Status Effects

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Disambig.png This article is about effects which can be inflicted on monsters. For the different kinds of effects which Isaac's primary weapon can have, see Tear Effects.

Status effects are special effects that can be inflicted on an enemy from a variety of sources, such as tears, bombs, and items. Each status effect has a color and symbol/effect associated with them for easy identification. These colorations are not to be confused with champions.

Effects[edit | edit source]

Effect Appearance Description
Burn Burn Effect.png Afflicted enemies take 4 to 6 fire damage over time, like poison. Afflicted enemies will be tinted orange for the duration and have a fire symbol above them.
Added in Afterbirth Afflicted enemies will sustain double Isaac's tear damage over time.
Charm Charm Effect.png Afflicted enemies will temporarily fight on Isaac's side, running toward other enemies and damaging them for 25% of their maximum HP per touch, 5 damage with half heart projectiles and 10 with full heart ones. If no other enemies are in the room, a charmed enemy will instead run towards Isaac. (Charmed enemies can still hurt Isaac.) Afflicted enemies will be tinted pink for the duration and have a heart symbol above them. Most enemies with ranged attacks will not fire them.
Added in Afterbirth † Charmed enemies will prioritize non-charmed enemies and won't target invincible enemies. Charmed Portals will also spawn friendly enemies.
Confusion Confusion Effect.png Afflicted enemies are slowed and walk around randomly. While confused, most non-boss enemies will be unable to attack. Afflicted enemies will be tinted pale gray and have stars above them.
Fear Fear Effect.png Afflicted enemies are scared of Isaac and will run away from him. While scared, most non-boss enemies will be unable to attack or charge towards Isaac. Afflicted enemies will be tinted purple and have a skull symbol above them.
Petrified Petrified Effect.png Afflicted enemies are stopped in place. They cannot move or attack. Afflicted enemies will be shaded brown-gray as if turned to stone (unless petrified by Midas' Touch, in which case they will be shaded gold).
Poison Poison Effect.png Afflicted enemies sustain 4 to 6 damage over time. Afflicted enemies will be tinted green and have a bubbly effect surrounding them.
Added in Afterbirth Afflicted enemies will sustain double Isaac's tear damage over time.
Slow Slow Effect.png Afflicted enemies are slowed down. Any projectiles they shoot will also be slowed down. Attacks that end when the enemy runs out of momentum, such as the charging attacks of Gurdy Jr. and Dingle, will be vastly shortened in duration. Depending on the item that triggers the slow effect, afflicted enemies will be tinted black or white with a snail icon above them.
Added in Afterbirth
Friendly
Friendly Effect.png Afflicted enemies are permanently charmed and will fight on Isaac's side until they die. Most enemies under this effect will follow Isaac across rooms, like a familiar. Friendly enemies cannot hurt Isaac. Friendly enemies are not tinted but still have heart effects.
Added in Afterbirth
Shrink
Gaper.png Afflicted enemies are shrunken and will run away from Isaac. Isaac can walk over shrunken enemies to kill them.
Added in Afterbirth †
Bleed
Bleed Effect.png Afflicted enemies take damage equal to 10% of their maximum health every 5 seconds.
Added in Repentance
Chained
50px Afflicted enemies are chained in place, preventing them from taking any action.
Added in Repentance
Frozen
50px Enemies that are killed by items that can inflict Frozen become ice statues on death that block both Isaac's tears and enemy shots. Ice statues can also be pushed by Isaac, causing them to slide until they hit an obstacle or enemy, dealing 35 damage to enemies they collide with. After an ice statue blocks 10 shots or collides with something while sliding, it shatters into a ring of 10 icicles which slow and deal 8 damage to enemies they hit. Enemies that are killed by these icicles also become ice statues.
Added in Repentance
Mark
50px Afflicted enemies will be attacked by other enemies, functioning like a reverse charm effect. Afflicted enemies are tinted red.

Notes[edit | edit source]

  • Host-type enemies will take burn and poison damage even if their skull is down, and all status effects can be applied by tears even if their skulls are down.
  • After a boss or mini-boss had a status effect applied on them, they will receive immunity against all status effects for 8 seconds. This means that no other status effect can be applied to that enemy during this period.
    • The slow effect is an exception to this rule.

Burn[edit | edit source]

Passive items that cause burning[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Fire Mind 5.100.257 Fire Mind Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion. 2

Trinkets that cause burning[edit | edit source]

Name ID Icon Quote Description
Added in Repentance A Lighter 5.350.135 A Lighter Watch the world burn Adds a chance for enemies to burn upon entering a room.

Charm[edit | edit source]

Activated items that cause charming[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Added in Afterbirth Kidney Bean 5.100.421
Kidney Bean
1 rooms
Love toots! Isaac farts, charming all nearby enemies. 0

Passive items that cause charming[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. 2
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies. 1
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. 1
Added in Afterbirth Betrayal 5.100.391 Betrayal Turn your enemy Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac. 0
Added in Afterbirth Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which Charms, Poisons, or knocks back nearby enemies. 1
Added in Afterbirth Glitter Bombs 5.100.432 Glitter Bombs Prize bombs! +5 bombs. Bombs have a chance to drop random pickups or charm enemies when they explode. 2
Added in Afterbirth † Bozo 5.100.513 Bozo Party time! Increases damage by a flat 0.1 and grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop. 2
Added in Repentance Venus 5.100.591 Venus HP up + you feel pretty Adds one red Heart container. Enemies near Isaac become charmed. 1

Pills that cause charming[edit | edit source]

Pill Effect
Pheromones Charms all enemies in the room for a short period of time.

Notes[edit | edit source]

  • First stage of Ball of Bandages cannot charm enemies. See 15►Ball of Bandages Ball of Bandages for details.
  • Charmed enemies will still target Isaac if they are the only enemy in the room.

Confusion[edit | edit source]

Passive items that cause confusion[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Butt Bombs 5.100.209 Butt Bombs Toxic blast +5 bombs +5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies. 2
Iron Bar 5.100.201 Iron Bar Concussive tears Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly. 3
Added in Afterbirth No. 2 5.100.378 No. 2 Uh oh... Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes. 2
Added in Afterbirth † Camo Undies 5.100.497 Camo Undies Camo kid Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused. 0
Added in Afterbirth † Glaucoma 5.100.460 Glaucoma Blind tears! Adds a chance to shoot tears that confuse enemies for an extremely long time. 2
Added in Afterbirth † Metal Plate 5.100.449 Metal Plate It itches... Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears. 1
Added in Repentance Knockout Drops 5.100.637 Knockout Drops They pack a punch! Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies. 3

Trinkets that cause confusion[edit | edit source]

Name ID Icon Quote Description
Added in Afterbirth Faded Polaroid 5.350.69 Faded Polaroid You feel faded Occasionally causes Isaac to blend into the ground, which briefly confuses all enemies in the room.

Fear[edit | edit source]

Activated items that cause fear[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Mom's Pad 5.100.41
Mom's Pad
3 rooms
Gross... Inflicts fear to all enemies in the room for 5 seconds. 0
The Gamekid 5.100.93
The Gamekid
4 rooms
Temporary Man-Pac Turns Isaac into a into a Pac-Man-like creature for 6 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing a Half Red Heart for every two enemies killed. 2

Passive Items that cause fear[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Abaddon 5.100.230 Abaddon Evil + DMG up + fear shot Grants +1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears. 4
Dark Matter 5.100.259 Dark Matter Fear shot +1 damage, adds a chance to shoot fear tears. 3
Mom's Perfume 5.100.228 Mom's Perfume Fear shot Adds a chance to shoot fear tears and decreases tear delay by 1. 2
Added in Afterbirth My Shadow 5.100.433 My Shadow Me! And my shaaaadow! Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much. 0
Added in Afterbirth Spear of Destiny 5.100.400 Spear of Destiny Your destiny In addition to tears, Isaac holds a spear in front of him which deals contact damage equal to 2x his tear damage, and occasionally inflicts fear. 1
Added in Afterbirth † Bozo 5.100.513 Bozo Party time! Increases damage by a flat 0.1 and grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop. 2
Added in Repentance 2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear. 2

Pills that cause fear[edit | edit source]

Pill Effect
Added in Afterbirth Power Pill! Temporarily grants invulnerability, inflicts fear on enemies in the room, and lets Isaac deal contact damage, similar to 15►The Gamekid The Gamekid.

Petrification[edit | edit source]

Activated items that petrify enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Mom's Bra 5.100.39
Mom's Bra
3 rooms
Mass Fear Petrifies all enemies in the current room for around 4 seconds. 1
The Boomerang 5.100.338
The Boomerang
4 seconds
It will never leave you Throws a boomerang which retrieves pickups, as well as damages and petrifies enemies hit for 2 seconds. 1
Added in Afterbirth Mega Bean 5.100.351
Mega Bean
3 rooms
Giga fart! Petrifies all enemies in the current room for a couple of seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing. 1

Passive items that petrify enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Holy Water 5.100.178 Holy Water Splash! Removed in Repentance Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep. The bottle respawns upon entering a different room.
Added in Repentance A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies. The bottle respawns after a few seconds.
0
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop coins. 2
Mom's Contacts 5.100.110 Mom's Contacts Freeze effect +0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. 3
Added in Afterbirth Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' Battery, gives an activate item charge, or petrifies all enemies in the room. 3
Added in Afterbirth † Dad's Ring 5.100.546 Dad's Ring Father's blessing Creates a ring of light around Isaac that petrifies enemies in contact. 3
Added in Afterbirth † Eye of Greed 5.100.450 Eye of Greed Gold tears! Every 20 tears, Isaac loses 1 coin and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins. 2
Added in Repentance Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2

Trinkets that petrify enemies[edit | edit source]

Name ID Icon Quote Description
Added in Repentance Ice Cube 5.350.188 Ice Cube Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.

Other sources that petrify enemies[edit | edit source]

  • Added in Afterbirth † Losing a Gold Heart briefly turns all nearby enemies into gold.

Poison[edit | edit source]

Activated items that poison enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Bob's Rotten Head 5.100.42
Bob's Rotten Head
2 rooms
Reusable ranged bomb Upon use, Isaac holds a poison bomb which can be thrown in the cardinal directions and explodes on impact. 1
The Bean 5.100.111
The Bean
1 rooms
Toot on command Isaac farts, poisoning any enemy in close range. 0
Added in Afterbirth Mega Bean 5.100.351
Mega Bean
3 rooms
Giga fart! Petrifies all enemies in the current room for a couple of seconds, poisons any enemies near Isaac, and sends a rock wave across the room in the direction Isaac is facing. 1

Passive items that poison enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Bob's Curse 5.100.140 Bob's Curse +5 poison bombs Gives 5 bombs and grants Isaac's bombs a poison effect. 1
Ipecac 5.100.149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. 4
Scorpio 5.100.305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted. 2
The Black Bean 5.100.180 The Black Bean Toot on touch When taking damage, Isaac farts, causing poison damage to all enemies in range. 0
The Common Cold 5.100.103 The Common Cold Poison Damage Adds a chance to shoot poison tears, dealing damage over time when inflicted. 1
The Virus 5.100.13 The Virus Poison touch Inflicts poison to enemies who make contact with Isaac. Speed down. Added in Afterbirth / Removed in RepentancePoisoned enemies have a chance to drop a black heart when killed. 0
Added in Afterbirth Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which Charms, Poisons, or knocks back nearby enemies. 1
Added in Afterbirth Serpent's Kiss 5.100.393 Serpent's Kiss The kiss of death Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a black heart when killed. 4
Added in Afterbirth Toxic Shock 5.100.350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short lasting pool of green creep on the ground. 3
Added in Afterbirth † Acid Baby 5.100.491 Acid Baby Pills pills pills! Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. 2
Added in Afterbirth † Contagion 5.100.466 Contagion Outbreak! The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death. 2
Added in Afterbirth † Dead Tooth 5.100.446 Dead Tooth Halitosis While firing, Isaac gains a green aura that poisons nearby enemies. 1
Added in Repentance Jupiter 5.100.594 Jupiter You're a gas giant! +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves with increased speed. 3

Trinkets that poison enemies[edit | edit source]

Name ID Icon Quote Description
Pinky Eye 5.350.30 Pinky Eye Poison shots Adds a 10% chance to shoot a poison tear, dealing damage over time when inflicted.
Added in Afterbirth † Black Tooth 5.350.95 Black Tooth It looks dead Adds a chance to fire a black tooth that deals double damage and poisons enemies.
Added in Afterbirth † Locust of Pestilence 5.350.114 Locust of Pestilence I bring Pestilence Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.
Added in Repentance Torn Card 5.350.157 Torn Card Death awaits Adds a chance to shoot an 15►Ipecac Ipecac + 15►My Reflection My Reflection tear.

Pills that poison enemies[edit | edit source]

Pill Effect
Bad Gas Isaac farts, poisoning enemies around him.

Slow[edit | edit source]

Activated items that slow enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Spider Butt 5.100.171
Spider Butt
2 rooms
Mass enemy slowdown + damage Deals 10 damage to all enemies in the room and slows them for 4 seconds. 1
The Hourglass 5.100.66
The Hourglass
2 rooms
Temporary enemy slowdown All enemies in the room are slowed for 8 seconds. 1

Passive items that slow enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Ball of Tar 5.100.231 Ball of Tar Sticky feet... Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed. 2
Broken Watch 5.100.337 Broken Watch I think it's broken Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up. 1
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. 2
Spider Bite 5.100.89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. 2
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... Removed in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth / Removed in Repentance Upon taking damage, inflicts slow to all enemies for the current room.
Added in Repentance Slows all enemies in every room to roughly half speed.
4
Added in Afterbirth Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
Added in Afterbirth Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots. 2
Added in Afterbirth † Large Zit 5.100.502 Large Zit Creep shots Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep. 1
Added in Afterbirth † Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
Added in Repentance Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Added in Repentance The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
Added in Repentance Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. 3

Trinkets that slow enemies[edit | edit source]

Name ID Icon Quote Description
Added in Afterbirth † Locust of Famine 5.350.115 Locust of Famine I bring Famine Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies.
Added in Repentance Chewed Pen 5.350.130 Chewed Pen It's leaking Adds a chance to fire tears that slow enemies.

Notes[edit | edit source]

Friendly Added in Afterbirth[edit | edit source]

Activated items that create friendly enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Friendly Ball 5.100.382
Friendly Ball
2 rooms
Gotta fetch 'em all! Throwing the ball at a monster instantly kills and captures it. The captured enemy can later be released and will be friendly, fighting for Isaac and persisting between rooms. 1
Added in Afterbirth † Book of the Dead 5.100.545
Book of the Dead
6 rooms
Rise from the grave Upon use, spawns a friendly Bony or an orbital bone for each enemy killed in the current room. 2
Added in Afterbirth † Delirious 5.100.510
Delirious
12 rooms
Unleash the power! Spawns Delirium as a random friendly boss that fights for Isaac. 1
Added in Repentance Friend Finder 5.100.687
Friend Finder
4 rooms
Best friends forever! Spawns a random friendly monster that mimics Isaac's movements and attacks. 3
Added in Repentance Plum Flute 5.100.650
Plum Flute
4 rooms
Play time! Summons the boss Baby Plum to fight for Isaac in the current room. 2

Passive items that create friendly enemies[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much. 0
Added in Afterbirth † Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room. 1
Added in Afterbirth † Poke Go 5.100.505 Poke Go Gotta catch em... Upon entering a room with enemies in it, has a chance to spawn a random friendly enemy that persists across rooms. 0
Added in Afterbirth † Shade 5.100.468 Shade It follows Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers. 0
Added in Repentance Dirty Mind 5.100.576 Dirty Mind Filthy friends Destroying poop spawns friendly Dips that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. 2

Shrink[edit | edit source]

Passive items that grant shrinking tears[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
God's Flesh 5.100.398 God's Flesh Shrink shot Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them. 1

Bleed Added in Afterbirth †[edit | edit source]

Passive items that inflict bleed[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
Backstabber 5.100.506 Backstabber Watch your back! Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac. 1
Mom's Razor 5.100.508 Mom's Razor It's sharp! Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. 1

Chained Added in Repentance[edit | edit source]

Activated items that inflict chained[edit | edit source]

Name ID Icon Quote Description Quality
Anima Sola 5.100.722
Anima Sola
30 seconds
Repent Chains down the nearest enemy for 5 seconds, preventing them from acting. 2

Frozen Added in Repentance[edit | edit source]

Passive items that freeze enemies[edit | edit source]

Name ID Icon Quote Description Quality
Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. 3

Trinkets that freeze enemies[edit | edit source]

Name ID Icon Quote Description
Ice Cube 5.350.188 Ice Cube Stay frosty Adds a chance to petrify enemies when entering the room. Killing the petrified enemy freezes it.

Mark Added in Repentance[edit | edit source]

Passive items that inflict mark[edit | edit source]

Name ID Icon Quote Description Quality
Rotten Tomato 5.100.618 Rotten Tomato Delicious! Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies. 1

Random[edit | edit source]

These items inflict random status effects on enemies.

Passive items that inflict random effects[edit | edit source]

Name ID Icon Quote Description Added in Repentance Quality
GB Bug 5.100.405 GB Bug Double tap glitch Removed in Repentance Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
Added in Repentance Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits. It respawns after clearing a room.
0
Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. 1
Added in Repentance Playdough Cookie 5.100.570 Playdough Cookie Tasty rainbow Grants multicolored tears. Each color comes with a different status or tear effect. 3

Other sources that inflict random effects[edit | edit source]

  • Added in Afterbirth † The Spider Baby transformation creates a spider familiar that applies random status effects to enemies that come in contact with it.


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