Temporary Buffs

Temporary buffs are effects applied to the player character that expire after a timed duration or on leaving a room.

Effects[]

Effect	Appearance	Description
Shield		Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machines, Devil Beggars, and environmental hazards like spikes, Curse Room doors and Sacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil Room deals, damage from IV Bag or spawning a baby. The shield effect does not prevent Isaac from shooting tears.
Invulnerability		Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machines, Devil Beggars, and environmental hazards like spikes, Curse Room doors and Sacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil Room deals, damage from IV Bag or spawning a baby. While invulnerable Isaac loses the ability to shoot tears, and flashes in multiple colors for the duration of the effect.

Invulnerability[]

Activated Items that grant invulnerability[]

Name	ID	Quote	Description	Quality
A Pony	5.100.130	Flight + dash attack	Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge and dealing damage to enemies hit.	2
My Little Unicorn	5.100.77	Temporary badass	Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies.	1
The Gamekid	5.100.93	Temporary Man-Pac	Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed.	2
Unicorn Stump	5.100.298	You feel stumped	Gives invulnerability and increased speed for five seconds, but removes the ability to shoot tears.	1
White Pony	5.100.181	Flight + holy death	Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge while also creating damaging beams of light.	2
Dark Arts	5.100.705	One with the shadows	Briefly grants +1 speed and makes Isaac invulnerable and intangible. When the effect ends, destroys all projectiles and damages all enemies Isaac ran through.	3
Mega Mush	5.100.625	I'm a big boy now!	Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.	4

Passive Items that grant invulnerability[]

Name	ID	Icon	Quote	Description	Quality
Taurus	5.100.299		Speed down + rage is building	-0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn effect for 5 seconds.	1

Trinkets that grant invulnerability[]

Name	ID	Icon	Quote	Description
Cartridge	5.350.8		I remember these	Chance to trigger The Gamekid effect upon taking damage.

Cards and Runes that grant invulnerability[]

Name	ID	Message	Description
VII - The Chariot	5.300.8	May nothing stand before you	Grants the temporary invulnerability effect of My Little Unicorn.
VII - The Chariot?	5.300.63	May nothing walk past you	Isaac becomes an invincible statue with extreme fire rate for 10 seconds. The statue can be nudged slightly by moving and is affected by knockback.
Soul of Judas	5.300.84	Right behind you	Stops time for 3 seconds and invokes Dark Arts, turning Isaac into a phantom that can pass through enemies to paralyze them, then attack them for quickly increasing chained damage and damage bonuses.

Shield[]

Activated Items that grant a shield[]

Name	ID	Icon	Quote	Description	Quality
Book of Shadows	5.100.58		Temporary invincibility	Creates a protective shield, nullifying all types of damage in the current room for 10 seconds.	3

Passive Items that grant a shield[]

Name	ID	Quote	Description	Quality
Celtic Cross	5.100.162	Blessing of protection	Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.	1
The Polaroid	5.100.327	Fate chosen	If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into Chest. Also allows access to Home.	2
Virgo	5.100.303	You feel refreshed and protected	Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills.	2
Empty Vessel	5.100.409	I reward an empty vessel	Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds.	2