Temporary buffs are effects applied to the player character that expire after a timed duration or on leaving a room.
Effects [ | ]
Effect
Appearance
Description
Shield
Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machines , Devil Beggars , and environmental hazards like spikes , Curse Room doors and Sacrifice Rooms . Does not prevent Heart Container or health loss from Health Down Pills , Devil Room deals, damage from IV Bag , or spawning a baby .
The shield effect does not prevent Isaac from shooting tears.
Invulnerability
Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machines , Devil Beggars , and environmental hazards like spikes , Curse Room doors and Sacrifice Rooms . Does not prevent Heart Container or health loss from Health Down Pills , Devil Room deals, damage from IV Bag , or spawning a baby .
While invulnerable, Isaac loses the ability to shoot tears, and flashes in multiple colors for the duration of the effect.
Invulnerability [ | ]
Activated Items that grant invulnerability [ | ]
Name
ID
Icon
Quote
Description
Quality
My Little Unicorn
5.100. 77
Temporary badass
Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
1
The Gamekid
5.100. 93
Temporary Man-Pac
Turns Isaac into a Pac-Man -like creature for 6.5 seconds, granting invulnerability , inflicting fear on all enemies, and has a chance of replenishing a Half Red Heart every time an enemy is killed.
1
Unicorn Stump
5.100. 298
You feel stumped
Gives invulnerability and increased speed for six seconds, but removes the ability to shoot tears.
1
Passive Items that grant invulnerability [ | ]
Name
ID
Icon
Quote
Description
Quality
Taurus
5.100. 299
Speed down + rage is building
-0.3 Speed . Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn effect for 5 seconds.
1
Trinkets that grant invulnerability [ | ]
Name
ID
Icon
Quote
Description
Cartridge
5.350. 8
I remember these
Chance to trigger The Gamekid effect upon taking damage.
Cards and Runes that grant invulnerability [ | ]
Name
ID
Icon
Message
Description
VII - The Chariot
5.300. 8
May nothing stand before you
Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies (same effect as My Little Unicorn ).
Shield [ | ]
Activated Items that grant a shield [ | ]
Name
ID
Icon
Quote
Description
Quality
Book of Shadows
5.100. 58
Temporary invincibility
Creates a protective shield , nullifying all types of damage in the current room for 10 seconds.
3
Passive Items that grant a shield [ | ]
Name
ID
Icon
Quote
Description
Quality
Celtic Cross
5.100. 162
Blessing of protection
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
1
The Polaroid
5.100. 327
Fate chosen
If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into Chest . Also allows access to Home .
2
Virgo
5.100. 303
You feel refreshed and protected
Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.
2
Empty Vessel
5.100. 409
I reward an empty vessel
Grants two Black Hearts . While Isaac has no red hearts , grants flight and periodically grants an invincibility shield for a few seconds.
2
Trinkets that grant a shield [ | ]
Name
ID
Icon
Quote
Description
Sigil of Baphomet
5.350. 189
Revel in death
Grants an invulnerability shield for 1 second after killing an enemy.
Runes that grant a shield [ | ]
Name
ID
Icon
Message
Description
Rune of Algiz
5.300. 39
Resistance
Grants a shield which lasts for 30 seconds. Grants a shield which lasts for 20 seconds.