Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Skatole is a passive item.



  • This item can only be naturally obtained from the Shell Game in the arcade.
    • Added in Repentance Skatole exists in an otherwise unused shellGame item pool. This means it can also be acquired with Chaos Chaos and bosses in The Void The Void can drop it.
  • Beelzebub's effect overrides Skatole.
  • Removed in Repentance Flies spawned by The Husk will not become passive.
  • Added in Repentance Due to being quality 0, Skatole cannot be obtained from Shell Games after Added in RepentanceSacred Orb Sacred Orb has been picked up.
  • This item makes The Duke of Flies a large amount easier, as most of his attacks, which spawn flies, will instantly be converted. Staying out of his way while having Skatole can even make it so he ends up killing himself.

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  • Skatole is a mildly toxic white crystalline organic compound that occurs naturally in feces.
  • According to Edmund McMillen's First post-Repentance Lore Stream, Skatole's visual was designed first, with McMillen then working backwards to create an appropriate effect to justify an item that puts a poop on Isaac's head.
  • Skatole was considered as a cosmetic hat for Team Fortress 2, alongside tears, Brimstone Brimstone, and Tiny Planet Tiny Planet. It was dropped as Valve "... didn't want players running around with a wet piece of poop on their heads."
  • Added in Repentance This item is used in Scat Man (challenge #36).
  • Added in Repentance This item is one of the only five that count towards 2 transformations, the other four being Hive Mind Hive Mind, The Bible The Bible, Magic Mushroom Magic Mushroom and Added in Afterbirth †Parasitoid Parasitoid.


Bug Bug! Skatole's slowdown effect also affects Tumors and its variants, despite them not being flies.