The following flies no longer deal contact damage, but retain their speed and can still damage Isaac through other means: Sucker, Soul Sucker, Spit, Ink, Level 2 Willo, and Mama Fly.
Flies spawned by The Husk will not become passive.
Due to being quality 0, Skatole cannot be obtained from Shell Games after Sacred Orb has been picked up.
This item makes The Duke of Flies a lot easier, as most of his attacks, which spawn flies, will instantly be converted. Staying out of his way while having Skatole can even make it so he ends up killing himself.
In-game footage[ | ]
Trivia[ | ]
Skatole is a mildly toxic white crystalline organic compound that occurs naturally in feces.
According to Edmund McMillen's First post-Repentance Lore Stream, Skatole's visual was designed first, with McMillen then working backwards to create an appropriate effect to justify an item that puts a poop on Isaac's head.
Skatole was considered as a cosmetic hat for Team Fortress 2, alongside tears, Brimstone, and Tiny Planet. It was dropped as Valve "... didn't want players running around with a wet piece of poop on their heads."