac and occasionally farts out a homing Ipecac shot at Isaac.
Fat Bat
Fat Bat
258.0 Slowly flies towards Isaac. Tries to align itself diagonally to Isaac and shoots at him when in that alignment.
Imp
Imp
259.0 Slowly drifts towards Isaac, frequently firing 5 blood shots in quick succession towards him. Tries to avoid Isaac's shots and occasionally teleports and reappears elsewhere.
Roundy
Roundy
276.0 Pops out of the ground in random locations, creating a small rock wave. Fires an explosive Ipecac shot at Isaac if he is in sight.
Black Bony
Black Bony
277.0 Wanders around the room and throws three bones in a row at Isaac when he is in sight. Explodes upon death.
Black Globin
Black Globin
278.0 Chases Isaac, dealing a full heart of contact damage and launching SpiderSpiders towards Isaac whenever it takes damage. Spawns a Spider, a Black Globin's HeadBlack Globin's Head, and a Black Globin's BodyBlack Globin's Body upon death.
Black Globin's Head
Black Globin's Head
279.0 Slides towards Isaac, leaving a trail of damaging Red Creep.
Black Globin's Body
Black Globin's Body
280.0 Walks aimlessly around the room, occasionally spawning spiders.
Swarm
Swarm
281.0 Follows Isaac in large, tightly-clustered groups and deals contact damage.
Mega Clotty
Mega Clotty
282.0 Slowly moves around the room, occasionally hopping and either firing 6 blood shots in all directions, leaving a puddle of Red Creep, or spawning a ClottyClotty or a collapsed GlobinGlobin. Splits into two ClottyClotties upon death.
Bone Knight
Bone Knight
283.0 Moves erratically around the room, charges toward Isaac when in line of sight, and leaves behind a short-lasting trail of damaging Red Creep. Can only be damaged from behind.
Cyclopia
Cyclopia
284.0 Walks towards Isaac, dealing contact damage and leaving behind a short-lasting trail of damaging Red Creep. Occasionally shoots a blood shot towards Isaac.
Red Ghost
Red Ghost
285.0 Disappears, then reappears near Isaac and fires a brimstone laser.
Flesh Death's Head
Flesh Death's Head
286.0 Moves diagonally around the room, dealing contact damage. Releases 6 blood shots in all directions upon death. Can be killed, but also dies when the room is cleared.
Mom's Dead Hand
Mom's Dead Hand
287.0 Falls from the ceiling. Upon landing, it spawns several rock waves that travel outwards. Spawns several spiders upon death. Entering a room containing Mom's Dead Hand will warn Isaac with Mom's laugh.
Dukie
Dukie
288.0 Flies around the room diagonally, occasionally spitting out 1-2 Dart FlyDart Flies.
Ulcer
Ulcer
289.0 Pops out of the ground in random locations and spawns a Dart Fly if Isaac is in sight. Fires a blood shot after spawning 6 Dart Flies.
Meatball
Meatball
290.0 Slides around the room. If Isaac is in sight, it will stop to spew a fountain of short-range blood shots in all directions or to spit a line of damaging Red Creep towards Isaac. Spawns a Host upon death.
Pitfall
Pitfall
291.0 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out after a short delay.
Suction Pitfall
Suction Pitfall
291.1 Invulnerable and stationary enemy which sucks Isaac towards itself. Isaac falls into it when walked over, taking damage and popping back out after a short delay.
Teleport Pitfall
Teleport Pitfall
291.2 Invulnerable and stationary enemy which Isaac falls into when walked over, taking damage and popping back out at a random location after a short delay.
Movable TNT
Movable TNT
292.0 {{{behavior}}}
Ultra Greed Coin (Spinner)
Ultra Greed Coin (Spinner)
293.0 Spins around the room, dealing contact damage.
Ultra Greed Coin (Key)
Ultra Greed Coin (Key)
293.1 Spins on itself and opens a golden door around the room if not destroyed, spawning hordes of Greed Gapers.
Ultra Greed Coin (Bomb)
Ultra Greed Coin (Bomb)
293.2 Spins on itself and explodes with a large radius if not destroyed.
Ultra Greed Coin (Heart)
Ultra Greed Coin (Heart)
293.3 Spins on itself and heals Ultra Greed for 13.125 HP each if not destroyed.
Corn Mine
Corn Mine
295.0 Goes off when destroyed or after some time, then releases a cloud of poisonous gas and fires corny shots in eight directions.
Hush Fly
Hush Fly
296.0 Gathers with other Hush Flies to form certain patterns. If spawned by Boss Hush ingameHush, can chase Isaac or orbit Hush. Deals contact damage.
Blue Gaper
Blue Gaper
297.0 Walks towards Isaac, dealing contact damage.
Blue Boil
Blue Boil
298.0 Stationary enemy that decreases in size when hit, but regenerates to its full size until fully destroyed. Fires 1-3 blood shots towards Isaac when fully swollen.
Greed Gaper
Greed Gaper
299.0 Walks towards Isaac, dealing contact damage.
Dark Ball
Dark Ball
404.1 Floats towards Isaac, doing contact damage.

Bosses[ | ]

Boss Rag Man
Boss Little Horn
Boss Dangle
Boss Turdlings
Rag Man Little Horn Dangle Turdlings
Boss The Frail
Boss The Stain
Boss The Forsaken
Boss Brownie
The Frail The Stain The Forsaken Brownie
Boss Hush
Boss Ultra Greed
Hush Ultra Greed

Beggars[ | ]

Bomb bum Bomb bum

Bomb Bums are extremely rare, and ask for bombs. Each bomb donated has a chance to have him drop 1-2 bomb pickups or an item from the Bomb Bum Item Pool. After spawning a pedestal item, the Bomb Bum will disappear and can no longer be donated to.

Environment[ | ]

Chapters[ | ]

Burning Basement Flooded Caves
Burning BasementBurning Basement Flooded CavesFlooded Caves
Dank Depths Scarred Womb
Dank DepthsDank Depths Scarred WombScarred Womb
???
??????

Challenges[ | ]

Name Conditions Goal Unlocked by Unlocks
21. XXXXXXXXL
Character Isaac appearance
Full red heartFull red heartFull red heart
Item Pool Treasure Room: yes
Item Pool Shop: yes
Every floor is the size of an XL WombWomb floor, but does not combine the floors of each chapter.
Boss Mom's Heart portrait XXXXXXXXL Defeat Mom Gold Heart Gold Heart
22. SPEED!
Character Isaac appearance
Full red heartFull red heartFull red heart
Item Pool Treasure Room: yes
Item Pool Shop: yes
Everything is sped up like the Collectible Broken Watch iconBroken Watch effect. After the game timer reaches 16 minutes, Isaac starts taking damage every 10 seconds.
Boss Mom's Heart portrait SPEED! Defeat Mom Get out of Jail Free Card Get out of Jail Free Card
23. Blue Bomber
Character ??? appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded
Starts with:
Collectible Brother Bobby iconBrother Bobby
Collectible Kamikaze! iconKamikaze!
Collectible Pyromaniac iconPyromaniac
Collectible Mr. Mega iconMr. Mega
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Satan portrait Blue Bomber Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times Gold Bomb Gold Bomb
24. PAY TO PLAY
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible Money = Power iconMoney = Power
Collectible Sack of Pennies iconSack of Pennies
50 coins
Item Pool Treasure Room: no
Item Pool Shop: yes
Every door costs 1 cent to enter. Isaac drops money when hit. Isaac dies if he run out of money.
Boss Isaac portrait PAY TO PLAY Defeat Isaac as Character Cain iconCain and destroy 10 Tinted Rocks 2 new pills 2 new pills
25. Have a Heart
Character Isaac appearance
Full red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Empty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heartEmpty red heart
Starts with:
Collectible Charm of the Vampire iconCharm of the Vampire
Item Pool Treasure Room: yes
Item Pool Shop: yes
PennyPennies drop instead of Red HeartRed Hearts. Many items that restore Red HeartRed Hearts have no effect.
Boss Mom's Heart portrait Have a Heart Defeat Mom 2 new pills 2 new pills
26. I RULE!
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible The Boomerang iconThe Boomerang
Collectible Key Piece 1 iconKey Piece 1
Collectible Key Piece 2 iconKey Piece 2
Collectible The Ladder iconThe Ladder
Collectible Mom's Knife iconMom's Knife
Collectible Trinity Shield iconTrinity Shield
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss Mega Satan portrait I RULE! (in Rebirth and Afterbirth) Defeat ??? or The Lamb, defeat Satan as Character Isaac iconIsaac, and unlock Collectible The Negative iconThe Negative
(in Afterbirth †) Defeat ??? or The Lamb, and defeat Satan as Character Isaac iconIsaac
(in Repentance) Defeat Mega Satan and unlock Collectible The Negative iconThe Negative
Poker Chip Poker Chip
27. BRAINS!
Character ??? appearance
Full soul heartFull soul heartFull soul heart
BlindfoldedBlindfolded
Starts with:
3 Collectible Bob's Brain iconBob's Brain
Collectible Thunder Thighs iconThunder Thighs
Item Pool Treasure Room: no
Item Pool Shop: yes
Boss ??? portrait BRAINS! Defeat Isaac 5 times Stud Finder Stud Finder
28. PRIDE DAY!
Character Isaac appearance
Full red heartFull red heartFull red heart
Starts with:
Collectible 3 Dollar Bill icon3 Dollar Bill
Collectible Rainbow Baby iconRainbow Baby
Rainbow WormRainbow Worm
Item Pool Treasure Room: no
Item Pool Shop: yes
Cannot drop or replace Rainbow WormRainbow Worm.
Boss Mom's Heart portrait PRIDE DAY! Defeat Mom D8 D8
29. Onan's Streak
Character Judas appearance
Full red heart
Starts with:
Collectible The Book of Belial iconThe Book of Belial
Collectible Chocolate Milk iconChocolate Milk
Item Pool Treasure Room: yes
Item Pool Shop: yes
Missing a shot deals damage to Character Judas iconJudas.
Boss Isaac portrait Onan's Streak (in Afterbirth and Afterbirth †) Defeat Boss Mom ingameMom
(in Repentance) Unlock Character Judas iconJudas and Boss It Lives ingameIt Lives.
Kidney Stone Kidney Stone
30. The Guardian
Character Isaac appearance
Full red heartFull red heartFull red heart
BlindfoldedBlindfolded
Starts with:
Collectible Holy Grail iconHoly Grail
Collectible Isaac's Heart iconIsaac's Heart
Collectible Punching Bag iconPunching Bag
Collectible Spear Of Destiny iconSpear Of Destiny
Item Pool Treasure Room: no
Item Pool Shop: yes
Collectible Isaac's Heart iconIsaac's Heart will follow Collectible Punching Bag iconPunching Bag instead of Isaac.
Boss Mom's Heart portrait The Guardian Defeat Mom Blank Rune Blank Rune

Changes[ | ]

Player[ | ]

Characters[ | ]

Azazel
  • His mini-brimstone's range can be increased with range up items or pills.
The Lost

Items[ | ]

Activated Collectibles[ | ]

Collectible Bob's Rotten Head iconBob's Rotten Head
  • The head deals 3 times Isaac's tear damage as poison over time instead of either 6 or 8 points.
Collectible The Book of Belial iconThe Book of Belial
  • Increases the chance to open the Devil Room or Angel Room by 12.5% after killing a boss while holding it instead of guaranteeing it.
Collectible Book of Revelations iconBook of Revelations
  • Increases chance for a Devil/Angel Room Door to open by 17.5% instead of 35%.
Collectible Butter Bean iconButter Bean
  • Knocks back enemy shots.
Collectible Crack the Sky iconCrack the Sky
  • The beams have a high chance to directly target enemies.
Collectible D4 iconD4
  • Previously held items are removed from the pause menu.
Collectible The D6 iconThe D6
  • Reroll an item after defeating The Fallen no longer replace the Devil Room item he drops to a random item from the normal boss item pool.
Collectible D10 Rebirth iconD10
  • Fly enemies are only rerolled into other fly enemies.
  • Red flies can't be rerolled anymore (even though enemies can be rerolled into them).
Collectible Flush! iconFlush!
  • Floods the whole room with water.
  • Flushes all poop-related enemies and bosses away.
  • The ladders are covered in water but the walls are not when used inside a crawl space.
Collectible Guppy's Paw iconGuppy's Paw
  • Can no longer be used without red heart containers.
Collectible Head of Krampus iconHead of Krampus
  • Has a 50% chance to rotate all beams around the player 90 degrees, similar to Krampus' second Brimstone attack.
Collectible The Jar Afterbirth iconThe Jar
  • Sprite changed.
Collectible Monstro's Tooth iconMonstro's Tooth
  • Does not affect if Monstro is in the room the item is used in.
Collectible The Poop iconThe Poop
  • Knocks back enemy shots.
Collectible Scissors iconScissors
  • Its recharge time is 2 rooms instead of 6 rooms.
Collectible Undefined iconUndefined
  • Dark Room can no longer be cleared repeatedly.

Passive Collectibles[ | ]

Collectible 20 20 Afterbirth icon20/20
  • Sprite changed.
Collectible 3 Dollar Bill icon3 Dollar Bill
  • The type of randomized tear changes every 2–3 seconds. The item appears to select two tear effects at once, perhaps staggering the times at which each of those effects changes.
  • If a run is quit, and then continued, 3 Dollar Bill will keep tear effects for the current room.
Collectible Abel iconAbel
  • Shoots tears towards Isaac regardless of which direction Isaac is shooting.
Collectible Ball of Bandages iconBall of Bandages
  • Blocks enemy shots.
Collectible Bob's Brain iconBob's Brain
  • Bob's Brain is fired directly from where it is located in the chain of familiars behind Isaac, making aiming it slightly more difficult.
  • Each copy takes up its own spot on the familiar line, but only the first one launches out. Respawning brains may end up stacking on top of each other.
Collectible Bomb Bag iconBomb Bag
Collectible Box Rebirth iconBox
Collectible Butt Bombs iconButt Bombs
Collectible Cain's Other Eye iconCain's Other Eye
  • Each tear deals Isaac's tear damage.
Collectible The Common Cold iconThe Common Cold
  • The poison hits twice, dealing a total of double Isaac's damage.
Collectible Dr. Fetus Rebirth iconDr. Fetus
  • Each bomb deals 5 times the character's normal tear damage instead of 3, plus a flat 30 damage. The flat 30 is not affected by damage multipliers.
Collectible Fire Mind iconFire Mind
  • Isaac gives a wide glow lighting up dark areas, such as those under the effects of the Curse of Darkness or the Dark One's attacks.
Collectible Isaac's Heart iconIsaac's Heart
  • Brimstone shots damage the heart.
Collectible Leo iconLeo
  • Nullifies effects of One Makes You Small pills, One Makes You Larger pills, and other items that decrease the size of Isaac, such as Caffeine Pill.
Collectible Lost Contact Rebirth iconLost Contact
  • Gives a shield to familiar's tears.
Collectible Lord of the Pit Rebirth iconLord of the Pit
  • Speed boost is applied immediately.
Collectible Mom's Contacts Rebirth iconMom's Contacts
  • Range and tear falling speed buffs are applied immediately.
Collectible Mom's Knife Rebirth iconMom's Knife
  • If picked up twice in the same run, two knives are fired at once.
Collectible Punching Bag iconPunching Bag
  • Dies after taking too much damage and then respawns after a long time. Exiting and continuing the run will cause it to reappear right away.
  • Dies instantly by enemies' beam-type attacks, such as Uriel's and Gabriel's beam. This also includes enemies' Technology lasers such as Eye and Camillo Jr..
  • Reappears instantly each time a familiar or orbital item is picked up.
Collectible Scorpio iconScorpio
  • The poison hits twice, dealing a total of double Isaac's damage.
Collectible Steam Sale iconSteam Sale
  • Having multiple Steam Sales reduces all shop prices to 0 coins.
  • Causes the Deals with the Devil not to convert the heart-type automatically.
Collectible Stop Watch iconStop Watch
  • The slow is only applied after the player is hit.
Collectible Strange Attractor Rebirth iconStrange Attractor
  • Isaac's bombs are magnetically attracted to the player character's tears.
Collectible Tech.5 Rebirth iconTech.5
Collectible The Virus iconThe Virus
  • Each poison hit deals damage equal to Isaac's tear damage instead of 4 or 6 damage.
  • Enemies killed after they have been inflicted with this type of poison have a 20% chance to drop Black Hearts.

Trinkets[ | ]

Match StickMatch Stick
  • Can replace the Tick.
Missing PosterMissing Poster
  • No longer displays a particular puzzle piece on the last will screen if Isaac dies in a Sacrifice Room while holding it.
  • Dying in a Sacrifice Room while holding it unlock The Lost, regardless of the current character.
    • If The Lost was already unlocked, Isaac will be revived as The Lost and Missing Poster will be consumed.
    • If the player's character is already The Lost, he will be revived in the previous room and Missing Poster will be consumed.
Mysterious PaperMysterious Paper
TickTick

Interactions[ | ]


Pickups[ | ]

Bombs[ | ]

Troll Bomb
  • Troll Bombs are now given a random amount of time before exploding. Before that, they always exploded at a fixed time. This means that if two Troll Bombs spawn at the exact time right next to each other, there's a high chance one Troll Bomb will blow up before the other, sending that Troll Bomb sliding outwards a bit before exploding.

Entities[ | ]

Monsters[ | ]

Bony
  • Only leaves behind bones when killed.

Environment[ | ]

Rooms[ | ]

Boss Room
  • Double Trouble boss rooms can now contain 2 bosses of different types. Additionally, they can appear as early as chapter 1.
Arcade

Arcade 12Arcade 13Arcade 14Arcade 15

Angel Room
  • Possible rewards found in the room include:
  • Urns might spawn in the room.
  • Killing Key Key Master and Shell Game Beggar no longer apply the 25% bonus.
  • Donating to a Beggar until it pays out with an item on the current floor applies a 10% bonus instead of 25%.
  • Donating to a Devil Beggar until it pays out with an item on the current floor applies a 10% bonus instead of 25%.
    • If this coin flip succeeds, a Devil Room will be generated regardless of the above coin flips.
  • "You feel blessed!" fortune in the Sacrifice Room of the current floor applies a bonus:
    • If the "You feel blessed!" fortune appeared on the 3rd sacrifice, the chance will be 15%.
    • If the "You feel blessed!" fortune appeared on the 5th sacrifice, the chance will be 50%.
    • If both "You feel blessed!" fortunes appeared, the chance will be 65%.
  • Angel Rooms that spawn after Isaac defeats Mom's Heart or It Lives will be normal Angel Rooms with items or pickups.
  • A Troll Bomb can sometimes appear behind the Angel Statue, blowing it up. If the Angel fights have been unlocked, this will begin the boss fight if the player is not careful or quick enough to move the bomb.
Bedroom
  • The clean bedroom occasionally has two clean beds instead of one.
  • The trapdoor in a dirty bedroom has a chance to lead to a Crawl Space.
  • Occasionally, one Rag Man will spawn inside the dirty bedroom.
Boss Rush

Boss Rush 2Boss Rush 3Boss Rush 4Boss Rush 5

  • If a sack spawns for whatever reason, picking it up will start the Boss Rush. The player can still pick up one of the pedestal items.
Black Market
  • Black Market can no longer be accessed in The Chest and The Dark Room, and therefore cannot be used to collect more items.
Curse Room
Challenge Room
  • The three waves appear in random orders rather than the original orders.
Sacrifice Room
  • The payouts only depend on the number of sacrifices made. The number of sacrifices is reset to 0 when the player goes to the next floor.
  • Rewards are reworked:
№ of sacrifices on Current Floor Chance Reward
1st/2nd 50% Nothing
50% 1 Penny
3rd 33% Nothing
67% "You feel blessed!" (increased chance to receive an Angel Room over a Devil Room for the current floor)
  • Does not increase the chance of a Devil/Angel room after defeating a boss, only the chance of getting an Angel Room over a Devil Room.
  • Can cause an Angel Room to spawn even if you already took a deal with the devil.
  • Less of a modifier than the "You feel blessed!" effect below.
4th 50% Nothing
50% 1 random chest (The type of chest is governed by the same mechanic as room drops. Thus, brown chests are more likely to spawn than any other kind of chest.)
5th 33% 3 Pennies (These coins do not have a chance to spawn as a nickel or a dime.)
67% You feel blessed!" (Same conditions as 3rd sacrifice but a stronger modifier.)
6th 33% Teleport to the Devil/Angel Room. (If the floor's Devil/Angel Room has not been entered yet, an Angel Room is guaranteed to spawn — even if you already took a Devil Deal.)
67% 1 random chest (The type of chest is governed by the same mechanic as room drops. Thus, brown chests are more likely to spawn than any other kind of chest.)
7th 33% 1 random Angel Room pedestal item.
67% 1 Soul Heart
8th 100% 6 Troll Bombs
9th 100% Uriel battle
10th 50% 7 Soul Hearts
50% 30 Pennies
11th 100% Gabriel battle
12th and onwards 50% Nothing
50% Teleport directly to the Dark Room
  • Losing red hearts due to the spikes will reduce the chance for a Devil Room to appear.
  • The amount of luck that the player has does not affect the payout probabilities.
  • Angels are normally able to fly over spikes but will take damage from sacrifice room spikes.
  • New layouts:

Sacrifice Room 2Sacrifice Room 3Sacrifice Room 4Sacrifice Room 5

Secret Room
Shop
  • There is a small chance when you bomb the Shopkeeper that they can turn into Greed and start attacking you.
Super Secret Room
Treasure Room
  • There's a rare chance that a treasure room might contain two items to choose from, only one of which can be taken.
  • Treasure rooms may also contain a Restock Machine, allowing Isaac to re-roll offered items if he has coins or bombs.
  • New layouts:

Treasure Room 13Treasure Room 14Treasure Room 15Treasure Room 16Treasure Room 17Treasure Room 18Treasure Room 19Treasure Room 20Treasure Room 21Treasure Room 22Treasure Room 23Treasure Room 26Treasure Room 27Treasure Room 28Treasure Room 31Treasure Room 32Treasure Room 33Treasure Room 34Treasure Room 35Treasure Room 36Treasure Room 37Treasure Room 38Treasure Room 39Treasure Room 24Treasure Room 30Treasure Room 25Treasure Room 29

Other[ | ]

  • When not having red hearts in Devil Room, the price of items switches to soul hearts.
  • Krampus has a new attack pattern.
  • The floor icons on the stage transition sprites are updated; instead of being large rectangles with the unknown ones being grey, the sprites feature a much thinner and more detailed border with the unknown floors being represented by a closed trap door.

Gallery[ | ]

Trivia[ | ]

  • Afterbirth is the placenta and fetal membranes discharged from the uterus after the birth of offspring, which might be why the title screen is bloody.


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