Binding of Isaac: Rebirth Wiki
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Temporary buffs are effects applied to the player character that expire after a timed duration or on leaving a room.

Effects[ | ]

Effect Appearance Description
Shield Book of Shadows App Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation MachineBlood Donation Machines, Devil BeggarDevil Beggars, and environmental hazards like spikes, Curse RoomCurse Room doors and Sacrifice RoomSacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil RoomDevil Room deals, damage from Collectible IV Bag iconIV Bag, or spawning a baby.

The shield effect does not prevent Isaac from shooting tears.

Invulnerability Invincibility App Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation MachineBlood Donation Machines, Devil BeggarDevil Beggars, and environmental hazards like spikes, Curse RoomCurse Room doors and Sacrifice RoomSacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil RoomDevil Room deals, damage from Collectible IV Bag iconIV Bag, or spawning a baby.

While invulnerable, Isaac loses the ability to shoot tears, and flashes in multiple colors for the duration of the effect.

Invulnerability[ | ]

Activated Items that grant invulnerability[ | ]

Name ID Icon Quote Description (in Repentance) Quality
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
Temporary badass Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies. 1
The Gamekid 5.100.93
The Gamekid
4 rooms
Temporary Man-Pac Turns Isaac into a Pac-Man-like creature for 6.5 seconds, granting invulnerability, inflicting fear on all enemies, and has a chance of replenishing a Half Red HeartHalf Red Heart every time an enemy is killed. 1
Unicorn Stump 5.100.298
Unicorn Stump
1 room
You feel stumped Gives invulnerability and increased speed for six seconds, but removes the ability to shoot tears. 1

Passive Items that grant invulnerability[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the Collectible My Little Unicorn iconMy Little Unicorn effect for 5 seconds. 1

Trinkets that grant invulnerability[ | ]

Name ID Icon Quote Description
Cartridge 5.350.8 Cartridge I remember these Chance to trigger Collectible The Gamekid iconThe Gamekid effect upon taking damage.

Cards and Runes that grant invulnerability[ | ]

Name ID Icon Message Description
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.

Shield[ | ]

Activated Items that grant a shield[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Book of Shadows 5.100.58
Book of Shadows
3 rooms
Temporary invincibility Creates a protective shield, nullifying all types of damage in the current room for 10 seconds. 3

Passive Items that grant a shield[ | ]

Name ID Icon Quote Description (in Repentance) Quality
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Collectible Book of Shadows iconBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
The Polaroid 5.100.327 The Polaroid Fate chosen If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into ChestChest. (in Repentance) Also allows access to HomeHome. 2
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
(except in Rebirth) Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black HeartBlack Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2

Trinkets that grant a shield[ | ]

Name ID Icon Quote Description
(in Repentance) Sigil of Baphomet 5.350.189 Sigil of Baphomet Revel in death Grants an invulnerability shield for 1 second after killing an enemy.

Runes that grant a shield[ | ]

Name ID Icon Message Description
Rune of Algiz 5.300.39 Rune of Algiz Resistance (except in Repentance) Grants a shield which lasts for 30 seconds.
(in Repentance) Grants a shield which lasts for 20 seconds.


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