Binding of Isaac: Rebirth Wiki
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(in Repentance)

Tainted Lost is a character added in The Binding of Isaac: Repentance. It is the alternate version of Character The Lost iconThe Lost. Tainted Lost is unlocked by reaching HomeHome and using the Collectible Red Key iconRed Key, Cracked KeyCracked Key, or Soul of CainSoul of Cain to access a special room in one of the walls while playing as the Lost.

Tainted Lost is just like The Lost, but instead of Collectible Holy Mantle iconHoly Mantle, it starts with a Holy CardHoly Card; it also does not start with the Collectible Eternal D6 iconEternal D6. Like the Lost, Tainted Lost has flight and spectral tears, but no health.

It also starts with a 1.3x damage multiplier, giving it higher starting damage and making most damage ups more powerful. Certain items will be automatically rerolled while playing as Tainted Lost, including most defense-oriented items (see Item Exclusion). To offset the lack of Collectible Holy Mantle iconHoly Mantle and limited defensive options, all cards that spawn have roughly a 10% chance of being turned into a Holy CardHoly Card.

Notes[ | ]

  • Just as the Holy Mantle effect from the Holy Card negates damage taken in the first place, items such as Collectible Birthright iconBirthright, Missing PosterMissing Poster and Soul of LazarusSoul of Lazarus will revive Tainted Lost after death. This means that items that normally take effect upon taking damage will affect Tainted Lost upon death and revival.
  • Beating Delirium with Character The Lost iconThe Lost is not required for Tainted Lost to obtain the Holy CardHoly Card, or for Holy Cards to spawn during the run.
  • As with The Lost, Devil RoomDevil Room items and Black MarketBlack Market items can be taken for free, but will be presented as a choice. Taking one item as a deal will cause the others in the room to disappear.

Item Exclusion[ | ]

Tainted Lost has two mechanics that determine what items it can encounter.

Offensive items[ | ]

The first mechanic makes it so that any items that are not tagged "offensive" cannot be naturally encountered while playing as Tainted Lost. This disallows items that it can't take advantage of, similar to Character The Lost iconThe Lost's Collectible Birthright iconBirthright, but it also prevents many powerful defensive items, such as Collectible Dead Cat iconDead Cat and Collectible Holy Mantle iconHoly Mantle, from naturally spawning. These items will be rerolled, and items that are set drops from mini-bosses (ex. Super Pride dropping Collectible Dead Cat iconDead Cat) will never be dropped.

Disallowed items can only appear by using Collectible Spindown Dice iconSpindown Dice, Collectible Death Certificate iconDeath Certificate, as set drops from props (ex. Collectible Dry Baby iconDry Baby from a skull) or Harbringers (ex. Collectible Ball of Bandages iconBall of Bandages), or from Soul of LilithSoul of Lilith.

Not all items tagged "offensive" are particularly offense-oriented items. Examples of this include Collectible Treasure Map iconTreasure Map and Collectible The D6 iconThe D6.

This mechanic seemingly does not work correctly in co-op.

Item quality[ | ]

The second mechanic uses the item quality system. Items with a quality value of 2 or less have a 20% chance of being rerolled when encountered as Tainted Lost. The new item chosen is not guaranteed to have quality over 2.

Excluded Items[ | ]

The following items cannot be found while playing as Tainted Lost.

Activated Collectibles[ | ]

Name ID Icon Quote Description Quality
Blood Rights 5.100.186
Blood Rights
Unlimited
Mass enemy damage at a cost Upon use, takes a full heart of health and deals 40 damage to all enemies in the room. (in Repentance) Repeated uses in the same room only take half a heart. 0
Book of Revelations 5.100.78
Book of Revelations
6 rooms
Reusable soul protection Increases the chance of a Devil RoomDevil Room / Angel RoomAngel Room appearing while held. On use, gives one Soul HeartSoul Heart, and replaces the boss of the current floor with a Harbinger if possible. 3
Breath of Life 5.100.326
Breath of Life
3 seconds
Invincibility at a cost Grants a brief moment of invincibility when the charge bar hits zero. Isaac begins taking damage if the item is held any longer. (in Repentance) Isaac creates beams of light when touching enemies while invulnerable, and creates a powerful 4-way beam if blocking damage exactly as the invincibility starts. 1
Converter 5.100.296
Converter
3 rooms
Convert your soul (except in Repentance) Converts two Soul HeartSoul Hearts or Black HeartBlack Hearts into one filled Red HeartRed Heart Container.
(in Repentance) Converts one Soul HeartSoul Heart or Black HeartBlack Heart into one filled Red HeartRed Heart Container.
2
Guppy's Paw 5.100.133
Guppy's Paw
Unlimited
Soul converter Upon use, converts one Red Heart Container into three Soul HeartSoul Hearts. 3
How to Jump 5.100.282
How to Jump
Unlimited
It's time you learned how Upon use, Isaac jumps in the direction he is currently moving, allowing travel over obstacles and enemies. 1
IV Bag 5.100.135
IV Bag
Unlimited
Portable blood bank Upon use, Isaac loses half a heart of health (or a full heart in Chapter 4 onward) for a random amount of coins, similar to a Blood Donation MachineBlood Donation Machine. 1
Kamikaze! 5.100.40
Kamikaze!
Unlimited
Become the bomb! Creates an explosion around Isaac, damaging him and nearby enemies as well as destroying obstacles. 0
Prayer Card 5.100.146
Prayer Card
6 rooms
Reusable eternity Gives an Eternal HeartEternal Heart per use. 3
Razor Blade 5.100.126
Razor Blade
Unlimited
Feel my pain Takes one Red HeartHeart of health and grants +1.2 damage for the current room. (in Repentance) Repeated uses in the same room only take half a heart. 0
Satanic Bible 5.100.292
Satanic Bible
6 rooms
Reusable evil... but at what cost? Gives one Black HeartBlack Heart. (in Repentance) Replaces the boss room item on the current floor with a Devil Deal. 4
The Jar 5.100.290
The Jar
Unlimited
Save your life When at full health, up to 4 extra Red HeartRed Hearts can be stored in The Jar. Activating drops the stored hearts on the ground. 0
The Nail 5.100.83
The Nail
6 rooms
Temporary demon form (except in Repentance) Gives one Soul HeartSoul Heart. For the current room; +0.7 damage, -0.18 speed, Isaac breaks rocks and deals contact damage.
(in Repentance) Gives half a Black HeartBlack Heart. For the current room; +2 damage, -0.18 speed, Isaac breaks rocks and deals contact damage.
2
The Poop 5.100.36
The Poop
1 room
Plop! Spawns a pile of PoopPoop where Isaac is standing and knocks back nearby enemies. May yield pickups like regular poop. 0
Unicorn Stump 5.100.298
Unicorn Stump
1 room
You feel stumped Gives invulnerability and increased speed for six seconds, but removes the ability to shoot tears. 1
Yum Heart 5.100.45
Yum Heart
4 rooms
Reusable regeneration Restores one full Red HeartRed Heart. 1
Clicker 5.100.482
Clicker
6 rooms
Change Transforms Isaac into a random character and removes the last item collected. 0
Dull Razor 5.100.486
Dull Razor
2 rooms
I feel numb... Hurts Isaac without depleting health, activating any items that trigger upon taking damage. 1
Potato Peeler 5.100.487
Potato Peeler
Unlimited
A pound of flesh Removes a Heart Container, increases damage and range, and grants a Collectible Cube of Meat iconCube of Meat. 2
Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Sumptorium 5.100.713
Sumptorium
10 seconds
Blood to blood Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As Character Tainted Eve iconTainted Eve, passively converts health into Clots while firing. Activating returns all Clots to health. 3
Yuck Heart 5.100.639
Yuck Heart
4 rooms
Gross! Gives Isaac a Rotten HeartRotten Heart. 1

Passive Collectibles[ | ]

Name ID Icon Quote Description Quality
<3 5.100.15 <3 HP up Grants Isaac one Red Heart container and fully restores Isaac's health. 2
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear. 2
A Snack 5.100.346 A Snack HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Anemic 5.100.214 Anemic Toxic blood After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. (except in Repentance) +5 range. (in Repentance) +1.5 range. 1
Ankh 5.100.161 Ankh Eternal life? Upon death, Isaac will respawn as Character ??? (Character) icon??? in the previous room, with 3 Soul HeartSoul Hearts. 1
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to Collectible Forever alone iconForever alone for the current room that deals high damage. 0
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Black Lotus 5.100.226 Black Lotus HP up x3! Grants one Red Heart Container, one Soul HeartSoul Heart, and one Black HeartBlack Heart. 2
Blood Bag 5.100.119 Blood Bag HP up Grants one filled Red Heart container, restores 4 Red HeartRed Hearts, and increases speed by 0.3. 2
Bloody Lust 5.100.157 Bloody Lust RAGE! Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor. 2
Breakfast 5.100.25 Breakfast HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Broken Watch 5.100.337 Broken Watch I think it's broken Slows all enemies in every fourth newly-discovered room, with a small chance to speed them up instead. 1
Bucket of Lard 5.100.129 Bucket of Lard HP up (except in Repentance) Grants two empty Red Heart containers, heals Isaac for a Half Red HeartHalf Red Heart, -0.2 speed.
(in Repentance) Grants two Red Heart containers, -0.2 speed.
1
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul HeartSoul Hearts. Grants Collectible The Wafer iconThe Wafer effect for the current room after taking damage. 3
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Collectible Book of Shadows iconBook of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
Charm of the Vampire 5.100.62 Charm of the Vampire DMG up + kills heal Heals Isaac for a Half Red HeartHalf Red Heart for every 13 enemies killed. (in Repentance) +0.3 damage. 1
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red HeartRed Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second. 0
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight. 3
Dessert 5.100.24 Dessert HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Dinner 5.100.23 Dinner HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering Collectible The Necronomicon iconThe Necronomicon effect. 3
E. Coli 5.100.236 E Turdy touch Enemies that touch Isaac are transformed into PoopPoop. 1
Fanny Pack 5.100.204 Fanny Pack Filled with goodies Has a chance to drop a random pickup when Isaac takes damage. 1
Fate 5.100.179 Fate Flight eternal Grants flight and one Eternal HeartEternal Heart. 3
Gimpy 5.100.225 Gimpy Sweet suffering Gives chance of spawning a Soul HeartSoul Heart when taking damage. Enemies have a chance to drop a Half Red HeartHalf Red Heart after being killed. 2
Gnawed Leaf 5.100.210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. 1
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals (except in Repentance) 105 /(in Repentance) 52.5 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guppy's Collar 5.100.212 Guppy's Collar Eternal life? Grants a permanent 50% chance to respawn with 1/2 of a Red HeartRed Heart after death. 1
Habit 5.100.156 Habit Item martyr When Isaac is hit, his active item gains 1 room's worth of charge. 2
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 2
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 3
Holy Mantle 5.100.313 Holy Mantle Holy shield Grants a shield that negates the first instance of damage taken, once per room. Does not apply to or negate self-damage (Blood Donation MachineBlood Donation Machines, etc). 4
Infamy 5.100.242 Infamy Blocks damage... sometimes Gives Isaac a 50% chance to block projectiles coming from any direction. 2
Infestation 5.100.148 Infestation Fly revenge (except in Repentance) 1-3 Blue Flies randomly spawn every time Isaac gets hit.
(in Repentance) 2-6 Blue Flies
0
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. (in Repentance) The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Judas' Shadow 5.100.311 Judas' Shadow Sweet revenge Upon death, respawns Isaac as Character Dark Judas iconDark Judas with two Black HeartBlack Hearts in the previous room. 3
Lazarus' Rags 5.100.332 Lazarus' Rags Eternal life? (except in Repentance) Upon dying, resurrect as Character Lazarus Risen iconLazarus Risen in the current room with one Red Heart container and Collectible Anemic iconAnemic.
(in Repentance) Upon dying, resurrect as Character Lazarus Risen iconLazarus Risen in the current room with one less Red Heart container, Collectible Anemic iconAnemic, and +0.5 Damage. Transform into Character Lazarus iconLazarus when reaching the next floor.
1
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red HeartHalf Red Heart every 3 rooms. 2
Lord of the Pit 5.100.82 Lord of the Pit Demon wings Grants flight and +0.3 speed. 3
Lunch 5.100.22 Lunch HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Maggy's Bow 5.100.312 Maggy's Bow HP up + you feel healthy Gives one Red Heart Container and doubles the healing provided by Red HeartRed Hearts. (in Repentance) Also heals 1 Red Heart when obtained. 2
Magic Scab 5.100.253 Magic Scab HP + luck up Grants one full Red Heart container, +1 luck. (in Repentance) Heals 1 additional Red HeartRed Heart. 2
Magneto 5.100.53 Magneto Item snatcher Pulls pickups towards Isaac. 1
MEAT! 5.100.193 MEAT! DMG + HP up Grants one full Red Heart container, +0.3 damage. (in Repentance) Heals 1 additional Red HeartRed Heart 2
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop PennyPennies. 2
Missing Page 2 5.100.262 Missing Page 2 Evil up. Your enemies will pay! Grants one Black HeartBlack Heart. Upon taking damage that reduces Isaac's health to one heart or less, deals damage to all enemies in the room. (in Repentance) Increases the damage of Black HeartBlack Hearts and Collectible The Necronomicon iconThe Necronomicon-like effects by 40. 0
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red HeartRed Heart pickups into Soul HeartSoul Hearts instead. 3
Old Bandage 5.100.219 Old Bandage HP up Grants an empty Red Heart container. Adds a chance of dropping a Red HeartRed Heart after taking damage. 2
Ouija Board 5.100.115 Ouija Board Spectral tears + tears up Grants spectral tears that travel through obstacles (but not enemies). (in Repentance) +0.5 tears. 2
Piggy Bank 5.100.227 Piggy Bank My life savings Gives 3 PennyPennies on pick-up. Every time Isaac is damaged, he will drop one or two additional pennies. 1
Placenta 5.100.218 Placenta Regeneration + HP up Grants one full Red Heart container, and a chance to regenerate a Half Red HeartHalf Red Heart of health every minute of gameplay. 2
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a MulliganMulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Pyromaniac 5.100.223 Pyromaniac It hurts so good +5 bombs +5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. (in Repentance) Also grants immunity to fire. 4
Raw Liver 5.100.16 Raw Liver HP up Grants 2 Red Heart containers and completely restores health. 2
Rosary 5.100.72 Rosary Tears + faith up Grants 3 Soul HeartSoul Hearts. Causes Collectible The Bible iconThe Bible to appear in any item pool. (in Repentance) +0.5 tears. 2
Rotten Meat 5.100.26 Rotten Meat HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. 2
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles. 1
Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul HeartSoul Heart. 2
Sharp Plug 5.100.205 Sharp Plug Infinite charge... at a cost Damages Isaac in exchange for fully recharging Isaac's current activated item. 2
Skatole 5.100.9 Skatole Fly love Flies become harmless or less dangerous depending on the type. 0
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 2
Spiderbaby 5.100.211 Spiderbaby Spider revenge (except in Repentance) Spawns 1-2 Blue Spiders when Isaac takes damage.
(in Repentance) Spawns 3-5 Blue Spiders when Isaac takes damage.
0
Spirit of the Night 5.100.159 Spirit of the Night Scary Grants spectral tears and flight. 3
Stem Cells 5.100.176 Stem Cells HP + shot speed up Grants one full Red Heart container and +0.16 shot speed. (in Repentance) Heals 1 additional Red HeartRed Heart 1
Stigmata 5.100.138 Stigmata DMG + HP up +0.3 damage, grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 2
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... (in Rebirth)+0.3 speed. Automatically inflicts slow to all enemies in every room.
(in Afterbirth and Afterbirth †)+0.3 speed. Upon taking damage, inflicts slow to all enemies for the current room.
(in Repentance)+0.3 speed. Slows all enemies in every room to 80% speed.
4
Super Bandage 5.100.92 Super Bandage +2 hearts Grants one full Red Heart container and 2 Soul HeartSoul Hearts. 2
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the Collectible My Little Unicorn iconMy Little Unicorn effect for 5 seconds. 1
The Black Bean 5.100.180 The Black Bean Toot on touch (except in Repentance) When taking damage, Isaac farts, poisoning enemies in range.
(in Repentance) When taking damage, Isaac farts five times, poisoning and knocking back nearby enemies and leaving lingering poison clouds.
0
The Body 5.100.334 The Body I feel all Adds 3 Red Heart Containers. 3
The Ladder 5.100.60 The Ladder Building bridges Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. 1
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul HeartSoul Heart after clearing enough rooms. 3
The Soul 5.100.335 The Soul I am all Grants two Soul HeartSoul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles. 3
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. (except in Repentance) -0.1 speed. (in Repentance) +0.2 speed. (in Afterbirth and Afterbirth †) Poisoned enemies have a chance to drop a black heart when killed. 2
The Wafer 5.100.108 The Wafer Damage resistance Most sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead. 4
Thunder Thighs 5.100.314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed. 1
Transcendence 5.100.20 Transcendence We all float down here... Grants flight. 3
Trinity Shield 5.100.243 Trinity Shield You feel guarded Isaac gains a shield that protects him from enemy shots. It aims in the direction Isaac fires from. 2
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 2
Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
Circle of Protection 5.100.423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears. 2
Crack Jacks 5.100.354 Crack Jacks HP up. Don't swallow the prize! Grants one full Red Heart container and drops a random trinket. (in Repentance) Heals 1 additional Red HeartRed Heart. 2
Curse of the Tower 5.100.371 Curse of the Tower Embrace chaos Upon taking damage, spawns six Troll BombTroll Bombs around the room, similar to the effect of XVI - The TowerXVI - The Tower. 0
Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black HeartBlack Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2
Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
Host Hat 5.100.375 Host Hat Blast resistance A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. 3
Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 1
Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room. 1
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! (except in Repentance) Inflicts fear on all enemies in the room upon taking damage and spawns black friendly ChargerChargers that attack enemies.
(in Repentance)Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly ChargerCharger whenever an enemy touches it.
2
Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots. 1
PJs 5.100.428 PJs You feel cozy Grants 4 Soul HeartSoul Hearts and fully restores Isaac's health. 2
Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal HeartEternal Heart. 3
Adrenaline 5.100.493 Adrenaline Panic = power Increases damage based on how many empty Red Heart containers Isaac has. 2
Blanket 5.100.535 Blanket You feel Safe Grants one Soul HeartSoul Heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears. 2
Bozo 5.100.513 Bozo Party time! +0.1 flat damage, grants a Soul HeartSoul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a Rainbow PoopRainbow Poop. 2
Brittle Bones 5.100.549 Brittle Bones Everything hurts Replaces all Red HeartRed Heart Containers with 6 empty Bone HeartBone Hearts. (except in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a tears up. (in Repentance) Upon losing a Bone Heart, Isaac fires bones in 8 directions and permanently gains a fire rate up. 3
Broken Modem 5.100.514 Broken Modem Lag! Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. 3
Cone Head 5.100.457 Cone Head Hard headed! Grants a Soul HeartSoul Heart. Gives Isaac a chance to ignore any damage taken. 2
Dad's Ring 5.100.546 Dad's Ring Father's blessing Creates a ring of light around Isaac that petrifies enemies in contact. 3
Dark Prince's Crown 5.100.442 Dark Prince's Crown Loss is power (except in Repentance) When at exactly one Red HeartRed Heart, +0.75 tears, +1.5 range, and +0.2 shot speed.
(in Repentance) When at exactly one Red HeartRed Heart, +2 fire rate, +1.5 range, and +0.2 shot speed.
1
Greed's Gullet 5.100.501 Greed's Gullet Money = health! Grants a Red Heart container for every 25 PennyCoins Isaac has. 1
Hallowed Ground 5.100.543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a White PoopWhite Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. (in Repentance) The aura also increases damage by 20% and gives homing. 1
Leprosy 5.100.525 Leprosy You're tearing me apart! Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. 1
Marbles 5.100.538 Marbles Choking hazard Spawns 3 random trinkets. Taking damage has a 5% chance to swallow Isaac's currently held trinket, gaining its effect permanently. 2
Marrow 5.100.541 Marrow HP up? Grants one Bone HeartBone Heart and spawns three Red HeartRed Hearts. 1
Metal Plate 5.100.449 Metal Plate It itches... Grants one Soul HeartSoul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears. 1
Midnight Snack 5.100.456 Midnight Snack HP up Grants one full Red Heart container. (in Repentance) Heals 1 additional Red HeartRed Heart. 1
Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage. 1
Shard of Glass 5.100.448 Shard of Glass Blood and guts! (except in Repentance) Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
(in Repentance) Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red HeartRed Heart.
1
Slipped Rib 5.100.542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots. 2
Varicose Veins 5.100.452 Varicose Veins I'm leaking... Taking damage releases a ring of 10 high damage tears. 1
2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear. 1
A Pound of Flesh 5.100.672 A Pound of Flesh Blood money Devil deals now cost PennyCoins, ShopShop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Astral Projection 5.100.677 Astral Projection The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Belly Jelly 5.100.690 Belly Jelly Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 3
Binge Eater 5.100.664 Binge Eater All you can eat +1 Red Heart Container and fully heals Isaac. Item pedestals also offer a random food item. Picking up a food item temporarily grants +3.6 damage and permanently boosts 2 stats. 4
Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Collectible Dead Bird iconDead Bird. 1
Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his Red HeartRed Hearts. Increases damage and speed for the floor based on the amount drained. 1
Bloody Gust 5.100.695 Bloody Gust May your rage bring haste The first 6 times Isaac takes damage on a given floor, he gains Speed and Fire Rate for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively. 2
Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Candy Heart 5.100.671 Candy Heart Power of love Gives Isaac a permanent stat boost whenever he heals with Red HeartRed Heart pickups. 1
Cracked Orb 5.100.675 Cracked Orb Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Divine Intervention 5.100.568 Divine Intervention Double tap shield Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. 2
Empty Heart 5.100.676 Empty Heart It multiplies If Isaac has one red heart or fewer at the beginning of a floor, he gains an empty red heart container. 1
Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. 1
Heartbreak 5.100.694 Heartbreak Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Hypercoagulation 5.100.724 Hypercoagulation Thick blooded After Isaac takes damage from an enemy or donates health, launches Red HeartRed Hearts from Isaac that despawn after 1.5 seconds. 2
Inner Child 5.100.688 Inner Child Let him free Upon death, Isaac respawns in the current room with half of a Red HeartRed Heart, a massive size down, and +0.2 Speed. 2
It Hurts 5.100.560 It Hurts No it doesn't... Releases a ring of tears and increases fire rate for the current room when Isaac takes damage. 1
Lost Soul 5.100.612 Lost Soul Protect him Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul HeartSoul Hearts, Eternal HeartEternal Hearts, or an Item. 2
Orphan Socks 5.100.571 Orphan Socks Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 Soul HeartSoul Hearts. 2
Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and blocks enemy shots. 4
Sanguine Bond 5.100.692 Sanguine Bond He awaits your offering Spawns a special set of spikes in the Devil RoomDevil Room. Taking damage from the spikes has a chance to grant a reward. 1
Spirit Shackles 5.100.674 Spirit Shackles Unfinished business On death, Isaac's ghost is chained to his dead body and he can continue to fight with 1/2 of a heart, returning to life after 10 seconds. After it activates, it must be recharged by picking up a Soul HeartSoul Heart. 2
Supper 5.100.707 Supper HP up Grants one full Red Heart container. Heals 1 additional Red HeartRed Heart. 1
The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Boss Teratoma ingameTeratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 1

Strategy[ | ]

With only a single Holy CardHoly Card for defense, defensive items become just as important as offensive ones, as taking more than a single hit in the entire run may prove fatal. However, because all items not marked as "offensive" will automatically be rerolled, defensive options available are less plentiful.

  • A good way to secure a powerful run is to visit as many Boss Challenge RoomBoss Challenge Rooms as possible. It is possible for the player to use the alternate floors to their advantage by sticking to the second floor of each chapter. By visiting DownpourDownpour II / DrossDross II, the player can also get an extra boss item from the Mirrored World. This strategy comes with the added risk of having to fight more bosses, but provides the potential to snowball the player's stats and make later floors much easier to survive in.
  • Be careful of any ChestChests, which could be a Mimic chest RepentanceMimic Chest or a Haunted ChestHaunted Chest.
  • Skulls can be a source of finding cards which in turn can be a Holy CardHoly Card.
  • Waiting before using the Holy CardHoly Card until after the Shop has been found in case a Collectible Blank Card iconBlank Card is available for sale can prove helpful.
  • Be wary of taking items that automatically attack enemies in case they kill exploding enemies nearby. Items like Collectible 120 Volt icon120 Volt, Collectible Demon Baby iconDemon Baby and items that spawn blue flies.

Items Interactions[ | ]

Favored Items[ | ]

These items provide significant benefits to Tainted Lost.

  • Ace of SpadesAce of Spades: Chance of changing the room drop reward to a card, and chance of getting a card as additional rewards from certain things, indirectly increasing the chance of getting a Holy Card.
  • Collectible Birthright iconBirthright: Grants an extra life, respawning in the same room and damaging nearby enemies.
    • This extra life item is the only one that can be naturally obtained as Tainted Lost, as all others are rerolled.
    • Taking a hit and using Birthright counts as taking damage and will affect items accordingly, such as losing PerfectionPerfection.
    • Summoning Birthright with Collectible Lemegeton iconLemegeton will grant infinite lives until the wisp is destroyed.
  • Collectible Blank Card iconBlank Card: Allows a four charge reuse of the Holy Card.
    • Collectible 9 Volt icon9 Volt and AAA BatteryAAA Battery each reduce the charge time required by one bar.
    • Collectible The Battery iconThe Battery allows storing an extra use of Blank Card, useful in case you take a hit multiple times in a short period.
  • Collectible Bone Spurs iconBone Spurs: Especially useful against enemies that spawn bullets or other enemies on death, as they will often be instantly blocked or damaged/killed, respectively.
  • Collectible Book of Shadows iconBook of Shadows: Very powerful in combination with Panic ButtonPanic Button and Collectible 4.5 Volt icon4.5 Volt.
  • Collectible Book of the Dead iconBook of the Dead: The Bone orbitals spawned from this item can block projectiles, greatly increasing survivability.
  • Collectible Book of Virtues iconBook of Virtues / Collectible Lemegeton iconLemegeton: Rings of wisps can block a lot of projectiles.
  • Collectible Booster Pack iconBooster Pack: Has about a 40% chance of spawning a Holy Card.
  • Collectible Camo Undies iconCamo Undies: Allows Tainted Lost to be invisible upon entering a room and plan out his first attack.
  • Collectible Clear Rune iconClear Rune: Can be used with protective runes like Rune of AlgizRune of Algiz or Soul of BethanySoul of Bethany. Similarly, Soul of the LostSoul of the Lost can be used for a single-use Collectible Holy Mantle iconHoly Mantle for the current room.
  • Collectible Clicker iconClicker: Becoming Tainted Lost by using Clicker allows Tainted Lost to keep all previously collected items. This allows many useful defensive items that Tainted Lost normally can't collect.
  • Collectible Coupon iconCoupon: Allows an extra item to be taken from devil deals.
  • Collectible Cursed Eye iconCursed Eye: The downside of the item is inconsequential due to Tainted Lost's lack of health.
  • Collectible D1 iconD1 / Collectible D infinity iconD infinity /Dice BagDice Bag: Cards duplicated by D1's effect have an increased chance to be Holy Cards.
  • Collectible Damocles iconDamocles: The downside of the item is inconsequential due to Tainted Lost's lack of health.
    • The item can still kill Tainted Lost if resurrected by Collectible Birthright iconBirthright or any other acquired respawn item.
  • Collectible Dark Arts iconDark Arts: Provides a powerful panic button to escape swarms of enemies and/or bullets.
  • Collectible Deck of Cards iconDeck of Cards: Allows more chances for Holy Cards.
  • Collectible Death Certificate iconDeath Certificate: Tainted Lost can now obtain defensive items, as Death Certificate's item generation ignores Tainted Lost's changes to item availability. This is extremely beneficial, as Tainted Lost can now obtain extra lives such as Collectible Dead Cat iconDead Cat and protective items such as Collectible Holy Mantle iconHoly Mantle.
  • Collectible Echo Chamber iconEcho Chamber: The next three consumables used after Holy Card will grant another mantle.
  • Endless NamelessEndless Nameless: Has a 25% chance to spawn another Holy Card when one is used.
  • Flat FileFlat File: Retracts almost all spikes and allows free Curse RoomCurse Room entrance.
  • Collectible The Gamekid iconThe Gamekid / Collectible My Little Unicorn iconMy Little Unicorn: On-demand invincibility with contact damage.
  • Collectible Glass Cannon iconGlass Cannon: High damage shots that allow removal of especially dangerous enemies fast. The downside of the item only comes into effect upon use of a reviving item and not from consuming a Holy Mantle.
  • Collectible Glitter Bombs iconGlitter Bombs: Bombs may drop a Holy Card when exploding.
  • Collectible Glowing Hourglass iconGlowing Hourglass: Allows recovery of a Holy Card shield.
  • Collectible Guppy's Tail iconGuppy's Tail: can increase the amount of Locked ChestLocked Chests found in a run, and thus allows more chances for Holy Cards to appear.
  • Homing tears: Allows Tainted Lost to safely position himself almost anywhere in a room while still dealing damage.
  • Collectible Little Horn iconLittle Horn / Collectible Euthanasia iconEuthanasia: can destroy almost all "invulnerable" enemies (e.g. PokyPoky, Stone GrimaceStone Grimace) before they can hurt Tainted Lost. However, Ball and ChainBall and Chain are still invulnerable and dangerous.
  • Collectible Lost Contact iconLost Contact: Blocks projectiles.
  • VI - The Lovers?VI - The Lovers?: Can be safely used to generate items with no loss of durability or risk of death.
  • Collectible Mercurius iconMercurius / Door StopDoor Stop: Most rooms can be checked for a safe plan of attack, or bypassed entirely.
  • Missing PosterMissing Poster: Allows a one-time revival upon death, respawning Tainted Lost in the previous room.
  • Panic ButtonPanic Button: Could save Tainted Lost from death when combining with suitable active items.
  • Collectible Paschal Candle iconPaschal Candle: Taking a hit and consuming a Holy Mantle effect allows it to stay at maximum level.
  • Collectible Pause iconPause: Can be used with a damaging orbital to get lots of damage on bosses for free.
  • PerfectionPerfection: +10 luck with no downside. Tainted Lost's lack of health make losing it during the run less likely as only using a reviving item will consume Perfection. Luck-based tear effects such as Collectible Apple! iconApple!, Collectible Tough Love iconTough Love, Collectible Holy Light iconHoly Light, and Collectible Euthanasia iconEuthanasia benefit greatly from this extra luck, while also making sure Tainted Lost has a steady supply of pickups from room clear rewards.
    • Collectible Bird's Eye iconBird's Eye and Collectible Ghost Pepper iconGhost Pepper are exceptionally powerful combined with high luck: at 10 luck, every tear has a 50% chance to be accompanied by a powerful flame that blocks enemy projectiles. This becomes even more potent when both items are held, as all tears will fire one of these two flames at only 7 luck.
  • Collectible Placebo iconPlacebo: Protective pills like Power Pill or Feels Like I'm Walking on Sunshine may be helpful.
  • Collectible Pluto iconPluto: Smaller size makes you harder to hit.
  • Soul of LazarusSoul of Lazarus: Acts as a substitute to Holy Card at the cost of losing Perfection.
  • Collectible Spindown Dice iconSpindown Dice: Allows Tainted Lost to obtain items otherwise hard-coded to not spawn for them.
  • Collectible Starter Deck iconStarter Deck: Increases the chances of finding Holy Cards and allows pill-generating items to spawn Holy Cards.
  • Collectible Teleport 2.0 iconTeleport 2.0 / Golden Broken RemoteBroken Remote / Teleporting cards: allows Tainted Lost to leave Curse RoomCurse Rooms safely.
  • Collectible The Stairway iconThe Stairway: Creates a ladder to an Angel RoomAngel Room shop at the start of every floor, with the shop potentially selling powerful Angel Room Item Pool items and Holy Cards.
  • Collectible Telekinesis iconTelekinesis: Can be used to block projectiles or enemies.
  • Collectible Tooth and Nail iconTooth and Nail: Timed invincibility allows exiting Curse RoomCurse Rooms safely.
  • Collectible Uranus iconUranus: Frozen enemies will not be able to spawn hazards (tears, explosives, other enemies) on death. Icicles from frozen enemies can also slow other enemies and potentially cause a chain reaction, freezing a whole group of enemies.
  • Wooden CrossWooden Cross: A single-use Holy Mantle per floor. Note that it does not break before Holy Card, thus it is wise to save them for when the shield from Wooden Cross is broken.

Disfavored Items[ | ]

These items provide significant drawbacks to Tainted Lost.

  • Any explosive tear effect, such as Collectible Fire Mind iconFire Mind or Collectible Ipecac iconIpecac, greatly increases the chance of fatal self-damage. Since Collectible Host Hat iconHost Hat and Collectible Pyromaniac iconPyromaniac cannot naturally appear as Tainted Lost, there are very few ways to reliably avoid explosive self-damage.
  • The Stompy effect makes firing from cover impossible – all but removing a safe method for Tainted Lost to attack non-flying enemies.
  • Collectible Finger! iconFinger!: May destroy TNT accidentally.
  • Collectible Little Baggy iconLittle Baggy: Holy Cards will no longer spawn.
  • Collectible IBS iconIBS: The effects of poop caused by damaging enemies is completely random, which can lead to an accidental death or mantle loss.
    • Butt bombs may hurt you if you aren't paying attention, gas clouds from stinky poop could explode in a chain back to you if thrown at fires, and farts generate a gas cloud that will explode if you are next to a fire, leading to an untimely death.

Neutral Items[ | ]

These items can provide both benefits and drawbacks to Tainted Lost.

  • Although items which provide temporary invincibility such as Collectible A Pony iconA Pony and Collectible Mars iconMars can allow Tainted Lost to negate damage, their effects are difficult to time, and could result in charging into an enemy and being damaged.
  • Collectible Buddy in a Box iconBuddy in a Box: The familiar's potential tear effects are the same as Collectible Fruit Cake iconFruit Cake, and as such have a small risk of carrying Collectible Fire Mind iconFire Mind for a floor.
  • Collectible Dead Sea Scrolls iconDead Sea Scrolls: Can cause items such as Collectible Anarchist Cookbook iconAnarchist Cookbook to trigger, potentially causing damage, but may also spawn a Holy Card via Collectible Deck of Cards iconDeck of Cards.
  • Collectible Experimental Treatment iconExperimental Treatment: HP is not a factor for Tainted Lost, so it may be included as one of the two stats which are reduced. However, it is more likely to be included as a stat increase, which has no effect.
  • Collectible Lemegeton iconLemegeton: Can give Tainted Lost very useful items, such as Collectible Birthright iconBirthright, allowing him to have infinite lives until the wisp is destroyed, but it can also give run-ending items such as Collectible Ipecac iconIpecac. Because Lemegeton's effect is random, this is completely out of the player's control. If a very bad wisp is gained using Lemegeton, it is recommended to destroy it as soon as possible, but be cautious as this could result in taking damage.
  • Collectible Monster Manual iconMonster Manual: Can spawn Collectible Bob's Brain iconBob's Brain or Collectible Lil Delirium iconLil Delirium, which may cause unavoidable damage to the player. However, it can spawn many useful familiars too.
  • Collectible Number One iconNumber One: Decreasing maximum range exposes Tainted Lost to danger, but increasing fire rate may make it easier to defeat enemies.
  • Collectible Sulfuric Acid iconSulfuric Acid /Collectible Terra iconTerra: Can skip rooms entirely by breaking doors but also prevent firing from cover.
  • Collectible Teleport! iconTeleport! : Can teleport Tainted Lost away from a dangerous room or before a fatal mistake is made. However, the player can teleport to a Curse RoomCurse Room (or to a Secret Room whose only opened exit is a Curse Room) which is inescapable without a Holy Card.

Unlockable Items[ | ]

Gallery[ | ]

Trivia[ | ]

  • While items like Collectible A Dollar iconA Dollar, Collectible Knife Piece 1 iconKnife Piece 1, and Collectible Knife Piece 2 iconKnife Piece 2 are not considered items that the Tainted Lost can find, they will still appear for him if the conditions for finding them are met.
  • While Harbingers will still drop Collectible Ball of Bandages iconBall of Bandages or Collectible Cube of Meat iconCube of Meat, Boss C.H.A.D. ingameC.H.A.D. will not drop Collectible Little C.H.A.D. iconLittle C.H.A.D..
  • If invincibility is used to play Blood Donation Machines, they can still produce a Collectible Blood Bag iconBlood Bag as a reward.
  • The achievement for unlocking Tainted Lost is "The Baleful", a possible title for the character.
    • "Baleful" means "ominous" or "harmful or malignant in intent or effect", possibly referring to how Tainted Lost has higher base damage than his regular counterpart and can find better items.
    • A more archaic meaning of "Baleful" is "Something/Someone wretched or miserable", and considering how Tainted Lost is incapable of using defensive heavy builds, being constantly at the mercy of enemies and dying usually at two hits, fit with this use of the word.
    • "The Baleful" is Tainted Lost's character name in Four Souls.
  • Before the 1.7.5 update, it was possible for Tainted Lost to find Collectible Yuck Heart iconYuck Heart and Collectible Best Bud iconBest Bud, despite these items being useless for the character.
    • Additionally, Collectible Heartbreak iconHeartbreak could be found and utilized to essentially gain 4 extra lives and extra damage, but was removed from the tag list.
  • Tainted Lost's unlock drawing could be a reference to a transition nightmare Isaac can have, depicting The Lost talking to Boss Mom ingameMom from the attic.
  • Tainted Lost unlocks 0 - The Fool?0 - The Fool?; the character can be linked to both the numeration and meaning of the Fool.
    • The Fool's numeration can be either 0 the lowest trump or 22 the highest trump, linked to his attributes — better items, no mantle, no health — as Tainted Lost will die in a single hit at any point, but can also build the strongest runs of any character because of those same attributes.
    • Reverse fool means apathy and nullity; this approach is often recommended to face Tainted Lost's runs because of how demanding the character is and how easy it is to lose these runs despite how powerful the character can become.
    • In a literal reversal of "the beginning of the journey" which The Fool represents, Tainted Lost represents the complete end of Isaac's existence, after his own mortal remains has vanished and even his own soul erodes into dust and cobwebs along with the house and material objects that hold his last remnant memories.
  • Tainted Lost's starting health is listed as "?" on the character selection screen.


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