Special items are items in the game that are considered stronger than normal by the developers. If the player sees a special item, even if the player has Curse of the Blind, subsequent special items have a chance of being re-rolled rather than being presented to Isaac, decreasing the likelihood of obtaining multiple special items on one run.
Special items were a mechanic that caused particularly strong items to have a chance to be rerolled if the player had seen a different special item earlier in the run. The system was removed in Repentance, and replaced with item weight. Items instead now have varying weights affecting how often they are chosen.
The list of special items is as follows:
Brimstone- D100
- The D6
- Dr. Fetus
- Epic Fetus
- Godhead
- Lil Brimstone
- The Ludovico Technique
- Mom's Knife
- Mutant Spider
- Polyphemus
- Pyromaniac
- Sacred Heart
- Soy Milk
- Stop Watch
Special Item Generation
When Isaac enters a room with an item in it, items are selected out of certain item pools depending upon the current room. Special items have a chance of being re-rolled depending on how many special items have been seen during the run:
| Number of Special Items Seen | Re-roll Chance |
|---|---|
| 0 | 0% |
| 1 | 50% |
| 2 | 90% |
| 3 | 98% |
| 4 or more | 99% |
Notes
- Isaac's The D6 doesn't count as a "seen" special item, as it is directly given to him when the run starts.
- Special items given by the D4, the D100, 1-pip Dice Rooms, and 6-pip Dice Rooms count as "seen" special items.
- Due to the nature of special items, it can sometimes require hundreds of The D6 rolls for special items that are not in the Treasure Room pool to appear. (Note that with infinite rolls, it is always possible to see a special item as long as it is not already removed from the pools.)
 The Binding of Isaac: Rebirth
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