Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth

After picking up three distinct items from the following list, Isaac turns into a buff berserker and a random pill spawns. Isaac gains +2 damage and +0.15 speed.

  • Removed in Repentance Also affects maximum speed. Maximum speed may never exceed 2.0.

(The items in the following list consist of all of the "syringe" items in the game.)

Passive Collectibles[]

Name ID Icon Quote Description Added in Repentance Quality
Experimental Treatment 5.100.240 Experimental Treatment Some stats up, some stats down Removed in Afterbirth † Randomly increases and decreases some of Isaac's stats.
Added in Afterbirth † Increases four random stats and decreases the other two.
Growth Hormones 5.100.70 Growth Hormones Speed + DMG up Removed in Repentance +1 damage, +0.4 speed.
Added in Repentance +1 damage, +0.2 speed.
Roid Rage 5.100.14 Roid Rage Speed and range up Removed in Repentance +0.6 speed, +5.25 range, +0.5 tear height.
Added in Repentance +0.3 speed, +1.50 range, +0.5 tear height.
Speed Ball 5.100.143 Speed Ball Speed + shot speed up +0.3 speed, +0.2 shot speed. 2
Synthoil 5.100.345 Synthoil DMG + range up +1 damage, +5.25 range, +0.5 tear height. 3
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. Removed in Repentance -0.1 speed. Added in Repentance +0.2 speed. Added in Afterbirth / Removed in Repentance Poisoned enemies have a chance to drop a black heart when killed. 0
Added in Afterbirth † Adrenaline 5.100.493 Adrenaline Panic = power Increases damage based on how many empty Red Heart containers Isaac has. 1
Added in Afterbirth † Euthanasia 5.100.496 Euthanasia Needle shot Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles. 3



PC Hard mode only KG4F IN87 (First Boss item & first two treasure rooms for a 2nd floor spun)

PC Greed mode only AGZ1 DPSX (First item room, first shop item, 2nd shop item (after buying first))

PC Added in Afterbirth † 2C1H 8F60 (XL floor, The Virus from Lust, Adrenaline in one of the Treasure Rooms, and Speed Ball by second Boss Room)

Mac VXG4 BN24 (First treasure room, second and third boss room)

Mac Greed mode only 9QYB 6FFL (First two treasure rooms, 2nd Gold treasure room)

PC hard MCR91A1E (First two treasure rooms, lust mini boss room)