Spider Butt is an activated item.
Effects[ | ]
- Deals 10 damage to all enemies in the room and slows them for 4 seconds.
Enemies killed by Spider Butt spawn 1-3 Blue Spiders.- This item belongs to the Spider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.
Enemies killed by Spider Butt spawn 1-3 
This item belongs to the 
Synergies[ | ]
- Book of Virtues: Spawns white wisps in the middle ring, looking like a spider. Wisps' tears have a 7.5% chance to inflict slow on enemies.
Interactions[ | ]
- Car Battery: Deals 10 damage to enemies twice but does not increase slow effect.
In-game Footage[ | ]
Gallery[ | ]
3DS The icon of Spider Butt as seen on the lower 3DS screen
Splash image which appears when Spider Butt is activated.
Trivia[ | ]
- This item resembles the abdominal segment of a Black Widow spider.
- This item originally in Wrath of the Lamb had to be unlocked by beating a challenge titled, "Spider Boy!".
 Spider Items
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| Items |
 The Binding of Isaac: Rebirth
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