Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Skatole is a passive item.



  • This item can only be naturally obtained from the Shell Game in the arcade.
  • Beelzebub's effect overrides Skatole.
  • Removed in Repentance Flies spawned by The Husk will not become passive.

In-game Footage[]


  • Skatole is a mildly toxic white crystalline organic compound that occurs naturally in feces.
  • According to Edmund McMillen's First post-Repentance Lore Stream, Skatole's visual was designed first, with McMillen then working backwards to create an appropriate effect to justify an item that puts a poop on Isaac's head.
  • Skatole was considered as a cosmetic hat for Team Fortress 2, alongside tears, 15►Brimstone Brimstone, and 15►Tiny Planet Tiny Planet. It was dropped as Valve "... didn't want players running around with a wet piece of poop on their heads."
  • Added in Repentance This item is used in Scat Man (challenge #36).
  • Added in Repentance This item is one of the only five that count towards 2 transformations, the other four being 15►Hive Mind Hive Mind, 15►The Bible The Bible, 15►Magic Mushroom Magic Mushroom and Added in Afterbirth †15►Parasitoid Parasitoid.


Bug Bug! Skatole's slowdown effect also affects Tumors and its variants, despite them not being flies.

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