Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Repentance
Disambig.png This article is about the trinket that opens the Hush fight and empowers Pandora's Box. For the trinket that creates Blue Womb rooms, see Blue Key.

Strange Key is a trinket added in The Binding of Isaac: Repentance.


  • Unlocks the passageway to ??? ???, regardless of run duration.
  • Unlocks 15►Pandora's Box Pandora's Box, giving it a new effect.
    • The normal effect of Pandora's Box for that level is ignored, and instead 6 generally higher quality items from random pools are spawned.
    • Both Pandora's Box and the trinket are consumed.


  • Both effects work even if the key has been turned into a passive item from items such as 15►Smelter Smelter or 15►Marbles Marbles.
    • Using Pandora's Box with the key in this state will remove the key from Isaac's Inventory.
  • If playing with modal characters such as Tainted Lazarus Tainted Lazarus, the character with the Strange Key must enter the room while holding it to cause the passage to open. Leaving and re-entering the room after switching to the correct character will open the door normally.
  • Unlike with 15►Mama Mega! Mama Mega!, It Lives must be beaten for the passageway to ??? ??? to open.

In-game Footage[]


  • Strange Key is likely a reference to the film by David Lynch, Mulholland Drive (2001), where a small blue box being unlocked by a strange key is a major plot point.