Binding of Isaac: Rebirth Wiki
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Special items are items in the game that are considered stronger than normal by the developers.
If Isaac sees a Special Item, subsequent Special Items have a chance of being re-rolled rather than being presented to Isaac, decreasing the likelihood of obtaining multiple Special Items on one run.
The current list of special items is as follows:

* - unlockable items

Special Item Generation

When you enter a room with an item in it, items are selected out of certain item pools depending upon the current room.
Special items have a chance of being re-rolled depending on how many special items already seen that run.
This percentage chance is 100% * (1 - 0.5 ^ (number of special items seen)).
This means, at the start, the game has a 0% chance of re-rolling the special item it generated first, then the chance increases to 50% after that, and subsequent special items seen increases the chance to 75%, 88%, 94%, and so on.

Notes

  • Isaac's D6 doesn't count as a "seen" special item, as it is directly given to him when the run starts.
  • Special items given by D4, D100, or 1- and 6-pip Dice Rooms are items generated by the game, and thus count as "seen" special items.
  • Since seeing a special item is enough, you have no way to prevent the re-roll chance from increasing, like you could do in the original by not taking special items.
  • Even if a special item will act like a normal item once it has been seen, this may not be a good idea to pick them all, as most of them are heavy tear modifiers and can override other tear items that Isaac has taken without increasing its DPS.
  • Since the re-roll chance rapidly increases to a high percentage, seeing 3-4 special items can be enough to make some special items that aren't in Treasure Room Pool (Godhead, Sacred Heart, Brimstone,..) require hundreds of D6 rolls before appearing.
    • However, these special items will always appear after a certain number of re-rolls, even if the Treasure Room Pool was emptied and Breakfast starts to appear. In these situations, infinite D6 uses and patience are required.
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