Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †
Disambig.png This article is about the trinket. For the item, see Stem Cells.

Stem Cell is an unlockable trinket added in The Binding of Isaac: Afterbirth †.


  • Removed in Repentance Heals for half a Red Heart upon traveling to the next floor.
  • Added in Repentance Heals 50% of Isaac's empty Red Hearts and Bone Hearts (rounded down), but at minimum a half heart, upon traveling to the next floor.


  • Added in RepentanceTainted Magdalene Tainted Magdalene: heals a lot of health back, usually resulting in full red health.


  • Added in Repentance15►Blood Oath Blood Oath: The healing will occur before any health is drained.
  • Added in RepentanceTainted Bethany Tainted Bethany: Adds 1 to her "blood charges" resource.
  • 15►Glowing Hour Glass Glowing Hour Glass: Returning to a previous floor will keep the health gained from Stem Cell, as well as granting another half-red heart after going down to the next floor again.

In-game Footage[]


  • A Stem Cell is an undifferentiated cell of a multicellular organism that is capable of giving rise to indefinitely more cells of the same type, and from which certain other kinds of cells arise by differentiation.

The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets