Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Synthoil is a passive item.


  • +1 damage.
  • Removed in Repentance +5.25 range.
  • Added in Repentance +1.5 range.
  • +0.5 tear height.
  • Added in Afterbirth This item belongs to the Spun set. Collecting three items from this set will transform Isaac into a buff berserker.

In-game Footage[]


  • Synthoil, or as it should correctly be spelled as "synthol", is a mixture of oil, lidocaine, and alcohol used to artificially increase muscle volume through scar tissue formation.


PC NFVA 693K (First floor Boss Room)

PC Added in Afterbirth † Greed mode only J2VH OJPC (First Silver Treasure Room)