Binding of Isaac: Rebirth Wiki

(in Afterbirth † and Repentance)
This article is about the trinket. For the item, see Stem Cells.

Stem Cell is an unlockable trinket added in The Binding of Isaac: Afterbirth †.

Effect[ | ]

  • (except in Repentance) Heals for a Half Red HeartHalf Red Heart upon traveling to the next floor.
  • (in Repentance) Heals 50% of Isaac's empty Red HeartRed Hearts and Bone HeartBone Hearts (rounded down), but at minimum a half heart, upon traveling to the next floor.

Synergies[ | ]

  • Collectible Blood Oath iconBlood Oath: The healing will occur before any health is drained, allowing for a greater stat bonus.
  • Collectible Glowing Hourglass iconGlowing Hourglass: Returning to a previous floor will keep the health gained from Stem Cell, as well as granting another half-red heart after going down to the next floor again.
  • Character Tainted Magdalene iconTainted Magdalene: Since all red heart healing is doubled, Stem Cell will bring her to full health.

Interactions[ | ]

In-game Footage[ | ]

Trivia[ | ]

  • A Stem Cell is an undifferentiated cell of a multicellular organism that is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cells arise by differentiation.