Binding of Isaac: Rebirth Wiki
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Player Effects
Attributes Flight Death

Temporary buffs are effects applied to the player character that expire after a timed duration or on leaving a room.

Effects[]

Effect Appearance Description
Shield Collectible Book of Shadows appearance.png Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machine.png Blood Donation Machines, Devil Beggar.png Devil Beggars, and environmental hazards like spikes, Curse Room Curse Room doors and Sacrifice Room Sacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil Room Devil Room deals, damage from IV Bag IV Bag or spawning a baby.

The shield effect does not prevent Isaac from shooting tears.

Invulnerability Invincibility App.gif Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machine.png Blood Donation Machines, Devil Beggar.png Devil Beggars, and environmental hazards like spikes, Curse Room Curse Room doors and Sacrifice Room Sacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil Room Devil Room deals, damage from IV Bag IV Bag or spawning a baby.

While invulnerable Isaac loses the ability to shoot tears, and flashes in multiple colors for the duration of the effect.

Invulnerability[]

Activated Items that grant invulnerability[]

Name ID Icon Quote Description Added in Repentance Quality
A Pony 5.100.130
A Pony
2 rooms
Flight + dash attack Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge and dealing damage to enemies hit. 2
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
Temporary badass Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies. 1
The Gamekid 5.100.93
The Gamekid
4 rooms
Temporary Man-Pac Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart Half Red Heart for every two enemies killed. 2
Unicorn Stump 5.100.298
Unicorn Stump
1 rooms
You feel stumped Gives invulnerability and increased speed for five seconds, but removes the ability to shoot tears. 1
White Pony 5.100.181
White Pony
2 rooms
Flight + holy death Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge while also creating damaging beams of light. 2
Added in Repentance Dark Arts 5.100.705
Dark Arts
6 seconds
One with the shadows Briefly grants +1 speed and makes Isaac invulnerable and intangible. When the effect ends, destroys all projectiles and damages all enemies Isaac ran through. 3
Added in Repentance Mega Mush 5.100.625
Mega Mush
12 rooms
I'm a big boy now! Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms. 4

Passive Items that grant invulnerability[]

Name ID Icon Quote Description Added in Repentance Quality
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn My Little Unicorn effect for 5 seconds. 1

Trinkets that grant invulnerability[]

Name ID Icon Quote Description
Cartridge 5.350.8 Cartridge I remember these Chance to trigger The Gamekid The Gamekid effect upon taking damage.

Cards and Runes that grant invulnerability[]

Name ID Icon Message Description
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Grants the temporary invulnerability effect of My Little Unicorn My Little Unicorn.
Added in Repentance VII - The Chariot? 5.300.63 VII - The Chariot? May nothing walk past you Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
Added in Repentance Soul of Judas 5.300.84 Soul of Judas Right behind you Stops time for 3 seconds and invokes Dark Arts Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.

Shield[]

Activated Items that grant a shield[]

Name ID Icon Quote Description Added in Repentance Quality
Book of Shadows 5.100.58
Book of Shadows
3 rooms
Temporary invincibility Creates a protective shield, nullifying all types of damage in the current room for 10 seconds. 3

Passive Items that grant a shield[]

Name ID Icon Quote Description Added in Repentance Quality
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
The Polaroid 5.100.327 The Polaroid Fate chosen If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into Chest Chest. Added in Repentance Also allows access to Home Home. 2
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
Added in Afterbirth Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black Heart Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2

Trinkets that grant a shield[]

Name ID Icon Quote Description
Added in Repentance Sigil of Baphomet 5.350.189 Sigil of Baphomet Revel in death Grants an invulnerability shield for 1 second after killing an enemy.

Runes that grant a shield[]

Name ID Icon Message Description
Rune of Algiz 5.300.39 Rune of Algiz Resistance Removed in Repentance Grants a shield which lasts for 30 seconds.
Added in Repentance Grants a shield which lasts for 20 seconds.


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