- When picked up, all future items become "Glitched", causing them to become random combinations of 2-3 effects based on other items.
- Additionally, the currently playing music will fade out. The silence will remain until another music track plays.
- "Glitched" items can be passive or active and are completely randomly generated with practically infinite possibilities.
- Random effects combine effects that exist on other items, and assign them to a random event (e.g. on enemy death, on room clear, on damage taken etc.).
- These effects include effects added in mods
- Glitched items sold for money cost a random amount of pennies up to 99 pennies.
- Plot-critical items ( The Polaroid, The Negative, and Dad's Note) do NOT have immunity against TMTRAINER's effect. Picking this item up will render Chest, Dark Room, or Home inaccessible.
- TMTRAINER will not affect Knife Piece 2 due to the game suppressing TMTRAINER's effect. However, it will affect Knife Piece 1; as such, Knife Piece 1 must be picked up before obtaining TMTRAINER to gain access to the Corpse.
- TMTRAINER will affect both Key Pieces dropped by Angels, preventing Isaac from opening the door to Mega Satan this way.
- Once Corrupted Data is unlocked, the TMTRAINER effect may be randomly applied to items found in Secret and Error rooms.
- Items affected by TMTRAINER may take the effect of rerolling all of your items. This includes TMTRAINER itself, meaning any future items you encounter will not be under its effect, nor will the items obtained by rerolling due to the glitched item.
- If crashes are commonly encountered in the DELETE THIS challenge, TMTRAINER has the same effect and may be unstable.
- 'M: Rerolls glitched actives into other glitched actives.
- Bag of Crafting: Recipes are not glitched. Can craft TMTRAINER but will have no effect.
- Binge Eater: Functions as intended, cycling pedestals between a glitched item and an HP up item.
- Book of Virtues: Glitched actives spawn random wisps upon use.
- Death Certificate: TMTRAINER will not apply to Death Certificate's items.
- Diplopia: Glitched items are copied normally. Pedestals spawned before acquiring TMTRAINER will duplicate into a glitched item.
- Dream Catcher: Cannot identify glitched items.
- Genesis: No items will be offered in exchange for glitched items.
- Lemegeton: Spawns wisps of glitched items. All wisps look like The Sad Onion, but this is purely aesthetic. The wisps do not have any items' effects.
- Magic Skin: All summoned items will be glitched. Magic Skin cannot replace future glitched items after being left behind.
- Missing No.: Can reroll TMTRAINER, but not any previously acquired glitched items.
- Modeling Clay: Cannot transform into glitched items. Will visually vanish from sight, but is still held and can be dropped as normal.
- Spindown Dice: Glitch items will disappear if rerolled.
- The name and description of the item comes from the result of glitches in Pokémon Red and Blue. Certain glitch moves in that game can have names so long they run into the memory, corrupting it and causing glitchy effects, like the opponent's name becoming "TMTRAINER". A certain other glitch (commonly referred to as the ZZAZZ glitch) replaces the letters in the player's name with capital Zs except for every third letter.
- The sprite is a reference to how sprites corrupt in Pokémon Red and Blue, especially after encountering glitch Pokémon.
- The effect of the item is similar to a "Randomizer" for other games.
- The music fading out upon acquiring the item is a direct reference to the effects of TMTRAINER in Pokémon Red and Blue, which fades the music out upon use until another song is triggered to play (assuming the game survives the effects).
- The item's effect is a reference to an old randomizer mod that came out before Afterbirth+.
- The pickup quote for the item is defined as "Isaac and his mother lived alone in a small house on a hill", but is different in game, with the pattern of Zs overlaid on top.
- This item is used in DELETE THIS (challenge #45).
- DELETE THIS will always be unlocked before TMTRAINER on any given file. This item, The Small Rock, Dirty Mind, and Spirit Sword are the only items that appear in challenges before they are unlocked. Small Rock and TMTRAINER are also notable for not being unlocked by beating the challenge they appear in.
- MEAT!, YO LISTEN!, and TMTRAINER are the only ALL CAPS items in the game. ( PHD is not counted since it's an acronym.)
- All glitched item sprites are shown as Mega Blast in Isaac's last will.
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