Temporary Buffs

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Player Effects
Attributes Flight Death

Temporary buffs are effects applied to the player character that expire after a timed duration or on leaving a room.

Effects[edit | edit source]

Effect Appearance Description
Shield Collectible Book of Shadows appearance.png Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machines, Devil Beggars, and environmental hazards like spikes, Curse Room doors and Sacrifice Rooms. Does not prevent Heart Container or health loss from Health Down Pills, Devil Room deals, damage from 15►IV Bag IV Bag or spawning a baby.

The shield effect does not prevent Isaac from shooting tears.

Invulnerability Invincibility App.gif Negates all types of damage for a variable amount of time depending on the item it's granted by, including health loss from Blood Donation Machines, Devil Beggars, and environmental hazards like spikes, Curse Room doors and Sacrifice Rooms. Does not prevent Heart Container or Soul Heart loss from Health Down Pills, Devil Room deals, damage from IV Bag, or spawning a baby.

While invulnerable Isaac loses the ability to shoot tears, and flashes in multiple colors for the duration of the effect.

Invulnerability[edit | edit source]

Activated Items that grant invulnerability[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
My Little Unicorn 5.100.77
My Little Unicorn
4 rooms
Temporary badass Gives invulnerability and +0.28 speed for six seconds, removing the ability to shoot tears and replacing it with the ability to deal 40 contact damage to enemies. 1
The Gamekid 5.100.93
The Gamekid
4 rooms
Temporary Man-Pac Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed. 2
Unicorn Stump 5.100.298
Unicorn Stump
1 rooms
You feel stumped Gives invulnerability and increased speed for five seconds, but removes the ability to shoot tears. 1
White Pony 5.100.181
White Pony
2 rooms
Flight + holy death Passively gives flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge and dealing 40 damage while also casting the effect of Crack the Sky. 2
Added in Repentance Mega Mush 5.100.625
Mega Mush
12 rooms
I'm a big boy now! Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms. 4

Passive Items that grant invulnerability[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the 15►My Little Unicorn My Little Unicorn effect for 5 seconds. 1

Trinkets that grant invulnerability[edit | edit source]

Name ID Icon Quote Description
Cartridge 5.350.8 Cartridge I remember these Chance to trigger 15►The Gamekid The Gamekid effect upon taking damage.

Cards that grant invulnerability[edit | edit source]

Name ID Icon Message Desciption
VII - The Chariot 5.300.8 VII - The Chariot May nothing stand before you Grants the temporary invulnerability effect of 15►My Little Unicorn My Little Unicorn.

Shield[edit | edit source]

Activated Items that grant a shield[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Book of Shadows 5.100.58
Book of Shadows
3 rooms
Temporary invincibility Creates a protective shield, nullifying all types of damage for 10 seconds. 2

Passive Items that grant a shield[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the 15►Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
The Polaroid 5.100.327 The Polaroid Fate chosen If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into The Chest The Chest. Added in Repentance Also allows access to Home Home. 2
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
Added in Afterbirth Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2

Trinkets that grant a shield[edit | edit source]

Name ID Icon Quote Description
Added in Repentance Sigil of Baphomet 5.350.189 Sigil of Baphomet Revel in death Grants an invulnerability shield for 1 second after killing an enemy.

Runes that grant a shield[edit | edit source]

Name ID Icon Message Desciption
Rune of Algiz 5.300.39 Rune of Algiz Resistance Removed in RepentanceGrants a shield which lasts for 30 seconds. Added in RepentanceGrants a shield which lasts for 20 seconds.


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