|Guppy||Beelzebub||Super Bum||Yes Mother?||Bob||Fun Guy||Leviathan||Conjoined|
|Spun||Seraphim||Oh Crap||Bookworm||Spider Baby||Adult||Stompy|
|This article is about the transformation. For the passive item, see Spider Baby.|
Upon picking up 3 spider items, Isaac will gain a Spider familiar that applies random status effects to enemies it comes into contact with. Contrary to popular belief, this transformation does not generate friendly spiders on hit. Confusingly, that effect is given by the item of the same name, which also contributes to this transformation.
|Box of Spiders||5.100.288||It's a box of spiders|| Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.
Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
|Spider Butt||5.100.171||Mass enemy slowdown + damage||Deals 10 damage to all enemies in the room and slows them for 4 seconds. Enemies killed by Spider Butt spawn Blue Spiders.||1|
|Mutant Spider||5.100.153||Quad shot||Grants quadruple shot but decreases tears.||3|
|Spider Bite||5.100.89||Slow effect||Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.||2|
|Spiderbaby||5.100.211||Spider revenge|| When hit, spawns 1-2 Blue Spiders.
When hit, spawns 3-5 Blue Spiders.
|Spider Mod||5.100.403||Mod buddy!||Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room.||1|
|Keeper's Kin||5.100.717||Under a rock||Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.||2|
|The Intruder||5.100.575||Invasive friend||A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.||3|
|Daddy Longlegs||5.100.170||Daddy's love||Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.||3|
|Hive Mind||5.100.248||Giant spiders and flies||Increases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal. Also increases the effectiveness of fly and spider familiars.||2|
|Infestation 2||5.100.234||Infestation shot||Spawns allied Blue Spiders from killed enemies.||4|
|Juicy Sack||5.100.266||Sticky babies||Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.||2|
|Sissy Longlegs||5.100.280||She loves you||Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders.||1|
|Bursting Sack||5.100.377||Spider love||Spider enemies no longer target or deal contact damage to Isaac.||1|
|Sticky Bombs||5.100.367||Egg sack bombs!||+5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.||1|
|Parasitoid||5.100.461||Egg tears!||Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.||3|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|