Binding of Isaac: Rebirth Wiki

Added in Afterbirth †
Disambig.png This article is about the transformation. For the passive item, see Spiderbaby.

Upon picking up 3 spider items (Added in Repentance 3 items with the spider item tag), Isaac will gain a Spider familiar that applies random status effects to enemies it comes into contact with. Contrary to popular belief, this transformation does not generate friendly spiders on hit. Confusingly, that effect is given by the item of the same name, which also contributes to this transformation.

Activated Collectibles[]

Name ID Icon Quote Description Added in Repentance Quality
Box of Spiders 5.100.288
Box of Spiders
2 rooms
It's a box of spiders Removed in Repentance Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.
Added in Repentance Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
Spider Butt 5.100.171
Spider Butt
2 rooms
Mass enemy slowdown + damage Deals 10 damage to all enemies in the room and slows them for 4 seconds. Added in Repentance Enemies killed by Spider Butt spawn Blue Spiders. 1

Passive Collectibles[]

Name ID Icon Quote Description Added in Repentance Quality
Mutant Spider 5.100.153 Mutant Spider Quad shot Grants quadruple shot but decreases Tears. 3
Spider Bite 5.100.89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. 2
Spiderbaby 5.100.211 Spiderbaby Spider revenge Removed in Repentance When hit, spawns 1-2 Blue Spiders.
Added in Repentance When hit, spawns 3-5 Blue Spiders.
Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery Lil' Battery/Blue spider upon clearing a room. 1
Added in Repentance Bursting Sack 5.100.377 Bursting Sack Spider love Spider enemies no longer target or deal contact damage to Isaac. 1
Added in Repentance Daddy Longlegs 5.100.170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. 3
Added in Repentance Hive Mind 5.100.248 Hive Mind Giant spiders and flies Increases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal. Added in Repentance Also increases the effectiveness of fly and spider familiars. 2
Added in Repentance Infestation 2 5.100.234 Infestation 2 Infestation shot Spawns allied Blue Spiders from killed enemies. 4
Added in Repentance Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Added in Repentance Keeper's Kin 5.100.717 Keeper's Kin Under a rock Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
Added in Repentance Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
Added in Repentance Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. 1
Added in Repentance Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 Bomb Bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. 1
Added in Repentance The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3