Binding of Isaac: Rebirth Wiki

Added in Afterbirth †
Disambig.png This article is about the trinket. For the item, see Stem Cells.

Stem Cell is an unlockable trinket added in The Binding of Isaac: Afterbirth †.


  • Removed in Repentance Heals for a Half Red Heart Half Red Heart upon traveling to the next floor.
  • Added in Repentance Heals 50% of Isaac's empty Red Heart Red Hearts and Bone Heart Bone Hearts (rounded down), but at minimum a half heart, upon traveling to the next floor.


  • Glowing Hour Glass Glowing Hour Glass: Returning to a previous floor will keep the health gained from Stem Cell, as well as granting another half-red heart after going down to the next floor again.
  • Added in Repentance Tainted Magdalene Tainted Magdalene: Heals a lot of health back, usually resulting in full red health.


In-game Footage[]


  • A Stem Cell is an undifferentiated cell of a multicellular organism that is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cells arise by differentiation.