Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Sinus Infection is a passive item added in The Binding of Isaac: Afterbirth †.


  • Grants a 20% chance to fire a booger that sticks to an enemy and deals damage over time.
    • Multiple boogers can stick to one enemy to deal extra damage.
    • Each booger deals damage equal to Isaac's tear damage every second.
    • The booger lasts for 60 seconds or until the enemy dies.
      • Added in Repentance The booger lasts 10 seconds.
    • Boogers cannot pierce and stick to the first enemy that they come in contact with, but will pass through fireplaces even without piercing shots.


  • The booger falls off the enemy after they die. If it hits another enemy before it touches the ground, it will stick to them and deal damage.
  • Jumping enemies or bosses like Monstro Monstro and Leaper Leapers and burrowing enemies like Round Worm Round Worms and Lump Lumps can get rid of the booger when they leap or burrow.
    • Bosses like The Harbingers or Dark One Dark One, or enemies like Oob Oob that have dash attacks do not lose the booger when they go off-screen.
  • The tear-sticking effect is similar to Explosivo Explosivo and Added in RepentanceMucormycosis Mucormycosis's.
  • Booger shots behave like piercing shots against bombs and fireplaces, making it potentially difficult to evade hostile bombs or push bombs along.
  • The Nose Goblin Nose Goblin trinket's effect is almost identical to Sinus Infection, with an added homing bonus.
    • The effects have independent chances to trigger. If Isaac has both, there is a chance to fire either homing or non-homing boogers.
  • Not affected by Luck.


  • Cricket's Body Cricket's Body: Booger tears will split into split booger tears that can attach to enemies.
  • Godhead Godhead: Shots retain their aura while stuck to an enemy, but the aura can damage only enemies other than the booger victim. If the enemy dies while duration remains, it will resume homing and will often stick to a second enemy.
  • Guppy Guppy: Every damage instance (Added in Repentance 50% of instances) that a booger shot does while attached to an enemy will trigger a fly to spawn.
  • Lachryphagy Lachryphagy: All tears have a chance to burst into boogers. Boogers will always burst into more boogers, though some of the boogers may incorrectly appear to be normal tears. When a booger sticks to an enemy, it will burst into 8 boogers which have a high chance of sticking again to the same enemy.
  • Lost Contact Lost Contact: Boogers that stick to enemies will block shots, and will not be destroyed in the process.
  • Polyphemus Polyphemus: Booger shots lose the Polyphemus pierce effect, but stick to enemies while dealing the full damage of the Polyphemus shot. Damage does not degrade.
  • Added in RepentanceSpirit Sword Spirit Sword: Swing has chance to apply booger on enemy.
  • Strange Attractor Strange Attractor: Attraction effect will remain on the booger shot stuck to an enemy. This can drag the enemy across the whole room until they reach one wall and get stuck on it, effectively disabling their normal movement.


  • Any status effect: A booger tear cannot inflict status effects, even if the booger's appearance changes.
  • Removed in Repentance Brimstone Brimstone: Overrides Sinus Infection.
    • Added in Repentance Hit enemies have a chance for a booger to be applied to them.
  • Compound Fracture Compound Fracture/The Parasite The Parasite: Booger tears will not split after killing enemies.
  • Dr. Fetus Dr. Fetus: Overrides Sinus Infection.
  • Epic Fetus Epic Fetus: Overrides Sinus Infection.
  • Holy Light Holy Light: Holy light strikes do not activate on booger shots.
  • Ipecac Ipecac: Overrides Sinus Infection. Booger tears will still appear, but will act identically to other Ipecac shots.
  • Jacob's Ladder Jacob's Ladder: Lightning strikes do not activate on booger shots.
  • The Ludovico Technique The Ludovico Technique: The large tear has a chance to stick to enemies. The tear cannot be controlled while it is stuck to an enemy, and cannot be removed until the enemy has died.
    • Added in Repentance The Ludovico tear no longer forcibly sticks to an enemy. Instead, damaging an enemy can create an individual booger that sticks to them. Can proc off of every tick of damage, multiple times on the same enemy, like usual.
  • Mom's Knife Mom's Knife: Overrides Sinus Infection.
  • Removed in Repentance Technology Technology: Overrides Sinus Infection.
    • Added in Repentance Hit enemies have a chance for a booger to be applied to them.
  • Removed in Repentance Tech X Tech X: Overrides Sinus Infection.
    • Added in Repentance Hit enemies have a chance for a booger to be applied to them.
  • Technology Zero Technology Zero: Boogers can be connected with electricity while being attached.
  • Removed in Repentance Trisagion Trisagion: Overrides Sinus Infection.
    • Added in Repentance Each shot has a chance to attach a booger tear to the affected enemy every tick.

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